LOCUS       NM_025768               1310 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus GH regulated TBC protein 1 (Grtp1), transcript variant
            1, mRNA.
ACCESSION   NM_025768
VERSION     NM_025768.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1310)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1310)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 1310)
  AUTHORS   Shalom-Barak,T., Zhang,X., Chu,T., Timothy Schaiff,W., Reddy,J.K.,
            Xu,J., Sadovsky,Y. and Barak,Y.
  TITLE     Placental PPARgamma regulates spatiotemporally diverse genes and a
            unique metabolic network
  JOURNAL   Dev Biol 372 (1), 143-155 (2012)
   PUBMED   22967998
REFERENCE   4  (bases 1 to 1310)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   5  (bases 1 to 1310)
  AUTHORS   Lu,C., Kasik,J., Stephan,D.A., Yang,S., Sperling,M.A. and
            Menon,R.K.
  TITLE     Grtp1, a novel gene regulated by growth hormone
  JOURNAL   Endocrinology 142 (10), 4568-4571 (2001)
   PUBMED   11564724
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK007905.1 and AK149322.1.
            
            On Jan 28, 2006 this sequence version replaced NM_025768.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149322.1, AK007905.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1249              AK007905.1         6-1254
            1250-1310           AK149322.1         1247-1307
FEATURES             Location/Qualifiers
     source          1..1310
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 5.73 cM"
     gene            1..1310
                     /gene="Grtp1"
                     /gene_synonym="5430401C05Rik; Tbc1d6"
                     /note="GH regulated TBC protein 1"
                     /db_xref="GeneID:66790"
                     /db_xref="MGI:MGI:1914040"
     exon            1..144
                     /gene="Grtp1"
                     /gene_synonym="5430401C05Rik; Tbc1d6"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1126
                     /gene="Grtp1"
                     /gene_synonym="5430401C05Rik; Tbc1d6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     growth hormone-regulated TBC protein 1; TBC1 domain family
                     member 6"
                     /codon_start=1
                     /product="growth hormone-regulated TBC protein 1 isoform
                     1"
                     /protein_id="NP_080044.2"
                     /db_xref="CCDS:CCDS22107.1"
                     /db_xref="GeneID:66790"
                     /db_xref="MGI:MGI:1914040"
                     /translation="MDPAERAQAARARVPRIDPYGFERPEDFDYAAYEEFFSTYLVIL
                     TKRAIKWSKLLKGNGGVRKSVTVKRYVRKGIPLEHRARVWMAVSGAQARMDQSPGYYH
                     RLLEGESSSSLDEAIRTDLNRTFPDNVMFRKTADPCLQKTLYNVLLAYGLHNPDVGYC
                     QGMNFIAGYLILITKNEEESFWLLDALVGRILPDYYSPAMLGLKTDQEVLAELVRMKL
                     PAVAALMDGHGVLWTLLVSRWFICLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLI
                     KQHQEFILEASSIPDICDKFKQITKGDFVTECHAFMQKIFSEPGSLSMTTITRLRKSC
                     RAALQAQS"
     exon            145..296
                     /gene="Grtp1"
                     /gene_synonym="5430401C05Rik; Tbc1d6"
                     /inference="alignment:Splign:2.1.0"
     exon            297..455
                     /gene="Grtp1"
                     /gene_synonym="5430401C05Rik; Tbc1d6"
                     /inference="alignment:Splign:2.1.0"
     exon            456..580
                     /gene="Grtp1"
                     /gene_synonym="5430401C05Rik; Tbc1d6"
                     /inference="alignment:Splign:2.1.0"
     exon            581..677
                     /gene="Grtp1"
                     /gene_synonym="5430401C05Rik; Tbc1d6"
                     /inference="alignment:Splign:2.1.0"
     exon            678..850
                     /gene="Grtp1"
                     /gene_synonym="5430401C05Rik; Tbc1d6"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1036
                     /gene="Grtp1"
                     /gene_synonym="5430401C05Rik; Tbc1d6"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1310
                     /gene="Grtp1"
                     /gene_synonym="5430401C05Rik; Tbc1d6"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1254
                     /gene="Grtp1"
                     /gene_synonym="5430401C05Rik; Tbc1d6"
                     /note="major polyA site"
     regulatory      1288..1293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grtp1"
                     /gene_synonym="5430401C05Rik; Tbc1d6"
                     /note="hexamer: CATAAA"
     polyA_site      1310
                     /gene="Grtp1"
                     /gene_synonym="5430401C05Rik; Tbc1d6"
ORIGIN      
        1 cggaagcact cgcgcgcccc ggggccagcg gcgcaccggg gtccagcgct cggggctgca
       61 gaggttgtga gtcccgcggt ccctggccct tctccgcatg gatcccgcag agcgcgcgca
      121 ggcggcgcga gctcgggtgc ccaggatcga tccgtatggg tttgaaaggc ccgaagactt
      181 tgactatgcg gcttatgaag aattcttttc cacgtacctg gtgatactca ccaagagggc
      241 gatcaaatgg tccaaacttc taaaaggaaa cggtggtgtc cggaaaagcg tgacagtgaa
      301 gcgctatgtc cggaagggaa tcccgctgga gcatcgggcc cgtgtgtgga tggccgtgag
      361 tggagctcag gcccggatgg accagagccc tggatactac catcgactgc tcgagggcga
      421 gagcagctcc agcctggacg aggccatcag gacagacttg aaccggacat tccctgacaa
      481 cgtgatgttt cggaagacag cggatccttg tctccagaag accctgtaca acgtgctcct
      541 ggcatatggg ctacacaacc cagacgtggg gtactgccag ggaatgaatt tcatagctgg
      601 gtatctgatc cttatcacga agaatgaaga ggagtctttc tggcttttgg acgctcttgt
      661 tggaaggata ctacctgatt actatagccc agcaatgctg gggctgaaga ctgaccaaga
      721 ggtcctagca gagctggtga ggatgaagct accagcagtg gcagccctga tggatggcca
      781 tggtgtgttg tggaccctgc tggtgtcccg ctggttcatc tgcctgtttg tggacatcct
      841 acctgtggag acggtgctac ggatctggga ctgtctgttc aatgagggct ccaaaatcat
      901 attccgggtt gctctgacct taattaagca acaccaggaa tttatattgg aagccagcag
      961 tattccagac atctgtgaca agtttaagca gatcaccaaa ggggactttg tgacagagtg
     1021 tcacgcattc atgcagaaaa tcttttcaga accaggaagc ctgtccatga cgaccatcac
     1081 caggcttcgg aagagctgcc gagcagcgct gcaggcacag agctgagtgc acaggcgccc
     1141 acagctgcag ttctcttcag agcacacact tcaccaattc ctaccacaac gttcctgctg
     1201 taaatacttg aaatcacgac actcaatgtg aacttttaaa agaatgactt aaaattagtg
     1261 ttctccattt tttcctacct ttggagtcat aaactgaatt ctctggccca
//
