LOCUS       NM_146066               6856 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus G1 to S phase transition 1 (Gspt1), transcript variant
            1, mRNA.
ACCESSION   NM_146066
VERSION     NM_146066.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6856)
  AUTHORS   Sasayama,T., Hamada,T., Tanaka,K., Nagashima,H., Yamanishi,S. and
            Ueyama,T.
  TITLE     Potential of GSPT1 as a novel target for glioblastoma therapy
  JOURNAL   Cell Death Dis 15 (8), 572 (2024)
   PUBMED   39117611
  REMARK    GeneRIF: Potential of GSPT1 as a novel target for glioblastoma
            therapy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6856)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6856)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6856)
  AUTHORS   Ishii,T., Ueyama,T., Shigyo,M., Kohta,M., Kondoh,T., Kuboyama,T.,
            Uebi,T., Hamada,T., Gutmann,D.H., Aiba,A., Kohmura,E., Tohda,C. and
            Saito,N.
  TITLE     A Novel Rac1-GSPT1 Signaling Pathway Controls Astrogliosis
            Following Central Nervous System Injury
  JOURNAL   J Biol Chem 292 (4), 1240-1250 (2017)
   PUBMED   27941025
  REMARK    GeneRIF: Rac1-GSPT1 represents a novel signaling axis in astrocytes
            that accelerates proliferation in response to inflammation, which
            is one important factor in the development of astrogliosis/glial
            scar following CNS injury
REFERENCE   5  (bases 1 to 6856)
  AUTHORS   Li,X., Rayman,J.B., Kandel,E.R. and Derkatch,I.L.
  TITLE     Functional role of Tia1/Pub1 and Sup35 prion domains: directing
            protein synthesis machinery to the tubulin cytoskeleton
  JOURNAL   Mol Cell 55 (2), 305-318 (2014)
   PUBMED   24981173
REFERENCE   6  (bases 1 to 6856)
  AUTHORS   Alkalaeva,E.Z., Pisarev,A.V., Frolova,L.Y., Kisselev,L.L. and
            Pestova,T.V.
  TITLE     In vitro reconstitution of eukaryotic translation reveals
            cooperativity between release factors eRF1 and eRF3
  JOURNAL   Cell 125 (6), 1125-1136 (2006)
   PUBMED   16777602
REFERENCE   7  (bases 1 to 6856)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 6856)
  AUTHORS   Hoshino,S., Imai,M., Mizutani,M., Kikuchi,Y., Hanaoka,F., Ui,M. and
            Katada,T.
  TITLE     Molecular cloning of a novel member of the eukaryotic polypeptide
            chain-releasing factors (eRF). Its identification as eRF3
            interacting with eRF1
  JOURNAL   J Biol Chem 273 (35), 22254-22259 (1998)
   PUBMED   9712840
REFERENCE   9  (bases 1 to 6856)
  AUTHORS   Doggett,N.A. and Callen,D.F.
  TITLE     Report and abstracts of the third international workshop on human
            chromosome 16 mapping 1994. Pittsburgh, Pennsylvania, May 7-9, 1994
  JOURNAL   Cytogenet Cell Genet 68 (3-4), 165-184 (1995)
   PUBMED   7842732
REFERENCE   10 (bases 1 to 6856)
  AUTHORS   Hoshino,S., Miyazawa,H., Enomoto,T., Hanaoka,F., Kikuchi,Y.,
            Kikuchi,A. and Ui,M.
  TITLE     A human homologue of the yeast GST1 gene codes for a GTP-binding
            protein and is expressed in a proliferation-dependent manner in
            mammalian cells
  JOURNAL   EMBO J 8 (12), 3807-3814 (1989)
   PUBMED   2511002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB631229.1, AK148603.1, AC087541.23 and CJ260597.1.
