LOCUS       NM_021347               2726 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus gasdermin A (Gsdma), mRNA.
ACCESSION   NM_021347
VERSION     NM_021347.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2726)
  AUTHORS   Fattinger,S.A., Maurer,L., Geiser,P., Bernard,E.M., Enz,U.,
            Ganguillet,S., Gul,E., Kroon,S., Demarco,B., Mack,V., Furter,M.,
            Barthel,M., Pelczar,P., Shao,F., Broz,P., Sellin,M.E. and
            Hardt,W.D.
  TITLE     Gasdermin D is the only Gasdermin that provides protection against
            acute Salmonella gut infection in mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (48), e2315503120 (2023)
   PUBMED   37988464
REFERENCE   2  (bases 1 to 2726)
  AUTHORS   Huang,L.Y., Li,S.T., Lin,S.C., Kao,C.H., Hong,C.H., Lee,C.H. and
            Yang,L.T.
  TITLE     Gasdermin A Is Required for Epidermal Cornification during Skin
            Barrier Regeneration and in an Atopic Dermatitis-Like Model
  JOURNAL   J Invest Dermatol 143 (9), 1735-1745 (2023)
   PUBMED   36965577
  REMARK    GeneRIF: Gasdermin A Is Required for Epidermal Cornification during
            Skin Barrier Regeneration and in an Atopic Dermatitis-Like Model.
REFERENCE   3  (bases 1 to 2726)
  AUTHORS   Deng,W., Bai,Y., Deng,F., Pan,Y., Mei,S., Zheng,Z., Min,R., Wu,Z.,
            Li,W., Miao,R., Zhang,Z., Kupper,T.S., Lieberman,J. and Liu,X.
  TITLE     Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers
            pyroptosis
  JOURNAL   Nature 602 (7897), 496-502 (2022)
   PUBMED   35110732
  REMARK    Erratum:[Nature. 2022 Aug;608(7923):E28. doi:
            10.1038/s41586-022-05109-x.. PMID: 35896754]
REFERENCE   4  (bases 1 to 2726)
  AUTHORS   Fu,L., Zhang,J., Lin,Z., Li,Y. and Qin,G.
  TITLE     CircularRNA circ_0071269 knockdown protects against from diabetic
            cardiomyopathy injury by microRNA-145/gasdermin A axis
  JOURNAL   Bioengineered 13 (2), 2398-2411 (2022)
   PUBMED   35034587
  REMARK    GeneRIF: CircularRNA circ_0071269 knockdown protects against from
            diabetic cardiomyopathy injury by microRNA-145/gasdermin A axis.
REFERENCE   5  (bases 1 to 2726)
  AUTHORS   Zhang,Y., Huang,K., Zhang,Y., Han,T., Li,L., Ruan,C., Sun,Y.H.,
            Shi,W., Han,W., Wu,S.Q., Song,J., Liu,J. and Han,J.
  TITLE     A unique death pathway keeps RIPK1 D325A mutant mice in check at
            embryonic day 10.5
  JOURNAL   PLoS Biol 19 (8), e3001304 (2021)
   PUBMED   34437534
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2726)
  AUTHORS   Tanaka,S., Mizushina,Y., Kato,Y., Tamura,M. and Shiroishi,T.
  TITLE     Functional conservation of Gsdma cluster genes specifically
            duplicated in the mouse genome
  JOURNAL   G3 (Bethesda) 3 (10), 1843-1850 (2013)
   PUBMED   23979942
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2726)
  AUTHORS   Tamura,M., Tanaka,S., Fujii,T., Aoki,A., Komiyama,H., Ezawa,K.,
            Sumiyama,K., Sagai,T. and Shiroishi,T.
  TITLE     Members of a novel gene family, Gsdm, are expressed exclusively in
            the epithelium of the skin and gastrointestinal tract in a highly
            tissue-specific manner
  JOURNAL   Genomics 89 (5), 618-629 (2007)
   PUBMED   17350798
REFERENCE   8  (bases 1 to 2726)
  AUTHORS   Saeki,N., Kuwahara,Y., Sasaki,H., Satoh,H. and Shiroishi,T.
  TITLE     Gasdermin (Gsdm) localizing to mouse Chromosome 11 is predominantly
            expressed in upper gastrointestinal tract but significantly
            suppressed in human gastric cancer cells
  JOURNAL   Mamm Genome 11 (9), 718-724 (2000)
   PUBMED   10967128
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK028698.1.
