LOCUS       NM_029727               1673 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus gasdermin A2 (Gsdma2), transcript variant 1, mRNA.
ACCESSION   NM_029727
VERSION     NM_029727.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1673)
  AUTHORS   Fattinger,S.A., Maurer,L., Geiser,P., Bernard,E.M., Enz,U.,
            Ganguillet,S., Gul,E., Kroon,S., Demarco,B., Mack,V., Furter,M.,
            Barthel,M., Pelczar,P., Shao,F., Broz,P., Sellin,M.E. and
            Hardt,W.D.
  TITLE     Gasdermin D is the only Gasdermin that provides protection against
            acute Salmonella gut infection in mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (48), e2315503120 (2023)
   PUBMED   37988464
REFERENCE   2  (bases 1 to 1673)
  AUTHORS   Tamura,M., Tanaka,S., Fujii,T., Aoki,A., Komiyama,H., Ezawa,K.,
            Sumiyama,K., Sagai,T. and Shiroishi,T.
  TITLE     Members of a novel gene family, Gsdm, are expressed exclusively in
            the epithelium of the skin and gastrointestinal tract in a highly
            tissue-specific manner
  JOURNAL   Genomics 89 (5), 618-629 (2007)
   PUBMED   17350798
REFERENCE   3  (bases 1 to 1673)
  AUTHORS   Runkel,F., Marquardt,A., Stoeger,C., Kochmann,E., Simon,D.,
            Kohnke,B., Korthaus,D., Wattler,F., Fuchs,H., Hrabe de Angelis,M.,
            Stumm,G., Nehls,M., Wattler,S., Franz,T. and Augustin,M.
  TITLE     The dominant alopecia phenotypes Bareskin, Rex-denuded, and Reduced
            Coat 2 are caused by mutations in gasdermin 3
  JOURNAL   Genomics 84 (5), 824-835 (2004)
   PUBMED   15475261
REFERENCE   4  (bases 1 to 1673)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Evolutionary recombination hotspot around GSDML-GSDM locus is
            closely linked to the oncogenomic recombination hotspot around the
            PPP1R1B-ERBB2-GRB7 amplicon
  JOURNAL   Int J Oncol 24 (4), 757-763 (2004)
   PUBMED   15010812
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY090779.1, BC109336.1 and AK008663.1.
            
            On May 12, 2018 this sequence version replaced NM_029727.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008663.1, BC109336.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                BY090779.1         1-66
            67-1514             BC109336.1         1-1448
            1515-1673           AK008663.1         1511-1669
FEATURES             Location/Qualifiers
     source          1..1673
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 62.28 cM"
     gene            1..1673
                     /gene="Gsdma2"
                     /gene_synonym="2200001G21Rik; 2210006M16Rik;
                     2210009F20Rik; 2210411P14Rik; Gsdm2; GsdmA-2; Gsdml2"
                     /note="gasdermin A2"
                     /db_xref="GeneID:76758"
                     /db_xref="MGI:MGI:1921490"
     exon            1..96
                     /gene="Gsdma2"
                     /gene_synonym="2200001G21Rik; 2210006M16Rik;
                     2210009F20Rik; 2210411P14Rik; Gsdm2; GsdmA-2; Gsdml2"
                     /inference="alignment:Splign:2.1.0"
     exon            97..127
                     /gene="Gsdma2"
                     /gene_synonym="2200001G21Rik; 2210006M16Rik;
                     2210009F20Rik; 2210411P14Rik; Gsdm2; GsdmA-2; Gsdml2"
                     /inference="alignment:Splign:2.1.0"
     exon            128..346
                     /gene="Gsdma2"
                     /gene_synonym="2200001G21Rik; 2210006M16Rik;
                     2210009F20Rik; 2210411P14Rik; Gsdm2; GsdmA-2; Gsdml2"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1464
                     /gene="Gsdma2"
                     /gene_synonym="2200001G21Rik; 2210006M16Rik;
                     2210009F20Rik; 2210411P14Rik; Gsdm2; GsdmA-2; Gsdml2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     gasdermin-2; gasderminA-2"
                     /codon_start=1
                     /product="gasdermin-A2 isoform 1"
                     /protein_id="NP_084003.2"
                     /db_xref="CCDS:CCDS36301.1"
                     /db_xref="GeneID:76758"
                     /db_xref="MGI:MGI:1921490"
                     /translation="MSMFEDVTRALARQLNPRGDLTPLDSLIDFKRFHPFCLVLRKRK
                     STLFWGARYVRTDYTLLDVLEPGSSPSDPTLLGNFSFKNMLDVRVEGDVEVPTMMKVK
                     GTVGLSQSSTLEVQMLSVAPTALENLHMERKLSADHPFLKEMREYKQNLYVVMEVVKA
                     KQEVTLKRASNAISKFSLNLPSLGLQGSVNHKEAVTIPKGCVLAYRVRQLIIYGKDEW
                     GIPYICTDNMPTFNPLCVLQRQGSTVQMISGEMHEDFKTLKKEVQQETQEVEKLSPVG
                     RSSLLTSLSHLLGKKKELQDLEQMLEGALDKGHEVTLEALPKDVLLLKDAMDAILYFL
                     GALTELSEEQLKILVKSLENKVLPVQLKLVESILEQNFLQDKEDVFPLRPDLLSSLGE
