LOCUS       NM_019827               8303 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus glycogen synthase kinase 3 beta (Gsk3b), transcript
            variant 1, mRNA.
ACCESSION   NM_019827 XM_358795
VERSION     NM_019827.7
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8303)
  AUTHORS   Chen,F., Li,Y., Zhao,L., Lin,C., Zhou,Y., Ye,W., Wan,W., Zou,H. and
            Xue,Y.
  TITLE     Anti-inflammatory effects of MerTK by inducing M2 macrophage
            polarization via PI3K/Akt/GSK-3beta pathway in gout
  JOURNAL   Int Immunopharmacol 142 (Pt A), 112942 (2024)
   PUBMED   39217874
  REMARK    GeneRIF: Anti-inflammatory effects of MerTK by inducing M2
            macrophage polarization via PI3K/Akt/GSK-3beta pathway in gout.
REFERENCE   2  (bases 1 to 8303)
  AUTHORS   Naillat,F., Deshar,G., Hankkila,A., Rak-Raszewska,A., Sharma,A.,
            Prunskaite-Hyyrylainen,R., Railo,A., Shan,J. and Vainio,S.J.
  TITLE     Calcium signaling induces partial EMT and renal fibrosis in a
            Wnt4mCherry knock-in mouse model
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167180 (2024)
   PUBMED   38653356
REFERENCE   3  (bases 1 to 8303)
  AUTHORS   Ueno,K., Kurazumi,H., Suzuki,R., Yanagihara,M., Mizoguchi,T.,
            Harada,T., Morikage,N. and Hamano,K.
  TITLE     miR-709 exerts an angiogenic effect through a FGF2 upregulation
            induced by a GSK3B downregulation
  JOURNAL   Sci Rep 14 (1), 11372 (2024)
   PUBMED   38762650
  REMARK    GeneRIF: miR-709 exerts an angiogenic effect through a FGF2
            upregulation induced by a GSK3B downregulation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8303)
  AUTHORS   Toshima,T., Yagi,M., Do,Y., Hirai,H., Kunisaki,Y., Kang,D. and
            Uchiumi,T.
  TITLE     Mitochondrial translation failure represses cholesterol gene
            expression via Pyk2-Gsk3beta-Srebp2 axis
  JOURNAL   Life Sci Alliance 7 (7), e202302423 (2024)
   PUBMED   38719751
  REMARK    GeneRIF: Mitochondrial translation failure represses cholesterol
            gene expression via Pyk2-Gsk3beta-Srebp2 axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8303)
  AUTHORS   McCurry,C.M., Sunilkumar,S., Subrahmanian,S.M., Yerlikaya,E.I.,
            Toro,A.L., VanCleave,A.M., Stevens,S.A., Barber,A.J.,
            Sundstrom,J.M. and Dennis,M.D.
  TITLE     NLRP3 Inflammasome Priming in the Retina of Diabetic Mice Requires
            REDD1-Dependent Activation of GSK3beta
  JOURNAL   Invest Ophthalmol Vis Sci 65 (3), 34 (2024)
   PUBMED   38546584
  REMARK    GeneRIF: NLRP3 Inflammasome Priming in the Retina of Diabetic Mice
            Requires REDD1-Dependent Activation of GSK3beta.
REFERENCE   6  (bases 1 to 8303)
  AUTHORS   Sakanaka,C. and Williams,L.T.
  TITLE     Functional domains of axin. Importance of the C terminus as an
            oligomerization domain
  JOURNAL   J Biol Chem 274 (20), 14090-14093 (1999)
   PUBMED   10318824
REFERENCE   7  (bases 1 to 8303)
  AUTHORS   Diehl,J.A., Cheng,M., Roussel,M.F. and Sherr,C.J.
  TITLE     Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and
            subcellular localization
  JOURNAL   Genes Dev 12 (22), 3499-3511 (1998)
   PUBMED   9832503
REFERENCE   8  (bases 1 to 8303)
  AUTHORS   Hart,M.J., de los Santos,R., Albert,I.N., Rubinfeld,B. and
            Polakis,P.
