LOCUS       NM_001007461            2200 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus gasdermin A3 (Gsdma3), mRNA.
ACCESSION   NM_001007461
VERSION     NM_001007461.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2200)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2200)
  AUTHORS   Fattinger,S.A., Maurer,L., Geiser,P., Bernard,E.M., Enz,U.,
            Ganguillet,S., Gul,E., Kroon,S., Demarco,B., Mack,V., Furter,M.,
            Barthel,M., Pelczar,P., Shao,F., Broz,P., Sellin,M.E. and
            Hardt,W.D.
  TITLE     Gasdermin D is the only Gasdermin that provides protection against
            acute Salmonella gut infection in mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (48), e2315503120 (2023)
   PUBMED   37988464
REFERENCE   3  (bases 1 to 2200)
  AUTHORS   Huang,L.Y., Li,S.T., Lin,S.C., Kao,C.H., Hong,C.H., Lee,C.H. and
            Yang,L.T.
  TITLE     Gasdermin A Is Required for Epidermal Cornification during Skin
            Barrier Regeneration and in an Atopic Dermatitis-Like Model
  JOURNAL   J Invest Dermatol 143 (9), 1735-1745 (2023)
   PUBMED   36965577
REFERENCE   4  (bases 1 to 2200)
  AUTHORS   Mari,S.A., Pluhackova,K., Pipercevic,J., Leipner,M., Hiller,S.,
            Engel,A. and Muller,D.J.
  TITLE     Gasdermin-A3 pore formation propagates along variable pathways
  JOURNAL   Nat Commun 13 (1), 2609 (2022)
   PUBMED   35545613
  REMARK    GeneRIF: Gasdermin-A3 pore formation propagates along variable
            pathways.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2200)
  AUTHORS   Xia,S., Zhang,Z., Magupalli,V.G., Pablo,J.L., Dong,Y., Vora,S.M.,
            Wang,L., Fu,T.M., Jacobson,M.P., Greka,A., Lieberman,J., Ruan,J.
            and Wu,H.
  TITLE     Gasdermin D pore structure reveals preferential release of mature
            interleukin-1
  JOURNAL   Nature 593 (7860), 607-611 (2021)
   PUBMED   33883744
REFERENCE   6  (bases 1 to 2200)
  AUTHORS   Porter,R.M., Jahoda,C.A., Lunny,D.P., Henderson,G., Ross,J.,
            McLean,W.H., Whittock,N.V., Wilson,N.J., Reichelt,J., Magin,T.M.
            and Lane,E.B.
  TITLE     Defolliculated (dfl): a dominant mouse mutation leading to poor
            sebaceous gland differentiation and total elimination of pelage
            follicles
  JOURNAL   J Invest Dermatol 119 (1), 32-37 (2002)
   PUBMED   12164921
REFERENCE   7  (bases 1 to 2200)
  AUTHORS   Hrabe de Angelis,M.H., Flaswinkel,H., Fuchs,H., Rathkolb,B.,
            Soewarto,D., Marschall,S., Heffner,S., Pargent,W., Wuensch,K.,
            Jung,M., Reis,A., Richter,T., Alessandrini,F., Jakob,T., Fuchs,E.,
            Kolb,H., Kremmer,E., Schaeble,K., Rollinski,B., Roscher,A.,
            Peters,C., Meitinger,T., Strom,T., Steckler,T., Holsboer,F.,
            Klopstock,T., Gekeler,F., Schindewolf,C., Jung,T., Avraham,K.,
            Behrendt,H., Ring,J., Zimmer,A., Schughart,K., Pfeffer,K., Wolf,E.
            and Balling,R.
  TITLE     Genome-wide, large-scale production of mutant mice by ENU
            mutagenesis
  JOURNAL   Nat Genet 25 (4), 444-447 (2000)
   PUBMED   10932192
REFERENCE   8  (bases 1 to 2200)
  AUTHORS   Sato,H., Koide,T., Sagai,T., Ishiguro,S.I., Tamai,M., Saitou,N. and
            Shiroishi,T.
  TITLE     The genomic organization of type I keratin genes in mice
  JOURNAL   Genomics 56 (3), 303-309 (1999)
   PUBMED   10087197
REFERENCE   9  (bases 1 to 2200)
  AUTHORS   Shiraishi,A., Kao,C.W., Ishizaki,M., Zhang,Z., Converse,R.L.,
            Tseng,S.C., Svoboda,K.K. and Kao,W.W.