                     EDQILTEALVGLSGLEVQRSGPQYTWNPDTCHNLCALYAGLSLLHLLSRDS"
     exon            347..527
                     /gene="Gsdma2"
                     /gene_synonym="2200001G21Rik; 2210006M16Rik;
                     2210009F20Rik; 2210411P14Rik; Gsdm2; GsdmA-2; Gsdml2"
                     /inference="alignment:Splign:2.1.0"
     exon            528..690
                     /gene="Gsdma2"
                     /gene_synonym="2200001G21Rik; 2210006M16Rik;
                     2210009F20Rik; 2210411P14Rik; Gsdm2; GsdmA-2; Gsdml2"
                     /inference="alignment:Splign:2.1.0"
     exon            691..787
                     /gene="Gsdma2"
                     /gene_synonym="2200001G21Rik; 2210006M16Rik;
                     2210009F20Rik; 2210411P14Rik; Gsdm2; GsdmA-2; Gsdml2"
                     /inference="alignment:Splign:2.1.0"
     exon            788..877
                     /gene="Gsdma2"
                     /gene_synonym="2200001G21Rik; 2210006M16Rik;
                     2210009F20Rik; 2210411P14Rik; Gsdm2; GsdmA-2; Gsdml2"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1032
                     /gene="Gsdma2"
                     /gene_synonym="2200001G21Rik; 2210006M16Rik;
                     2210009F20Rik; 2210411P14Rik; Gsdm2; GsdmA-2; Gsdml2"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1147
                     /gene="Gsdma2"
                     /gene_synonym="2200001G21Rik; 2210006M16Rik;
                     2210009F20Rik; 2210411P14Rik; Gsdm2; GsdmA-2; Gsdml2"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1221
                     /gene="Gsdma2"
                     /gene_synonym="2200001G21Rik; 2210006M16Rik;
                     2210009F20Rik; 2210411P14Rik; Gsdm2; GsdmA-2; Gsdml2"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1673
                     /gene="Gsdma2"
                     /gene_synonym="2200001G21Rik; 2210006M16Rik;
                     2210009F20Rik; 2210411P14Rik; Gsdm2; GsdmA-2; Gsdml2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1647..1652
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gsdma2"
                     /gene_synonym="2200001G21Rik; 2210006M16Rik;
                     2210009F20Rik; 2210411P14Rik; Gsdm2; GsdmA-2; Gsdml2"
                     /note="hexamer: AATAAA"
     polyA_site      1665
                     /gene="Gsdma2"
                     /gene_synonym="2200001G21Rik; 2210006M16Rik;
                     2210009F20Rik; 2210411P14Rik; Gsdm2; GsdmA-2; Gsdml2"
                     /note="major polyA site"
ORIGIN      
        1 ggacagtcag tcattctctc accctataga cagaacgagc tctggttcct taccacacat
       61 ctgctgccag acaggaccca gcatcaccct tccctggaaa atctggatgt gtctcctgga
      121 tgctcagaga caatgtctat gtttgaggat gtcacccggg ccctggctag acagctgaac
      181 cctcgagggg atctgacacc cctagacagc ctcatcgact tcaaacgctt ccatcccttc
      241 tgcctggtgc tgaggaagag gaagagcaca ctgttctggg gagcccgcta tgtgcgcacc
      301 gactacactc tcctggatgt gctggagccg ggcagctccc cctcagatcc aacactcctt
      361 ggcaatttta gctttaagaa tatgctggat gtcagagtag agggagatgt ggaggtgcca
      421 acaatgatga aggtaaaggg gactgtgggc ctgtcacaaa gcagcacgct ggaggtacag
      481 atgctcagtg tggctcccac ggctctggag aacttgcaca tggagaggaa actgtcagca
      541 gaccacccgt tcctgaagga gatgcgggaa tacaagcaaa acctgtatgt ggtgatggag
      601 gtggtgaaag ccaagcagga agtcactctg aagcgagcta gcaacgcaat ttccaaattc
      661 tctctcaacc ttccctcact gggactacag ggatccgtga accacaagga ggctgtaacc
      721 atccccaagg gctgtgttct ggcctatcga gtgagacaac tgatcatcta tgggaaagat
      781 gagtggggca ttccatacat ttgtactgac aacatgccaa cctttaaccc cctgtgtgtg
      841 cttcagagac aaggcagtac tgtccagatg atatctgggg agatgcacga agacttcaag
      901 acattaaaga aagaggttca gcaagagact caagaagtgg agaagttgag tccagtgggg
      961 cgaagctccc tactcacttc cctcagccat ctcctaggaa agaagaaaga gctccaggac
     1021 cttgagcaga tgcttgaagg ggctctagac aagggacacg aagtgaccct tgaagcactc
     1081 cccaaagatg tcctgctgtt aaaggacgct atggacgcca tcctctactt cctcggggct
     1141 ctgacagagc taagtgaaga acaactgaag attctagtaa aatccttgga gaacaaggtc
     1201 ctaccggtgc aactgaagct ggttgagagc atcttggaac agaacttcct gcaagataaa
     1261 gaggatgttt tccccctgcg acctgatctg ctctcctccc tcggggagga ggaccagatt
     1321 ctaacagaag cactggtggg actaagcggc ctggaagtcc agagatcagg gccccagtac
     1381 acgtggaatc cagacacttg tcacaacctc tgtgccctct atgctggcct ctccctcctt
     1441 cacctgctaa gcagggattc ctaatgcaac ttctctgcct gctgccctaa agccttcccg
     1501 gccttactgt gctctgtctg aaacactcca agatggtggc attcaccttt aatcccagca
     1561 gtcaggaggc agaggcagtg agttcaagac cagccttgtc tacaggctgg ttccaggata
     1621 acaagggcta tgttgtctca aaaataaata aataaaaata tcaaataaat tag
//
