LOCUS       NM_001033426            1998 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus glutaredoxin, cysteine rich 2 (Grxcr2), mRNA.
ACCESSION   NM_001033426 XM_288842 XM_910107
VERSION     NM_001033426.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1998)
  AUTHORS   Li,J., Liu,C., Muller,U. and Zhao,B.
  TITLE     RIPOR2-mediated autophagy dysfunction is critical for
            aminoglycoside-induced hearing loss
  JOURNAL   Dev Cell 57 (18), 2204-2220 (2022)
   PUBMED   36113482
REFERENCE   2  (bases 1 to 1998)
  AUTHORS   Li,J., Liu,C. and Zhao,B.
  TITLE     N-Terminus of GRXCR2 Interacts With CLIC5 and Is Essential for
            Auditory Perception
  JOURNAL   Front Cell Dev Biol 9, 671364 (2021)
   PUBMED   34026762
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1998)
  AUTHORS   Liu,C., Luo,N., Tung,C.Y., Perrin,B.J. and Zhao,B.
  TITLE     GRXCR2 Regulates Taperin Localization Critical for Stereocilia
            Morphology and Hearing
  JOURNAL   Cell Rep 25 (5), 1268-1280 (2018)
   PUBMED   30380417
  REMARK    GeneRIF: Stereocilia lacking GRXCR2 are longer than normal and
            disorganized due to the mislocalization of taperin, which could
            modulate the actin cytoskeleton in stereocilia.
REFERENCE   4  (bases 1 to 1998)
  AUTHORS   Avenarius,M.R., Jung,J.Y., Askew,C., Jones,S.M., Hunker,K.L.,
            Azaiez,H., Rehman,A.U., Schraders,M., Najmabadi,H., Kremer,H.,
            Smith,R.J.H., Geleoc,G.S.G., Dolan,D.F., Raphael,Y. and
            Kohrman,D.C.
  TITLE     Grxcr2 is required for stereocilia morphogenesis in the cochlea
  JOURNAL   PLoS One 13 (8), e0201713 (2018)
   PUBMED   30157177
  REMARK    GeneRIF: GRXCR2 plays an intrinsic role in bundle orientation,
            organization, and sensory function in the inner ear during
            development and at maturity
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1998)
  AUTHORS   Scheffer,D.I., Shen,J., Corey,D.P. and Chen,Z.Y.
  TITLE     Gene Expression by Mouse Inner Ear Hair Cells during Development
  JOURNAL   J Neurosci 35 (16), 6366-6380 (2015)
   PUBMED   25904789
REFERENCE   6  (bases 1 to 1998)
  AUTHORS   Imtiaz,A., Kohrman,D.C. and Naz,S.
  TITLE     A frameshift mutation in GRXCR2 causes recessively inherited
            hearing loss
  JOURNAL   Hum Mutat 35 (5), 618-624 (2014)
   PUBMED   24619944
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158418.1, AC132427.4 and AK158432.1.
            
            On Nov 19, 2015 this sequence version replaced NM_001033426.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158432.1, AK158418.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-443               AK158418.1         2-444
            444-444             AC132427.4         95455-95455         c
            445-879             AK158418.1         446-880
            880-880             AC132427.4         89951-89951         c
            881-1690            AK158432.1         766-1575
            1691-1691           AC132427.4         89140-89140         c
            1692-1998           AK158432.1         1577-1883
FEATURES             Location/Qualifiers
     source          1..1998
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 22.14 cM"
     gene            1..1998
                     /gene="Grxcr2"
                     /gene_synonym="Gm851"
                     /note="glutaredoxin, cysteine rich 2"
                     /db_xref="GeneID:332309"
                     /db_xref="MGI:MGI:2685697"
     exon            1..383
                     /gene="Grxcr2"
                     /gene_synonym="Gm851"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..812
                     /gene="Grxcr2"
