LOCUS       NM_178613               2787 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus GSK3B interacting protein (Gskip), mRNA.
ACCESSION   NM_178613
VERSION     NM_178613.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2787)
  AUTHORS   Sakai,S.S., Hasegawa,A., Ishimura,R., Tamura,N., Kageyama,S.,
            Komatsu-Hirota,S., Abe,M., Ling,Y., Okuda,S., Funayama,M.,
            Kikkawa,M., Miura,Y., Sakimura,K., Narita,I., Waguri,S., Shimizu,R.
            and Komatsu,M.
  TITLE     Loss of Atg2b and Gskip Impairs the Maintenance of the
            Hematopoietic Stem Cell Pool Size
  JOURNAL   Mol Cell Biol 42 (1), e0002421 (2022)
   PUBMED   34748402
  REMARK    GeneRIF: Loss of Atg2b and Gskip Impairs the Maintenance of the
            Hematopoietic Stem Cell Pool Size.
REFERENCE   2  (bases 1 to 2787)
  AUTHORS   Yan,L., Cheng,G. and Yang,G.
  TITLE     GSKIP protects cardiomyocytes from hypoxia/reoxygenation-induced
            injury by enhancing Nrf2 activation via GSK-3beta inhibition
  JOURNAL   Biochem Biophys Res Commun 532 (1), 68-75 (2020)
   PUBMED   32828530
  REMARK    GeneRIF: GSKIP protects cardiomyocytes from
            hypoxia/reoxygenation-induced injury by enhancing Nrf2 activation
            via GSK-3beta inhibition.
REFERENCE   3  (bases 1 to 2787)
  AUTHORS   Deak,V.A., Skroblin,P., Dittmayer,C., Knobeloch,K.P., Bachmann,S.
            and Klussmann,E.
  TITLE     The A-kinase Anchoring Protein GSKIP Regulates GSK3beta Activity
            and Controls Palatal Shelf Fusion in Mice
  JOURNAL   J Biol Chem 291 (2), 681-690 (2016)
   PUBMED   26582204
  REMARK    GeneRIF: These findings reveal a novel, crucial role for GSKIP in
            the coordination of GSK3beta signaling in palatal shelf fusion.
REFERENCE   4  (bases 1 to 2787)
  AUTHORS   Chou,H.Y., Howng,S.L., Cheng,T.S., Hsiao,Y.L., Lieu,A.S., Loh,J.K.,
            Hwang,S.L., Lin,C.C., Hsu,C.M., Wang,C., Lee,C.I., Lu,P.J.,
            Chou,C.K., Huang,C.Y. and Hong,Y.R.
  TITLE     GSKIP is homologous to the Axin GSK3beta interaction domain and
            functions as a negative regulator of GSK3beta
  JOURNAL   Biochemistry 45 (38), 11379-11389 (2006)
   PUBMED   16981698
REFERENCE   5  (bases 1 to 2787)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK017049.1 and AC158526.3.
            
            On Sep 22, 2006 this sequence version replaced NM_178613.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.714438.1, AK168962.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-366               AK017049.1         525-890
            367-2787            AC158526.3         133778-136198       c
FEATURES             Location/Qualifiers
     source          1..2787
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 55.92 cM"
     gene            1..2787
                     /gene="Gskip"
                     /gene_synonym="4933433P14Rik"
                     /note="GSK3B interacting protein"
                     /db_xref="GeneID:66787"
                     /db_xref="MGI:MGI:1914037"
     exon            1..107
                     /gene="Gskip"
                     /gene_synonym="4933433P14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..528
                     /gene="Gskip"
                     /gene_synonym="4933433P14Rik"
                     /note="GSK3-beta interaction protein"
                     /codon_start=1
                     /product="GSK3B-interacting protein"
                     /protein_id="NP_848728.2"
                     /db_xref="CCDS:CCDS49161.1"
                     /db_xref="GeneID:66787"
                     /db_xref="MGI:MGI:1914037"
                     /translation="MGARRMETDYNPVELSSMSGFEEGSELNGFEGADMKDMQLEAEA
                     VVNDVLFAVNHMFVSKSMPCADDVAYINVETKERNRYCLELTEAGLRVVGYAFDQVED
                     HLQTPYHETVYSLLDTLSPAYREAFGNALLQRLEALKRDGQS"
     exon            108..366
                     /gene="Gskip"
                     /gene_synonym="4933433P14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            367..2787
                     /gene="Gskip"
                     /gene_synonym="4933433P14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1633..1638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gskip"
                     /gene_synonym="4933433P14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1677