  TITLE     Characterization of Bsk mice: I. The Bsk mutation does not involve
            a recombination of cornea-specific keratin 12 and skin-specific
            hair keratin genes
  JOURNAL   Curr Eye Res 17 (5), 531-540 (1998)
   PUBMED   9617549
REFERENCE   10 (bases 1 to 2200)
  AUTHORS   Sato,H., Koide,T., Masuya,H., Wakana,S., Sagai,T., Umezawa,A.,
            Ishiguro,S., Tamai,M. and Shiroishi,T.
  TITLE     A new mutation Rim3 resembling Re(den) is mapped close to retinoic
            acid receptor alpha (Rara) gene on mouse chromosome 11
  JOURNAL   Mamm Genome 9 (1), 20-25 (1998)
   PUBMED   9434940
  REMARK    Erratum:[Mamm Genome 1998 Apr;9(4):344. Tama M [corrected to Tamai
            M]]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591125.20 and AY679090.1.
            
            On Feb 15, 2019 this sequence version replaced NM_001007461.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB103373.1, AY679090.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849375,
                                           SAMN00849383 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AL591125.20        37494-37504         c
            12-1488             AY679090.1         1-1477
            1489-2200           AL591125.20        25052-25763         c
FEATURES             Location/Qualifiers
     source          1..2200
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 62.21 cM"
     gene            1..2200
                     /gene="Gsdma3"
                     /gene_synonym="Bsk; Dfl; Fgn; Gsdm1l; Gsdm3; GsdmA-3;
                     Rco2; Rim3"
                     /note="gasdermin A3"
                     /db_xref="GeneID:450219"
                     /db_xref="MGI:MGI:3044668"
     exon            1..88
                     /gene="Gsdma3"
                     /gene_synonym="Bsk; Dfl; Fgn; Gsdm1l; Gsdm3; GsdmA-3;
                     Rco2; Rim3"
                     /inference="alignment:Splign:2.1.0"
     exon            89..307
                     /gene="Gsdma3"
                     /gene_synonym="Bsk; Dfl; Fgn; Gsdm1l; Gsdm3; GsdmA-3;
                     Rco2; Rim3"
                     /inference="alignment:Splign:2.1.0"
     exon            308..488
                     /gene="Gsdma3"
                     /gene_synonym="Bsk; Dfl; Fgn; Gsdm1l; Gsdm3; GsdmA-3;
                     Rco2; Rim3"
                     /inference="alignment:Splign:2.1.0"
     exon            489..654
                     /gene="Gsdma3"
                     /gene_synonym="Bsk; Dfl; Fgn; Gsdm1l; Gsdm3; GsdmA-3;
                     Rco2; Rim3"
                     /inference="alignment:Splign:2.1.0"
     exon            655..751
                     /gene="Gsdma3"
                     /gene_synonym="Bsk; Dfl; Fgn; Gsdm1l; Gsdm3; GsdmA-3;
                     Rco2; Rim3"
                     /inference="alignment:Splign:2.1.0"
     exon            752..847
                     /gene="Gsdma3"
                     /gene_synonym="Bsk; Dfl; Fgn; Gsdm1l; Gsdm3; GsdmA-3;
                     Rco2; Rim3"
                     /inference="alignment:Splign:2.1.0"
     exon            848..874
                     /gene="Gsdma3"
                     /gene_synonym="Bsk; Dfl; Fgn; Gsdm1l; Gsdm3; GsdmA-3;
                     Rco2; Rim3"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1029
                     /gene="Gsdma3"
                     /gene_synonym="Bsk; Dfl; Fgn; Gsdm1l; Gsdm3; GsdmA-3;
                     Rco2; Rim3"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1144
                     /gene="Gsdma3"
                     /gene_synonym="Bsk; Dfl; Fgn; Gsdm1l; Gsdm3; GsdmA-3;
