LOCUS       NM_001018019            1127 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus glutaredoxin, cysteine rich 1 (Grxcr1), mRNA.
ACCESSION   NM_001018019 XM_485620
VERSION     NM_001018019.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1127)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1127)
  AUTHORS   Lorente-Canovas,B., Eckrich,S., Lewis,M.A., Johnson,S.L.,
            Marcotti,W. and Steel,K.P.
  TITLE     Grxcr1 regulates hair bundle morphogenesis and is required for
            normal mechanoelectrical transduction in mouse cochlear hair cells
  JOURNAL   PLoS One 17 (3), e0261530 (2022)
   PUBMED   35235570
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1127)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1127)
  AUTHORS   Liu,C., Luo,N., Tung,C.Y., Perrin,B.J. and Zhao,B.
  TITLE     GRXCR2 Regulates Taperin Localization Critical for Stereocilia
            Morphology and Hearing
  JOURNAL   Cell Rep 25 (5), 1268-1280 (2018)
   PUBMED   30380417
REFERENCE   5  (bases 1 to 1127)
  AUTHORS   Potter,P.K., Bowl,M.R., Jeyarajan,P., Wisby,L., Blease,A.,
            Goldsworthy,M.E., Simon,M.M., Greenaway,S., Michel,V., Barnard,A.,
            Aguilar,C., Agnew,T., Banks,G., Blake,A., Chessum,L., Dorning,J.,
            Falcone,S., Goosey,L., Harris,S., Haynes,A., Heise,I., Hillier,R.,
            Hough,T., Hoslin,A., Hutchison,M., King,R., Kumar,S., Lad,H.V.,
            Law,G., MacLaren,R.E., Morse,S., Nicol,T., Parker,A., Pickford,K.,
            Sethi,S., Starbuck,B., Stelma,F., Cheeseman,M., Cross,S.H.,
            Foster,R.G., Jackson,I.J., Peirson,S.N., Thakker,R.V., Vincent,T.,
            Scudamore,C., Wells,S., El-Amraoui,A., Petit,C.,
            Acevedo-Arozena,A., Nolan,P.M., Cox,R., Mallon,A.M. and Brown,S.D.
  TITLE     Novel gene function revealed by mouse mutagenesis screens for
            models of age-related disease
  JOURNAL   Nat Commun 7, 12444 (2016)
   PUBMED   27534441
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1127)
  AUTHORS   Erven,A., Skynner,M.J., Okumura,K., Takebayashi,S., Brown,S.D.,
            Steel,K.P. and Allen,N.D.
  TITLE     A novel stereocilia defect in sensory hair cells of the deaf mouse
            mutant Tasmanian devil
  JOURNAL   Eur J Neurosci 16 (8), 1433-1441 (2002)
   PUBMED   12405956
REFERENCE   7  (bases 1 to 1127)
  AUTHORS   Beyer,L.A., Odeh,H., Probst,F.J., Lambert,E.H., Dolan,D.F.,
            Camper,S.A., Kohrman,D.C. and Raphael,Y.
  TITLE     Hair cells in the inner ear of the pirouette and shaker 2 mutant
            mice
  JOURNAL   J Neurocytol 29 (4), 227-240 (2000)
   PUBMED   11276175
REFERENCE   8  (bases 1 to 1127)
  AUTHORS   .
  TITLE     British Society of Audiology short papers meeting on experimental
            studies of hearing and deafness. Cambridge, United Kingdom, 22-23
            September 1996. Abstracts
  JOURNAL   Br J Audiol 31 (2), 73-132 (1997)
   PUBMED   9183385
REFERENCE   9  (bases 1 to 1127)
  AUTHORS   Lane,P.W.
  TITLE     Linkage groups 3 and XVII in the mouse and the position of the
            light-ear locus
  JOURNAL   J Hered 58 (1), 21-24 (1967)
   PUBMED   6031678
REFERENCE   10 (bases 1 to 1127)
  AUTHORS   Sidman,M., Ray,B.A., Sidman,R.L. and Klinger,J.M.
  TITLE     Hearing and vision in neurological mutant mice: a method for their
            evaluation
  JOURNAL   Exp Neurol 16 (4), 377-402 (1966)
   PUBMED   5957201
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160555.4 and AC107758.19.
            
            On Aug 9, 2021 this sequence version replaced NM_001018019.2.
