LOCUS       NM_031378               2382 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus gasdermin C (Gsdmc), mRNA.
ACCESSION   NM_031378 XM_001006928
VERSION     NM_031378.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2382)
  AUTHORS   Jena,K.K., Mambu,J., Boehmer,D., Sposito,B., Millet,V., de Sousa
            Casal,J., Muendlein,H.I., Spreafico,R., Fenouil,R., Spinelli,L.,
            Wurbel,S., Riquier,C., Galland,F., Naquet,P., Chasson,L.,
            Elkins,M., Mitsialis,V., Ketelut-Carneiro,N., Bugda Gwilt,K.,
            Thiagarajah,J.R., Ruan,H.B., Lin,Z., Lien,E., Shao,F., Chou,J.,
            Poltorak,A., Ordovas-Montanes,J., Fitzgerald,K.A., Snapper,S.B.,
            Broggi,A. and Zanoni,I.
  TITLE     Type III interferons induce pyroptosis in gut epithelial cells and
            impair mucosal repair
  JOURNAL   Cell (2024) In press
   PUBMED   39500322
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 2382)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2382)
  AUTHORS   Fattinger,S.A., Maurer,L., Geiser,P., Bernard,E.M., Enz,U.,
            Ganguillet,S., Gul,E., Kroon,S., Demarco,B., Mack,V., Furter,M.,
            Barthel,M., Pelczar,P., Shao,F., Broz,P., Sellin,M.E. and
            Hardt,W.D.
  TITLE     Gasdermin D is the only Gasdermin that provides protection against
            acute Salmonella gut infection in mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (48), e2315503120 (2023)
   PUBMED   37988464
REFERENCE   4  (bases 1 to 2382)
  AUTHORS   Du,J., Sarkar,R., Li,Y., He,L., Kang,W., Liao,W., Liu,W.,
            Nguyen,T., Zhang,L., Deng,Z., Dougherty,U., Kupfer,S.S., Chen,M.,
            Pekow,J., Bissonnette,M., He,C. and Li,Y.C.
  TITLE     N6-adenomethylation of GsdmC is essential for Lgr5+ stem cell
            survival to maintain normal colonic epithelial morphogenesis
  JOURNAL   Dev Cell 57 (16), 1976-1994 (2022)
   PUBMED   35917813
  REMARK    GeneRIF: N(6)-adenomethylation of GsdmC is essential for Lgr5(+)
            stem cell survival to maintain normal colonic epithelial
            morphogenesis.
REFERENCE   5  (bases 1 to 2382)
  AUTHORS   Zhao,M., Ren,K., Xiong,X., Xin,Y., Zou,Y., Maynard,J.C., Kim,A.,
            Battist,A.P., Koneripalli,N., Wang,Y., Chen,Q., Xin,R., Yang,C.,
            Huang,R., Yu,J., Huang,Z., Zhang,Z., Wang,H., Wang,D., Xiao,Y.,
            Salgado,O.C., Jarjour,N.N., Hogquist,K.A., Revelo,X.S.,
            Burlingame,A.L., Gao,X., von Moltke,J., Lin,Z. and Ruan,H.B.
  TITLE     Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth
            alarmin response dependent on tuft cell hyperplasia and Gasdermin C
  JOURNAL   Immunity 55 (4), 623-638 (2022)
   PUBMED   35385697
  REMARK    Erratum:[Immunity. 2022 Jul 12;55(7):1327. doi:
            10.1016/j.immuni.2022.06.011. PMID: 35830826]
REFERENCE   6  (bases 1 to 2382)
  AUTHORS   Uslu,V.V., Petretich,M., Ruf,S., Langenfeld,K., Fonseca,N.A.,
            Marioni,J.C. and Spitz,F.
  TITLE     Long-range enhancers regulating Myc expression are required for
            normal facial morphogenesis
  JOURNAL   Nat Genet 46 (7), 753-758 (2014)
   PUBMED   24859337
REFERENCE   7  (bases 1 to 2382)
  AUTHORS   Yu,J., Valerius,M.T., Duah,M., Staser,K., Hansard,J.K., Guo,J.J.,
            McMahon,J., Vaughan,J., Faria,D., Georgas,K., Rumballe,B., Ren,Q.,
            Krautzberger,A.M., Junker,J.P., Thiagarajan,R.D., Machanick,P.,
            Gray,P.A., van Oudenaarden,A., Rowitch,D.H., Stiles,C.D., Ma,Q.,
            Grimmond,S.M., Bailey,T.L., Little,M.H. and McMahon,A.P.
