LOCUS       NM_010351               1183 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Mus musculus goosecoid homeobox (Gsc), mRNA.
ACCESSION   NM_010351
VERSION     NM_010351.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1183)
  AUTHORS   Qin,T., So,K.K.H., Hui,C.C. and Sham,M.H.
  TITLE     Ptch1 is essential for cochlear marginal cell differentiation and
            stria vascularis formation
  JOURNAL   Cell Rep 43 (4), 114083 (2024)
   PUBMED   38602877
REFERENCE   2  (bases 1 to 1183)
  AUTHORS   Luzzio,A., Edie,S., Palmer,K., Caddle,L.B., Urban,R., Goodwin,L.O.,
            Welsh,I.C., Reinholdt,L.G., Bergstrom,D.E., Cox,T.C., Donahue,L.R.
            and Murray,S.A.
  TITLE     The spontaneous mouse mutant low set ears (Lse) is caused by tandem
            duplication of Fgf3 and Fgf4
  JOURNAL   Mamm Genome 34 (3), 453-463 (2023)
   PUBMED   37341808
REFERENCE   3  (bases 1 to 1183)
  AUTHORS   Iyyanar,P.P.R., Wu,Z., Lan,Y., Hu,Y.C. and Jiang,R.
  TITLE     Alx1 Deficient Mice Recapitulate Craniofacial Phenotype and Reveal
            Developmental Basis of ALX1-Related Frontonasal Dysplasia
  JOURNAL   Front Cell Dev Biol 10, 777887 (2022)
   PUBMED   35127681
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1183)
  AUTHORS   Abrams,S.R. and Reiter,J.F.
  TITLE     Ciliary Hedgehog signaling regulates cell survival to build the
            facial midline
  JOURNAL   Elife 10, e68558 (2021)
   PUBMED   34672258
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1183)
  AUTHORS   Zhang,H., Xie,J., So,K.K.H., Tong,K.K., Sae-Pang,J.J., Wang,L.,
            Tsang,S.L., Chan,W.Y., Wong,E.Y.M. and Sham,M.H.
  TITLE     Hoxb3 Regulates Jag1 Expression in Pharyngeal Epithelium and
            Affects Interaction With Neural Crest Cells
  JOURNAL   Front Physiol 11, 612230 (2021)
   PUBMED   33505317
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1183)
  AUTHORS   Proetzel,G., Pawlowski,S.A., Wiles,M.V., Yin,M., Boivin,G.P.,
            Howles,P.N., Ding,J., Ferguson,M.W. and Doetschman,T.
  TITLE     Transforming growth factor-beta 3 is required for secondary palate
            fusion
  JOURNAL   Nat Genet 11 (4), 409-414 (1995)
   PUBMED   7493021
REFERENCE   7  (bases 1 to 1183)
  AUTHORS   Acampora,D., Mazan,S., Lallemand,Y., Avantaggiato,V., Maury,M.,
            Simeone,A. and Brulet,P.
  TITLE     Forebrain and midbrain regions are deleted in Otx2-/- mutants due
            to a defective anterior neuroectoderm specification during
            gastrulation
  JOURNAL   Development 121 (10), 3279-3290 (1995)
   PUBMED   7588062
REFERENCE   8  (bases 1 to 1183)
  AUTHORS   Rivera-Perez,J.A., Mallo,M., Gendron-Maguire,M., Gridley,T. and
            Behringer,R.R.
  TITLE     Goosecoid is not an essential component of the mouse gastrula
            organizer but is required for craniofacial and rib development
  JOURNAL   Development 121 (9), 3005-3012 (1995)
   PUBMED   7555726
REFERENCE   9  (bases 1 to 1183)
  AUTHORS   Yamada,G., Mansouri,A., Torres,M., Stuart,E.T., Blum,M.,
            Schultz,M., De Robertis,E.M. and Gruss,P.
  TITLE     Targeted mutation of the murine goosecoid gene results in
            craniofacial defects and neonatal death
  JOURNAL   Development 121 (9), 2917-2922 (1995)
   PUBMED   7555718
REFERENCE   10 (bases 1 to 1183)
  AUTHORS   Blum,M., Gaunt,S.J., Cho,K.W., Steinbeisser,H., Blumberg,B.,
            Bittner,D. and De Robertis,E.M.