            
            CCDS Note: The coding region has been reverted to start at a
            downstream in-frame start codon that is supported by conservation
            data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY616753.1, BC147269.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN01164132,
                                           SAMN01164138 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-511               AC160555.4         80201-80711
            512-754             AC160555.4         158734-158976
            755-820             AC107758.19        116688-116753
            821-1127            AC107758.19        126953-127259
FEATURES             Location/Qualifiers
     source          1..1127
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 36.59 cM"
     gene            1..1127
                     /gene="Grxcr1"
                     /gene_synonym="pi; tde; Tg(Eno2-Gabrb3)0370Brll"
                     /note="glutaredoxin, cysteine rich 1"
                     /db_xref="GeneID:433899"
                     /db_xref="MGI:MGI:3577767"
     exon            1..511
                     /gene="Grxcr1"
                     /gene_synonym="pi; tde; Tg(Eno2-Gabrb3)0370Brll"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..1000
                     /gene="Grxcr1"
                     /gene_synonym="pi; tde; Tg(Eno2-Gabrb3)0370Brll"
                     /note="glutaredoxin cysteine-rich 1 protein"
                     /codon_start=1
                     /product="glutaredoxin domain-containing cysteine-rich
                     protein 1"
                     /protein_id="NP_001018019.3"
                     /db_xref="CCDS:CCDS19319.2"
                     /db_xref="GeneID:433899"
                     /db_xref="MGI:MGI:3577767"
                     /translation="MLRRETKPESDRPRKVRFRIASSHSGRVLKEVYEDGQAPGSLDS
                     ECASICAIDGLSDSEGQQNGHIGSEDNEQEKDQDNLLVLARTASEKAFGTRRVNILSK
                     NGTVRGVKYKVSAGQALFNNLTKVLQQPSADLEFDRVVIYTTCLRVVRTTFERCELVR
                     KIFQNHRVKFEEKNIALNGDYGKELDERCRRVSEAPSLPVVFIDGHYLGGAEKILSMN
                     ESGELQDLLTKIERVQHPHECPSCGGFGFLPCSVCHGSKMSVFRNCFTDAFKALKCTA
                     CNENGLQRCKNCTC"
     exon            512..754
                     /gene="Grxcr1"
                     /gene_synonym="pi; tde; Tg(Eno2-Gabrb3)0370Brll"
                     /inference="alignment:Splign:2.1.0"
     exon            755..820
                     /gene="Grxcr1"
                     /gene_synonym="pi; tde; Tg(Eno2-Gabrb3)0370Brll"
                     /inference="alignment:Splign:2.1.0"
     exon            821..1127
                     /gene="Grxcr1"
                     /gene_synonym="pi; tde; Tg(Eno2-Gabrb3)0370Brll"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttttctttc gctgtcacag gagggctacc atctctggaa ttcagctctg ccgttgctgt
       61 ggcaaggggg atgaactgac agcagatcca taatggtgta aactggttca tgtgggtgga
      121 ggtgaccatg ctaagaaggg agacaaagcc agaaagtgac aggccacgga aagtccggtt
      181 tcgaattgcc tcatctcaca gtgggagagt tctgaaagag gtctatgaag atggacaagc
      241 accaggctct ctggattctg aatgtgctag tatttgtgcc atagatgggc taagtgactc
      301 tgagggacag caaaacggcc acattggatc agaggataat gaacaggaga aagatcagga
      361 taacctgctg gtattagcca ggacagccag cgagaaggct tttggcacaa gaagagtcaa
      421 cattttaagc aaaaatggta cagtcagagg cgtcaagtac aaagtgagtg ctggccaggc
      481 tctgtttaac aatttgacca aagtgttgca gcagccatca gctgacctgg aatttgaccg
      541 tgtggtaatt tatacaacct gccttcgtgt ggtgaggacg accttcgaga gatgcgaact
      601 ggttagaaag atcttccaaa accatcgagt aaagtttgaa gagaaaaaca tagctctaaa
      661 cggtgactat gggaaagagt tggatgaacg gtgcaggaga gtctccgaag ctccttccct
      721 tcctgttgtc ttcattgatg gccattatct tgggggtgct gagaaaattt tgtcaatgaa
      781 tgaatcagga gaactgcaag accttttaac caaaattgag agggtccagc atccgcacga
      841 gtgtccttcc tgtggaggct ttggcttcct tccatgctct gtgtgccacg gaagcaagat
      901 gtcagtgttt cgcaattgct ttacggacgc tttcaaagcc ctcaagtgta cagcttgcaa
      961 tgagaatggt ctccagcgtt gtaagaactg cacctgctaa ctggagcttc tgcctagaga
     1021 aagcctcatt tcattaaaca aaggataaaa tttgacttct aagctttttt ttttttttta
     1081 aagaaagtca tgtttttaga ttaaacaata aagtttgtat attataa
//
