LOCUS       NM_010352               1448 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus germ cell associated 1 (Gsg1), transcript variant 3,
            mRNA.
ACCESSION   NM_010352
VERSION     NM_010352.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1448)
  AUTHORS   Lu,Y., Oura,S., Matsumura,T., Oji,A., Sakurai,N., Fujihara,Y.,
            Shimada,K., Miyata,H., Tobita,T., Noda,T., Castaneda,J.M.,
            Kiyozumi,D., Zhang,Q., Larasati,T., Young,S.A.M., Kodani,M.,
            Huddleston,C.A., Robertson,M.J., Coarfa,C., Isotani,A.,
            Aitken,R.J., Okabe,M., Matzuk,M.M., Garcia,T.X. and Ikawa,M.
  TITLE     CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched
            genes dispensable for male fertility in micedagger
  JOURNAL   Biol Reprod 101 (2), 501-511 (2019)
   PUBMED   31201419
REFERENCE   2  (bases 1 to 1448)
  AUTHORS   Park,K.U., Randazzo,G., Jones,K.L. and Brzezinski,J.A. 4th.
  TITLE     Gsg1, Trnp1, and Tmem215 Mark Subpopulations of Bipolar
            Interneurons in the Mouse Retina
  JOURNAL   Invest Ophthalmol Vis Sci 58 (2), 1137-1150 (2017)
   PUBMED   28199486
REFERENCE   3  (bases 1 to 1448)
  AUTHORS   Turner,L.M., Chuong,E.B. and Hoekstra,H.E.
  TITLE     Comparative analysis of testis protein evolution in rodents
  JOURNAL   Genetics 179 (4), 2075-2089 (2008)
   PUBMED   18689890
REFERENCE   4  (bases 1 to 1448)
  AUTHORS   Choi,H.S., Lee,S.H., Kim,H. and Lee,Y.
  TITLE     Germ cell-specific gene 1 targets testis-specific poly(A)
            polymerase to the endoplasmic reticulum through protein-protein
            interactions
  JOURNAL   FEBS Lett 582 (8), 1203-1209 (2008)
   PUBMED   18325338
  REMARK    GeneRIF: expression of GSG1 stimulates TPAP targeting to the ER,
            suggesting that interactions between the two proteins lead to the
            redistribution of TPAP from the cytosol to the ER
REFERENCE   5  (bases 1 to 1448)
  AUTHORS   Matsui,M., Ichihara,H., Kobayashi,S., Tanaka,H., Tsuchida,J.,
            Nozaki,M., Yoshimura,Y., Nojima,H., Rochelle,J.M., Nishimune,Y.,
            Taketo,M.M. and Seldin,M.F.
  TITLE     Mapping of six germ-cell-specific genes to mouse chromosomes
  JOURNAL   Mamm Genome 8 (11), 873-874 (1997)
   PUBMED   9337410
REFERENCE   6  (bases 1 to 1448)
  AUTHORS   Tanaka,H., Yoshimura,Y., Nishina,Y., Nozaki,M., Nojima,H. and
            Nishimune,Y.
  TITLE     Isolation and characterization of cDNA clones specifically
            expressed in testicular germ cells
  JOURNAL   FEBS Lett 355 (1), 4-10 (1994)
   PUBMED   7957958
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY098420.1, CA465575.1 and BC023009.1.
            
            [WARNING] On Jan 31, 2025 this sequence was replaced by
            NM_010352.3.
            
            On Jan 19, 2007 this sequence version replaced NM_010352.1.
            
