LOCUS       NM_146120               2663 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus gelsolin (Gsn), transcript variant 1, mRNA.
ACCESSION   NM_146120 NM_010354
VERSION     NM_146120.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2663)
  AUTHORS   Lee,J., Sasaki,F., Koike,E., Cho,M., Lee,Y., Dho,S.H., Lee,J.,
            Lee,E., Toyohara,E., Sunakawa,M., Ishibashi,M., Hung,H.H.,
            Nishioka,S., Komine,R., Okura,C., Shimizu,M., Ikawa,M.,
            Yoshimura,A., Morita,R. and Kim,L.K.
  TITLE     Gelsolin alleviates rheumatoid arthritis by negatively regulating
            NLRP3 inflammasome activation
  JOURNAL   Cell Death Differ 31 (12), 1679-1694 (2024)
   PUBMED   39179640
REFERENCE   2  (bases 1 to 2663)
  AUTHORS   Paul,M., Hong,F., Falet,H. and Kim,H.
  TITLE     Gelsolin regulates receptor-mediated and fluid-phase endocytosis in
            platelets
  JOURNAL   J Thromb Haemost 22 (9), 2601-2607 (2024)
   PUBMED   38777258
  REMARK    GeneRIF: Gelsolin regulates receptor-mediated and fluid-phase
            endocytosis in platelets.
REFERENCE   3  (bases 1 to 2663)
  AUTHORS   Kuwabara,Y., York,A.J., Lin,S.C., Sargent,M.A., Grimes,K.M.,
            Pirruccello,J.P. and Molkentin,J.D.
  TITLE     A human FLII gene variant alters sarcomeric actin thin filament
            length and predisposes to cardiomyopathy
  JOURNAL   Proc Natl Acad Sci U S A 120 (19), e2213696120 (2023)
   PUBMED   37126682
REFERENCE   4  (bases 1 to 2663)
  AUTHORS   Paul,M., Golla,K. and Kim,H.
  TITLE     Gelsolin Modulates Platelet Dense Granule Secretion and Hemostasis
            via the Actin Cytoskeleton
  JOURNAL   Thromb Haemost 123 (2), 219-230 (2023)
   PUBMED   36522181
  REMARK    GeneRIF: Gelsolin Modulates Platelet Dense Granule Secretion and
            Hemostasis via the Actin Cytoskeleton.
REFERENCE   5  (bases 1 to 2663)
  AUTHORS   Ebeid,M., Barnas,K., Zhang,H., Yaghmour,A., Noreikaite,G. and
            Bjork,B.C.
  TITLE     PRDM16 expression and function in mammalian cochlear development
  JOURNAL   Dev Dyn 251 (10), 1666-1683 (2022)
   PUBMED   35451126
REFERENCE   6  (bases 1 to 2663)
  AUTHORS   Witke,W., Sharpe,A.H., Hartwig,J.H., Azuma,T., Stossel,T.P. and
            Kwiatkowski,D.J.
  TITLE     Hemostatic, inflammatory, and fibroblast responses are blunted in
            mice lacking gelsolin
  JOURNAL   Cell 81 (1), 41-51 (1995)
   PUBMED   7720072
REFERENCE   7  (bases 1 to 2663)
  AUTHORS   Ishizaki,A., Fujita,H. and Kuzumaki,N.
  TITLE     Growth-inhibitory functions of a mutated gelsolin (His321) in
            NIH/3T3 mouse fibroblasts
  JOURNAL   Exp Cell Res 217 (2), 448-452 (1995)
   PUBMED   7698245
REFERENCE   8  (bases 1 to 2663)
  AUTHORS   Merrick,B.A., Patterson,R.M., Witcher,L.L., He,C. and Selkirk,J.K.
  TITLE     Separation and sequencing of familiar and novel murine proteins
            using preparative two-dimensional gel electrophoresis
  JOURNAL   Electrophoresis 15 (5), 735-745 (1994)
   PUBMED   7523108
REFERENCE   9  (bases 1 to 2663)
  AUTHORS   Pilz,A., Moseley,H., Peters,J. and Abbott,C.
  TITLE     Comparative mapping of mouse chromosome 2 and human chromosome 9q:
            the genes for gelsolin and dopamine beta-hydroxylase map to mouse
            chromosome 2
  JOURNAL   Genomics 12 (4), 715-719 (1992)
   PUBMED   1315305
REFERENCE   10 (bases 1 to 2663)
  AUTHORS   Dieffenbach,C.W., SenGupta,D.N., Krause,D., Sawzak,D. and
            Silverman,R.H.
  TITLE     Cloning of murine gelsolin and its regulation during
            differentiation of embryonal carcinoma cells
  JOURNAL   J Biol Chem 264 (22), 13281-13288 (1989)
   PUBMED   2546951
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL773523.4, AK143664.1 and BY655071.1.
