LOCUS       NM_183194               2142 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus gasdermin C3 (Gsdmc3), mRNA.
ACCESSION   NM_183194 XM_907263
VERSION     NM_183194.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2142)
  AUTHORS   Fattinger,S.A., Maurer,L., Geiser,P., Bernard,E.M., Enz,U.,
            Ganguillet,S., Gul,E., Kroon,S., Demarco,B., Mack,V., Furter,M.,
            Barthel,M., Pelczar,P., Shao,F., Broz,P., Sellin,M.E. and
            Hardt,W.D.
  TITLE     Gasdermin D is the only Gasdermin that provides protection against
            acute Salmonella gut infection in mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (48), e2315503120 (2023)
   PUBMED   37988464
REFERENCE   2  (bases 1 to 2142)
  AUTHORS   Rutledge,E.A., Benazet,J.D. and McMahon,A.P.
  TITLE     Cellular heterogeneity in the ureteric progenitor niche and
            distinct profiles of branching morphogenesis in organ development
  JOURNAL   Development 144 (17), 3177-3188 (2017)
   PUBMED   28705898
REFERENCE   3  (bases 1 to 2142)
  AUTHORS   Tamura,M., Tanaka,S., Fujii,T., Aoki,A., Komiyama,H., Ezawa,K.,
            Sumiyama,K., Sagai,T. and Shiroishi,T.
  TITLE     Members of a novel gene family, Gsdm, are expressed exclusively in
            the epithelium of the skin and gastrointestinal tract in a highly
            tissue-specific manner
  JOURNAL   Genomics 89 (5), 618-629 (2007)
   PUBMED   17350798
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK037079.1 and BC099685.1.
            
            On Apr 1, 2009 this sequence version replaced NM_183194.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK037079.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1299              AK037079.1         2-1300
            1300-2142           BC099685.1         1344-2186
FEATURES             Location/Qualifiers
     source          1..2142
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 27.99 cM"
     gene            1..2142
                     /gene="Gsdmc3"
                     /gene_synonym="9930109F21Rik"
                     /note="gasdermin C3"
                     /db_xref="GeneID:270328"
                     /db_xref="MGI:MGI:3580656"
     exon            1..98
                     /gene="Gsdmc3"
                     /gene_synonym="9930109F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            99..149
                     /gene="Gsdmc3"
                     /gene_synonym="9930109F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            150..361
                     /gene="Gsdmc3"
                     /gene_synonym="9930109F21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1596
                     /gene="Gsdmc3"
                     /gene_synonym="9930109F21Rik"
                     /codon_start=1
                     /product="gasdermin-C3"
                     /protein_id="NP_899017.2"
                     /db_xref="CCDS:CCDS37088.1"
                     /db_xref="GeneID:270328"
                     /db_xref="MGI:MGI:3580656"
                     /translation="MGYSFDRASKDVVKKLQGRDLRPVECLSDATKFRLFHILQETPR
                     SGWETEDIPVGFTLLDLLEPNFPVPEPEVSAPKPFIHVQSTDLEANLNVADIARGGVG
                     YVGYGGYNIEVQSTSIPNPKLEILQNRKLLDKLPTFMKFCRMERKNLYVVTEAYEVSK
                     DTMLTGLSSVNLLVKGFFKQLFKVRGKAGRSEKYSIPIPKGSVLAYKKQQLVIENNTC
                     VILPSATKKKMTFPGTPKYASASEPTEIYRTELQGLWINDIEPIGRIQEPAHLDFKCL
                     QYEVSEQTRLLPELSKDVQEVVLSSFLSMLYEGDRNVLHDLMKMLELSQLGHMDGPGG
                     KILDELRKDSSNPCVDLKDLILYLLQALMVLSDSQLNLLARSVEMRLLPHQVELVTSI
                     LQPNFKYPWNIPFTVQPQLLAPLQGEGLAITYELLEECGLKMELNNPRSTWDLEAKMP
                     LSALYGSLSFLQQLQKANSSFKPSLRPGYI"
     exon            362..539
                     /gene="Gsdmc3"
                     /gene_synonym="9930109F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            540..702
                     /gene="Gsdmc3"
