LOCUS       NM_029469               1133 bp    mRNA    linear   ROD 03-AUG-2024
DEFINITION  Mus musculus goosecoid homebox 2 (Gsc2), mRNA.
ACCESSION   NM_029469 XM_001476809 XM_001480613 XM_001480751
VERSION     NM_029469.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1133)
  AUTHORS   Ruiz-Reig,N., Rakotobe,M., Bethus,I., Le Menn,G., Huditz,H.I.,
            Marie,H., Lamonerie,T. and D'Autreaux,F.
  TITLE     Developmental Requirement of Homeoprotein Otx2 for Specific
            Habenulo-Interpeduncular Subcircuits
  JOURNAL   J Neurosci 39 (6), 1005-1019 (2019)
   PUBMED   30593496
REFERENCE   2  (bases 1 to 1133)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   3  (bases 1 to 1133)
  AUTHORS   Chung,Y.C., Tsai,Y.J., Shiu,T.Y., Sun,Y.Y., Wang,P.F. and Chen,C.L.
  TITLE     Screening large numbers of expression patterns of transcription
            factors in late stages of the mouse thymus
  JOURNAL   Gene Expr Patterns 11 (1-2), 84-92 (2011)
   PUBMED   20932939
REFERENCE   4  (bases 1 to 1133)
  AUTHORS   Funato,H., Sato,M., Sinton,C.M., Gautron,L., Williams,S.C.,
            Skach,A., Elmquist,J.K., Skoultchi,A.I. and Yanagisawa,M.
  TITLE     Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in
            interpeduncular nucleus results in altered regulation of rapid eye
            movement sleep
  JOURNAL   Proc Natl Acad Sci U S A 107 (42), 18155-18160 (2010)
   PUBMED   20921407
  REMARK    GeneRIF: results indicate that the absence of Gscl and Dgcr14 in
            the IP results in altered regulation of REM sleep
REFERENCE   5  (bases 1 to 1133)
  AUTHORS   Maynard,T.M., Haskell,G.T., Peters,A.Z., Sikich,L., Lieberman,J.A.
            and LaMantia,A.S.
  TITLE     A comprehensive analysis of 22q11 gene expression in the developing
            and adult brain
  JOURNAL   Proc Natl Acad Sci U S A 100 (24), 14433-14438 (2003)
   PUBMED   14614146
REFERENCE   6  (bases 1 to 1133)
  AUTHORS   Puech,A., Saint-Jore,B., Funke,B., Gilbert,D.J., Sirotkin,H.,
            Copeland,N.G., Jenkins,N.A., Kucherlapati,R., Morrow,B. and
            Skoultchi,A.I.
  TITLE     Comparative mapping of the human 22q11 chromosomal region and the
            orthologous region in mice reveals complex changes in gene
            organization
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14608-14613 (1997)
   PUBMED   9405660
REFERENCE   7  (bases 1 to 1133)
  AUTHORS   Funke,B., Saint-Jore,B., Puech,A., Sirotkin,H., Edelmann,L.,
            Carlson,C., Raft,S., Pandita,R.K., Kucherlapati,R., Skoultchi,A.
            and Morrow,B.E.
  TITLE     Characterization and mutation analysis of goosecoid-like (GSCL), a
            homeodomain-containing gene that maps to the critical region for
            VCFS/DGS on 22q11
  JOURNAL   Genomics 46 (3), 364-372 (1997)
   PUBMED   9441739
REFERENCE   8  (bases 1 to 1133)
  AUTHORS   Botta,A., Lindsay,E.A., Jurecic,V. and Baldini,A.
  TITLE     Comparative mapping of the DiGeorge syndrome region in mouse shows
            inconsistent gene order and differential degree of gene
            conservation
  JOURNAL   Mamm Genome 8 (12), 890-895 (1997)
   PUBMED   9383280
  REMARK    Erratum:[Mamm Genome 1998 Apr;9(4):344]
REFERENCE   9  (bases 1 to 1133)
  AUTHORS   Galili,N., Baldwin,H.S., Lund,J., Reeves,R., Gong,W., Wang,Z.,
            Roe,B.A., Emanuel,B.S., Nayak,S., Mickanin,C., Budarf,M.L. and
            Buck,C.A.
  TITLE     A region of mouse chromosome 16 is syntenic to the DiGeorge,
            velocardiofacial syndrome minimal critical region
  JOURNAL   Genome Res 7 (1), 17-26 (1997)
   PUBMED   9037598
  REMARK    Erratum:[Genome Res. 1997 Apr;7(4):399.. PMID: 9110179]
REFERENCE   10 (bases 1 to 1133)
  AUTHORS   Halford,S., Wadey,R., Roberts,C., Daw,S.C., Whiting,J.A.,
            O'Donnell,H., Dunham,I., Bentley,D., Lindsay,E., Baldini,A. et al.
