LOCUS       NM_008182                855 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Mus musculus glutathione S-transferase, alpha 2 (Yc2) (Gsta2),
            mRNA.
ACCESSION   NM_008182
VERSION     NM_008182.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 855)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   2  (bases 1 to 855)
  AUTHORS   Brewer,A.C., Murray,T.V., Arno,M., Zhang,M., Anilkumar,N.P.,
            Mann,G.E. and Shah,A.M.
  TITLE     Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo
  JOURNAL   Free Radic Biol Med 51 (1), 205-215 (2011)
   PUBMED   21554947
REFERENCE   3  (bases 1 to 855)
  AUTHORS   Baur,J.A., Pearson,K.J., Price,N.L., Jamieson,H.A., Lerin,C.,
            Kalra,A., Prabhu,V.V., Allard,J.S., Lopez-Lluch,G., Lewis,K.,
            Pistell,P.J., Poosala,S., Becker,K.G., Boss,O., Gwinn,D., Wang,M.,
            Ramaswamy,S., Fishbein,K.W., Spencer,R.G., Lakatta,E.G., Le
            Couteur,D., Shaw,R.J., Navas,P., Puigserver,P., Ingram,D.K., de
            Cabo,R. and Sinclair,D.A.
  TITLE     Resveratrol improves health and survival of mice on a high-calorie
            diet
  JOURNAL   Nature 444 (7117), 337-342 (2006)
   PUBMED   17086191
REFERENCE   4  (bases 1 to 855)
  AUTHORS   Ki,S.H., Cho,I.J., Choi,D.W. and Kim,S.G.
  TITLE     Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta
            TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene
            repression
  JOURNAL   Mol Cell Biol 25 (10), 4150-4165 (2005)
   PUBMED   15870285
REFERENCE   5  (bases 1 to 855)
  AUTHORS   Thomson,R.E., Bigley,A.L., Foster,J.R., Jowsey,I.R., Elcombe,C.R.,
            Orton,T.C. and Hayes,J.D.
  TITLE     Tissue-specific expression and subcellular distribution of murine
            glutathione S-transferase class kappa
  JOURNAL   J Histochem Cytochem 52 (5), 653-662 (2004)
   PUBMED   15100242
REFERENCE   6  (bases 1 to 855)
  AUTHORS   Shibata,H., Yoshino,K., Muramatsu,M., Plass,C., Chapman,V.M. and
            Hayashizaki,Y.
  TITLE     The use of restriction landmark genomic scanning to scan the mouse
            genome for endogenous loci with imprinted patterns of methylation
  JOURNAL   Electrophoresis 16 (2), 210-217 (1995)
   PUBMED   7774561
REFERENCE   7  (bases 1 to 855)
  AUTHORS   Shibata,H., Hirotsune,S., Okazaki,Y., Komatsubara,H., Muramatsu,M.,
            Takagi,N., Ueda,T., Shiroishi,T., Moriwaki,K., Katsuki,M. et al.
  TITLE     Genetic mapping and systematic screening of mouse endogenously
            imprinted loci detected with restriction landmark genome scanning
            method (RLGS)
  JOURNAL   Mamm Genome 5 (12), 797-800 (1994)
   PUBMED   7894162
REFERENCE   8  (bases 1 to 855)
  AUTHORS   Buetler,T.M. and Eaton,D.L.
  TITLE     Complementary DNA cloning, messenger RNA expression, and induction
            of alpha-class glutathione S-transferases in mouse tissues
  JOURNAL   Cancer Res 52 (2), 314-318 (1992)
   PUBMED   1728405
REFERENCE   9  (bases 1 to 855)
  AUTHORS   Kasahara,M., Matsumura,E., Webb,G., Board,P.G., Figueroa,F. and
            Klein,J.
  TITLE     Mapping of class alpha glutathione S-transferase 2 (GST-2) genes to
            the vicinity of the d locus on mouse chromosome 9
  JOURNAL   Genomics 8 (1), 90-96 (1990)
   PUBMED   1981995
REFERENCE   10 (bases 1 to 855)
  AUTHORS   Pearson,W.R., Reinhart,J., Sisk,S.C., Anderson,K.S. and Adler,P.N.
  TITLE     Tissue-specific induction of murine glutathione transferase mRNAs
            by butylated hydroxyanisole
  JOURNAL   J Biol Chem 263 (26), 13324-13332 (1988)
   PUBMED   3417659
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138587.11.
