LOCUS       NM_010344               2692 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus glutathione reductase (Gsr), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_010344
VERSION     NM_010344.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2692)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2692)
  AUTHORS   Munoz-Gallardo,M.D.M., Garcia-Padilla,C., Vicente-Garcia,C.,
            Carvajal,J., Arenega,A. and Franco,D.
  TITLE     miR-195b is required for proper cellular homeostasis in the elderly
  JOURNAL   Sci Rep 14 (1), 810 (2024)
   PUBMED   38191655
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2692)
  AUTHORS   Robbins,M.E., Cho,H.Y., Hansen,J.M., Luchsinger,J.R., Locy,M.L.,
            Velten,M., Kleeberger,S.R., Rogers,L.K. and Tipple,T.E.
  TITLE     Glutathione reductase deficiency alters lung development and
            hyperoxic responses in neonatal mice
  JOURNAL   Redox Biol 38, 101797 (2021)
   PUBMED   33254076
REFERENCE   4  (bases 1 to 2692)
  AUTHORS   Zhang,L., Virgous,C. and Si,H.
  TITLE     How Does Ginsenoside Rh2 Mitigate Adipogenesis in Cultured Cells
            and Obese Mice?
  JOURNAL   Molecules 25 (10), 2412 (2020)
   PUBMED   32455850
  REMARK    GeneRIF: How Does Ginsenoside Rh2 Mitigate Adipogenesis in Cultured
            Cells and Obese Mice?
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2692)
  AUTHORS   Kim,V.Y., Batty,A., Li,J., Kirk,S.G., Crowell,S.A., Jin,Y.,
            Tang,J., Zhang,J., Rogers,L.K., Deng,H.X., Nelin,L.D. and Liu,Y.
  TITLE     Glutathione Reductase Promotes Fungal Clearance and Suppresses
            Inflammation during Systemic Candida albicans Infection in Mice
  JOURNAL   J Immunol 203 (8), 2239-2251 (2019)
   PUBMED   31501257
REFERENCE   6  (bases 1 to 2692)
  AUTHORS   Firth,S., Peters,J. and Bulfield,G.
  TITLE     Activity and electrophoretic mobility of glutathione reductase
            allozymes in different tissues of the mouse
  JOURNAL   Biochem Genet 17 (3-4), 229-232 (1979)
   PUBMED   486069
REFERENCE   7  (bases 1 to 2692)
  AUTHORS   Kozak,C.A. and Ruddle,F.H.
  TITLE     Assignment of the genes for thymidine kinase and galactokinase to
            Mus musculus chromosome 11 and the preferential segregation of this
            chromosome in Chinese hamster/mouse somatic cell hybrids
  JOURNAL   Somatic Cell Genet 3 (2), 121-133 (1977)
   PUBMED   204065
REFERENCE   8  (bases 1 to 2692)
  AUTHORS   Francke,U., Lalley,P.A., Moss,W., Ivy,J. and Minna,J.D.
  TITLE     Gene mapping in Mus musculus by interspecific cell hybridization:
            assignment of the genes for tripeptidase-1 to chromosome 10,
            dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome
            12, and adenylate kinase-1 to chromosome 2
  JOURNAL   Cytogenet Cell Genet 19 (2-3), 57-84 (1977)
   PUBMED   198184
REFERENCE   9  (bases 1 to 2692)
  AUTHORS   Kozak,C., Nichols,E. and Ruddle,F.H.
  TITLE     Gene linkage analysis in the mouse by somatic cell hybridization:
            assignment of adenine phosphoribosyltransferase to chromosome 8 and
            alpha-galactosidase to the X chromosome
  JOURNAL   Somatic Cell Genet 1 (4), 371-382 (1975)
   PUBMED   1235912
REFERENCE   10 (bases 1 to 2692)
  AUTHORS   Nichols,E.A. and Ruddle,F.H.
  TITLE     Polymorphism and linkage of glutathione reductase in Mus musculus
  JOURNAL   Biochem Genet 13 (5-6), 323-329 (1975)
   PUBMED   1180875
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC056357.1 and BQ178602.1.
