LOCUS       NM_008181                861 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus glutathione S-transferase, alpha 1 (Ya) (Gsta1), mRNA.
ACCESSION   NM_008181 XM_001004544 XM_001004546 XM_001005630
VERSION     NM_008181.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 861)
  AUTHORS   Habeos,G.I., Filippopoulou,F., Habeos,E.E., Kalaitzopoulou,E.,
            Skipitari,M., Papadea,P., Lagoumintzis,G., Niarchos,A.,
            Georgiou,C.D. and Chartoumpekis,D.V.
  TITLE     Maternal Calorie Restriction Induces a Transcriptional
            Cytoprotective Response in Embryonic Liver Partially Dependent on
            Nrf2
  JOURNAL   Antioxidants (Basel) 11 (11), 2274 (2022)
   PUBMED   36421460
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 861)
  AUTHORS   Chang,Y.C., Liu,F.P., Ma,X., Li,M.M., Li,R., Li,C.W., Shi,C.X.,
            He,J.S., Li,Z., Lin,Y.X., Zhao,C.W., Han,Q., Zhao,Y.L., Wang,D.N.
            and Liu,J.L.
  TITLE     Glutathione S-transferase A1 - a sensitive marker of alcoholic
            injury on primary hepatocytes
  JOURNAL   Hum Exp Toxicol 36 (4), 386-394 (2017)
   PUBMED   27198676
  REMARK    GeneRIF: GSTA1 can be detected at the early stage of low
            concentration ethanol exposure and that GSTA1 is more sensitive and
            reliable marker in ethanol-induced hepatic injury.
REFERENCE   3  (bases 1 to 861)
  AUTHORS   Liu,F., Lin,Y., Li,Z., Ma,X., Han,Q., Liu,Y., Zhou,Q., Liu,J.,
            Li,R., Li,J. and Gao,L.
  TITLE     Glutathione S-transferase A1 (GSTA1) release, an early indicator of
            acute hepatic injury in mice
  JOURNAL   Food Chem Toxicol 71, 225-230 (2014)
   PUBMED   24964013
  REMARK    GeneRIF: results suggest that GSTA1 can be detected at low
            concentrations during the early stages of acute hepatic injury and
            that GSTA1 is a more sensitive and more accurate indicator than ALT
REFERENCE   4  (bases 1 to 861)
  AUTHORS   Sohn,S.W., Jung,J.W., Lee,S.Y., Kang,H.R., Park,H.W., Min,K.U. and
            Cho,S.H.
  TITLE     Expression pattern of GSTP1 and GSTA1 in the pathogenesis of asthma
  JOURNAL   Exp Lung Res 39 (4-5), 173-181 (2013)
   PUBMED   23647087
  REMARK    GeneRIF: Report increased GSTA1 in airways of asthmatic mice.
REFERENCE   5  (bases 1 to 861)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   6  (bases 1 to 861)
  AUTHORS   Oh,S.P., Taylor,R.W., Gerecke,D.R., Rochelle,J.M., Seldin,M.F. and
            Olsen,B.R.
  TITLE     The mouse alpha 1(XII) and human alpha 1(XII)-like collagen genes
            are localized on mouse chromosome 9 and human chromosome 6
  JOURNAL   Genomics 14 (2), 225-231 (1992)
   PUBMED   1427837
REFERENCE   7  (bases 1 to 861)
  AUTHORS   Sladka,M., Michalova,K., Hejnar,J., Pravenec,M., Forejt,J. and
            Kren,V.
  TITLE     In situ hybridization of a rat cDNA probe for glutathione
            S-transferase gene Ya subunit (GST Ya) to rat chromosome 8
  JOURNAL   Folia Biol (Praha) 38 (2), 84-89 (1992)
   PUBMED   1526290
REFERENCE   8  (bases 1 to 861)
  AUTHORS   Miles,J.S., Moss,J.E., Taylor,B.A., Burchell,B. and Wolf,C.R.
  TITLE     Mapping genes encoding drug-metabolizing enzymes in recombinant
            inbred mice
  JOURNAL   Genomics 11 (2), 309-316 (1991)
   PUBMED   1685137
REFERENCE   9  (bases 1 to 861)
  AUTHORS   McLellan,L.I., Kerr,L.A., Cronshaw,A.D. and Hayes,J.D.
  TITLE     Regulation of mouse glutathione S-transferases by chemoprotectors.
            Molecular evidence for the existence of three distinct alpha-class
            glutathione S-transferase subunits, Ya1, Ya2, and Ya3, in mouse
            liver
  JOURNAL   Biochem J 276 (Pt 2) (Pt 2), 461-469 (1991)
   PUBMED   2049074
REFERENCE   10 (bases 1 to 861)
  AUTHORS   Kasahara,M., Matsumura,E., Webb,G., Board,P.G., Figueroa,F. and
            Klein,J.