  TITLE     Downregulation of beta-catenin by human Axin and its association
            with the APC tumor suppressor, beta-catenin and GSK3 beta
  JOURNAL   Curr Biol 8 (10), 573-581 (1998)
   PUBMED   9601641
REFERENCE   9  (bases 1 to 8303)
  AUTHORS   Behrens,J., Jerchow,B.A., Wurtele,M., Grimm,J., Asbrand,C.,
            Wirtz,R., Kuhl,M., Wedlich,D. and Birchmeier,W.
  TITLE     Functional interaction of an axin homolog, conductin, with
            beta-catenin, APC, and GSK3beta
  JOURNAL   Science 280 (5363), 596-599 (1998)
   PUBMED   9554852
REFERENCE   10 (bases 1 to 8303)
  AUTHORS   Cohen,J.S.
  TITLE     Provide fluoxetine information vital to clinicians
  JOURNAL   J Clin Psychiatry 56 (12), 591 (1995)
   PUBMED   8530339
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120020.9 and AC154284.1.
            
            On Mar 19, 2018 this sequence version replaced NM_019827.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB066114.1, AK154293.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1613              AC120020.9         92082-93694         c
            1614-1807           AC120020.9         38242-38435         c
            1808-1891           AC120020.9         11948-12031         c
            1892-2002           AC154284.1         73752-73862         c
            2003-2133           AC154284.1         70356-70486         c
            2134-2240           AC154284.1         66663-66769         c
            2241-2338           AC154284.1         64303-64400         c
            2339-2434           AC154284.1         50207-50302         c
            2435-2621           AC154284.1         38139-38325         c
            2622-2720           AC154284.1         29521-29619         c
            2721-8303           AC154284.1         12213-17795         c
FEATURES             Location/Qualifiers
     source          1..8303
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 26.54 cM"
     gene            1..8303
                     /gene="Gsk3b"
                     /gene_synonym="7330414F15Rik; 8430431H08Rik; GSK-3;
                     GSK-3beta; GSK3"
                     /note="glycogen synthase kinase 3 beta"
                     /db_xref="GeneID:56637"
                     /db_xref="MGI:MGI:1861437"
     exon            1..1613
                     /gene="Gsk3b"
                     /gene_synonym="7330414F15Rik; 8430431H08Rik; GSK-3;
                     GSK-3beta; GSK3"
                     /inference="alignment:Splign:2.1.0"
     CDS             1526..2788
                     /gene="Gsk3b"
                     /gene_synonym="7330414F15Rik; 8430431H08Rik; GSK-3;
                     GSK-3beta; GSK3"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.26"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine-protein kinase GSK3B"
                     /codon_start=1
                     /product="glycogen synthase kinase-3 beta isoform 1"
                     /protein_id="NP_062801.1"
                     /db_xref="CCDS:CCDS28163.1"
                     /db_xref="GeneID:56637"
                     /db_xref="MGI:MGI:1861437"
                     /translation="MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATP
                     GQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMR
                     KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKL
                     YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYIC
