LOCUS       NM_018769               2135 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus gasdermin E (Gsdme), mRNA.
ACCESSION   NM_018769
VERSION     NM_018769.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2135)
  AUTHORS   Jena,K.K., Mambu,J., Boehmer,D., Sposito,B., Millet,V., de Sousa
            Casal,J., Muendlein,H.I., Spreafico,R., Fenouil,R., Spinelli,L.,
            Wurbel,S., Riquier,C., Galland,F., Naquet,P., Chasson,L.,
            Elkins,M., Mitsialis,V., Ketelut-Carneiro,N., Bugda Gwilt,K.,
            Thiagarajah,J.R., Ruan,H.B., Lin,Z., Lien,E., Shao,F., Chou,J.,
            Poltorak,A., Ordovas-Montanes,J., Fitzgerald,K.A., Snapper,S.B.,
            Broggi,A. and Zanoni,I.
  TITLE     Type III interferons induce pyroptosis in gut epithelial cells and
            impair mucosal repair
  JOURNAL   Cell 187 (26), 7533-7550 (2024)
   PUBMED   39500322
REFERENCE   2  (bases 1 to 2135)
  AUTHORS   Grin,P.M., Baid,K., de Jesus,H.C.R., Kozarac,N., Bell,P.A.,
            Jiang,S.Z., Kappelhoff,R., Butler,G.S., Leborgne,N.G.F., Pan,C.,
            Pablos,I., Machado,Y., Vederas,J.C., Kim,H., Benarafa,C.,
            Banerjee,A. and Overall,C.M.
  TITLE     SARS-CoV-2 3CLpro (main protease) regulates caspase activation of
            gasdermin-D/E pores leading to secretion and extracellular activity
            of 3CLpro
  JOURNAL   Cell Rep 43 (12), 115080 (2024)
   PUBMED   39673710
REFERENCE   3  (bases 1 to 2135)
  AUTHORS   Zhu,J.H., Ouyang,S.X., Zhang,G.Y., Cao,Q., Xin,R., Yin,H., Wu,J.W.,
            Zhang,Y., Zhang,Z., Liu,Y., Fu,J.T., Chen,Y.T., Tong,J.,
            Zhang,J.B., Liu,J., Shen,F.M., Li,D.J. and Wang,P.
  TITLE     GSDME promotes MASLD by regulating pyroptosis, Drp1
            citrullination-dependent mitochondrial dynamic, and energy balance
            in intestine and liver
  JOURNAL   Cell Death Differ 31 (11), 1467-1486 (2024)
   PUBMED   39009654
REFERENCE   4  (bases 1 to 2135)
  AUTHORS   Sun,S.J., Jiao,X.D., Chen,Z.G., Cao,Q., Zhu,J.H., Shen,Q.R.,
            Liu,Y., Zhang,Z., Xu,F.F., Shi,Y., Tong,J., Ouyang,S.X., Fu,J.T.,
            Zhao,Y., Ren,J., Li,D.J., Shen,F.M. and Wang,P.
  TITLE     Gasdermin-E-mediated pyroptosis drives immune checkpoint
            inhibitor-associated myocarditis via cGAS-STING activation
  JOURNAL   Nat Commun 15 (1), 6640 (2024)
   PUBMED   39103324
  REMARK    GeneRIF: Gasdermin-E-mediated pyroptosis drives immune checkpoint
            inhibitor-associated myocarditis via cGAS-STING activation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2135)
  AUTHORS   Xiao,Y., Chen,L., Xu,K., Zhou,M., Han,Y., Luo,J., Ai,Y., Wang,M.,
            Jin,Y., Qiao,R., Kong,S., Fan,Z., Xu,L. and Wang,H.
  TITLE     Gain-of-function variants in GSDME cause pyroptosis and apoptosis
            associated with post-lingual hearing loss
  JOURNAL   Hum Genet 143 (8), 979-993 (2024)
   PUBMED   39066985
  REMARK    GeneRIF: Gain-of-function variants in GSDME cause pyroptosis and
            apoptosis associated with post-lingual hearing loss.
