LOCUS       NM_178700               2753 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus G-rich RNA sequence binding factor 1 (Grsf1),
            transcript variant 1, mRNA.
ACCESSION   NM_178700 XM_977004
VERSION     NM_178700.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2753)
  AUTHORS   Li,Y., Shen,Q., Huang,L., Li,B., Zhang,Y., Wang,W., Zhao,B. and
            Gao,W.
  TITLE     Anti-aging Factor GRSF1 Attenuates Cerebral Ischemia-Reperfusion
            Injury in Mice by Inhibiting GPX4-Mediated Ferroptosis
  JOURNAL   Mol Neurobiol 61 (4), 2151-2164 (2024)
   PUBMED   37861894
  REMARK    GeneRIF: Anti-aging Factor GRSF1 Attenuates Cerebral
            Ischemia-Reperfusion Injury in Mice by Inhibiting GPX4-Mediated
            Ferroptosis.
REFERENCE   2  (bases 1 to 2753)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2753)
  AUTHORS   Dumoulin,B., Heydeck,D., Jahn,D., Lasse,M., Sofi,S., Ufer,C. and
            Kuhn,H.
  TITLE     Male guanine-rich RNA sequence binding factor 1 knockout mice
            (Grsf1-/-) gain less body weight during adolescence and adulthood
  JOURNAL   Cell Biosci 12 (1), 199 (2022)
   PUBMED   36494688
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2753)
  AUTHORS   Driscoll,R.K., Krasniewski,L.K., Cockey,S.G., Yang,J.H., Piao,Y.,
            Lehrmann,E., Zhang,Y., Michel,M., Noh,J.H., Cui,C.Y. and Gorospe,M.
  TITLE     GRSF1 deficiency in skeletal muscle reduces endurance in aged mice
  JOURNAL   Aging (Albany NY) 13 (11), 14557-14570 (2021)
   PUBMED   34078750
  REMARK    GeneRIF: GRSF1 deficiency in skeletal muscle reduces endurance in
            aged mice.
REFERENCE   5  (bases 1 to 2753)
  AUTHORS   Butterfield,N.C., Curry,K.F., Steinberg,J., Dewhurst,H.,
            Komla-Ebri,D., Mannan,N.S., Adoum,A.T., Leitch,V.D., Logan,J.G.,
            Waung,J.A., Ghirardello,E., Southam,L., Youlten,S.E.,
            Wilkinson,J.M., McAninch,E.A., Vancollie,V.E., Kussy,F.,
            White,J.K., Lelliott,C.J., Adams,D.J., Jacques,R., Bianco,A.C.,
            Boyde,A., Zeggini,E., Croucher,P.I., Williams,G.R. and
            Bassett,J.H.D.
  TITLE     Accelerating functional gene discovery in osteoarthritis
  JOURNAL   Nat Commun 12 (1), 467 (2021)
   PUBMED   33473114
  REMARK    Erratum:[Nat Commun. 2021 May 28;12(1):3302. doi:
            10.1038/s41467-021-23768-8. PMID: 34050183]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2753)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2753)
  AUTHORS   Lickert,H., Cox,B., Wehrle,C., Taketo,M.M., Kemler,R. and
            Rossant,J.
  TITLE     Dissecting Wnt/beta-catenin signaling during gastrulation using RNA
            interference in mouse embryos
  JOURNAL   Development 132 (11), 2599-2609 (2005)
   PUBMED   15857914
  REMARK    GeneRIF: Grsf1 is important for axial elongation, mid/hindbrain
            development and axial mesoderm specification.
REFERENCE   8  (bases 1 to 2753)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   9  (bases 1 to 2753)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 2753)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044889.1, AK077782.1, AK045986.1 and AC121541.31.
            
            On Nov 6, 2013 this sequence version replaced NM_178700.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077782.1, AK045986.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-334               AK044889.1         2-335
            335-820             AK077782.1         336-821
            821-821             AK045986.1         775-775
            822-2528            AK077782.1         823-2529
            2529-2753           AC121541.31        9873-10097
FEATURES             Location/Qualifiers
     source          1..2753
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 43.85 cM"
     gene            1..2753
                     /gene="Grsf1"
                     /gene_synonym="D5Wsu31e"
                     /note="G-rich RNA sequence binding factor 1"
                     /db_xref="GeneID:231413"
                     /db_xref="MGI:MGI:106479"
     exon            1..414
                     /gene="Grsf1"
                     /gene_synonym="D5Wsu31e"
                     /inference="alignment:Splign:2.1.0"
     exon            415..571
                     /gene="Grsf1"
                     /gene_synonym="D5Wsu31e"
                     /inference="alignment:Splign:2.1.0"
     exon            572..727
                     /gene="Grsf1"
                     /gene_synonym="D5Wsu31e"
                     /inference="alignment:Splign:2.1.0"
     exon            728..871
                     /gene="Grsf1"
                     /gene_synonym="D5Wsu31e"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1007
                     /gene="Grsf1"
                     /gene_synonym="D5Wsu31e"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1192