                     SRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP
                     TREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEA
                     CAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASPPA
                     NATAASDTNAGDRGQTNNAASASASNST"
     exon            1614..1807
                     /gene="Gsk3b"
                     /gene_synonym="7330414F15Rik; 8430431H08Rik; GSK-3;
                     GSK-3beta; GSK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1891
                     /gene="Gsk3b"
                     /gene_synonym="7330414F15Rik; 8430431H08Rik; GSK-3;
                     GSK-3beta; GSK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..2002
                     /gene="Gsk3b"
                     /gene_synonym="7330414F15Rik; 8430431H08Rik; GSK-3;
                     GSK-3beta; GSK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2133
                     /gene="Gsk3b"
                     /gene_synonym="7330414F15Rik; 8430431H08Rik; GSK-3;
                     GSK-3beta; GSK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2240
                     /gene="Gsk3b"
                     /gene_synonym="7330414F15Rik; 8430431H08Rik; GSK-3;
                     GSK-3beta; GSK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2338
                     /gene="Gsk3b"
                     /gene_synonym="7330414F15Rik; 8430431H08Rik; GSK-3;
                     GSK-3beta; GSK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2434
                     /gene="Gsk3b"
                     /gene_synonym="7330414F15Rik; 8430431H08Rik; GSK-3;
                     GSK-3beta; GSK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2621
                     /gene="Gsk3b"
                     /gene_synonym="7330414F15Rik; 8430431H08Rik; GSK-3;
                     GSK-3beta; GSK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2622..2720
                     /gene="Gsk3b"
                     /gene_synonym="7330414F15Rik; 8430431H08Rik; GSK-3;
                     GSK-3beta; GSK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..8303
                     /gene="Gsk3b"
                     /gene_synonym="7330414F15Rik; 8430431H08Rik; GSK-3;
                     GSK-3beta; GSK3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7657..7662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gsk3b"
                     /gene_synonym="7330414F15Rik; 8430431H08Rik; GSK-3;
                     GSK-3beta; GSK3"
                     /note="hexamer: AATAAA"
     polyA_site      7691
                     /gene="Gsk3b"
                     /gene_synonym="7330414F15Rik; 8430431H08Rik; GSK-3;
                     GSK-3beta; GSK3"
                     /note="major polyA site"
     regulatory      8277..8282
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gsk3b"
                     /gene_synonym="7330414F15Rik; 8430431H08Rik; GSK-3;
                     GSK-3beta; GSK3"
                     /note="hexamer: AATAAA"
     polyA_site      8299
                     /gene="Gsk3b"
                     /gene_synonym="7330414F15Rik; 8430431H08Rik; GSK-3;
                     GSK-3beta; GSK3"
ORIGIN      
        1 acacgcccag cggagttgtc cagccaatga ggaaacgggc gcggcgccca gccgtgcagt
       61 tcctcccgcg actcgggagt ttcgccgtcc ttaactcttg aggcttttcc ctgagggcca
      121 acagctctga ttggccactg tcgctattgt cgactcttct ctctagccag ccacaggaca
