LOCUS       NM_028992               2084 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus gasdermin C4 (Gsdmc4), mRNA.
ACCESSION   NM_028992 XM_001474104 XM_135511
VERSION     NM_028992.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2084)
  AUTHORS   Fattinger,S.A., Maurer,L., Geiser,P., Bernard,E.M., Enz,U.,
            Ganguillet,S., Gul,E., Kroon,S., Demarco,B., Mack,V., Furter,M.,
            Barthel,M., Pelczar,P., Shao,F., Broz,P., Sellin,M.E. and
            Hardt,W.D.
  TITLE     Gasdermin D is the only Gasdermin that provides protection against
            acute Salmonella gut infection in mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (48), e2315503120 (2023)
   PUBMED   37988464
REFERENCE   2  (bases 1 to 2084)
  AUTHORS   Grassmeyer,J., Mukherjee,M., deRiso,J., Hettinger,C., Bailey,M.,
            Sinha,S., Visvader,J.E., Zhao,H., Fogarty,E. and Surendran,K.
  TITLE     Elf5 is a principal cell lineage specific transcription factor in
            the kidney that contributes to Aqp2 and Avpr2 gene expression
  JOURNAL   Dev Biol 424 (1), 77-89 (2017)
   PUBMED   28215940
REFERENCE   3  (bases 1 to 2084)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2084)
  AUTHORS   Combes,A.N., Lesieur,E., Harley,V.R., Sinclair,A.H., Little,M.H.,
            Wilhelm,D. and Koopman,P.
  TITLE     Three-dimensional visualization of testis cord morphogenesis, a
            novel tubulogenic mechanism in development
  JOURNAL   Dev Dyn 238 (5), 1033-1041 (2009)
   PUBMED   19334288
REFERENCE   5  (bases 1 to 2084)
  AUTHORS   Tamura,M., Tanaka,S., Fujii,T., Aoki,A., Komiyama,H., Ezawa,K.,
            Sumiyama,K., Sagai,T. and Shiroishi,T.
  TITLE     Members of a novel gene family, Gsdm, are expressed exclusively in
            the epithelium of the skin and gastrointestinal tract in a highly
            tissue-specific manner
  JOURNAL   Genomics 89 (5), 618-629 (2007)
   PUBMED   17350798
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK163061.1, AK018537.1 and BY460367.1.
            
            On or before Jul 25, 2009 this sequence version replaced
            XM_001474104.1, XM_135511.7.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK018537.1, AK163061.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-320               AK163061.1         2-321
            321-330             AK018537.1         322-331
            331-1627            AK163061.1         332-1628
            1628-2007           AK018537.1         1629-2008
            2008-2012           BY460367.1         391-395
            2013-2084           AK018537.1         2014-2085
FEATURES             Location/Qualifiers
     source          1..2084
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 28.07 cM"
     gene            1..2084
                     /gene="Gsdmc4"
                     /gene_synonym="9030605I04Rik; GsdmC-2"
                     /note="gasdermin C4"
                     /db_xref="GeneID:74548"
                     /db_xref="MGI:MGI:1921798"
     exon            1..98
                     /gene="Gsdmc4"
                     /gene_synonym="9030605I04Rik; GsdmC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            99..310
                     /gene="Gsdmc4"
                     /gene_synonym="9030605I04Rik; GsdmC-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1545
                     /gene="Gsdmc4"
                     /gene_synonym="9030605I04Rik; GsdmC-2"
                     /note="gasderminC-2"
                     /codon_start=1
                     /product="gasdermin-C4"
                     /protein_id="NP_083268.1"
                     /db_xref="CCDS:CCDS49617.1"
                     /db_xref="GeneID:74548"
                     /db_xref="MGI:MGI:1921798"
                     /translation="MGYSFDRASKDVVKKLQGRDLRPVECLSDATKFRLFHILQETPR
                     SGWETEDIPVGFTLLDLLEPNFPVPEPEVSAPKPFIHVQSTDLEANLNVADIARGGVG
                     YVGYGGYNIEVQSTSIPNPKLEILQNRKLLDKLPTFMKFCRMERKNLYVVTEAYEVSK
                     DTMLTGLSSVNLLVKGFFKQLFKVRGKAGRSEKYSIPIPKGSVLAYKKQQLVIENNTC
                     VILPSATKKKMTFPDRPLKLYDLPVTLRYQEEVIETGSWIDDIDPIGTIEEPANLNFM
                     CLQHEVSEQTQLLAELSKDVQEVVFSSFLHMLSDRDVLYDLMKMLELNQLGHMDGPGG
                     KILDELRKDSSTPHDVLKDLNLYLLQALLVLSDTQLCLLAQSVKMGLLPHQVELVKSI
                     LQTNFKYSSNTPFTLQPQLLAPLQGEGLAITYELLEECGLKMELNNPRSTWDLEAKMP
                     LSALYGSLSFLQQLQKANSSSKPSLSPGYI"
     exon            311..488
                     /gene="Gsdmc4"