REFERENCE   6  (bases 1 to 2135)
  AUTHORS   Delmaghani,S., del Castillo,F.J., Michel,V., Leibovici,M.,
            Aghaie,A., Ron,U., Van Laer,L., Ben-Tal,N., Van Camp,G., Weil,D.,
            Langa,F., Lathrop,M., Avan,P. and Petit,C.
  TITLE     Mutations in the gene encoding pejvakin, a newly identified protein
            of the afferent auditory pathway, cause DFNB59 auditory neuropathy
  JOURNAL   Nat Genet 38 (7), 770-778 (2006)
   PUBMED   16804542
REFERENCE   7  (bases 1 to 2135)
  AUTHORS   Van Laer,L., Pfister,M., Thys,S., Vrijens,K., Mueller,M., Umans,L.,
            Serneels,L., Van Nassauw,L., Kooy,F., Smith,R.J., Timmermans,J.P.,
            Van Leuven,F. and Van Camp,G.
  TITLE     Mice lacking Dfna5 show a diverging number of cochlear fourth row
            outer hair cells
  JOURNAL   Neurobiol Dis 19 (3), 386-399 (2005)
   PUBMED   16023581
REFERENCE   8  (bases 1 to 2135)
  AUTHORS   Maeda,Y., Fukushima,K., Kasai,N., Maeta,M. and Nishizaki,K.
  TITLE     Quantification of TECTA and DFNA5 expression in the developing
            mouse cochlea
  JOURNAL   Neuroreport 12 (15), 3223-3226 (2001)
   PUBMED   11711860
REFERENCE   9  (bases 1 to 2135)
  AUTHORS   Van Laer,L., Huizing,E.H., Verstreken,M., van Zuijlen,D.,
            Wauters,J.G., Bossuyt,P.J., Van de Heyning,P., McGuirt,W.T.,
            Smith,R.J., Willems,P.J., Legan,P.K., Richardson,G.P. and Van
            Camp,G.
  TITLE     Nonsyndromic hearing impairment is associated with a mutation in
            DFNA5
  JOURNAL   Nat Genet 20 (2), 194-197 (1998)
   PUBMED   9771715
REFERENCE   10 (bases 1 to 2135)
  AUTHORS   Guthridge,M.A., Seldin,M. and Basilico,C.
  TITLE     Induction of expression of growth-related genes by FGF-4 in mouse
            fibroblasts
  JOURNAL   Oncogene 12 (6), 1267-1278 (1996)
   PUBMED   8649829
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153819.5.
            
            On May 29, 2018 this sequence version replaced NM_018769.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086618.1, AF073309.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AC153819.5         28244-28279
            37-274              AC153819.5         38500-38737
            275-467             AC153819.5         43891-44083
            468-639             AC153819.5         60556-60727
            640-760             AC153819.5         62614-62734
            761-925             AC153819.5         67113-67277
            926-1053            AC153819.5         68897-69024
            1054-1255           AC153819.5         70575-70776
            1256-1329           AC153819.5         73590-73663
            1330-2135           AC153819.5         81807-82612
FEATURES             Location/Qualifiers
     source          1..2135
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 24.13 cM"
     gene            1..2135
                     /gene="Gsdme"
                     /gene_synonym="2310037D07Rik; 4932441K13Rik; Dfna5;
                     Dfna5h; EG14210; Fin15"
                     /note="gasdermin E"
                     /db_xref="GeneID:54722"
                     /db_xref="MGI:MGI:1889850"
     exon            1..36
                     /gene="Gsdme"
                     /gene_synonym="2310037D07Rik; 4932441K13Rik; Dfna5;
                     Dfna5h; EG14210; Fin15"