                     /gene="Grsf1"
                     /gene_synonym="D5Wsu31e"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1314
                     /gene="Grsf1"
                     /gene_synonym="D5Wsu31e"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1450
                     /gene="Grsf1"
                     /gene_synonym="D5Wsu31e"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1526
                     /gene="Grsf1"
                     /gene_synonym="D5Wsu31e"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..2753
                     /gene="Grsf1"
                     /gene_synonym="D5Wsu31e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2498..2503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grsf1"
                     /gene_synonym="D5Wsu31e"
                     /note="hexamer: AATAAA"
     polyA_site      2517
                     /gene="Grsf1"
                     /gene_synonym="D5Wsu31e"
                     /note="major polyA site"
     regulatory      2731..2736
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grsf1"
                     /gene_synonym="D5Wsu31e"
                     /note="hexamer: AATGAA"
     polyA_site      2748
                     /gene="Grsf1"
                     /gene_synonym="D5Wsu31e"
ORIGIN      
        1 acttcccctc cgctcgcgcc acagcggcca cctccaggcc ccgcgccgcc tccggagccg
       61 atggccggga cgcgctgggt gctaggcgcg ttgctccggg gctgcggctg caactgcagc
      121 agctgccggc ggaccggcgc cgcctgcctg cctttctact ccgccgccgg caccttcccg
      181 tcgggcgtct ctggccgccg ccgcctgctg ctactcctcg gggccgccgc ggccgccgct
      241 tcgcagacgc ggggcctgca gctcgggcct gcggccgccg ggaggctggc gggtcccatc
      301 cctgcccgtc cctccgccgc cgcggccgcc gccgcgtcct actcggccct gcgcgccccg
      361 ctgtttccgc gatcgctggc agccgccgcg ggcccggcgc ggggttacag tcaggaatcc
      421 aaaactacct acctggaaga cctcccacca ctgcctgagt acgagttgag cccatccaag
      481 ctaggagacg aggtggatga tgtttatctc attcgagctc aggggctgcc gtggtcctgc
      541 actgtggaag atgttcttaa ctttttctca gactgcagaa tccgaaacag tgagaatgga
      601 atacatttcc tcctaaatag agatgggaaa cggaggggcg atgccttaat agagatggag
      661 tccgagcagg atgtacagaa ggccttagaa aagcaccgga tgtacatggg gcagcggtat
      721 gtggaagtgt atgaaataaa caacgaagat gtggatgcct taatgaagag cctgcaggtc
      781 aagccttcgc ctgtgctcag tgatggtgtg gtccgcctga gaggacttcc ttacagctgc
      841 aatgaaaagg acattgtgga cttctttgca ggactgaaca tagtagacat tacttttgtg
      901 atggactata gagggagaag aaaaacgggg gaagcctatg tacagtttga agaaccagaa
      961 atggccaacc aagcgcttct aaagcacagg gaagaaattg gtaaccgata catagagata
     1021 tttccaagca gaaggaatga agttcgaaca catgttggat ctcataaagg aaagaaaatg
     1081 acatcgtctc ctcctactaa atatataact gaaccagaag tggtatttga ggaacatgaa
     1141 gtaaatgaag atattcggcc tatgacggct tttgagagtg ataaagagat agaattgcct
     1201 aaggagatgt cagaaaaact tccagaggct gtcgattttg gaactctgcc ttccctgcat
     1261 tttgtccaca tgagaggatt gcctttccaa gccaatgccc aagacattat aaatttcttt
     1321 gctcccctga agcctgtgag aatcaccatg gaatacagct ccagtgggaa ggccactgga
     1381 gaagctgacg tgcactttga tacccatgag gatgctgttg cagccatgct caaggatcgg
     1441 tcccatgtcc aacataggta tattgagctg ttcctaaatt catgtcctaa aggaaaataa
     1501 gacttcaaca gaccccagaa aataaggatg aagcaggaag catctcattt gcacatctct
     1561 ctgagacgtg gaatacaaag atccagttga ttggcagcaa ctgctggaga aaggatctgt
     1621 gcatcttagt gctgtgttta cacacagaaa gattcggttt gggattatga aataagctac
     1681 aaatttaaaa ttctgttcaa acagtccagg ttgagattga gaaagtctgg tctgtgtgac
     1741 ttagttttcc gtcctgaggc tctgctacag actaagatga tgtttccacc cagtgccgct
     1801 cctcagatcc ttgctcccgc ctgttgttgc ctgtgattga gagctctgat acaaactcat
     1861 ggaacacatt cacggtgtat ttttaccaaa cactcaccaa agcaacagaa ggtttcagaa
     1921 ctttaataag ccagtctgat ttggtcaaat agcttttcat tttatctgta tttgattact
     1981 tagggataga agttttaaaa aatagcaaac cacaggttag tgaatgtaag tggccactca
     2041 gcagttaacg tctttagaaa cttggcctcc ctaagccttg acctgaaggc atttgacatt
     2101 ggtgcctgtc tgtcagtgtc atggaagtct aggcaacctt cacttttttt tcttggacag
     2161 acaaatctta aggctattag gtttgaaatc gtaatgtgac atatcaaagc agtccagact
     2221 ggtaaggaca ttaatagctt cacttgaatt gaaccagctc tagataggga aaacaatcta
     2281 agtcccctcg tttgcttttc cagtggggta gccatcccat acttagaaca ggtaggggtg
     2341 ccttgcttaa atcaaactag catttcatgt ataattgtgt gaaagatctg tggataaagc
     2401 tgtatttctg tcacattgtg gcagcacctc tgctttaata ctaaatagct tgttatttaa
     2461 atattggaca aaatggctgg cttcaaaaat agtcattaat aaacttaact ttatgtatac
     2521 ctgtgtagaa gaatcaaagt tctgtatatt ttctttacct tgttcctatt ctcagggtga
     2581 cagctaccac caagagatga taaatctcac gcttcagact gaattttctg agctttcaca
     2641 ggtggtaacc tggaagagac gtgcattgct tagtacatag ccacatgtga ttaccagcta
     2701 aggggcaaaa ttactgttct gtagacaata aatgaaagtt tgttttaagt tgg
//