                     /gene_synonym="9030605I04Rik; GsdmC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            489..651
                     /gene="Gsdmc4"
                     /gene_synonym="9030605I04Rik; GsdmC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            652..757
                     /gene="Gsdmc4"
                     /gene_synonym="9030605I04Rik; GsdmC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            758..865
                     /gene="Gsdmc4"
                     /gene_synonym="9030605I04Rik; GsdmC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            866..895
                     /gene="Gsdmc4"
                     /gene_synonym="9030605I04Rik; GsdmC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            896..922
                     /gene="Gsdmc4"
                     /gene_synonym="9030605I04Rik; GsdmC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1062
                     /gene="Gsdmc4"
                     /gene_synonym="9030605I04Rik; GsdmC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1192
                     /gene="Gsdmc4"
                     /gene_synonym="9030605I04Rik; GsdmC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1266
                     /gene="Gsdmc4"
                     /gene_synonym="9030605I04Rik; GsdmC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..2084
                     /gene="Gsdmc4"
                     /gene_synonym="9030605I04Rik; GsdmC-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1606..1611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gsdmc4"
                     /gene_synonym="9030605I04Rik; GsdmC-2"
                     /note="hexamer: AATAAA"
     polyA_site      1627
                     /gene="Gsdmc4"
                     /gene_synonym="9030605I04Rik; GsdmC-2"
                     /note="major polyA site"
ORIGIN      
        1 gcttgtttgc ctgcttgcac ttccttgctg gcacttcggt tgttacccag ttcttctgga
       61 ttctagttta tacagaagac cagctgaaac acctagagca acatgggcta cagttttgac
      121 cgggctagca aggatgtggt taaaaagctt caaggaagag atctgaggcc tgtggaatgc
      181 ctgtcagatg caaccaaatt ccgcctattt cacatactcc aggagactcc tcgatcaggt
      241 tgggaaactg aagatattcc agttggattt acccttctgg atctcttgga gcccaacttt
      301 cctgttccag agcctgaagt gtctgctccc aagcccttca tacatgtcca atcaacagac
      361 ctggaggcta acttgaatgt cgcagacatt gcaagaggag gtgtagggta tgttgggtac
      421 ggtggataca acatcgaggt tcagagtaca agcatcccaa atccaaaact ggaaattctt
      481 caaaacagga aactgttgga taagttgccc acatttatga agttttgccg gatggaaagg
      541 aagaacctgt atgtggtgac agaggcctat gaagtgtcca aggatactat gctgacagga
      601 ttaagcagtg tcaatctttt agttaaaggg ttcttcaaac agcttttcaa ggttcgaggc
      661 aaggcgggaa ggtcggaaaa gtattcaata cctatcccaa agggttcggt gttggcctat
      721 aagaagcagc aacttgtcat tgagaataac acttgtgtca ttctcccttc tgctactaag
      781 aagaagatga cctttccaga cagacctttg aaattatatg atttacctgt aacgctaaga
      841 tatcaggagg aagtcattga gacaggctct tggatagatg acatcgatcc aattggaaca
      901 attgaggagc ctgccaatct aaattttatg tgtctacaac atgaagtatc tgaacaaaca
      961 caactactgg ctgagctctc aaaggatgtt caagaagttg tgttctccag tttcctgcat
     1021 atgctcagtg acagggatgt tctgtatgac ctgatgaaaa tgctggagtt gaatcagttg
     1081 gggcatatgg atggcccagg tggcaaaatc ctggatgagc tgcgaaagga ttctagcacc
     1141 ccacatgatg tcctaaagga cctcaatctt tatctccttc aagctctgtt ggtgctgagt
     1201 gatacccaac tctgtctgct ggcccagtct gtgaagatgg ggctcctccc gcaccaagta
     1261 gagttggtaa agagcatctt acagacaaac ttcaagtatt cctcaaacac tcccttcaca
     1321 ctccagcctc agcttcttgc cccactccag ggtgagggct tggccattac ttatgaattg
     1381 ctggaggagt gtggtctgaa gatggagctg aataatccca ggtcaacttg ggatttggaa
     1441 gccaagatgc ccctgtctgc tctctatgga agcctgtcat ttttacagca acttcagaag
     1501 gctaactctt cctccaagcc cagcctcagt cctggataca tttgagatat tacaccatag
     1561 catacacaag agtcgtgaat cgagtgcatg ttttaggctg gtgggaataa agatgctatg
     1621 gatcctttct tttctttttt tttttaagta ctattgattc acaattatac aaataatata
     1681 cttggatcag attgtaccta ccccattgtt tcttttaatc catcccttcc aagttccttt
     1741 ttcctcaaca acttctcatt caacatttgt ctgtttgatg ctatgctacg tttaattagg
     1801 gttgtttgca tatgtgtgtg attattcatt tgagcaaggg tagccttcca gaggctacct
     1861 cctgccagca gcattgagag cctataggtg ttttaggtag ggtgaggttc tcctccattc
     1921 atgtggaatg ttggtgggct caggtttgct tggtcttgtg tgggtaccca ttgccacttt
     1981 gagtttatgg gtttagctat tccatatcct tagcatgtct aggaaacagg atctatcaaa
     2041 actcctcaaa tggtatgcta aataaagatt tacacatttt ctct
//