            
            On Jul 17, 2009 this sequence version replaced NM_021347.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028698.1, AK028645.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1916              AK028698.1         2-1917
            1917-2726           AK028698.1         1921-2730
FEATURES             Location/Qualifiers
     source          1..2726
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 62.34 cM"
     gene            1..2726
                     /gene="Gsdma"
                     /gene_synonym="Gsdm; Gsdm1; Gsdma1; H312E"
                     /note="gasdermin A"
                     /db_xref="GeneID:57911"
                     /db_xref="MGI:MGI:1889509"
     exon            1..88
                     /gene="Gsdma"
                     /gene_synonym="Gsdm; Gsdm1; Gsdma1; H312E"
                     /inference="alignment:Splign:2.1.0"
     exon            89..307
                     /gene="Gsdma"
                     /gene_synonym="Gsdm; Gsdm1; Gsdma1; H312E"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1434
                     /gene="Gsdma"
                     /gene_synonym="Gsdm; Gsdm1; Gsdma1; H312E"
                     /note="gasdermin 1; gasdermin-A1"
                     /codon_start=1
                     /product="gasdermin-A"
                     /protein_id="NP_067322.1"
                     /db_xref="CCDS:CCDS25358.1"
                     /db_xref="GeneID:57911"
                     /db_xref="MGI:MGI:1889509"
                     /translation="MTMFENVTRALARQLNPRGDLTPLDSLIDFKRFHPFCLVLRKRK
                     STLFWGARYVHTDYTLLDVLEPGSSPSDPTDSGNFSFKNMLDARVEGDVDVPKTVKVK
                     GTAGLSRSSTLEVQTLSVAPTALENLHKERKLSADHPFLKEMRERGENLYVVMEVVET
                     LQEVTLERAGKAEGCFSLPFFAPLGLQGSVNHKEAVTIPKGCVLAYRVRQLMVNGKDE
                     WGIPHICNDSMQTFPPGEKPGEGKFILIQASDVGEMHEDFKTLKEEVQRETQEVEKLS
                     PVGRSSLLTSLSHLLGKKKELQDLEQTLEGALDKGHEVTLEALPKDVLLSKDAMDAIL
                     YFLGALTVLSEAQQKLLVKSLEKKILPVQLKLVESTMEKNFLQDKEGVFPLQPDLLSS
                     LGEEELILTEALVGLSGLEVQRSGPQYTWDPDTLPHLCALYAGLSLLQLLSKNS"
     exon            308..488
                     /gene="Gsdma"
                     /gene_synonym="Gsdm; Gsdm1; Gsdma1; H312E"
                     /inference="alignment:Splign:2.1.0"
     exon            489..654
                     /gene="Gsdma"
                     /gene_synonym="Gsdm; Gsdm1; Gsdma1; H312E"
                     /inference="alignment:Splign:2.1.0"
     exon            655..751
                     /gene="Gsdma"
                     /gene_synonym="Gsdm; Gsdm1; Gsdma1; H312E"
                     /inference="alignment:Splign:2.1.0"
     exon            752..799
                     /gene="Gsdma"
                     /gene_synonym="Gsdm; Gsdm1; Gsdma1; H312E"
                     /inference="alignment:Splign:2.1.0"
     exon            800..826
                     /gene="Gsdma"
                     /gene_synonym="Gsdm; Gsdm1; Gsdma1; H312E"
                     /inference="alignment:Splign:2.1.0"
     exon            827..847
                     /gene="Gsdma"
                     /gene_synonym="Gsdm; Gsdm1; Gsdma1; H312E"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1002
                     /gene="Gsdma"
                     /gene_synonym="Gsdm; Gsdm1; Gsdma1; H312E"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1117
                     /gene="Gsdma"
                     /gene_synonym="Gsdm; Gsdm1; Gsdma1; H312E"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1191
                     /gene="Gsdma"
                     /gene_synonym="Gsdm; Gsdm1; Gsdma1; H312E"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..2726
                     /gene="Gsdma"