      181 aggagaaccc tcttcccttc tgttcggcta ccttcggcat tcctcgttgc tggggcgtgg
      241 tctcccagcg gcgtctcctc attggttatc caggtcgctc ggctttttcc ggcaggagct
      301 gcaagcaagc gacgtctctg attggttccg gcttgggttt cggctctaca gccgaagctg
      361 gcgggcgcgg gctcggcgag cgattcccag acgcctgtaa cgcgggcggc ggggcgctgg
      421 gcggtgtaag ggctgggtgg gggaggaagg aggcggagga cgagtaggaa gggggagggg
      481 gagtggggaa gggctaggcg gctgcgcaga cggcgcgcct cgcacagagc agcccccgac
      541 ccggccgaat gcgggcttgt gtcgccgccg tcgccgccgc ctgggccgag tgacaaagga
      601 aggaaggcag caaggaggag ccggccttgc agccgctgac agggcttcgg gctccgggca
      661 cagcgcggac acttcccgag cagccgctga gcaaaggcga ggggcggagg ccggccgtgc
      721 cggggccacg gacgggggag gggaccccga gggacggaag cggttgcctg gttcccatgt
      781 ccccggcgta tggggagcag tcagggagcc gctgcctggg gtctgaaggg agctgcctcc
      841 gccgccgctg ccgccatggc cgctggatcc agccaccgcc tgcagctgct cctggcgcaa
      901 tgaggagagg agccgccgcc accgcccgcc gctgactcgc gactgcgctg ccctccggtt
      961 cacccggccg ccgccgccgt cagaccgccg gatcccgctg ctgccggagc cgcagcgttt
     1021 gccgtcgcat ctccgagcca tctcctccct ccttcccatc ccccttctct tcaagcgtga
     1081 ggctcgtgat ccttccgccg cttcccttct tcattgactc ggaaaaaaat ccccgaggaa
     1141 aaatataata ctcagagtac ttattttcaa tcaagtattt gccctcgttc acgtgatata
     1201 tatatatttt taaggattcc actccaccct ttttctcctc ttccaggaaa gggaggtgaa
     1261 agaattgtat ttttctccca gctctaaatc atctatgtgt taaatatccg taccgatctg
     1321 tcttgaagaa atacatagct cctttttttt ttccttcttc ttaaatagct atacaaaagg
     1381 agtgaaaagc caagagaacg aagtctttct ttctctttct tgcgggagaa cttaatgctg
     1441 catttatcat taacctagca ccctaacata aaacaaaagg aagaaaagga ttaaggaagg
     1501 aaaaggtgat tcaagaagag ccatcatgtc ggggcgaccg agaaccacct cctttgcgga
     1561 gagctgcaag ccagtgcagc agccttcagc ttttggtagc atgaaagtta gcagagataa
     1621 agatggcagc aaggtaacca cagtagtggc aactcctggc cagggtcctg acaggccaca
     1681 ggaagtcagt tatacagaca cgaaagtgat tggaaatgga tcatttggtg tggtatatca
     1741 agccaaactt tgtgattctg gagaactggt tgccatcaag aaagttctac aggacaagcg
     1801 atttaagaac cgagagctcc agatcatgag aaagctagac cactgtaaca tagtccgact
     1861 gcggtatttc ttctactcga gtggtgagaa gaaagatgag gtctacctta acctggtgct
     1921 ggactatgtt ccggagacag tgtacagagt cgccagacac tatagtcgag ccaagcagac
     1981 actccctgtg atctatgtca agttgtatat gtatcagctg ttcagaagtc tagcctatat
     2041 ccattccttt ggaatctgcc atcgagacat taaaccacag aacctcttgt tggatcctga
     2101 tacagctgta ttaaaactct gtgactttgg aagtgcaaag cagctggtcc gaggagagcc
     2161 caatgtttca tatatctgtt ctcggtacta cagggcacca gagttgatct ttggagccac
     2221 tgattacacg tccagtatag atgtatggtc tgcaggctgt gtgttggctg aattgttgct
     2281 aggacaacca atatttcctg gggacagtgg tgtggatcag ttggtggaaa taataaaggt
     2341 cctaggaaca ccaacaaggg agcaaattag agaaatgaac ccaaattata cagaattcaa
     2401 attccctcaa atcaaggcac atccttggac aaaggtcttc cggccccgaa ctccaccaga
     2461 ggcaattgca ctgtgcagcc gtctgctgga gtacacacct accgcccggc taacaccact
     2521 ggaagcttgt gcacattcat ttttcgatga attgcgggac ccaaatgtca aactaccaaa
     2581 tgggcgagac acacctgcac tcttcaactt taccactcaa gaactgtcaa gtaacccccc
     2641 tctggccacc atccttatcc ctccacatgc tcggattcag gccgctgctt caccgcctgc
     2701 caacgccaca gcagcctcag atactaatgc tggagaccgt ggacagacca ataacgccgc
     2761 ttctgcatca gcttccaact ccacctgaac agcccccagg agccagctgc gcgggaaaga
     2821 ccagcactta cttgagtgcc actcagcaac actggtcacg tttggaaaga aaattaaaaa