  TITLE     Isolation of a putative transcriptional regulator from the region
            of 22q11 deleted in DiGeorge syndrome, Shprintzen syndrome and
            familial congenital heart disease
  JOURNAL   Hum Mol Genet 2 (12), 2099-2107 (1993)
   PUBMED   8111380
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC125356.1 and AK016252.1.
            
            On Feb 12, 2019 this sequence version replaced NM_029469.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC132637.1, SRR7345562.1450018.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-693               BC125356.1         33-725
            694-1133            AK016252.1         245-684
FEATURES             Location/Qualifiers
     source          1..1133
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 11.1 cM"
     gene            1..1133
                     /gene="Gsc2"
                     /gene_synonym="4930568H22Rik; GSC-2; Gscl"
                     /note="goosecoid homebox 2"
                     /db_xref="GeneID:195333"
                     /db_xref="MGI:MGI:892006"
     exon            1..274
                     /gene="Gsc2"
                     /gene_synonym="4930568H22Rik; GSC-2; Gscl"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..630
                     /gene="Gsc2"
                     /gene_synonym="4930568H22Rik; GSC-2; Gscl"
                     /note="GSC-L"
                     /codon_start=1
                     /product="homeobox protein goosecoid-2"
                     /protein_id="NP_083745.2"
                     /db_xref="CCDS:CCDS49786.2"
                     /db_xref="GeneID:195333"
                     /db_xref="MGI:MGI:892006"
                     /translation="MATAGSAASRRDPGRPCPFSIEHILSSLPERRPATRPPQPVGGR
                     NPAELDEPEAPVPAAPCACCCCCNPRAATRGTPETSSGPGLRLAWPLRLAPATPSPLT
                     APRAGSPALTGTSGPGPQRRTRRHRTIFSEEQLQALEALFVQNQYPDVGTRERLAVRI
                     RLREERVEVWFKNRRAKWRHQKRASSSRLLPGTKKTPKESC"
     exon            275..528
                     /gene="Gsc2"
                     /gene_synonym="4930568H22Rik; GSC-2; Gscl"
                     /inference="alignment:Splign:2.1.0"
     exon            529..1133
                     /gene="Gsc2"
                     /gene_synonym="4930568H22Rik; GSC-2; Gscl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttgcgcc gcccgcccgc gggcatggcg actgcaggca gcgcggccag ccgcagggac
       61 cccgggcgac cctgcccttt ctccatcgag cacatcctct ccagcctgcc ggagcgcagg
      121 cccgcgacgc ggccaccgca gcccgtcggt ggtcggaacc ccgccgagct agacgaaccc
      181 gaggcgcccg tccccgctgc tccttgcgcc tgctgctgct gctgcaaccc gcgcgctgcg
      241 acccgcggaa ccccggagac atcgtccggg ccgggcttgc ggctggcgtg gccgctgagg
      301 ttggcgcccg ccacgccctc tcccttgacg gcgcctagag caggctcccc ggcgctgact
      361 ggcacgagcg gccccggccc gcagaggcgc acgcggcgcc accgtaccat cttcagcgag
      421 gagcagctgc aggcgctcga ggcactcttc gtacagaacc agtatcccga cgtaggcaca
      481 cgcgaacgct tggcggtccg catccgcctg cgagaggagc gcgtggaggt ctggttcaag
      541 aaccgccggg caaagtggcg acaccaaaag cgtgcttcct catcgaggct cctgcctggg
      601 actaagaaaa ctcccaagga gagttgttga tgctgtccgg agtttatctg gctttatgaa
      661 gtagagcaca aggaaggagg agggggacag acctacctga acaggaacta acgctgccag
      721 cactggcagc caggggatcc aaagccgcct tctcacccat gaagggaggg catgtggggc
      781 aggaaccaga gacctcctgc aggtcaagtg cagacacaga gcaggtcaac ttcctcagcc
      841 accctcagca cctagagaag ccctagctcc atgcaggacg aagagcctaa ctccccacct
      901 catgcctgtc accaagactg gcctcttctc tgtccttcca ccttcttatg caaggcagtg
      961 gtgtctgctc agccctgggc gtactctgtc ctcacaggcc ctgcacttta gggccctggt
     1021 gtcatgacct gtggaagaag aaggttgtag ttggtagttt ccagattcct gcatctgctc
     1081 cttcacctca gccttgagct gatgccaaga aataaacgag atcttcaaag acc
//