  TITLE     Mapping of class alpha glutathione S-transferase 2 (GST-2) genes to
            the vicinity of the d locus on mouse chromosome 9
  JOURNAL   Genomics 8 (1), 90-96 (1990)
   PUBMED   1981995
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY080629.1, BC132572.1 and CJ228212.1.
            
            On Aug 1, 2007 this sequence version replaced NM_008181.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ947704.1, BC132572.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BY080629.1         1-17
            18-674              BC132572.1         1-657
            675-861             CJ228212.1         532-718
FEATURES             Location/Qualifiers
     source          1..861
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 43.65 cM"
     gene            1..861
                     /gene="Gsta1"
                     /gene_synonym="Gst2-1"
                     /note="glutathione S-transferase, alpha 1 (Ya)"
                     /db_xref="GeneID:14857"
                     /db_xref="MGI:MGI:1095417"
     exon            1..62
                     /gene="Gsta1"
                     /gene_synonym="Gst2-1"
                     /inference="alignment:Splign:2.1.0"
     exon            63..171
                     /gene="Gsta1"
                     /gene_synonym="Gst2-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..756
                     /gene="Gsta1"
                     /gene_synonym="Gst2-1"
                     /EC_number="2.5.1.18"
                     /note="GST class-alpha member 1; glutathione S-transferase
                     Ya; glutathione S-transferase Ya1;
                     androst-5-ene-3,17-dione isomerase;
                     13-hydroperoxyoctadecadienoate peroxidase"
                     /codon_start=1
                     /product="glutathione S-transferase A1"
                     /protein_id="NP_032207.3"
                     /db_xref="CCDS:CCDS23358.1"
                     /db_xref="GeneID:14857"
                     /db_xref="MGI:MGI:1095417"
                     /translation="MAGKPVLHYFNARGRMECIRWLLAAAGVEFEEKFIQSPEDLEKL
                     KKDGNLMFDQVPMVEIDGMKLAQTRAILNYIATKYDLYGKDMKERALIDMYSEGILDL
                     TEMIGQLVLCPPDQREAKTALAKDRTKNRYLPAFEKVLKSHGQDYLVGNRLTRVDIHL
                     LEVLLYVEEFDASLLTPFPLLKAFKSRISSLPNVKKFLQPGSQRKPPMDAKQIQEARK
                     AFKIQ"
     exon            172..223
                     /gene="Gsta1"
                     /gene_synonym="Gst2-1"
                     /inference="alignment:Splign:2.1.0"
     exon            224..356
                     /gene="Gsta1"
                     /gene_synonym="Gst2-1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..498
                     /gene="Gsta1"
                     /gene_synonym="Gst2-1"
                     /inference="alignment:Splign:2.1.0"
     exon            499..630
                     /gene="Gsta1"
                     /gene_synonym="Gst2-1"
                     /inference="alignment:Splign:2.1.0"
     exon            631..861
                     /gene="Gsta1"
                     /gene_synonym="Gst2-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcacactc ctctggagct ggactgtgag ctgagtggag aagaagccag gactctcact
       61 agaccgtgaa ccacagttgc tgcaatggcc gggaagcccg tgcttcacta cttcaatgcc
      121 cggggcagaa tggagtgcat caggtggctc ctggctgcag caggggtgga gtttgaagag
      181 aagtttatac agagtccgga agatttggaa aagctaaaaa aagatgggaa tttgatgttt
      241 gaccaagtgc ccatggtgga gattgatggg atgaagctgg cgcagaccag agccattctc
      301 aactacatcg ccaccaaata tgacctctat gggaaggaca tgaaggagag agccctgatt
      361 gacatgtatt cagaaggtat tttagatctg actgaaatga ttgggcaatt ggtattatgt
      421 cccccagacc aaagagaagc caagactgcc ttggcaaaag ataggaccaa aaaccgttac
      481 ttgcctgcct ttgaaaaggt gttgaagagc catggacaag actaccttgt gggcaacagg
      541 ctgaccaggg tggacatcca cctactggaa gttctcctct atgttgaaga gtttgatgcc
      601 agccttctga cccctttccc tctgctgaag gccttcaaga gcagaatcag cagcctcccc
      661 aatgtgaaga agttcctaca gcctggcagc cagagaaagc ctcccatgga tgcaaaacaa
      721 attcaagaag caaggaaggc tttcaagatt cagtgaagct gcattgatgg agccacagat
      781 actggcctct aatggtttgc aattataaaa agcaattgtt gatcctggct attttgcaat
      841 aataaaaaat taacaactgg t
//