     2881 gaggaaaaca aaaacaaaaa caaaaaaacc ctgttcattt tagtgttcaa ttttttttat
     2941 tgttgttctt atttaacctt gtaaaatatc tatataaata caaaccagtt tcattgtatt
     3001 ctcacttttc aggagatcca agaggtgggg agggttgggc ggggaggagc agagcattaa
     3061 acacaatctc tcccacgaca atcttttctt ttctttttaa agtcagaagt ccgctattgt
     3121 ataccttaaa aaccagactc ctgcctcacg cccccaccgc aacagaagaa aacctgttct
     3181 gtgctggttt attttctgga tttgttttct tttaaagcct ggcgtaagac tttgatacag
     3241 tgcacagctt gaaattggtt gggagcttag caggtgtaac tcaccaggga cttactgtca
     3301 cttgtacaat gtgtacttat ccttaggatt tgaagacttg cctttggcgt gtgatgtcag
     3361 gtatgacaga caaaaaaaaa aaagacaaag aaaaaccaag gtgtattatt ggtagcccag
     3421 ggaggtcact aaaatctgaa gctctaaggg aagatcagag atggattact taaggtttgt
     3481 tttgctcttg accagtgcag gtgttgcaga tgccagctta ggaaggctgc tgccaaagga
     3541 gagagcgcga cagagtctgt tgggccctga ggtagatctt ggttcacctg accaaaggcc
     3601 gcctgcttct cccggtattg ttttgagctg gtaccctagg atgaggctgg agatggtgtt
     3661 aagggggcag ctctgggtgc atcggaaagc gaagaacagg aaggtggcag gccaggggca
     3721 gatctcacca ctgtgagtga gcttgtccag attttaataa agtcgtttcc cttagaaaaa
     3781 cacttgagag aagacatcat agctaagtaa tgtgaactgt tagccagcct actgctttgt
     3841 tttccttact ttaattgaaa accaagcttg caagaattgc cacattctta tgcatagctc
     3901 taattttaaa tccaaatcta gactctgtat ttaatttctg cttttttaac atcatgcttt
     3961 ttaaatttat ttattgatgc atgtcagatc ggccactatg attttaagtg gtagtaatat
     4021 taaaaaccac acatcaaaat aataaagtca cttgtatctg ctgactttat aggaaaactg
     4081 attatattaa tgtgtatata tgttttatat atacatatat tcaatactgc cttttctttt
     4141 tgtctacagt atcaaaattg actgactgaa tcatgaaaag aatgttcccc caccatcacc
     4201 attaagagtt ttatttttgt tttctttgtt tatcaatgaa tggtgtaaga atcagtctct
     4261 tgttttttga agaaaaagca atattccttg gaaagcaagg tggattgaag gattacgttt
     4321 gtgtgaggaa cagaactcat aactagtttg ttgatacttt taaggttggt gtctttgtgg
     4381 gccttatata ctctaaaatg aaccttggtg cttatgggcc attacttgac ctatgaatct
     4441 ttaaggcaca atcagttatc ttttacattt aaagatcact tgagtaatgg ccaccgctcc
     4501 ttccttcctt cccactccct ccccacacat ctgctaaggt gagctgatga ctagggctgt
     4561 agggcccttg gttatgtatg agacacagac tcctttaccc tcattacctg accttaagtc
     4621 acgttgaggt cttgccctcc aggtggttag gaagaggagt ctcttggcgg cccttataca
     4681 ggccctagca ccctgccttg cttctccgac cgtgtgtgta actctccaag agagttgtat
     4741 tgtctgccga aatgagttga tgctagaaag acatcagtga ggctgtgcgg ctggctgatc
     4801 tcttcaggcc accgaagggg tttctcagac ctccgtttag atcagacttg acaagaaagg
     4861 aagcaagccc aaagcaaaca aaggcgcttt tggtaaagcg cttctcagat aattgccgtg
     4921 cgaaagactt ctgaaattaa gttatttgac cgcatagttc cttgaagggg gtgacttgga
     4981 agaccatttt cagaaagaat ttgtaaagaa tctgagcaag caggtctgtg gcctgagaag
     5041 ggaacctgct ttcagattaa actgcccagc ccgacacaga cagtactcca gacttggtgt
     5101 gcgtgctaga gtccataaaa gtcagtgctt gttagtgaat actccccacc cccagatacg
     5161 gggtaagaga agagtggagg aaagtcaggt gcttttctct gtgtgtgtgt gtgtgcgcgc
     5221 gcgcgcgcgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgcgcgtgt gcgtgtgtgc
     5281 gcacatgtgt gcgtccgtgt gtgtgtgagt gtgtgcctgt gtgtgtgcgc gcgcgcgtgt
     5341 gtgtgtgtgt gtatgtgtgt gtgtatgtat gtgggcatgc atgcatatat gagggcttag
     5401 gtgcacgatt tttctttctc aaggatcatg gcaggatccc agaactctta tccaagtgag
     5461 atccaggtct ctgaatatct ttttgtaaat aataattaaa agctcctcac caaattcaag
     5521 cttgtatatt atattttctt tcaatgtttt taaatttaag ttttattgtt ttgtatgtaa