                     /gene="Gskip"
                     /gene_synonym="4933433P14Rik"
                     /note="major polyA site"
     polyA_site      1683
                     /gene="Gskip"
                     /gene_synonym="4933433P14Rik"
     regulatory      2728..2733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gskip"
                     /gene_synonym="4933433P14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2752
                     /gene="Gskip"
                     /gene_synonym="4933433P14Rik"
     regulatory      2759..2764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gskip"
                     /gene_synonym="4933433P14Rik"
                     /note="hexamer: CATAAA"
     polyA_site      2787
                     /gene="Gskip"
                     /gene_synonym="4933433P14Rik"
ORIGIN      
        1 ggtggtgaat gggcggggca actgcggggg cgggggtggt gccggcgccg cgatcctggc
       61 cccagcagtc tccggacgag gaaggataag aacatgggcg ctcgcagaat ggaaacagac
      121 tataatcccg tggagctaag cagtatgtct ggatttgaag aaggctccga gctcaatggg
      181 tttgaaggag cggatatgaa ggacatgcag ctggaggccg aggcagttgt aaacgatgta
      241 ctctttgctg tcaaccacat gtttgtctca aaaagcatgc cctgtgcaga tgatgtggct
      301 tacatcaatg tggagacaaa ggaaaggaac agatactgcc tggagctcac agaagcaggg
      361 ctcagggtgg tgggctatgc ttttgaccag gtggaggatc atttgcaaac cccctaccat
      421 gagacagtct actccttgtt ggatactctc agccctgcct accgggaagc attcggaaac
      481 gcgctccttc agagactgga agctttgaaa cgagatggac agtcatgact catgactcat
      541 cttcctccta atggggccgc tgctggtata gaatctaaca taaggcttga cacccttgcg
      601 tacagtcact gtagaaagcg catcattcat tggctttgtg tgttcgccat tccttcacac
      661 gcaggctttt gactcccagc gtaattgagt tgtcttagtt tcagcttcat ggaaggggat
      721 ttaattttga gaccattgct ctgacactcc cattctgagt ttcacaccca gcactctgca
      781 tttcaatccc tagtcagctc ttcattctcc tgttacaggg cttcaatgct gccagcactc
      841 ttttacatag aaaattctag atttgcacag tgatacagaa attagaatca cctaacttca
      901 gacctggatt cagcctgcta aatcaggggt ttactactag cttggagtaa ctttgtagtg
      961 gttattttgt acctggcctt attggaaaca aactgtcaac tagtttcccc tgcacaaatt
     1021 ctgaaatgta ctgctctgct taatctagtc acatgaccaa gtgggctggt gaagatgggt
     1081 tgctcatctg tttcttaact aagataaaat ggaaggcagg gacagaaatc gttctccatt
     1141 ccttgtttgc aacagccagc cagcctagag cggacagacc attcgcaaat gaatgtaaca
     1201 attactcatc tccatgatgt ctaagcacat gagcaaatag aggaacaggc ccacctcatc
     1261 ctccagtgtg gatctcttca aaggaagaag atcctggttt cctaggaaac ggtattttgg
     1321 cctgtgttga ttcttactct gaatgtttgt ttacaatgta cagtatatat atatatatat
     1381 gcacatatat attcagaacg tatttttgct tcaatgctta ctttctataa agcagtgctt
     1441 tggtattcct acagcgccct tcttccccag cagttggaca gtgctctgtc tcattgccac
     1501 atgaacagtg taacatgagt gcattgtatg gttcgaaacc aaaggatgaa tgaagcattc
     1561 agaaacttga tatttaaaaa agagatgctc tgtattttat attttattac agtccccggt
     1621 gtttataaac gtaataaagt cctccgtgct gctgcatgtt ttccagtatg tgacaaacag
     1681 aaaggacctg gctctgttct agttgtcacc cagagctgcc tcagctgcca ccgtctgcat
     1741 ctgggcacac cttcatacac tggtcatcag cagatgtttt tgtcgttagt ttgcaaaggg
     1801 catttttagc ctctgaagac catgggagga aaggtgaagg gtagagccct tgcctgtcgt
     1861 gggtaagcac ccagccctgt cctgaggatc taaacagtct taaaatgctt ctggggacca
     1921 ggcttggtag agttccctct gcattgccaa tgccaccgag agttcactgg gtgtttgacc
     1981 ctggctttac aagactcttt ttctggtgtg atgtctggtt gcctgcagtg tgcacagtga
     2041 agcccagcct caggctctct ttctggtgtg atgtctggtg tgatgcctgc agtgtgcaca
     2101 gtgaagccca gcctcaggct ctctttctgg tgtgatttct ggttgcctgc agtatgcaca
     2161 gtgaagtccg gcctcaggct ctctttctgg tgtgatgtct ggttgcctgc ggtgtgcaca
     2221 gtgaagtccg gcctcaggct ctctttctgg tgtgatttct ggttgcctgc agtgtgcaca
     2281 gtgaagtccg gcctcaggct ctctttctgg tgtgatgtct ggttgcctgc ggtgtgcaca
     2341 gtgaagcccg gcctcaggct ctctttctgg tgtgatgtct ggtgtgatgc ctgcagtgtg
     2401 cacagtgaag ccctgcctca ggctctcttt ctggtgtgat gtctggttgc ctgcagtgtg
     2461 cacagtgaag cccagcctca ggctctcttt ctggtgtgat gtctggtgtg atgcctgcag
     2521 tgtgcacagt gaagcccagc ctcaggctct ctttctggtg tgatttctgg ttgcctgtgg
     2581 ggtgcacaga gaagcccggc ctcaggctct ctttctggtg tgatgtctgg ttgcctgcag
     2641 tgtgcacagt gaagcccggc ctcaggttga actttcttgt gcttaatctc aggctaacat
     2701 tttaaaaaat gatgtttgta gagtttaaat aaaattattt acttgatttt gagttgagca
     2761 taaagcagtc atgcttaaaa actgaaa
//
