LOCUS       NM_001031667            2276 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus glycogen synthase kinase 3 alpha (Gsk3a), mRNA.
ACCESSION   NM_001031667
VERSION     NM_001031667.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2276)
  AUTHORS   Patel,S., Shah,N., D'Mello,B., Lee,A. and Werstuck,G.H.
  TITLE     Myeloid GSK3alpha Deficiency Reduces Lesional Inflammation and
            Neovascularization during Atherosclerotic Progression
  JOURNAL   Int J Mol Sci 25 (20), 10897 (2024)
   PUBMED   39456687
  REMARK    GeneRIF: Myeloid GSK3alpha Deficiency Reduces Lesional Inflammation
            and Neovascularization during Atherosclerotic Progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2276)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2276)
  AUTHORS   Mohanty,G., Sanchez-Cardenas,C., Paudel,B., Tourzani,D.A.,
            Salicioni,A.M., Santi,C.M., Gervasi,M.G., Pilsner,J.R., Darszon,A.
            and Visconti,P.E.
  TITLE     Differential role of bovine serum albumin and HCO3- in the
            regulation of GSK3 alpha during mouse sperm capacitation
  JOURNAL   Mol Hum Reprod 30 (3) (2024)
   PUBMED   38341666
  REMARK    GeneRIF: Differential role of bovine serum albumin and HCO3- in the
            regulation of GSK3 alpha during mouse sperm capacitation.
REFERENCE   4  (bases 1 to 2276)
  AUTHORS   Park,S.H. and Gye,M.C.
  TITLE     Inhibition of mitochondrial cyclophilin D, a downstream target of
            glycogen synthase kinase 3alpha, improves sperm motility
  JOURNAL   Reprod Biol Endocrinol 22 (1), 15 (2024)
   PUBMED   38254112
  REMARK    GeneRIF: Inhibition of mitochondrial cyclophilin D, a downstream
            target of glycogen synthase kinase 3alpha, improves sperm motility.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2276)
  AUTHORS   Ahmad,F., Marzook,H., Gupta,A., Aref,A., Patil,K., Khan,A.A.,
            Saleh,M.A., Koch,W.J., Woodgett,J.R. and Qaisar,R.
  TITLE     GSK-3alpha aggravates inflammation, metabolic derangement, and
            cardiac injury post-ischemia/reperfusion
  JOURNAL   J Mol Med (Berl) 101 (11), 1379-1396 (2023)
   PUBMED   37707557
  REMARK    GeneRIF: GSK-3alpha aggravates inflammation, metabolic derangement,
            and cardiac injury post-ischemia/reperfusion.
REFERENCE   6  (bases 1 to 2276)
  AUTHORS   Umans,L., Vermeire,L., Francis,A., Chang,H., Huylebroeck,D. and
            Zwijsen,A.
  TITLE     Generation of a floxed allele of Smad5 for cre-mediated conditional
            knockout in the mouse
  JOURNAL   Genesis 37 (1), 5-11 (2003)
   PUBMED   14502571
REFERENCE   7  (bases 1 to 2276)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2276)
  AUTHORS   Bennett,C.N., Ross,S.E., Longo,K.A., Bajnok,L., Hemati,N.,
            Johnson,K.W., Harrison,S.D. and MacDougald,O.A.
  TITLE     Regulation of Wnt signaling during adipogenesis
  JOURNAL   J Biol Chem 277 (34), 30998-31004 (2002)
   PUBMED   12055200
REFERENCE   9  (bases 1 to 2276)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
REFERENCE   10 (bases 1 to 2276)
  AUTHORS   Hart,M.J., de los Santos,R., Albert,I.N., Rubinfeld,B. and
            Polakis,P.
  TITLE     Downregulation of beta-catenin by human Axin and its association
            with the APC tumor suppressor, beta-catenin and GSK3 beta
  JOURNAL   Curr Biol 8 (10), 573-581 (1998)
   PUBMED   9601641
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK624130.1, BQ885209.1, BI987440.1, BE847593.1, AV131869.2 and
            AW046583.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-607               CK624130.1         1-607
            608-1095            BQ885209.1         201-688
            1096-1652           BI987440.1         44-600
            1653-1895           BE847593.1         146-388
            1896-2248           AV131869.2         656-1008
            2249-2276           AW046583.1         1-28                c
FEATURES             Location/Qualifiers
     source          1..2276
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 13.73 cM"
     gene            1..2276
                     /gene="Gsk3a"
                     /gene_synonym="2700086H06Rik"
                     /note="glycogen synthase kinase 3 alpha"
                     /db_xref="GeneID:606496"
                     /db_xref="MGI:MGI:2152453"
     exon            1..474
                     /gene="Gsk3a"
                     /gene_synonym="2700086H06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..1664
                     /gene="Gsk3a"
                     /gene_synonym="2700086H06Rik"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.26"
                     /note="GSK-3 alpha; serine/threonine-protein kinase GSK3A"
                     /codon_start=1
                     /product="glycogen synthase kinase-3 alpha"
                     /protein_id="NP_001026837.1"
                     /db_xref="CCDS:CCDS20976.1"
                     /db_xref="GeneID:606496"
                     /db_xref="MGI:MGI:2152453"
                     /translation="MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPG
                     GTGGGKASVGAMGGGVGASSSGGGPSGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTT
