LOCUS       NM_001168274            2312 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus gasdermin C2 (Gsdmc2), transcript variant 1, mRNA.
ACCESSION   NM_001168274 XM_003945970
VERSION     NM_001168274.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2312)
  AUTHORS   Fattinger,S.A., Maurer,L., Geiser,P., Bernard,E.M., Enz,U.,
            Ganguillet,S., Gul,E., Kroon,S., Demarco,B., Mack,V., Furter,M.,
            Barthel,M., Pelczar,P., Shao,F., Broz,P., Sellin,M.E. and
            Hardt,W.D.
  TITLE     Gasdermin D is the only Gasdermin that provides protection against
            acute Salmonella gut infection in mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (48), e2315503120 (2023)
   PUBMED   37988464
REFERENCE   2  (bases 1 to 2312)
  AUTHORS   Xi,R., Montague,J., Lin,X., Lu,C., Lei,W., Tanaka,K., Zhang,Y.V.,
            Xu,X., Zheng,X., Zhou,X., Urban,J.F. Jr., Iwatsuki,K.,
            Margolskee,R.F., Matsumoto,I., Tizzano,M., Li,J. and Jiang,P.
  TITLE     Up-regulation of gasdermin C in mouse small intestine is associated
            with lytic cell death in enterocytes in worm-induced type 2
            immunity
  JOURNAL   Proc Natl Acad Sci U S A 118 (30) (2021)
   PUBMED   34290141
REFERENCE   3  (bases 1 to 2312)
  AUTHORS   Brunskill,E.W., Aronow,B.J., Georgas,K., Rumballe,B.,
            Valerius,M.T., Aronow,J., Kaimal,V., Jegga,A.G., Yu,J.,
            Grimmond,S., McMahon,A.P., Patterson,L.T., Little,M.H. and
            Potter,S.S.
  TITLE     Atlas of gene expression in the developing kidney at microanatomic
            resolution
  JOURNAL   Dev Cell 15 (5), 781-791 (2008)
   PUBMED   19000842
  REMARK    Erratum:[Dev Cell. 2009 Mar;16(3):482. Yu, Jing [added]]
REFERENCE   4  (bases 1 to 2312)
  AUTHORS   Tamura,M., Tanaka,S., Fujii,T., Aoki,A., Komiyama,H., Ezawa,K.,
            Sumiyama,K., Sagai,T. and Shiroishi,T.
  TITLE     Members of a novel gene family, Gsdm, are expressed exclusively in
            the epithelium of the skin and gastrointestinal tract in a highly
            tissue-specific manner
  JOURNAL   Genomics 89 (5), 618-629 (2007)
   PUBMED   17350798
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK033603.1 and AC140673.4.
            
            On Oct 10, 2012 this sequence version replaced XM_003945970.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC113155.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                AK033603.1         2-99
            99-165              AC140673.4         48193-48259         c
            166-333             AC140673.4         47652-47819         c
            334-876             AK033603.1         100-642
            877-877             AC140673.4         36821-36821         c
            878-2312            AK033603.1         644-2078
FEATURES             Location/Qualifiers
     source          1..2312
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 27.91 cM"
     gene            1..2312
                     /gene="Gsdmc2"
                     /gene_synonym="9130023H10"
                     /note="gasdermin C2"
                     /db_xref="GeneID:331063"
                     /db_xref="MGI:MGI:2146102"
     exon            1..98
                     /gene="Gsdmc2"
                     /gene_synonym="9130023H10"
                     /inference="alignment:Splign:2.1.0"
     exon            99..165
                     /gene="Gsdmc2"
                     /gene_synonym="9130023H10"
                     /inference="alignment:Splign:2.1.0"
     exon            166..333
                     /gene="Gsdmc2"
                     /gene_synonym="9130023H10"
                     /inference="alignment:Splign:2.1.0"
     exon            334..545
                     /gene="Gsdmc2"
                     /gene_synonym="9130023H10"
                     /inference="alignment:Splign:2.1.0"
     CDS             338..1780
                     /gene="Gsdmc2"
                     /gene_synonym="9130023H10"
                     /codon_start=1
                     /product="gasdermin-C2"
                     /protein_id="NP_001161746.1"
                     /db_xref="CCDS:CCDS37087.1"
                     /db_xref="GeneID:331063"
                     /db_xref="MGI:MGI:2146102"
                     /translation="MGYSFDRASKDVVKKLQGRDLRPVECLSDATKFRLFHILQETPR
                     SGWETEDIPVGFTLLDLLEPNFPVPEPEVSAPKPFIHVQSTDLEANLNVADIARGGVG
                     YVGYGGYNIEVQSTSIPNPKLEILQNRKLLDNLPTFMKFCRMERKNLYVVTEAYEVSK
                     DTMLTGLSSVNLSVKGFFKQLFKVRGKAGRSEKYSIPIPKGSVLAYKKQQLVIENNTC
                     VILPSATKKKMTFPGTPKYASASEPTEIYRTELQGLWINDIVPIGRIQEPAHLDFMCL
                     QNEVYKQTEQLAELSKGVQEVVLSSILSMLYEGDRKVLYDLMNMLELNQLGHMDGPGG
                     KILDELRKDSSNPCVDLKDLILYLLQALMVLSDSQLNLLAQSVEMGILPHQVELVKSI
                     LQPNFKYPWNIPFTLQPQLLAPLQGEGLAITYELLEECGLKMELNNPRSTWDLEAKMP