            
            On Nov 14, 2007 this sequence version replaced NM_010344.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056357.1, AK159678.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1235              BC056357.1         1-1235
            1236-1437           BQ178602.1         546-747
            1438-2598           BC056357.1         1438-2598
            2599-2692           BC056357.1         2600-2693
FEATURES             Location/Qualifiers
     source          1..2692
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 20.69 cM"
     gene            1..2692
                     /gene="Gsr"
                     /gene_synonym="D8Ertd238e; Gr-1; Gr1"
                     /note="glutathione reductase"
                     /db_xref="GeneID:14782"
                     /db_xref="MGI:MGI:95804"
     exon            1..542
                     /gene="Gsr"
                     /gene_synonym="D8Ertd238e; Gr-1; Gr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             303..1805
                     /gene="Gsr"
                     /gene_synonym="D8Ertd238e; Gr-1; Gr1"
                     /EC_number="1.8.1.7"
                     /note="glutathione reductase, mitochondrial; GR; GRase;
                     glutathione reductase 1"
                     /codon_start=1
                     /product="glutathione reductase, mitochondrial precursor"
                     /protein_id="NP_034474.4"
                     /db_xref="CCDS:CCDS22235.1"
                     /db_xref="GeneID:14782"
                     /db_xref="MGI:MGI:95804"
                     /translation="MALLPRALGVGAAPSLRRAARALTCAMASPGEPQPPAPDTSSFD
                     YLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMH
                     DHVDYGFQSCEGKFSWHVIKQKRDAYVSRLNTIYQNNLTKSHIEIIHGYATFADGPRP
                     TVEVNGKKFTAPHILIATGGVPTVPHESQIPGASLGITSDGFFQLEDLPSRSVIVGAG
                     YIAVEIAGILSALGSKTSLMIRHDKVLRNFDSLISSNCTEELENAGVEVLKFTQVKEV
                     KKTSSGLELQVVTSVPGRKPTTTMIPDVDCLLWAIGRDPNSKGLNLNKVGIQTDEKGH
                     ILVDEFQNTNVKGVYAVGDVCGKALLTPVAIAAGRKLAHRLFECKQDSKLDYDNIPTV
                     VFSHPPIGTVGLTEDEAVHKYGKDNVKIYSTAFTPMYHAVTTRKTKCVMKMVCANKEE
                     KVVGIHMQGIGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR"
     exon            543..569
                     /gene="Gsr"
                     /gene_synonym="D8Ertd238e; Gr-1; Gr1"
                     /inference="alignment:Splign:2.1.0"
     exon            570..658
                     /gene="Gsr"
                     /gene_synonym="D8Ertd238e; Gr-1; Gr1"
                     /inference="alignment:Splign:2.1.0"
     exon            659..728
                     /gene="Gsr"
                     /gene_synonym="D8Ertd238e; Gr-1; Gr1"
                     /inference="alignment:Splign:2.1.0"
     exon            729..876
                     /gene="Gsr"
                     /gene_synonym="D8Ertd238e; Gr-1; Gr1"
                     /inference="alignment:Splign:2.1.0"
     exon            877..931
                     /gene="Gsr"
                     /gene_synonym="D8Ertd238e; Gr-1; Gr1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1031
                     /gene="Gsr"
                     /gene_synonym="D8Ertd238e; Gr-1; Gr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1118
                     /gene="Gsr"
                     /gene_synonym="D8Ertd238e; Gr-1; Gr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1277
                     /gene="Gsr"
                     /gene_synonym="D8Ertd238e; Gr-1; Gr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1389
                     /gene="Gsr"
                     /gene_synonym="D8Ertd238e; Gr-1; Gr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1521
                     /gene="Gsr"
                     /gene_synonym="D8Ertd238e; Gr-1; Gr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1655
                     /gene="Gsr"