                     /gene_synonym="9930109F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            703..808
                     /gene="Gsdmc3"
                     /gene_synonym="9930109F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            809..910
                     /gene="Gsdmc3"
                     /gene_synonym="9930109F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            911..940
                     /gene="Gsdmc3"
                     /gene_synonym="9930109F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            941..967
                     /gene="Gsdmc3"
                     /gene_synonym="9930109F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1113
                     /gene="Gsdmc3"
                     /gene_synonym="9930109F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1243
                     /gene="Gsdmc3"
                     /gene_synonym="9930109F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1317
                     /gene="Gsdmc3"
                     /gene_synonym="9930109F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..2142
                     /gene="Gsdmc3"
                     /gene_synonym="9930109F21Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttgtttgc ctgcttgcac ttccttgctg gcacttcggt tgttacctac ttcttctgga
       61 ttctagttta tacagaagac cagctgaaac acctagagat atttagattg tttctacatt
      121 ttggcctttg tgaatagtct gccatgaacc aacatgggct acagttttga ccgggctagc
      181 aaggatgtgg ttaaaaagct tcaaggaaga gatctgaggc ctgtggaatg cttgtcagat
      241 gcaaccaaat tccgcctatt tcacatactc caggagactc ctcgatcagg ttgggaaact
      301 gaagatattc cagttggatt tacccttctg gatctcttgg agcccaactt tcctgttcca
      361 gagcctgaag tgtctgctcc caagcccttc atacatgtcc aatcaacgga cctggaggct
      421 aacttgaatg tcgcagacat tgcaagagga ggtgtagggt atgttgggta cggtggatac
      481 aacatcgagg ttcagagtac aagcatccca aatccaaaac tggaaattct tcaaaacagg
      541 aaactgttgg ataagttgcc cacatttatg aagttttgcc ggatggaaag gaagaacctg
      601 tatgtggtga cagaggctta tgaagtgtcc aaggatacta tgctgacagg cttaagcagt
      661 gtcaatcttt tagttaaagg gttcttcaaa cagcttttca aggttcgagg caaggcggga
      721 aggtcggaaa agtattcaat acctatccca aagggttcgg tgttggccta taagaagcag
      781 caacttgtca ttgagaataa cacttgtgtc attctccctt ctgctactaa gaagaagatg
      841 acctttccag gcacacctaa gtacgcttct gcttccgaac ccactgagat ttatagaaca
      901 gaattacaag gtttgtggat aaatgacatc gaaccaattg gaagaatcca ggagcccgcc
      961 catctagatt tcaagtgcct acaatatgaa gtttctgaac aaacacgact actgcctgaa
     1021 ctctcaaagg atgttcaaga agttgtgttg tccagtttcc tgtccatgct ctatgaaggt
     1081 gacaggaacg ttctgcatga cctgatgaaa atgctggagt tgagtcagtt ggggcatatg
     1141 gatggcccag gtggcaaaat cctggatgag cttcgaaagg attctagcaa cccatgtgtt
     1201 gacctaaagg acctcattct ttatctcctt caagcgctga tggtgctcag tgatagccaa
     1261 ctcaatctgc tggcccggtc tgtggagatg cggctcctcc cgcaccaagt agagctggta
     1321 acgagcatcc tacagccaaa cttcaagtat ccctggaaca ttcccttcac agtccagcct
     1381 cagcttcttg ccccactcca gggtgagggc ttggccatta cttatgaatt gctggaggag
     1441 tgtggtctga agatggagct gaataatccc aggtcaactt gggatttgga agccaagatg
     1501 cccttgtctg ctctctatgg aagcctgtca tttttacagc aacttcagaa ggctaactct
     1561 tccttcaagc ccagcctccg acctggatac atttgatata ttgcaccatg gcatacacaa
     1621 gagtcgtgat ttgagtgcat gttttaggcc agtgggaata aagatgctat ggctcctttt
     1681 tttaaaaaag tattattgat tcacaattat acaaataata tacttggatc agattgtacc
     1741 tacccccatt gtttctttta atccaccact tccaagtccc ccttttcctc aacaacttct
     1801 cattcaacat ttgtctgttt gtttgatgct atgctacgtt taattagggt tgtttgcata
     1861 agtgtgtgat tattcatttg agcaagggta gccttccaga ggctacctcc tgccagcagc
     1921 attgagagtc tgtaggtgtt ttagggaggg tgaggttctc ctccattctt gtggaatgtt
     1981 ggtgggctcg ggtttgcttg gtcttgtgag ggtacccatt gccactttga gtttatgggt
     2041 ttagctattc catatcctta ccacgtctag gaaacaggat gttgttatct gtcaaaaata
     2101 cttaaatggt atgttaaata aagatttaca cattttctct at
//