            
            On Jul 10, 2008 this sequence version replaced NM_146066.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148603.1, AK030760.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-561               BB631229.1         2-562
            562-2196            AK148603.1         459-2093
            2197-6713           AC087541.23        88072-92588
            6714-6856           CJ260597.1         278-420
FEATURES             Location/Qualifiers
     source          1..6856
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 6.38 cM"
     gene            1..6856
                     /gene="Gspt1"
                     /gene_synonym="G1st; Gst-1"
                     /note="G1 to S phase transition 1"
                     /db_xref="GeneID:14852"
                     /db_xref="MGI:MGI:1316728"
     exon            1..683
                     /gene="Gspt1"
                     /gene_synonym="G1st; Gst-1"
                     /inference="alignment:Splign:2.1.0"
     exon            684..719
                     /gene="Gspt1"
                     /gene_synonym="G1st; Gst-1"
                     /inference="alignment:Splign:2.1.0"
     exon            720..761
                     /gene="Gspt1"
                     /gene_synonym="G1st; Gst-1"
                     /inference="alignment:Splign:2.1.0"
     exon            762..989
                     /gene="Gspt1"
                     /gene_synonym="G1st; Gst-1"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1023
                     /gene="Gspt1"
                     /gene_synonym="G1st; Gst-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1101
                     /gene="Gspt1"
                     /gene_synonym="G1st; Gst-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1282
                     /gene="Gspt1"
                     /gene_synonym="G1st; Gst-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1437
                     /gene="Gspt1"
                     /gene_synonym="G1st; Gst-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1578
                     /gene="Gspt1"
                     /gene_synonym="G1st; Gst-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1672
                     /gene="Gspt1"
                     /gene_synonym="G1st; Gst-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1753
                     /gene="Gspt1"
                     /gene_synonym="G1st; Gst-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1927
                     /gene="Gspt1"
                     /gene_synonym="G1st; Gst-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2017
                     /gene="Gspt1"
                     /gene_synonym="G1st; Gst-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2186
                     /gene="Gspt1"
                     /gene_synonym="G1st; Gst-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..6826
                     /gene="Gspt1"
                     /gene_synonym="G1st; Gst-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2648..2653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gspt1"