                     VVATVGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRE
                     LQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLITPI
                     IYIKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPN
                     VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIK
                     VLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSSKTPPEAIALCSSLLEYTPSSR
                     LSPLEACAHSFFDELRRLGAQLPNDRPLPPLFNFSPGELSIQPSLNAILIPPHLRSPA
                     GPASPLTTSYNPSSQALTEAQTGQDWQPSDATTATLASSS"
     exon            475..662
                     /gene="Gsk3a"
                     /gene_synonym="2700086H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            663..746
                     /gene="Gsk3a"
                     /gene_synonym="2700086H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            747..857
                     /gene="Gsk3a"
                     /gene_synonym="2700086H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            858..988
                     /gene="Gsk3a"
                     /gene_synonym="2700086H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1095
                     /gene="Gsk3a"
                     /gene_synonym="2700086H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1193
                     /gene="Gsk3a"
                     /gene_synonym="2700086H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1289
                     /gene="Gsk3a"
                     /gene_synonym="2700086H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1479
                     /gene="Gsk3a"
                     /gene_synonym="2700086H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1587
                     /gene="Gsk3a"
                     /gene_synonym="2700086H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..2259
                     /gene="Gsk3a"
                     /gene_synonym="2700086H06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2235..2240
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gsk3a"
                     /gene_synonym="2700086H06Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2259
                     /gene="Gsk3a"
                     /gene_synonym="2700086H06Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtggtgacaa cgaagccgac ggcagaggga cttcatctcc cggcgtgccc cgcggcgggc
       61 gctgggccgg agccggagcc cgaacggcgc ggcctggaag aggccggagc ccaggggagg
      121 cggcggcaga ggcagcggcg ggggcagccc aggcagcccg agccccgcgg cctgggcctg
      181 cgctcggcgc catgagcggc ggcgggcctt cgggaggcgg ccctgggggc tcgggccggg
      241 cgcggaccag ctcgttcgcg gagccaggag gcggaggcgg aggtggtggc ggcggccccg
      301 ggggctcggc ctctggccca ggaggcactg gcggcgggaa agcgtcagtc ggggctatgg
      361 gtgggggcgt gggagcctcg agctccgggg gtggccccag cggcagcggc ggaggaggca
      421 gcggtggccc cggcgcgggc actagcttcc cgccgccggg agtgaagctg ggccgtgaca
      481 gcgggaaggt gaccacagtg gtagccactg taggccaagg cccagagcgt tcccaagaag
      541 tggcttacac tgacatcaaa gtgattggta atggctcatt cggagtagta taccaggcac
      601 ggctggcaga gacgagggaa ctggtggcca tcaagaaggt tcttcaggac aaaaggttca
      661 agaaccgaga actgcagatt atgcgtaagc tggaccactg caatattgtg aggctgcggt
      721 actttttcta ctccagtggg gagaagaagg acgagctgta tttgaatctg gtgctggagt
      781 atgtgcccga gacggtgtac cgagtggccc gccacttcac caaggccaag ctgatcaccc
      841 ctatcatcta catcaaggtg tacatgtacc agctcttccg gagcttggcc tacatccact
      901 cccaaggtgt gtgtcaccgt gacatcaagc cccagaattt gcttgtggac cctgacactg
      961 ctgtcctcaa gctctgcgat tttggcagtg caaagcagct ggttcggggg gagcccaatg
     1021 tgtcctacat ctgctctcgg tactaccgtg ctccagaact catctttgga gccacagatt
     1081 acacctcgtc catcgatgtg tggtcggctg gctgtgtact tgctgagcta cttctcggcc
     1141 agcccatctt ccctggggac agtggggtgg accagcttgt ggagatcatc aaggtactag
     1201 gaacgccaac cagggaacaa atccgagaga tgaaccctaa ctatacggag ttcaagttcc
     1261 cccagatcaa agctcaccct tggacaaagg tgttcaaatc ttcaaagaca ccacctgagg
     1321 ccattgcact ctgctctagc ctactggagt acacgccatc ctcaaggctc tccccactcg
     1381 aggcttgtgc ccacagcttc ttcgatgaac tgcggagact cggagcccag ctccccaacg
     1441 accgcccgct tccccccctg ttcaacttca gtcctggtga actgtccatc caaccatctc
     1501 tcaatgccat tctcatccct cctcacttga ggtccccagc aggccctgct tctcccctca
     1561 ccacttccta caacccatcc tcacaagctt taactgaagc tcagactggc caagattggc
     1621 agccatctga tgccacaact gctaccctcg ctagctcttc ctgagggccc caccgactac
     1681 ccctccacgt ccatctggga aggcccaagt ggcgctggga agggggccac agcccatcaa
     1741 gctcctgccc tggctgggcc cctagactag agggcagagg taaatgaact acccccagca
     1801 tctaggcctc cctcagcagc ctaacctctg tggtgggctt tttaaagagg attttaactg
     1861 tttgtagggg aggggagaaa aggaaggacg gggtttgggg gtgtgaggac cttctacccc
     1921 cttggtcccc tcccctcccc caggctacca ctccttccct ccccccctct cccaggtccc
     1981 ttgtaaatag aaccagccca gcccatctct cgtcttccct tccctggccc cctgggtgta
     2041 aatagattgt tataattttt tcttaaagaa aacgtcaatt cacaccattc aacttgcccc
     2101 ccccagctgt accccttctt gtcctctgct cccaaggctt cctccctctc cccatcctgg
     2161 aaggagggga gtagagagag tccctggtgt cttagtttcc acagtaaggt ttgcctgtgt
     2221 acagacctct gttcaataaa ttattggcat gaaaccctta aaaaaaaaaa aaaaaa
//