            
            On Apr 22, 2011 this sequence version replaced NM_146120.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143664.1, BC023143.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AL773523.4         126457-126489
            34-2657             AK143664.1         1-2624
            2658-2663           BY655071.1         400-405
FEATURES             Location/Qualifiers
     source          1..2663
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 23.5 cM"
     gene            1..2663
                     /gene="Gsn"
                     /gene_synonym="ADF"
                     /note="gelsolin"
                     /db_xref="GeneID:227753"
                     /db_xref="MGI:MGI:95851"
     exon            1..222
                     /gene="Gsn"
                     /gene_synonym="ADF"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..2427
                     /gene="Gsn"
                     /gene_synonym="ADF"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; brevin; actin-depolymerizing factor"
                     /codon_start=1
                     /product="gelsolin isoform 1 precursor"
                     /protein_id="NP_666232.2"
                     /db_xref="CCDS:CCDS15960.1"
                     /db_xref="GeneID:227753"
                     /db_xref="MGI:MGI:95851"
                     /translation="MAPYRSSLLCALLLLALCALSPSHAATTSRGRAQERAPQSRVSE
                     ARPSTMVVEHPEFLKAGKEPGLQIWRVEKFDLVPVPPNLYGDFFTGDAYVILKTVQLR
                     NGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESSTFSGYFK
                     SGLKYKKGGVASGFKHVVPNEVVVQRLFQVKGRRVVRATEVPVSWDSFNNGDCFILDL
                     GNNIYQWCGSGSNKFERLKATQVSKGIRDNERSGRAQVHVSEEGGEPEAMLQVLGPKP
                     ALPEGTEDTAKEDAANRRLAKLYKVSNGAGSMSVSLVADENPFAQGALRSEDCFILDH
                     GRDGKIFVWKGKQANMEERKAALKTASDFISKMQYPRQTQVSVLPEGGETPLFKQFFK
                     NWRDPDQTDGPGLGYLSSHIANVERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRI
                     EGSNKVPVDPATYGQFYGGDSYIILYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILT
                     AQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSRDGGQTAPASIRLFQV
                     RASSSGATRAVEVMPKSGALNSNDAFVLKTPSAAYLWVGAGASEAEKTGAQELLKVLR
                     SQHVQVEEGSEPDAFWEALGGKTAYRTSPRLKDKKMDAHPPRLFACSNRIGRFVIEEV
                     PGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRT
                     PITVVRQGFEPPSFVGWFLGWDDNYWSVDPLDRALAELAA"
     exon            223..427
                     /gene="Gsn"
                     /gene_synonym="ADF"
                     /inference="alignment:Splign:2.1.0"
     exon            428..582
                     /gene="Gsn"
                     /gene_synonym="ADF"
                     /inference="alignment:Splign:2.1.0"
     exon            583..744
                     /gene="Gsn"
                     /gene_synonym="ADF"
                     /inference="alignment:Splign:2.1.0"
     exon            745..894
                     /gene="Gsn"
                     /gene_synonym="ADF"
                     /inference="alignment:Splign:2.1.0"
     exon            895..984
                     /gene="Gsn"
                     /gene_synonym="ADF"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1117
                     /gene="Gsn"
                     /gene_synonym="ADF"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1206
                     /gene="Gsn"
                     /gene_synonym="ADF"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1422
                     /gene="Gsn"
                     /gene_synonym="ADF"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1556
                     /gene="Gsn"
                     /gene_synonym="ADF"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1647
                     /gene="Gsn"
                     /gene_synonym="ADF"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1818
                     /gene="Gsn"
                     /gene_synonym="ADF"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1993
                     /gene="Gsn"
                     /gene_synonym="ADF"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2118