  TITLE     Gastrulation in the mouse: the role of the homeobox gene goosecoid
  JOURNAL   Cell 69 (7), 1097-1106 (1992)
   PUBMED   1352187
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Y13149.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y13149.1, X99239.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1183
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 54.32 cM"
     gene            1..1183
                     /gene="Gsc"
                     /note="goosecoid homeobox"
                     /db_xref="GeneID:14836"
                     /db_xref="MGI:MGI:95841"
     exon            1..476
                     /gene="Gsc"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..892
                     /gene="Gsc"
                     /codon_start=1
                     /product="homeobox protein goosecoid"
                     /protein_id="NP_034481.1"
                     /db_xref="CCDS:CCDS26153.1"
                     /db_xref="GeneID:14836"
                     /db_xref="MGI:MGI:95841"
                     /translation="MPASMFSIDNILAARPRCKDAVLPVAPSAAAPVVFPALHGDSLY
                     GAGGGTSSDYGAFYPRPVAPGGAGLPAAVGSSRLGYNSYFYGQLHVQAAPVGPACCGA
                     VPPLGAQQCSCVPTPPGYEGPGSVLVSPVPHQMLPYMNVGTLSRTELQLLNQLHCRRK
                     RRHRTIFTDEQLEALENLFQETKYPDVGTREQLARKVHLREEKVEVWFKNRRAKWRRQ
                     KRSSSEESENAEKWNKTSSKASPEKREEEGKSDLDSDS"
     exon            477..736
                     /gene="Gsc"
                     /inference="alignment:Splign:2.1.0"
     exon            737..1174
                     /gene="Gsc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1144..1149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gsc"
                     /note="hexamer: AATAAA"
     polyA_site      1168
                     /gene="Gsc"
                     /note="major polyA site"
ORIGIN      
        1 ctcgcccgcg ggagcagaga gtgggacaat tcccaacccc caccccaaac aacaccactt
       61 ggagacttct tcttcttcgg cgcgtccccg ccgccccccg gtcccgacgc ggggctcggg
      121 gatgcccgcc agcatgttca gcatcgacaa catcctggcc gcccggccgc gctgcaaaga
      181 cgcggtgctc ccggtggcgc ccagcgccgc ggctccggtg gtcttcccgg ctctacacgg
      241 ggactcgctc tacggcgccg gcggcggcac ctcctcggac tacggcgcct tctacccgcg
      301 ccctgtggcc cccggaggcg cgggcctccc ggccgcggtc ggcagctccc gcctgggcta
      361 caacagctac ttctacgggc agctgcacgt gcaggcggcg cccgtgggcc cggcttgctg
      421 cggggctgtg ccgccgctgg gcgcccagca gtgctcctgc gtcccgacgc ccccaggcta
      481 cgagggcccc ggttctgtac tggtgtctcc ggtgccgcac cagatgctgc cctacatgaa
      541 cgtgggcacg ctgtcgcgca ctgagctgca gctgctcaac cagctgcact gtcggcggaa
      601 gcggcggcac cgcaccatct tcaccgatga gcagctcgaa gccctggaga acctcttcca
      661 ggagacgaag tacccagacg tgggcactcg ggagcagctg gccaggaagg tgcaccttcg
      721 ggaggagaag gtggaggtct ggtttaagaa ccgccgagcc aagtggagac gacagaagcg
      781 atcctcctcg gaggagtcag aaaacgccga gaagtggaac aagacgtcct caaaagcctc
      841 gccggagaag agggaagagg aaggtaaaag cgatttggac tcggacagct gacggccgcg
      901 gccgcgggcc ggccggggcg cttgcctgac gcaaggactt gcacagacag tcgatgctac
      961 ttgcacacac cctgccttgc gggagggggt cgagaaagca acgaggagct agctgtaaat
     1021 aatgtacagg cccaggactg ctggggacag gcgcgtgggg accgcagccc cactgtcccg
     1081 ggctgcctgc gtgagcctcg tcccccaccg tagtatttat agttaagtta acggtgacaa
     1141 tacaataaag tgatggcaat gtagaccagc catgaaaaaa aaa
//