            
            On Nov 17, 2006 this sequence version replaced NM_008182.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J03958.1, AK002712.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC138587.11        130589-130645       c
            58-166              AC138587.11        125330-125438       c
            167-218             AC138587.11        122145-122196       c
            219-351             AC138587.11        121059-121191       c
            352-493             AC138587.11        117261-117402       c
            494-625             AC138587.11        115587-115718       c
            626-855             AC138587.11        114520-114749       c
FEATURES             Location/Qualifiers
     source          1..855
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 43.65 cM"
     gene            1..855
                     /gene="Gsta2"
                     /gene_synonym="Gst2-2; Gstc-2; Gstc2"
                     /note="glutathione S-transferase, alpha 2 (Yc2)"
                     /db_xref="GeneID:14858"
                     /db_xref="MGI:MGI:95863"
     exon            1..57
                     /gene="Gsta2"
                     /gene_synonym="Gst2-2; Gstc-2; Gstc2"
                     /inference="alignment:Splign:2.1.0"
     exon            58..166
                     /gene="Gsta2"
                     /gene_synonym="Gst2-2; Gstc-2; Gstc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..748
                     /gene="Gsta2"
                     /gene_synonym="Gst2-2; Gstc-2; Gstc2"
                     /EC_number="2.5.1.18"
                     /note="GST class-alpha member 2; glutathione S-transferase
                     GT41A"
                     /codon_start=1
                     /product="glutathione S-transferase A2"
                     /protein_id="NP_032208.2"
                     /db_xref="CCDS:CCDS23359.1"
                     /db_xref="GeneID:14858"
                     /db_xref="MGI:MGI:95863"
                     /translation="MAGKPVLHYFNARGRMECIRWLLAAAGVEFEEKFIQSPEDLEKL
                     KKDGNLMFDQVPMVEIDGMKLVQTRAILNYIATKYDLYGKDMKERALIDMYTEGILDL
                     TEMIGQLVLCPPDQREAKTALAKDRTKNRYLPAFEKVLKSHGQDYLVGNRLTRVDVHL
                     LELLLYVEELDASLLTPFPLLKAFKSRISSLPNVKKFLHPGSQRKPPLDAKQIEEARK
                     VFKF"
     exon            167..218
                     /gene="Gsta2"
                     /gene_synonym="Gst2-2; Gstc-2; Gstc2"
                     /inference="alignment:Splign:2.1.0"
     exon            219..351
                     /gene="Gsta2"
                     /gene_synonym="Gst2-2; Gstc-2; Gstc2"
                     /inference="alignment:Splign:2.1.0"
     exon            352..493
                     /gene="Gsta2"
                     /gene_synonym="Gst2-2; Gstc-2; Gstc2"
                     /inference="alignment:Splign:2.1.0"
     exon            494..625
                     /gene="Gsta2"
                     /gene_synonym="Gst2-2; Gstc-2; Gstc2"
                     /inference="alignment:Splign:2.1.0"
     exon            626..855
                     /gene="Gsta2"
                     /gene_synonym="Gst2-2; Gstc-2; Gstc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cactcctctg gagctggatt gggagctgag tggagaagaa gccaggactc tcactagacc
       61 gtgaaccaca gttgctgcaa tggccgggaa gcccgtgctt cactacttca atgcccgggg
      121 cagaatggag tgcatcaggt ggctcctggc tgcagcaggg gtggagtttg aagagaagtt
      181 tatacagagt ccggaagatt tggaaaagct aaaaaaagat gggaatttga tgtttgacca
      241 agtgcccatg gtggagattg atgggatgaa gctggtgcag accagagcca ttctcaacta
      301 catcgccacc aaatatgacc tctatgggaa ggacatgaag gagagagccc tgattgacat
      361 gtatacagaa ggtattttag atctgactga aatgattggg caattggtat tatgtccccc
      421 agaccaaaga gaagccaaga ctgccttggc aaaagacagg accaaaaacc gttacttgcc
      481 tgcctttgaa aaggtgttga agagccatgg acaagactac cttgtgggca acaggctgac
      541 cagggtggac gtccacctgc tggaacttct tctctatgtt gaagagcttg atgccagcct
      601 tctgacccct ttccctctgc tgaaggcctt caagagcaga atcagcagcc tccccaatgt
      661 gaagaagttc ctacatcctg gcagccagag aaagcctccc ttggatgcaa aacaaattga
      721 agaagcaagg aaggttttca agttttagtg tggctgcatt gatggagcca cagatactgg
      781 cctctaattg tttgcaatta taaaatacaa ttgttgattc tggctattgt gcaataataa
      841 aaaattaaca actgg
//