  TITLE     Identification of molecular compartments and genetic circuitry in
            the developing mammalian kidney
  JOURNAL   Development 139 (10), 1863-1873 (2012)
   PUBMED   22510988
REFERENCE   8  (bases 1 to 2382)
  AUTHORS   Brunskill,E.W., Aronow,B.J., Georgas,K., Rumballe,B.,
            Valerius,M.T., Aronow,J., Kaimal,V., Jegga,A.G., Yu,J.,
            Grimmond,S., McMahon,A.P., Patterson,L.T., Little,M.H. and
            Potter,S.S.
  TITLE     Atlas of gene expression in the developing kidney at microanatomic
            resolution
  JOURNAL   Dev Cell 15 (5), 781-791 (2008)
   PUBMED   19000842
  REMARK    Erratum:[Dev Cell. 2009 Mar;16(3):482. Yu, Jing [added]]
REFERENCE   9  (bases 1 to 2382)
  AUTHORS   Tamura,M., Tanaka,S., Fujii,T., Aoki,A., Komiyama,H., Ezawa,K.,
            Sumiyama,K., Sagai,T. and Shiroishi,T.
  TITLE     Members of a novel gene family, Gsdm, are expressed exclusively in
            the epithelium of the skin and gastrointestinal tract in a highly
            tissue-specific manner
  JOURNAL   Genomics 89 (5), 618-629 (2007)
   PUBMED   17350798
REFERENCE   10 (bases 1 to 2382)
  AUTHORS   Watabe,K., Ito,A., Asada,H., Endo,Y., Kobayashi,T., Nakamoto,K.,
            Itami,S., Takao,S., Shinomura,Y., Aikou,T., Yoshikawa,K.,
            Matsuzawa,Y., Kitamura,Y. and Nojima,H.
  TITLE     Structure, expression and chromosome mapping of MLZE, a novel gene
            which is preferentially expressed in metastatic melanoma cells
  JOURNAL   Jpn J Cancer Res 92 (2), 140-151 (2001)
   PUBMED   11223543
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK137662.1.
            
            On Apr 6, 2007 this sequence version replaced NM_031378.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137662.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2382              AK137662.1         2-2383
FEATURES             Location/Qualifiers
     source          1..2382
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 27.79 cM"
     gene            1..2382
                     /gene="Gsdmc"
                     /gene_synonym="Gsdmc1; Mlze"
                     /note="gasdermin C"
                     /db_xref="GeneID:83492"
                     /db_xref="MGI:MGI:1933176"
     exon            1..265
                     /gene="Gsdmc"
                     /gene_synonym="Gsdmc1; Mlze"
                     /inference="alignment:Splign:2.1.0"
     exon            266..480
                     /gene="Gsdmc"
                     /gene_synonym="Gsdmc1; Mlze"
                     /inference="alignment:Splign:2.1.0"
     exon            481..658
                     /gene="Gsdmc"
                     /gene_synonym="Gsdmc1; Mlze"
                     /inference="alignment:Splign:2.1.0"
     exon            659..821
                     /gene="Gsdmc"
                     /gene_synonym="Gsdmc1; Mlze"
                     /inference="alignment:Splign:2.1.0"
     exon            822..933
                     /gene="Gsdmc"
                     /gene_synonym="Gsdmc1; Mlze"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1035
                     /gene="Gsdmc"
                     /gene_synonym="Gsdmc1; Mlze"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1065
                     /gene="Gsdmc"
                     /gene_synonym="Gsdmc1; Mlze"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1092
                     /gene="Gsdmc"
                     /gene_synonym="Gsdmc1; Mlze"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1232
                     /gene="Gsdmc"