                     /gene_synonym="Gm851"
                     /note="GRXCR1-like protein; glutaredoxin domain-containing
                     cysteine-rich protein 1-like protein"
                     /codon_start=1
                     /product="glutaredoxin domain-containing cysteine-rich
                     protein 2"
                     /protein_id="NP_001028598.1"
                     /db_xref="CCDS:CCDS29209.1"
                     /db_xref="GeneID:332309"
                     /db_xref="MGI:MGI:2685697"
                     /translation="MEDSEKKLNQKSDDKPRKVRFKISSSYSGRVLKQVFEDGQELES
                     PKEEYPHSFLQEALEPMDGVYGSGEVPKPQPYSPKLTAQRISVFRDSGAYTLAGSQPL
                     FNDYKANDHKPPPIIDFGKIIIYTNNLKIIRTPMDKRDFMRKILQKEDVAEEASLMIT
                     GENDGDREQGCPLPERNGSPLPESERTFLHSQHTQDGLVPEDCLHCQGSGIATCSLCH
                     GSKFSMLANRFKESYRALRCPACNENGLQPCRICSP"
     exon            384..632
                     /gene="Grxcr2"
                     /gene_synonym="Gm851"
                     /inference="alignment:Splign:2.1.0"
     exon            633..1998
                     /gene="Grxcr2"
                     /gene_synonym="Gm851"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgggctac tcggaggcct ggaaacctga gcgggaactt tctgctgatg gaggactccg
       61 agaagaaact gaatcagaag agcgacgaca aacccagaaa agtccggttt aaaatctcct
      121 cttcctacag tggccgagtg ttgaagcagg tttttgagga tgggcaagaa ttagagtcgc
      181 ccaaagaaga atatcctcac agttttctcc aggaggccct tgaaccaatg gatggcgttt
      241 atgggtctgg ggaagtcccc aagccccagc cgtactcccc caagctgact gctcagagaa
      301 tcagcgtatt cagagacagc ggcgcctaca ctctggcggg cagccagcct ctgttcaatg
      361 actacaaggc gaatgaccat aagcctccac ccattataga ctttgggaag ataattatct
      421 ataccaacaa cctgaaaatc atccgaaccc cgatggacaa aagggacttc atgaggaaaa
      481 tcctccaaaa ggaagatgtg gctgaggaag cgtccctgat gatcacaggg gagaatgatg
      541 gagacaggga gcaaggctgc cccctgccgg agcggaacgg cagccccctg ccggagtcgg
      601 agcgcacatt tcttcatagt cagcacacac aggatgggtt ggtccctgag gactgcctcc
      661 actgccaggg gtctggcatt gccacctgtt ctctgtgcca cggcagcaag ttctccatgc
      721 tggctaacag attcaaggag tcctaccgag ccctcaggtg ccctgcctgc aacgagaatg
      781 gcctgcaacc ttgccgaatt tgcagcccat agcccgtagc cctggttttc acatgtgcct
      841 ttcttgtact ctcttaccac gttactccta atatagcacc ctgcttcctt ctgcctctct
      901 ccgaaaggga gcctactgca gcagcaatca cttctaccac tagcaaatct cacaaaatct
      961 gatgacattt tgtgaagttg gtaccatctc tacatgcgcc taagtgacag gggcattttt
     1021 gaattagaat ccgctctgaa actgcttcta aaattatcct tccaggagca tgtgcatgca
     1081 tctcacttga tttagttcag ccttcccctt gcgccagtgc acaaataact aaatgtacac
     1141 tccagacagc aggttgaagt catttttccg ggccgggagc tattttgcaa aattatgtgg
     1201 tcagaaagga ataaagaagt agatttccaa caaaccagat tcctgtttct tataatgcat
     1261 ctgaaattgt ctttggtaaa attgaaattt ctaatgaggc agaagaggga aggggcagtc
     1321 aacactggag gctctcacgg gcctctgcaa gcaaaataga atgctcattc cagagccatc
     1381 caagctgagg aggtccttct tctgtggctg cttttgtggc acgttctagc gcttactagc
     1441 cagacacgag ctagaatgct tctgtgcatt tctaactggt gaggttataa gccacaccaa
     1501 agctattggg agaaggttgg cactcaagca cgtatctatg ataagatttc tgccagcccc
     1561 acagccaatt agcaaacaga caggtctatt ttaagactaa gatctagcca gccgctcttt
     1621 agaaaggaca gcaggtgttt caggcttatc tatggcaact cttgaagaga agaaccaaga
     1681 ggtctcatag ttagacatgg tttctacagc ccacgaatga gcacgtgaag ggagactctc
     1741 ccctcttaac gacagctatt aacttttaaa agcacgtttg ttaatgaact tttgcagctt
     1801 gaacacccac tctccacact cagtgagaat gacaccggtg tttgttattc agcgagactc
     1861 actgcttatc ttcaagaata actctgactt catgtcttag taacccttca aggcttctta
     1921 ttctctgtgt tctgttacat caacagtggg ttgcgcccgg gcaataggaa tagttctaat
     1981 aaaaagatgt gaatactc
//