                     /inference="alignment:Splign:2.1.0"
     exon            37..274
                     /gene="Gsdme"
                     /gene_synonym="2310037D07Rik; 4932441K13Rik; Dfna5;
                     Dfna5h; EG14210; Fin15"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1602
                     /gene="Gsdme"
                     /gene_synonym="2310037D07Rik; 4932441K13Rik; Dfna5;
                     Dfna5h; EG14210; Fin15"
                     /note="non-syndromic hearing impairment protein 5 homolog;
                     deafness, autosomal dominant 5 homolog; deafness
                     associated tumor suppressor"
                     /codon_start=1
                     /product="gasdermin-E precursor"
                     /protein_id="NP_061239.1"
                     /db_xref="CCDS:CCDS20130.1"
                     /db_xref="GeneID:54722"
                     /db_xref="MGI:MGI:1889850"
                     /translation="MFAKATRNFLKEVDAGGDLISVSHLNDSDKLQLLSLVTKKKRYW
                     CWQRPKYQILSATLEDVLTEGHCLSPVVVESDFVKYESKCENHKSGAIGTVVGKVKLN
                     VGGKGVVESHSSFGTLRKQEVDVQQLIQDAVKRTVNMDNLVLQQVLESRNEVLCVLTQ
                     KIMTTQKCVISEHVQSEETCGGMVGIQTKTIQVSATEDGTVTTDTNVVLEIPAATTIA
                     YGIMELFVKQDGQFEFCLLQGKHGGFEHERKLDSVYLDPLAYREFAFLDMLDGGQGIS
                     SQDGPLRVVKQATLHLERSFHPFAVLPAQQQRALFCVLQKILFDEELLRALEQVCDDV
                     AGGLWSSQAVLAMEELTDSQQQDLTAFLQLVGYRIQGEHPGPQDEVSNQKLFATAYFL
                     VSALAEMPDNATVFLGTCCKLHVISSLCCLLHALSDDSVCDFHNPTLAPLRDTERFGI
                     VQRLFASADIALERMQFSAKATILKDSCIFPLILHITLSGLSTLSKEHEEELCQSGHA
                     TGQD"
     exon            275..467
                     /gene="Gsdme"
                     /gene_synonym="2310037D07Rik; 4932441K13Rik; Dfna5;
                     Dfna5h; EG14210; Fin15"
                     /inference="alignment:Splign:2.1.0"
     exon            468..639
                     /gene="Gsdme"
                     /gene_synonym="2310037D07Rik; 4932441K13Rik; Dfna5;
                     Dfna5h; EG14210; Fin15"
                     /inference="alignment:Splign:2.1.0"
     exon            640..760
                     /gene="Gsdme"
                     /gene_synonym="2310037D07Rik; 4932441K13Rik; Dfna5;
                     Dfna5h; EG14210; Fin15"
                     /inference="alignment:Splign:2.1.0"
     exon            761..925
                     /gene="Gsdme"
                     /gene_synonym="2310037D07Rik; 4932441K13Rik; Dfna5;
                     Dfna5h; EG14210; Fin15"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1053
                     /gene="Gsdme"
                     /gene_synonym="2310037D07Rik; 4932441K13Rik; Dfna5;
                     Dfna5h; EG14210; Fin15"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1255
                     /gene="Gsdme"
                     /gene_synonym="2310037D07Rik; 4932441K13Rik; Dfna5;
                     Dfna5h; EG14210; Fin15"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1329
                     /gene="Gsdme"
                     /gene_synonym="2310037D07Rik; 4932441K13Rik; Dfna5;
                     Dfna5h; EG14210; Fin15"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..2135
                     /gene="Gsdme"