                     /gene_synonym="Gsdm; Gsdm1; Gsdma1; H312E"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1673
                     /gene="Gsdma"
                     /gene_synonym="Gsdm; Gsdm1; Gsdma1; H312E"
                     /note="major polyA site"
ORIGIN      
        1 agtcattccc tcaccctata gacagaacga gctctggttc ctcaccacac accagctgcc
       61 agacaggatc cagcatcacc cttccctgag acaatgacta tgtttgagaa tgtcacccgg
      121 gccctggcta gacagctgaa ccctcgaggg gatctgacac ccctagacag cctcatcgac
      181 ttcaaacgct tccatccctt ctgcctggtg ctgaggaaga ggaagagcac actgttctgg
      241 ggagcccgct atgtgcacac cgactacact ctcctggatg tgctggagcc gggcagctcc
      301 ccctcagatc cgacagacag tggcaacttt agctttaaga atatgctgga tgctcgagta
      361 gagggagatg tggatgtgcc aaagacagtg aaggtaaagg ggactgcggg tctgtcacgg
      421 agcagcacac tggaggtgca gacgctcagc gtggctccca cggctctgga gaacttgcac
      481 aaggagagga aactgtcagc agaccaccca ttcctgaagg agatgcggga acgcggggag
      541 aacctctatg tggtgatgga ggtggtggaa accctacagg aagtcactct ggagcgagcc
      601 ggcaaggcag agggctgctt ctctctcccc ttctttgccc cactgggact acagggatcc
      661 gtgaaccaca aggaggctgt aaccatcccc aagggctgtg ttctggccta tcgagtgaga
      721 caactgatgg tcaacggcaa agatgagtgg ggcattccac acatttgcaa tgacagcatg
      781 caaaccttcc ctcctggaga aaagccagga gaagggaagt tcatattgat ccaggcatct
      841 gatgttgggg agatgcacga agacttcaag acattaaagg aagaggttca gcgagagact
      901 caggaagtgg agaagttaag tccagtgggg cgaagctcac tactcacttc cctcagccat
      961 ctcctaggaa agaagaaaga gctccaggac cttgagcaga cgcttgaagg ggctctagac
     1021 aagggacacg aagtgaccct ggaagcactc cccaaagatg tcctgctgtc aaaggacgct
     1081 atggacgcca tcctttactt cctcggggct ctgacagtgc taagtgaagc ccaacagaag
     1141 cttctagtaa aatccttgga gaaaaagatc ctaccggtgc aactgaagct ggttgaaagc
     1201 accatggaga agaacttcct gcaagataaa gagggtgttt tccccctgca acctgatctg
     1261 ctctcctccc tcggggagga ggaactgatc ctaacagaag cactggtggg actaagcggc
     1321 ctggaagtcc agagatcagg cccccagtac acgtgggatc cggacacgct cccccacctt
     1381 tgtgccctct atgctggcct ctccctcctt caactgctaa gcaagaattc ctaatgcacc
     1441 ttctttgcct gctgccctaa agccttccca gccttactgt gctccatctg taacactgca
     1501 agacactaca gagcctccag gctgaggaca actgaaatgc cagctcaaaa atcagtctcc
     1561 aagttccttc tgcctcacca tctatctctc tccttctgtc ctccagctca gcacccacta
     1621 agcccatctc ctgatgctta aatcctgaag atacagaatc attcaaaccc ttactacttt
     1681 gagtcacttc attaagaggg gttgggggga ggcttggggt ggtgatggtg gtggttatgg
     1741 tgtgaggcag aggcaggtga atctcttaag ttcgaggcca gcctggtctg cagagtgaac
     1801 tccaggacag ccagggcaac acagagaaac cttgtcttga aaacaacaaa accacattta
     1861 tttcctagtc tgatccttcc catgtgtgcc tcaaaaaaaa aaaaaaaaaa aaaaaactgg
     1921 tcttacaaga atgaatggag aatactatgt caatcctaga agaagctgtc ttctggtttt
     1981 tctgtttaag ggaattgtcc caggtaaaga aacagccatg atccatacat acacgttact
     2041 gcccacactg ttcctcaggc ctgctggaaa atgctcccag tgctcagagg gttagaatcc
     2101 agaacatctg ctgtacactg gaaagatcat ccaagctgcc tgacctcacc aaagcgccca
     2161 tgttctccag ccctggctga gggcttggga gaggaaagga aggtctaggg gactaagata
     2221 caagcagaaa acaagacaat agatttcatg ttgattaagt agaaaatgaa ggtgaggttc
     2281 tttctcaaaa taaataaata aataaataaa taaattagag gaagagggag ggggcaccca
     2341 agaataagac ctaaaccttt aaatcagtgg tttgacctgt gagtcgcgac cccggtggga
     2401 ggtcagatga ctcacaggag ttgcatatca gatatccttc atatcaaata tttacattat
     2461 gacttctaac aggagcaaaa ttggagctat gaatttacaa tgaaaataat tctatggttg
     2521 ggggtcacca cagcatgagg aactggatca aagggtcgca gtgttaggaa ggctgagagc
     2581 cgctgcttca gttttgtttt caaccctcaa ctcaggatga gtgtggatga gcttggcttg
     2641 tatattataa tctcattaaa catctgtata ttataatctc attaaacgtc tgggatctca
     2701 tcaccctctg cccaacgctg gctttg
//