                     /gene_synonym="D8Ertd238e; Gr-1; Gr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..2672
                     /gene="Gsr"
                     /gene_synonym="D8Ertd238e; Gr-1; Gr1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2652..2657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gsr"
                     /gene_synonym="D8Ertd238e; Gr-1; Gr1"
                     /note="hexamer: TATAAA"
     polyA_site      2672
                     /gene="Gsr"
                     /gene_synonym="D8Ertd238e; Gr-1; Gr1"
                     /note="major polyA site"
ORIGIN      
        1 gtttagttgg cagctccatc tcagtccgtt ctttaagctt cctctatgga tcacaaaaaa
       61 tcatttcggc cactccactc attattccag cctttttttc ttcttcattt tacgagtacc
      121 aagtgccctg aaagcggaaa gtaggttaag gcctgcagga atccgagaag ctgggggtgg
      181 ggaaacaaaa cctgcacgtt ctcgccctcg gtccacgcgc tgcggggcgg ggacaggggc
      241 cctcgggcgc ggtgcttagt cacggcgacg ctgcaccccg ctcccggcgc gcacttccgc
      301 gcatggcgct gctgccccgg gcgctgggcg tgggcgcggc cccgagcctg cggcgggcag
      361 cgcgcgcgct cacctgcgcc atggcgagtc ccggcgagcc gcagcccccg gccccggaca
      421 cctcttcctt cgactacctg gtgatcggcg gcggctccgg cgggctggcc agcgcgcggc
      481 gggcggcgga gctcggcgcc agggccgcgg tggtggagag tcacaagctg ggtggcactt
      541 gcgtgaatgt tggatgtgta cccaaaaagg taatgtggaa cacagcagtg cactcggaat
      601 tcatgcacga tcacgtggat tacggctttc aaagctgtga gggtaaattc agttggcatg
      661 tcatcaagca gaaaagggat gcctatgtga gccgcctgaa caccatctat caaaataatt
      721 taaccaagtc tcacatagaa attatccacg gctatgcaac attcgcagat ggtcctcggc
      781 ccacggtgga agtcaatggg aaaaagttta ccgctccaca catcctgatt gccacaggag
      841 gcgtgcccac agttcctcac gagagccaga tcccaggcgc cagcctgggg atcaccagtg
      901 atggcttctt tcagctggag gacttgccca gccgcagcgt catcgtgggg gccgggtaca
      961 ttgctgtgga gatcgcgggc atcctctctg ccctgggctc caagacatct cttatgatca
     1021 ggcatgataa ggtactgaga aattttgatt cactcatcag ttccaactgc accgaggaac
     1081 tggagaatgc cggcgtggag gtgttgaagt tcacacaggt taaggaagta aaaaagacat
     1141 catcaggcct ggagctccaa gtggtgactt ccgtgcctgg taggaagccc accacgacca
     1201 tgattccaga tgttgactgc ctgctctggg ccattggacg ggacccaaat tctaagggcc
     1261 tgaatctgaa taaagtgggc attcagacgg atgaaaaggg ccacatccta gtagacgaat
     1321 tccagaatac caatgtcaaa ggcgtctatg ctgtgggaga cgtctgtggg aaagcgcttc
     1381 tcaccccagt tgcaatcgct gctggccgga aacttgccca tagactgttt gaatgcaaac
     1441 aagattccaa attagactat gacaacatcc ctactgtggt cttcagccac ccccctattg
     1501 ggaccgtggg gctcactgaa gacgaagctg ttcataagta tgggaaagac aatgtgaaaa
     1561 tctactcgac tgcctttacc ccgatgtatc acgctgtgac cacgaggaag acgaaatgcg
     1621 tcatgaagat ggtttgtgcc aacaaagagg aaaaggtggt tggcattcac atgcagggga
     1681 ttggctgtga tgagatgctg cagggcttcg ctgtagcggt gaaaatgggg gccaccaagg
     1741 ccgacttcga caacacagtt gccattcatc ctacctcttc agaggagctg gtcaccctgc
     1801 gctgagagcc tggggaccca ggtggctagc ggtgcgacca gcaggcctcc gggaggaacc
     1861 gatcgagttt acgcccagct tctacagatc tctgtatttt aatcaggaat ttctggtggt
     1921 gtaaatttcc agctatacac acgcacagaa gaacttatgt atctaatcag aaggttgttt
     1981 tgttaatccg gggttggttt tcatttgata atatttataa ttaatatttt gatttttttg
     2041 ttgttgttta attaacagcc ttgtgtttgt tgtgtttttc ttgctttggc cccattccaa
     2101 gtttaaatgt acatgacata cactcaagtt agtgtacctg atggatgaat attgctggct
     2161 aatttctttt attttttatt tttttccttt ttttatgcag cccaaggtgg cctcaaacaa
     2221 ctcagaatcc tccagctata gcctcatggg tgctggaatt ctaggcctgc atggcctctc
     2281 ctggcctagc ttgctagttt tatatgatgg gaagtctgca gaatatacgt ggtatttttg
     2341 ttctgtattg gaaagctgcc ccaatgttac ctctctattc ttgttttatt ctttgctctg
     2401 tgttaaatga tttaaaatgg tttgtgttat tttcatggaa caaagtgcat taaagttaga
     2461 cttgaggctg gttaggtaaa ggagaaatga cagtacatgc aagacggaag gctgaggcac
     2521 tcgggagccc tttcttcttc tgagtattcc tggttcattc agtcatttct gtatctctgc
     2581 gtttgttttt ttttttttgt tttgtttttt atgaaaactg ttccaaattt ttgaaattca
     2641 ctgcattgtc ttataaaatt tattacgaac taaaaaaaaa aaaaaaaaaa aa
//