                     /gene="Gsn"
                     /gene_synonym="ADF"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2196
                     /gene="Gsn"
                     /gene_synonym="ADF"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2257
                     /gene="Gsn"
                     /gene_synonym="ADF"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2663
                     /gene="Gsn"
                     /gene_synonym="ADF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2632..2637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gsn"
                     /gene_synonym="ADF"
                     /note="hexamer: AATAAA"
     polyA_site      2653
                     /gene="Gsn"
                     /gene_synonym="ADF"
                     /note="major polyA site"
ORIGIN      
        1 gctagggcgg gatgggacgg ccggttactt aaaggttggg gcgaccaagg gtccgcggcc
       61 gcagcctggg tcctcaccgt cgccatggct ccgtaccgct cttcactgct ctgcgcgctg
      121 ctcctcctgg cgctgtgcgc actgtcgcct tcccatgcag ccaccacatc acggggcagg
      181 gcccaagaga gggcgcccca aagtcgggtg tctgaggcgc ggcccagcac tatggtggtg
      241 gagcaccccg aattcctgaa ggcagggaag gagcctggcc tgcagatctg gcgtgtggag
      301 aagtttgacc tggtgcctgt gccccccaac ctctatggag acttcttcac gggtgatgcc
      361 tatgtcatcc taaagactgt gcagctgagg aatgggaatc tgcagtatga cctccactat
      421 tggctgggca atgaatgcag ccaggatgag agcggggctg ctgccatctt tactgtgcaa
      481 ctggatgact acctgaacgg ccgggctgta cagcaccgtg aggttcaggg ctttgagtcg
      541 tccaccttct ccggctactt caagtctgga cttaagtaca agaaaggagg tgtggcatct
      601 ggattcaaac acgtggtacc caatgaggtg gtggtccaga ggctcttcca ggtcaaagga
      661 cgccgtgtag tccgtgctac tgaggtacct gtgtcctggg acagtttcaa caatggcgac
      721 tgcttcattc tggacctggg aaacaatatc tatcagtggt gtggctctgg cagcaacaaa
      781 tttgaaaggc tgaaggccac acaggtgtcc aagggcatcc gggacaacga gaggagtggc
      841 cgtgctcaag tacacgtgtc tgaagaggga ggagagccag aagccatgct gcaggtgctg
      901 ggccccaagc cagctctgcc tgaaggtacc gaggacacag ccaaggaaga tgcagccaac
      961 cgaaggctgg ccaagctcta caaggtctcc aacggtgcag gtagcatgtc agtctcccta
     1021 gtggctgatg agaacccctt cgcccagggc gccctgagat ctgaggactg cttcatcctg
     1081 gaccatggca gagatgggaa aatctttgtt tggaaaggca agcaggccaa catggaggag
     1141 cggaaggctg ccctcaaaac agcctctgac ttcatctcca agatgcagta ccccaggcag
     1201 acccaggttt cagttctccc agagggcggt gagacccctc tctttaagca gttcttcaag
     1261 aactggcggg acccagacca gacagacggc cccggcctgg gctacctctc cagccacatt
     1321 gccaacgtgg agcgcgtacc tttcgatgct gctacgctgc acacctccac cgccatggcc
     1381 gctcagcacg gcatggatga tgatggaact ggccagaaac agatctggag aattgaaggt
     1441 tccaacaagg tgccagtgga ccctgccaca tacgggcagt tctatggagg cgacagctac
     1501 atcattctgt acaactaccg ccacggtggc cgccagggac agatcatcta caactggcag
     1561 ggtgcccagt ctacccagga tgaggttgct gcttctgcca tcctgactgc ccagctggat
     1621 gaggagctgg gaggaactcc tgtccagagc cgagtggtcc aaggcaaaga gcctgcacac
     1681 ctcatgagct tgtttggcgg gaagcccatg atcatctaca agggtggcac ctcccgtgat
     1741 ggtgggcaga cagctcctgc cagtatccgc ctcttccaag tgcgagccag cagctctgga
     1801 gccaccaggg ctgtggaggt gatgcctaag tctggtgctc tgaactccaa cgatgccttt
     1861 gtgctgaaaa ccccctccgc tgcctacctg tgggtgggcg caggagccag tgaggcggag
     1921 aagaccggcg cccaggagct tctgaaggtg cttcggtccc agcatgtgca ggtggaagaa
     1981 ggcagtgagc cagatgcctt ctgggaggct ctgggcggga agactgccta ccgcacatcc
     2041 cccaggctta aggacaagaa gatggatgcc catcctcctc gactctttgc ctgctccaac
     2101 aggatcggac gctttgtgat cgaagaggtt cctggcgagc ttatgcagga agacctggct
     2161 actgatgacg tcatgctcct ggacacctgg gaccaggtct ttgtctgggt tggaaaagac
     2221 tcccaggaag aggaaaagac ggaagccttg acttctgcta agcggtacat cgagacagat
     2281 ccagcaaatc gggacaggcg gacccccatc acagtcgtta ggcagggctt tgagcctcct
     2341 tccttcgtgg gctggttcct cggctgggat gacaactact ggtcggtgga tcctttggac
     2401 cgggccttgg ctgagctggc tgcctgagta aggaccaaag ccatcaatgt caccaatcag
     2461 tgcctttgag ggttgtccat ctcccaaaga catcatatgg caagcaggaa aactatgatg
     2521 tgtgcgcgcg tgtttttgtt tttgtttttt acggtagcca aaacaagccc tgtggaaact
     2581 cagggtcttt acagaattgc ttcaaatgtc tgtactttgg aaatgaaagc caataaaagc
     2641 tttttgaagt gtgttctccc cag
//