                     /gene_synonym="G1st; Gst-1"
                     /note="hexamer: AATAAA"
     polyA_site      2667
                     /gene="Gspt1"
                     /gene_synonym="G1st; Gst-1"
                     /note="major polyA site"
     regulatory      6806..6811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gspt1"
                     /gene_synonym="G1st; Gst-1"
                     /note="hexamer: AATAAA"
     polyA_site      6826
                     /gene="Gspt1"
                     /gene_synonym="G1st; Gst-1"
ORIGIN      
        1 gggaactacc gaggcgaagg tacgggtggt agcgagaggt caattctctc caaacgtggg
       61 gttggcggtg aggccggcgg cggtagttgg ggttgggtgg gaggagatcc tttcgcacac
      121 acgaggaggg ttgagccgct gtcgacctgg tctcgagtgt actgtctgga ctgtagctgc
      181 tgcccaggac gccggcgagt gagtcattga ctgtcagctc cccagtcttg ccgtcctccc
      241 cgggtcagcg cggcctgctc ctccccggtc ggccgccccc gcctccattt cccgccctct
      301 cttcaccaca cacacggccc ccccgatcat ggatcctagc agcggcggtg gcggcggtgg
      361 cggcggcggc gggagcagca gcagcagcga ctctgcgccc gactgctggg accagacgga
      421 tatggaggcc cccgggcccg ggccttgcgg cggcggcggg agcggcagcg gctccatggc
      481 cgcggtggcc gaggcccagc gtgagaacct cagcgcggct ttcagccggc aactcaacgt
      541 caacgccaag cctttcgtcc ccaacgtcca cgccgctgaa ttcgtgccgt ccttcctgcg
      601 gggtccggcc cagccgccgc tatccccagc tggcgcagcc ggaggcgacc acggagcagg
      661 cagcggcgcg ggaggccctt cggaacctgt agagtcctct caagaccagt cgtgtgaagg
      721 ttcaaattct actgttagca tggaactttc agaacctgtt gtagaaaatg gagagacaga
      781 aatgtcccca gaagaatcat gggagcacaa agaagaaata agtgaagcgg agccaggggg
      841 tggttcctca ggagatggaa ggccaccaga ggaaagcacc caagaaatga tggaggagga
      901 ggaagaaata ccgaaaccta agtcagcggt ggcaccacca ggtgctccca agaaggaaca
      961 tgtaaatgta gtgttcatcg gacatgttga tgcaggcaag tcaaccattg gaggacaaat
     1021 aatgtatttg actggaatgg tcgacaaaag gacacttgag aagtatgaac gagaagctaa
     1081 agaaaaaaac agagaaactt ggtacttgtc ttgggcctta gacacgaatc aggaagaacg
     1141 agacaagggc aaaaccgtgg aggtgggtcg tgcctatttt gaaacggaaa agaagcattt
     1201 tacaattcta gatgctcctg gccataagag ttttgtccca aatatgattg gtggtgcctc
     1261 tcaagctgac ttggctgtac tggtaatctc agccaggaaa ggagagtttg aaactggatt
     1321 tgaaaaagga ggacagacaa gagaacatgc aatgttggca aagacagcag gtgtcaaaca
     1381 cttaattgtg cttattaata agatggatga tccaacggta aactggagca acgagagata
     1441 tgaagaatgt aaagagaaac tagtaccatt tttgaaaaaa gttggcttca atcccaaaaa
     1501 ggacattcat tttatgccgt gctcaggact gacaggagcg aatcttaaag aacaatcaga
     1561 tttctgtcct tggtacattg gcttaccatt tattccatat ctggataatt tgccaaactt
     1621 caatagatca gttgatggac caatcaggct gccaattgtc gataagtaca aggatatggg
     1681 gactgtggtc ctgggaaagc tggaatctgg atctatttgt aaaggccagc agcttgtaat
     1741 gatgccaaat aagcacaacg tggaagttct tggaatactt tctgatgatg tagaaacgga
     1801 ctctgtagct ccaggtgaaa acctcaaaat cagactgaaa ggaattgaag aggaagagat
     1861 tcttccagga ttcatccttt gtgatcttaa taatctttgt cattctggac gcacatttga
     1921 tgctcagata gtgattatag agcacaagtc catcatctgc ccagggtata atgcggtgct