            Transcript Variant: This variant (3) contains a distinct 5' UTR and
            lacks an in-frame portion of the 5' coding region, compared to
            variant 1. The resulting isoform (b) has a shorter N-terminus,
            compared to isoform a. Variants 2 and 3 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D87325.1, SRR5189670.157968.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BY098420.1         17-29
            14-386              CA465575.1         4-376
            387-1448            BC023009.1         259-1320
FEATURES             Location/Qualifiers
     source          1..1448
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 66.07 cM"
     gene            1..1448
                     /gene="Gsg1"
                     /note="germ cell associated 1"
                     /db_xref="GeneID:14840"
                     /db_xref="MGI:MGI:1194499"
     exon            1..204
                     /gene="Gsg1"
                     /inference="alignment:Splign:2.1.0"
     exon            205..264
                     /gene="Gsg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..1362
                     /gene="Gsg1"
                     /note="isoform b is encoded by transcript variant 3; germ
                     cell-specific gene 1 protein; germ cell-associated protein
                     1"
                     /codon_start=1
                     /product="germ cell-specific gene 1 protein isoform b"
                     /protein_id="NP_034482.2"
                     /db_xref="CCDS:CCDS39683.1"
                     /db_xref="GeneID:14840"
                     /db_xref="MGI:MGI:1194499"
                     /translation="MEFQKGSSDQRTFISAILNMLSLGLSTASLLSSEWFVGTQKVPK
                     PLCGQSLAAKCFDMPMSLDGGIANTSAQEVVQYTWETGDDRFSFLAFRSGMWLSCEET
                     MEEPGEKCRRFIELTPPAQRGEKGLLEFATLQGSCHPTLRFGGEWLMEKASLLHLPWG
                     PVAKVFWLSLGAQTAYIGLQLISFLLLLTDLLLTTNPGCGLKLSAFAAVSLVLSGLLG
                     MVAHMLYSQVFQATANLGPEDWRPHSWNYGWAFYTAWVSFTCCMASAVTTFNMYTRMV
                     LEFKCRHSKSFNTNPSCLAQHHRCFLPPPLTCTTHAGEPLSSCHQYPSHPIRSVSEAI
                     DLYSALQDKEFQQGISQELKEVVEPSVEEQR"
     exon            265..583
                     /gene="Gsg1"
                     /inference="alignment:Splign:2.1.0"
     exon            584..754
                     /gene="Gsg1"
                     /inference="alignment:Splign:2.1.0"
     exon            755..907
                     /gene="Gsg1"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1019
                     /gene="Gsg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1436
                     /gene="Gsg1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1436
                     /gene="Gsg1"
                     /note="major polyA site"
ORIGIN      
        1 tacccaagct ggcggcgtgc ctgaggggca ttcatcctct cccaactgcc cacataccac
       61 cttaccccct ctgctggcaa gaggggacct ggtgcaccct ctccctcaac acctgagcca
      121 cgcaactaag acctgtcaga gcagaagctg agacacattt tcaactcctg tcagctgact
      181 caaaatgttt gtctcaccca ggagatcttc agaacaaaac tgtagaggac tccccacctc
      241 tcccgccagc ccttggggaa gcagatggag ttccagaagg gttcctctga ccagcggacc
      301 ttcatttctg ccatcctcaa catgttatca ctcggcctct ccacagcatc cttgctcagc
      361 agcgagtggt ttgtgggcac acagaaggtg cccaagcccc tgtgcgggca aagtctggca
      421 gccaagtgct ttgacatgcc gatgtccttg gatgggggca tcgccaacac atcagcccag
      481 gaggtggtac aatacacctg ggagactggg gatgaccggt tctccttcct tgccttccgc
      541 agtggcatgt ggctatcctg tgaggaaacc atggaagagc caggggagaa gtgcagacgt
      601 ttcattgaac tcacaccacc agcccagaga ggtgagaaag gactactgga atttgccacg
      661 ttgcaaggct catgtcaccc cactctccga tttggagggg agtggttaat ggagaaggct
      721 tctctcctcc acctcccttg ggggcccgtg gcaaaggtct tttggctgtc actgggagcc
      781 cagactgcct atatcggact tcaactcatc agcttcctcc tgctactgac ggatctgttg
      841 ctcaccacga accctggctg tgggctcaag ctaagcgcgt ttgcagccgt ctccttggtc
      901 ctgtcaggac ttctggggat ggtggctcat atgctatatt cacaagtctt ccaggcaact
      961 gccaacttag gtccggagga ctggagacca cactcttgga attacggctg ggccttctac
     1021 acagcgtggg tttccttcac ctgctgcatg gcgtcagcgg tcaccacctt caacatgtac
     1081 acgaggatgg tgctggagtt caagtgcagg cacagcaaga gctttaacac caaccccagc
     1141 tgcctggcgc agcaccaccg ctgtttcctt cctcctccgc tgacgtgcac aacccacgca
     1201 ggggaacctt tgtccagctg ccatcagtac cccagccatc ccatccgctc tgtctctgaa
     1261 gctattgacc tctactcggc gctacaggac aaagaatttc aacaagggat cagccaggag
     1321 ctaaaggaag tggtcgagcc atctgtagaa gagcagcgtt aggagttaag tgggtttggg
     1381 aagcaggcta agtcctacca taggtgtcgc tcactatcaa catctgctta agcaaaaaaa
     1441 aaaaaaaa
//