                     Rco2; Rim3"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1218
                     /gene="Gsdma3"
                     /gene_synonym="Bsk; Dfl; Fgn; Gsdm1l; Gsdm3; GsdmA-3;
                     Rco2; Rim3"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..2200
                     /gene="Gsdma3"
                     /gene_synonym="Bsk; Dfl; Fgn; Gsdm1l; Gsdm3; GsdmA-3;
                     Rco2; Rim3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2173..2178
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gsdma3"
                     /gene_synonym="Bsk; Dfl; Fgn; Gsdm1l; Gsdm3; GsdmA-3;
                     Rco2; Rim3"
                     /note="hexamer: ATTAAA"
     polyA_site      2198
                     /gene="Gsdma3"
                     /gene_synonym="Bsk; Dfl; Fgn; Gsdm1l; Gsdm3; GsdmA-3;
                     Rco2; Rim3"
                     /note="major polyA site"
ORIGIN      
        1 agtcatttcc tcaacctata gaccgaaaga gctctgattt ctcaccaaac acctgctgct
       61 gaacaggacc tagcatcacc cttccctgag acaatgcctg tgtttgagga tgtcacccgg
      121 gccctggtta gagagctgaa ccctcgaggg gatctgacac ccctagacag cctcatcgac
      181 ttcaaacact ttcgtccctt ctgcctggtg ctgaggaaga ggaagagcac attgttctgg
      241 ggagcccgct atgtgcgcac cgactacact ctcctggatt tgctggagcc gggcagctcc
      301 ccctcagatc tgacagacag tggcaacttt agctttaaga atatgctgga tgtccaagta
      361 cagggacttg tggaagtgcc aaagacagtg aaggtaaagg ggactgcggg tctgtcacaa
      421 agcagcacac tggaggtgca gacactcagc gtggctccct cggctctgga gaacttgaag
      481 aaggagagga aactgtcagc agaccactcg ttcctgaacg agatgaggta tcatgagaag
      541 aacctgtatg tggtgatgga ggcagtagaa gccaagcagg aagttactgt ggagcaaact
      601 ggcaacgcaa atgccatctt ctctctcccc agcttggctc tactgggact acagggatcc
      661 ttgaacaaca acaaggctgt aaccatcccc aagggctgtg tcctggccta tcgagtgaga
      721 ctactgagag tctttttgtt caatctttgg gatattccgt acatttgcaa tgacagcatg
      781 caaaccttcc ctaagatcag gcgtgtacct tgcagtgcct tcatatctcc tacccagatg
      841 atatctgaag agccagaaga agagaagctc attggggaga tgcacgaaga cttcaagaca
      901 ttaaaggaag aggttcagcg agagactcaa gaagtggaga agttgagtcc agtgggtcga
      961 agctccctac tcacttccct cagccatctc ctaggaaaga agaaagagct ccaggacctt
     1021 gagcagaagc ttgaaggggc tttagacaag ggtcagaaag tgaccctgga agcactcccc
     1081 aaagatgtcc tgctgtcaaa ggacgctatg gatgccatcc tctacttcct cggggctctg
     1141 acagagctaa ctgaagaaca actgaagatt ctagtaaaat ccttggagaa aaagatctta
     1201 ccagtgcaac tgaagctggt tgaaagcacc ttggagcaga acttcctgca agataaagag
     1261 ggtgttttcc ccctgcaacc tgatctgctc tcctccctcg gggaggagga actgacccta
     1321 acggaagcac tggtgggact aagcggcctg gaagtccaga gatcaggccc ccagtacgcg
     1381 tgggatccag acactcgcca caacctttgt gccctctatg ctggcctctc cctccttcac
     1441 ctgctaagca ggaaatctaa tgcacttact tattgtgctc tatcttaaca ctccaagaca
     1501 ctacagagcc tccagtctga ggataactga aatgcctgct catcttgcct ctcgatatgt
     1561 ctctctcctt ctgtcctcca gctcagcacc cactaagccc atctcctgat gcttaaatcc
     1621 tgaagttact gaaagatccc gagagagaga gtaaaacatt atgtaagccc ctagacttgt
     1681 gtccaaaata gacctcacta atggcaggga gtaaaagtta aactcggggc tggagagatg
     1741 gctcagcggt taagagcact gactgctctt ccagagatcc tgagttcaaa ttccagagat
     1801 cctgagttca aatcccagca accacatggt ggctcacaac catccataac aatatctggc
     1861 gccctcttct ggagtgtctg aagacaccta cagtgtactt acatataata aataaataat
     1921 tttaaaaaaa agttaaacta gtcccattgt tccaggatgt actggccaca aagtagaagt
     1981 ttaacttgct ccattgtttc aggaaatgtt tgtacagaat actccttgaa cccttatgct
     2041 tgccaaatgc tatagcccca tgccaggtgt ttgcggtttc tgcctttata aacccctgac
     2101 cccttgagct cgggtcgact cctctacccc tgcgtgtgat acaagttgtc cccagtgcac
     2161 tggcctttcc cgattaaacc tcttgccgtt tgcatcaaga
//