                     /gene_synonym="2310037D07Rik; 4932441K13Rik; Dfna5;
                     Dfna5h; EG14210; Fin15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2113..2118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gsdme"
                     /gene_synonym="2310037D07Rik; 4932441K13Rik; Dfna5;
                     Dfna5h; EG14210; Fin15"
                     /note="hexamer: ATTAAA"
     polyA_site      2135
                     /gene="Gsdme"
                     /gene_synonym="2310037D07Rik; 4932441K13Rik; Dfna5;
                     Dfna5h; EG14210; Fin15"
                     /note="major polyA site"
ORIGIN      
        1 agaacggagc gtgcaggacg gagaggcggc gcgcggtttt tcaggtaatc tcaacccgac
       61 aaaatgtttg ccaaagcaac tcgaaatttt cttaaagaag ttgatgctgg aggagacctg
      121 atttcagtct cacacttgaa cgactctgac aagctgcaac ttctaagtct ggtgaccaaa
      181 aagaagagat actggtgctg gcagagaccc aagtaccaga ttttatctgc caccctggaa
      241 gatgtactca cagaagggca ctgtctcagt ccagtggttg tggagtcaga cttcgtgaaa
      301 tacgagagca agtgtgagaa ccataagagc ggggctattg ggacagtcgt ggggaaggtc
      361 aagctgaacg ttggtggcaa aggcgtggtg gagagtcact cttcgtttgg aaccctgagg
      421 aagcaggagg tggacgtgca gcagctcatc caggatgccg tcaagagaac agttaatatg
      481 gacaacctgg tacttcagca ggtgctagag agcaggaacg aggtcctgtg tgtgctgacg
      541 cagaagatca tgaccacgca gaagtgcgtg atttctgagc atgtgcagtc ggaggagacg
      601 tgtggaggca tggtggggat ccagaccaag actatacagg tgtcagcaac ggaggatggg
      661 acggtcacca cggacaccaa tgtagtgctg gagatccctg ctgccaccac cattgcctat
      721 ggcatcatgg agctgtttgt gaaacaagat ggccagtttg aattctgcct cctccaaggg
      781 aaacatggtg gcttcgagca tgagaggaaa ctagactctg tctacttgga ccccctggcc
      841 tacagagagt tcgcctttct ggacatgctg gatgggggtc aagggatctc ttcgcaggac
      901 gggcccctac gagttgtaaa acaagcaacc ctgcacctag agaggagttt ccatcccttt
      961 gcggtgttac ctgcccagca gcagagggcg ctgttctgtg tcctgcagaa aatcctgttt
     1021 gatgaagaac tccttcgggc cctggagcaa gtgtgtgatg atgtggctgg tggtctctgg
     1081 tcctcacagg ctgtattggc aatggaggag ctgaccgaca gtcagcagca ggacctcaca
     1141 gccttcttgc agctggtggg atacaggata caaggagagc atcctggccc acaggatgag
     1201 gtcagcaacc agaagctctt tgcaacagcc tacttcctgg tcagcgcact agcagaaatg
     1261 cctgataatg ccacagtttt cctggggact tgctgcaaac tccatgttat ttcttcgctg
     1321 tgctgcttgc tccatgctct gtctgatgac agcgtgtgtg attttcacaa ccccaccttg
     1381 gctcctctga gagacacaga gaggtttggc atcgtgcagc gattgtttgc ctctgctgac
     1441 attgccctgg agaggatgca gttttctgcg aaagccacca tcctgaagga ctcttgcatc
     1501 ttcccgctaa ttcttcacat cactctaagt gggctcagca ctctaagcaa agagcatgag
     1561 gaagagcttt gtcagtcagg acatgctaca ggtcaagact agctactttt caggattgag
     1621 aaactacttt gggattttgg gcccaagcag gttcagtctg ccagtgaatt ccagtgcacc
     1681 tcagaggtgg tgtctttgtg aatggctgcg agcgttgtca atgggttatt ctcatcagag
     1741 gcccactgca ctgacactgg agtcactgag ggaagaacca cctgtcagtc actttatctt
     1801 ccactcttat ctgatgtaca aaagcagaag agtctcagat tttacttcag agtccatcat
     1861 aagctgggaa tgcaacaggg aagcaatttc cttcccatcc ttcagacatg ctgtacacta
     1921 ctgggtgact gggaaaccag aaatgctact tgagtacata aaacaattat agtaagaaca
     1981 tctaatttga cccacctcaa catgagaact taaatatatt cctcttattt gactttgtta
     2041 tgctttaatg aacatattat gtctggggca attccagtgc gttctgggaa tttgtcacat
     2101 gttgcaattt ctattaaaag caattctgaa ctatg
//