     1981 gcatattcat acctgtatcg aagaagtcga aataacagcc ttaatctgct tggtagacaa
     2041 gaaatcagga gagaaaagta agactcgacc ccgttttgta aaacaagatc aagtatgcat
     2101 tgcgcgttta aggacagcag gaaccatctg cctggagacc tttaaggact tccctcagat
     2161 gggacgtttt accttaagag atgagggtaa gaccattgca attggaaaag ttctgaaact
     2221 ggttccagag aaagactaag cattttcttg atgaccctgc acaatactgt gaggaaaatt
     2281 gactgcaaaa gcctacttca caccgccttc tcttactttc tgcccattga caaacctctc
     2341 cccatacttt gcaaagaaaa ttcacagcaa aagtccacat tatgtcagct ttctcatatt
     2401 gagagctctg ctatgccact gttgaatttt cccaagattt tgcccccctt tcaaacttcg
     2461 cttccttgga cagatttggc aatagctttg taagtgatgt ggacataatt gcctacaata
     2521 atgaaaacct acaggaattt ttttattttt cattttcttc ttaggcatag ttagtctttt
     2581 tcccccaggc agatgattct gagtgtggga gtgtgtctgc acatgttaaa aagacaacta
     2641 ccatattaat aaaatattca atttgaaccc tttcggtatt tgaattgctt ttgaatactg
     2701 ttttttatct taatgtaaca ttgttgcatt agctttttaa ctgccaagta attgaataca
     2761 ttttattact tggatttttc taaactctcc ctacccactc actttgaatg gagcatttac
     2821 aaacactgct caagtttgta ttaaaggaag gattttggtt gagcccttat attgatggtt
     2881 aatgcataca taaacacctt tatgcaactt taacactgct ttactaacta tgtctattgg
     2941 ttatttcctg ccaattagta tgatttctta aagacagtaa gttgtttgca aattaataaa
     3001 acagcattcc tgtcaccttt gtaagtaaag cttaatgaaa ctatatccct gtggacagct
     3061 ccattagctt gttacattag tggaattctg agtaaagcat gggagactgg caaacccttt
     3121 gatttctctc agagctgcat gcatctagta tgaaaccctg tcagttccac aggttaccca
     3181 cattgtcaat aacgttaaag gatgaagagc cttgctgctt cgggccattt ctcaatccaa
     3241 agactaaata ttttagtcat cacaaactgc gtacactaac ataaacagga atagaatcaa
     3301 gtacagaata ggttttatct caattatttc ttaactgtaa gctggaattt gctaaccatg
     3361 atttggatga accacgtgca gcattgtggt gtggtggttt cagctcgaag gatgactttc
     3421 tactacagct atcatgcctg aaagtttttg tgagaatgaa tgggaagtag aagaggtttg
     3481 tcagaggcct cctttgtatg gaatgtgctt ccatttgtga gaatggcctc attgtgattg
     3541 tccattatga ttcctaagat atgttctgac gatatgttta atggtctggt ccgtccctgt
     3601 aatcttgttc tccagaaaga aaagccaact gtatttccag tcataaacca aaatacaatg
     3661 caatgccaac tgcaaagatg aatgagttgg tgtctcaagg acagggctaa ggttgtgcct
     3721 acagcttctt tgaactacac atatggctat taaattacat aaaatttaaa ttttatgatg
     3781 tctgcaaata tctgggcttt tattttctgt gatatatgga agctctaatg agaacaaatc
     3841 cttcttatat tgccatgcta ataaggaaaa atattagcaa atgcttgagt cttaatttcg
     3901 aaagatttcc cttttgaaac aagttctgtc tgctattaga acacttagac tcttaggaat
     3961 gttgtgtgcg tgctgccgag gttcttaagt cccagggctt ggccagcacc tatgaaaggc
     4021 ctacctctac aaggcaatag aaggacgaag gtaattctta aaagttttca ttggaattat
     4081 atcacatcaa cagaattaat caacaccata cattttaggg acttggaagt ttgaaagagt
     4141 atgtattatc atttcaaccc atccatttta aagcgatggt catatatcag cttgtcattt
     4201 cagtaaggag gtaagatgtc tgaagtgaac atgaaatgtg tgcagatgtt ggattgtgaa
     4261 agagcagtac atttttgtgc tatcattctg ccttctccaa gtttaaactt tacgtggttt
     4321 acaatgcaaa aggataatat attctggatt ctaaagagct tatgcttttc agctatactt
     4381 aacataggca tgttagcatc atgatttggt ttgccccatt ttacattaat gatcatcata