                     /gene_synonym="Gsdmc1; Mlze"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1362
                     /gene="Gsdmc"
                     /gene_synonym="Gsdmc1; Mlze"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1436
                     /gene="Gsdmc"
                     /gene_synonym="Gsdmc1; Mlze"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..2382
                     /gene="Gsdmc"
                     /gene_synonym="Gsdmc1; Mlze"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagtctttt gaatggtggc tttgagcact ggttctgagc tcagagctta gttcctggag
       61 aacagagttc atccccgagc ttacctggcc agaatactgc attgaaaatt gactcggacc
      121 tgctaaaagg aaggagacag taaagagaat cacgttgatt tggtcctgga tttcgtacaa
      181 gttatacttg gattagaagg tccaaggact aaggagccac attcaattgc actttctcta
      241 gaggagataa cgcagcttct gcctggaaca tgtcctacac atttgactgg cttagcaagg
      301 atgtggttaa aaagcttcaa ggaagagatc tgaggcctgt caaatgcctg tcagatgcaa
      361 ccaaattctg cctgtttaac atacttcagg aaacttcttc ccggttggct ttgaaaactg
      421 aatatattcc agttggattt acccttctgc atctcttgga gcccaatatt cctgttccag
      481 agcctgaagt gtcagctccc atccccctta aacacaccat atcccagaaa ctgaaggctg
      541 acctggatgt cgaaaccatt gcaggaggag aagcagggtt tgttaagtcc tgtggatatg
      601 acatcgaggt tcagagtaag agcatcccaa atccaaaact ggaaagtctt caaaacagaa
      661 aactgttgga tcagttgccc acatttatga agacttgctg gaaggatgga aagaacctgt
      721 atgtggtgac agaggcctat gaagtgacca aggatactgt gctggaaggc acaagcaata
      781 gcaaatttgc aatcaaaggg atcatcaacc agcttgtcaa ggttggaggc agtggacagt
      841 ggcaaacaga gaaaacagat tcaataccta tccaaaaggg ttcagtgttg gcctacaaga
      901 agcagcaatt ggtcattgag gataacactt gtgttattct cacttctgct aacactaaga
      961 agaagatgac ctttccaatg agatttgtgg gaatgtctgg acatctaaga tatcaggatc
     1021 tagtcattga gacaggctcg tggataaatg acatcgatcc aattggaaca attaaggagc
     1081 ccacccatct agatttcatg tgcctacaaa atgaagtttc tgaacaaaca cggctactgg
     1141 ctgaactctc aaaggatgtt caagaagttg tgttctccag tttcctgcac atgctctgtg
     1201 acagggatgt tctgtatgac ctgatgaaaa tgctggagtt gaatcagttg gggcatatgg
     1261 atggcccagg tggcaaaatc ctggatgagc ttcgaaagga ctcgagcctt tcatggatta
     1321 acctaaagga cctcattctt tatctccttc aagccctgat ggtgctgagt gatacccaac
     1381 tctgtctgct ggccctgtct gtggagatgc ggctcctccc gcaccaagtg gagctggtaa
     1441 agagcatctt acagccaaac ttcaagtatc cctggaacat tcccttcaca ctccagcctc
     1501 agcttcttgc cccactccag ggtgagggct tggccattac ttatgaattg ctggaggagt
     1561 gtggtctgaa gatggagctg aataatccca ggtcaacttg ggatttggaa gccaagatgc
     1621 ccctgtctgc tctctatgga agcctgtcat ttttacagca actttcagaa gcctaactct
     1681 tcttccaagc ccagcctcag tcctggatac atttgagata ttgcaccata gcatacacaa
     1741 gagttgtgat ttgagtgcat gctttaggct ggtgggaata aagatgctac ggctcctttt
     1801 tttttttttt aaagtattat tgattcacaa ttatacaaat aatatacttg gatcagattc
     1861 tacctacccc cattgcttct tttaatccac cccttccaag ttcctttttc ctcaacaact
     1921 tctcattcat catttgtctg tttgtttgat gctatgctac gtttaattag ggttgtttgc
     1981 ataagtgtgt gattattcat ttgagcaaga gtagccttcc agaggctacc tcctgccagc
     2041 agcattgaga gcctataggt gttttaggga gggtgagttt cttttccatt catgtggaat
     2101 gttggttggc ttgggtttgc ttggtcttgt gcgggtaccc attgccactt tgagtttatg
     2161 ggtttagcta ttccatatcc ttaccacgtc taggaaacag gatgttgtta tctatcaaaa
     2221 ctagtcaaat ggtatgctaa ataaagattt agatgttttc tctatataaa aggatatata
     2281 ttttactttt actcaattgt gtgcattttg agttgttctg ggtgaaaggt actggtgcca
     2341 gtaactttga aatgcatcag caataaattg ggatgtttta tg
//