     5581 atatgtggac ccaggaactg ttattaatga gcaaaaagtt actgttcagg gcagtgattc
     5641 tgttcaataa ccagacaaaa atgtagacga gctttttaaa gccatatagt tttaactctg
     5701 tacagtaggt accggcctgt attattgtaa caataactct agcaatgtat agtgtatcta
     5761 tatagtttgg agtgccttcg cttccatgtt tttgggtttt tttgttttgt ttttgttttc
     5821 tgacttcctt tatccatgtg tccctgtggc cccctttccc tctgagtaac agcagaacag
     5881 cacctttgcc cactccacag tttgaatggg gagaggaaac catgttggca gtctcacttc
     5941 attctagcct tgcctttgtt tttggttctg ggtgtgtctg tgtcctcagt aacagtgacc
     6001 ggtttcattg cggatgcact cagtccgtcc gggacttggt ggagcgctgg gggccccaga
     6061 gctgaagggt gtcagatggc atgggtttgt tcatcgcctc tccaagccct ggagtggatc
     6121 ctaagcagat tctgggagct cccgagcttg ctctctcctt acctacttcc ctcccaaatg
     6181 agagaaagat tgggtttgtt ttatttttaa aaaaaaaaaa aatcactgtc ttggtggcat
     6241 ttgggtgccc ccgtgacatt gttagcagtt actgcagggg tgctgtgcag atgagggctg
     6301 cgagtggact ctgagcccgt tcctccctcc taccatcttg ctagatgaaa tatcatttta
     6361 atttcttttt ttaaaaatca gtttaactgt gcctaatatg gcccatttga aagaaaaaaa
     6421 aaagtattcg ttttgccacc aactacttca tgtgtcttga atagaagaag aaaacaaaaa
     6481 aaattcacta ccaaaccaaa ggttgctatt tttgagacat cacgagttca ttgctcacgg
     6541 cagaagaatg caccttctct cccatgacag actgtcagtt tttaagtctt tttttttttt
     6601 tttttttttt ttttttttgg cccatttctt aggcttgtgt tttagcaaag tatacctgcg
     6661 tggccatctt gtccacgcca atgcagaggt cctaaaagga ctccctctat tctctatccc
     6721 tgtggacgta aagacactgg catctctgtt accttctctt ccctttgcaa gggttttaac
     6781 tttggaatct tccagagaaa gtttggccaa tgccagatct cccagagttg ggatttttgt
     6841 tatttttttt ctttgtttta aatcaaattt gtgtctggtt cctatttaca ctactgattg
     6901 ttctaatccc agagatgaat atgtttctcc tctgtatgag aagtaagcac cctttatggt
     6961 gaaacctgtc tcttgtggta gaaacggaag ccgctgaaaa caaacatcag cacaggagag
     7021 ccccaggcag aggtctccct tgagattctt ccgaagcaat cgttggggtc tgggtcagtt
     7081 tcacagggtt atgccatttt attcaagtcc gttgctccgt tgtgcagtct ccaccatata
     7141 agcaaaaatg acagccagta cataaggggt tagcttgaca aagtagactt ccttgtgttc
     7201 atttttaagg tttttttttt cttaactata tctgtctaca ggcagataca gataggtata
     7261 tggaaatgtg cttgcctgta aaatttgcat ttataaatgt gttgcgatgg atcacttcgg
     7321 cctgtacaca tccaattagc gtgaccactt ccatcttaaa aacaaatcta aacaaaattt
     7381 attattatta tatatatata aaggactgtg ggttgtatac aaactattgc aaacacttgt
     7441 gcaaatctgt cttgatataa aggaaaagca aacgctgtgt aacattacta cttgaatgcc
     7501 tttgtgactg aatttttttt ttcattttaa atataaactt ttttgtggaa agtatgctca
     7561 atgttttttt ccccctcccc cccattccct tgtaaataca ttttgttcta tgtgacttgg
     7621 tttggaaata gttaactggt actgtaattt gcattaaata aaaagtaggt tagcctggaa
     7681 atgaaattaa acttcaccag tgtgtggtct ttatttcagt gcccatcccc ctctcttcac
     7741 ccttcccact ctgccatcgc cacatgcagt cacactgccg tctccactcc tctgacagag
     7801 gaaacatgaa tccttgagag aaaaatcagg actctccttc tctgagatga ccttgctctg
     7861 atgtgtagac aggaggtgca gcttccagct tggaaacccc ctggacttaa tgtagagaaa
     7921 gctttgcaga cactgctttg gggaaaaaca aacaaaaaac cctgaaaggg acagttgtaa
     7981 aacatgtata agctgctgtc tttggttact gtgtccatgg tttggtgtgg ctgtatttat
     8041 tttaacttcc atcttattag taatggtcgt tgggagtctt tgtaaaccat gaacaccatg
     8101 gacattgggt cagtcccacc catgtaacca acacgtgtgt gagtctgctc atttccaata
     8161 ctggataatg tatgttaaca tgttatgtct catagtgcaa acagaaacac cattttttag
     8221 ggctggctca ttgtcaggcc taaaggttag atataaggtc atgtgactgc tgcttcaata
     8281 aagacaaatt tatattggac tca
//