     4441 tgacttttat gctaagttat ttaatctttc aagtaaatac attgaatttt aagagatggt
     4501 atttaaaaac aatgtaattg tcatcctttt cttactgtgg aagaggaagt acagcatttt
     4561 gttgttgtta ataaataatt tgctatccag tagggggtca ggagggtata taaaaccaaa
     4621 ccatcagaag ttgaactgag tgtatattgc ctgaaattta atgacaaagc aacatgttta
     4681 taaatgatta aacacatttt ctccttgttt tttattatta aaaatcttga aatacacagt
     4741 aattgcatgt aagaaactat aaactgatgt caagctattt cctgtaacaa gataattcat
     4801 ttctgaaacc actagatcta cttttacaat gtgggacttt gaaagtttga ttggacagtt
     4861 cctgtcatca gttgaagtac tgcaaatatt ttggcttata cttgtaacca gatacagttt
     4921 tacaacttag ggatccatga tgaatgaaca tttggagaaa aaaaagtcac ccaaactctt
     4981 tggcaaaaat gctagtaatt ccttcatgat cttggatgac tgtttacacg tgacagcact
     5041 ctagcacctt tgctcactgg cgtggacttg ctcactgact cctgcttcac tgaatgatga
     5101 cttcattgct ttgggtagag atttaggtag tcaagggaca aagctgtagc ttttaatgtt
     5161 tagaagactt gtgaagattc cagttacagt cctgtaactg actagaatga tcagatgttc
     5221 taccattgtt ggccgacctt atgagaataa acttcagtta atcctctcac agacctatat
     5281 gtaaagtaga tagatagcag tcaactgtat tttggggatt atctccaaat actgtatttc
     5341 ttccagctaa tttttcagtg attgtaacag atgccatcta attattcatg atcatgtttc
     5401 ttaagagatc ttgccatggc agcaacttgg ttaaataatt acatatgcac aattcataac
     5461 ttaataggtt taaatctagt cattgattag attttgtagt attcggaata gaaagtgtta
     5521 ttttctagca gcaatttagt caattgtatt tgaaccaatt tattgtcaga attcagatag
     5581 ggtagatttg atacttgatg tttcttgttc tgggatattc gtaactttta gaatcctaga
     5641 acaccattaa tgagtcttcc cttcaataaa tgtacttctc acatacctct aatcctatgc
     5701 ttccttgaaa caataatacg ctagccaggt tgcttactaa ggattgttag gagggcatgg
     5761 aggtactggg aggggtaaat attgaaagct tgatctctgg tgcaagggga aaataaatag
     5821 gcactaagcc tgcacaggca gaaaacacgg atttcctaag tagcccaaaa cagtattgct
     5881 ttctctccct tttcacatat gccactgtgc cctttagatc ttgacctgga aacctcaggt
     5941 ttgtggactg cgcagctgag tggcattttg tgcttcctga agctcccctt tgctaggtac
     6001 attaccttag tgcttcagac gtcagcctga ggccttgcta cctccatttg ctgcccaggg
     6061 aagagtttgt gctggagctg ggtggagctc tggccctcct cacgtgatgg tctgagtctg
     6121 cattttaagg gacatgatcc cagaaatgta cacacttatc tagttttaaa ggagaactgt
     6181 ggatctctca ggccaggatt ttgtgactga tttttaatta cttggttaat acctagagcc
     6241 cattataaaa aaacaagatt aatgagaact ggcaagattt gatgtttttg gcctaattcc
     6301 aaagcatgga tgctttggaa ggtaggaaga aaccctgttc ttatgatttg tagctacctt
     6361 ctgcgcctga cttggtgccg tgtgagagtt aagcccttag tctgctcttg caattactca
     6421 aatgactgaa gtttaaattt tttgttttgt aacaataaaa attgtcatct ttccttttga
     6481 tgtgcttgtc tgtttataat cacattgctg tactctgtgt tactttctct atatttttgt
     6541 atcaggcatt ggaaatatct aacagacttg ttggatggac ctaacaggtt gttacctccg
     6601 agtttaaaac atgtttgctt ggtgtgtgag gcttttgtat ggttatatat ataatgacct
     6661 tacagaacag aaacaagcct ccaggaaggg ttatgagata cttgatgata aataacatca
     6721 cagtgtagtt ttctatgaac agtagaactg gagagattaa agattattct gtccaagcta
     6781 tgaaccttaa aaattcagga tttttaataa agatcaagag accaaaaaaa aaaaaaaaaa
     6841 aaaaaaaaaa aaaaaa
//