                     LSALYGSLSFLQQLRKANSSSKPSLRPGYI"
     exon            546..723
                     /gene="Gsdmc2"
                     /gene_synonym="9130023H10"
                     /inference="alignment:Splign:2.1.0"
     exon            724..886
                     /gene="Gsdmc2"
                     /gene_synonym="9130023H10"
                     /inference="alignment:Splign:2.1.0"
     exon            887..992
                     /gene="Gsdmc2"
                     /gene_synonym="9130023H10"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1094
                     /gene="Gsdmc2"
                     /gene_synonym="9130023H10"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1124
                     /gene="Gsdmc2"
                     /gene_synonym="9130023H10"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1151
                     /gene="Gsdmc2"
                     /gene_synonym="9130023H10"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1297
                     /gene="Gsdmc2"
                     /gene_synonym="9130023H10"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1427
                     /gene="Gsdmc2"
                     /gene_synonym="9130023H10"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1501
                     /gene="Gsdmc2"
                     /gene_synonym="9130023H10"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..2312
                     /gene="Gsdmc2"
                     /gene_synonym="9130023H10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1814..1819
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gsdmc2"
                     /gene_synonym="9130023H10"
                     /note="hexamer: AATAAA"
     polyA_site      1843
                     /gene="Gsdmc2"
                     /gene_synonym="9130023H10"
                     /note="major polyA site"
ORIGIN      
        1 gcttgtttgc ctgcttgcac ttccttgctg gcacttcggt tgttacctac ttcttctgga
       61 ttctagttta tacagaagac cagctgaaac acctagaggt atgcatacat gagggcctga
      121 ggaggctgga agatagcatt caattccttg gagctggagt tacaggttct tccatgagtc
      181 cctgactgac ttccctcaaa gacagttatg acctgggagt gtaagatgaa ctaaatcctt
      241 ccctcgacat gcttgtagcc atggtggtta tcccagcaac agaaagcaaa ctaggaaacg
      301 acattcacct tcaatatctg aaagccagca acgcaacatg ggctacagtt ttgaccgggc
      361 tagcaaggat gtggttaaaa agcttcaagg aagagatctg aggcctgtgg aatgcttgtc
      421 cgatgcaacc aaattccgcc tatttcacat actccaggag actcctcgat caggttggga
      481 aactgaagat attccagttg gatttaccct tctggatctc ttggagccca actttcctgt
      541 tccagagcct gaagtgtctg ctcccaagcc cttcatacat gtccaatcaa cggacctgga
      601 ggctaacttg aatgtcgcag acattgcaag aggaggtgta gggtatgttg ggtacggtgg
      661 atacaacatc gaggttcaga gtacaagcat cccaaatcca aaactggaaa ttcttcaaaa
      721 caggaaactg ttggataatt tgcccacatt tatgaagttt tgccggatgg aaaggaagaa
      781 cctgtatgtg gtgacagagg cctatgaagt gtccaaggat actatgctga caggcttaag
      841 cagtgtcaat ctttcagtta aagggttctt caaacagctt ttcaaggttc gaggcaaggc
      901 gggaaggtcg gaaaagtatt caatacctat cccaaagggt tcggtgttgg cctataagaa
      961 gcagcaactt gtcattgaga ataacacttg tgtcattctc ccttctgcta ctaagaagaa
     1021 gatgactttt ccaggcacac ctaagtacgc ttctgcttcc gaacccactg agatttatag
     1081 aacagaattg caaggcttgt ggataaatga catcgttcca attggaagaa tacaggagcc
     1141 cgcccatcta gatttcatgt gcctacaaaa tgaagtttac aaacaaacag agcaactggc
     1201 tgaactctca aagggtgttc aagaagttgt gttgtccagt atcctgtcca tgctctatga
     1261 aggtgacagg aaagttctgt atgacctgat gaacatgctg gagttgaatc agttggggca
     1321 tatggatggc ccaggtggca aaatcctgga tgagctgcga aaggattcta gcaacccatg
     1381 tgttgaccta aaggacctca ttctttatct ccttcaagct ctgatggtgc tgagcgatag
     1441 ccaactcaat ctgctggccc agtctgtgga gatggggatc ctcccgcacc aagtagagct
     1501 ggtaaagagc atcttacagc caaacttcaa gtatccctgg aacattccct tcacactcca
     1561 gcctcagctt cttgccccac tccagggtga gggcttggcc attacttatg aattgctgga
     1621 ggagtgtggt ctgaagatgg agctgaataa tcccaggtca acttgggatt tggaagccaa
     1681 aatgcccctg tctgctctct atggaagcct gtcattttta cagcaacttc ggaaggctaa
     1741 ctcttcctcc aagcccagcc tacgtcctgg atacatttga tatattgcac catgcatgtt
     1801 ttaggccagt gggaataaag atgctatggc tccttttttt ttctttttta cgtattattg
     1861 attcacaatt atacaaataa tatacttgga tcagattcta cctaccctcc attgtttctt
     1921 ttaatccacc ccttccaagt tcctttttcc tcaacaactt ctcattcatc atttgtctgt
     1981 ttgtttgatg ctatgctacg tttaattagg gttgtttgca taagtgtgtg attattcatt
     2041 tgagcaaggg tagccttcca gaggctacct cctgccagca gcattgagag cctgtaggtg
     2101 ttttagggag ggtgaggttc tcctccattc ttgtggaatg ttggtgggct cgggcttgct
     2161 tggtcttgtg cgggtaccca ttgccacttt gagtttatgg gtttagctat tccatatcct
     2221 taccacgtct aggaaacagg atgttgttat ctgtcaaaaa tacttaaatg gtatgttaaa
     2281 taaagattta cacattttct ctatataaaa gg
//
