LOCUS       NP_848815                479 aa            linear   ROD 10-FEB-2025
DEFINITION  G-rich sequence factor 1 isoform 1 [Mus musculus].
ACCESSION   NP_848815 XP_982098
VERSION     NP_848815.2
DBSOURCE    REFSEQ: accession NM_178700.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 479)
  AUTHORS   Li,Y., Shen,Q., Huang,L., Li,B., Zhang,Y., Wang,W., Zhao,B. and
            Gao,W.
  TITLE     Anti-aging Factor GRSF1 Attenuates Cerebral Ischemia-Reperfusion
            Injury in Mice by Inhibiting GPX4-Mediated Ferroptosis
  JOURNAL   Mol Neurobiol 61 (4), 2151-2164 (2024)
   PUBMED   37861894
  REMARK    GeneRIF: Anti-aging Factor GRSF1 Attenuates Cerebral
            Ischemia-Reperfusion Injury in Mice by Inhibiting GPX4-Mediated
            Ferroptosis.
REFERENCE   2  (residues 1 to 479)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 479)
  AUTHORS   Dumoulin,B., Heydeck,D., Jahn,D., Lasse,M., Sofi,S., Ufer,C. and
            Kuhn,H.
  TITLE     Male guanine-rich RNA sequence binding factor 1 knockout mice
            (Grsf1-/-) gain less body weight during adolescence and adulthood
  JOURNAL   Cell Biosci 12 (1), 199 (2022)
   PUBMED   36494688
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 479)
  AUTHORS   Driscoll,R.K., Krasniewski,L.K., Cockey,S.G., Yang,J.H., Piao,Y.,
            Lehrmann,E., Zhang,Y., Michel,M., Noh,J.H., Cui,C.Y. and Gorospe,M.
  TITLE     GRSF1 deficiency in skeletal muscle reduces endurance in aged mice
  JOURNAL   Aging (Albany NY) 13 (11), 14557-14570 (2021)
   PUBMED   34078750
  REMARK    GeneRIF: GRSF1 deficiency in skeletal muscle reduces endurance in
            aged mice.
REFERENCE   5  (residues 1 to 479)
  AUTHORS   Butterfield,N.C., Curry,K.F., Steinberg,J., Dewhurst,H.,
            Komla-Ebri,D., Mannan,N.S., Adoum,A.T., Leitch,V.D., Logan,J.G.,
            Waung,J.A., Ghirardello,E., Southam,L., Youlten,S.E.,
            Wilkinson,J.M., McAninch,E.A., Vancollie,V.E., Kussy,F.,
            White,J.K., Lelliott,C.J., Adams,D.J., Jacques,R., Bianco,A.C.,
            Boyde,A., Zeggini,E., Croucher,P.I., Williams,G.R. and
            Bassett,J.H.D.
  TITLE     Accelerating functional gene discovery in osteoarthritis
  JOURNAL   Nat Commun 12 (1), 467 (2021)
   PUBMED   33473114
  REMARK    Erratum:[Nat Commun. 2021 May 28;12(1):3302. doi:
            10.1038/s41467-021-23768-8.. PMID: 34050183]
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 479)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 479)
  AUTHORS   Lickert,H., Cox,B., Wehrle,C., Taketo,M.M., Kemler,R. and
            Rossant,J.
  TITLE     Dissecting Wnt/beta-catenin signaling during gastrulation using RNA
            interference in mouse embryos
  JOURNAL   Development 132 (11), 2599-2609 (2005)
   PUBMED   15857914
  REMARK    GeneRIF: Grsf1 is important for axial elongation, mid/hindbrain
            development and axial mesoderm specification.
REFERENCE   8  (residues 1 to 479)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   9  (residues 1 to 479)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (residues 1 to 479)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044889.1, AK077782.1, AK045986.1 and AC121541.31.
            
            On Jun 5, 2007 this sequence version replaced NP_848815.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077782.1, AK045986.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 43.85 cM"
     Protein         1..479
                     /product="G-rich sequence factor 1 isoform 1"
                     /calculated_mol_wt=41694
     transit_peptide 1..116
                     /note="Mitochondrion. /evidence=ECO:0000255; propagated
                     from UniProtKB/Swiss-Prot (Q8C5Q4.2)"
                     /calculated_mol_wt=11400
     mat_peptide     117..479
                     /product="G-rich sequence factor 1. /id=PRO_0000081598"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C5Q4.2)"
                     /calculated_mol_wt=41694
     Region          148..226
                     /region_name="RRM1_GRSF1"
                     /note="RNA recognition motif 1 (RRM1) found in G-rich
                     sequence factor 1 (GRSF-1) and similar proteins; cd12730"
                     /db_xref="CDD:410129"
     Site            243
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12849; propagated from
                     UniProtKB/Swiss-Prot (Q8C5Q4.2)"
     Region          248..324
                     /region_name="RRM2_GRSF1"
                     /note="RNA recognition motif 2 (RRM2) found in G-rich
                     sequence factor 1 (GRSF-1) and similar proteins; cd12505"
                     /db_xref="CDD:409928"
     Site            334
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12849; propagated from
                     UniProtKB/Swiss-Prot (Q8C5Q4.2)"
     Region          400..474
                     /region_name="RRM3_GRSF1"
                     /note="RNA recognition motif 3 (RRM3) found in G-rich
                     sequence factor 1 (GRSF-1) and similar proteins; cd12733"
                     /db_xref="CDD:410132"
     CDS             1..479
                     /gene="Grsf1"
                     /gene_synonym="D5Wsu31e"
                     /coded_by="NM_178700.5:61..1500"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS19404.1"
                     /db_xref="GeneID:231413"
                     /db_xref="MGI:MGI:106479"
ORIGIN      
        1 magtrwvlga llrgcgcncs scrrtgaacl pfysaagtfp sgvsgrrrll lllgaaaaaa
       61 sqtrglqlgp aaagrlagpi parpsaaaaa aasysalrap lfprslaaaa gpargysqes
      121 kttyledlpp lpeyelspsk lgdevddvyl iraqglpwsc tvedvlnffs dcrirnseng
      181 ihfllnrdgk rrgdalieme seqdvqkale khrmymgqry vevyeinned vdalmkslqv
      241 kpspvlsdgv vrlrglpysc nekdivdffa glnivditfv mdyrgrrktg eayvqfeepe
      301 manqallkhr eeignryiei fpsrrnevrt hvgshkgkkm tsspptkyit epevvfeehe
      361 vnedirpmta fesdkeielp kemseklpea vdfgtlpslh fvhmrglpfq anaqdiinff
      421 aplkpvritm eysssgkatg eadvhfdthe davaamlkdr shvqhryiel flnscpkgk
//
