LOCUS       NM_008177               2582 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus gastrin releasing peptide receptor (Grpr), mRNA.
ACCESSION   NM_008177
VERSION     NM_008177.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2582)
  AUTHORS   Matsumoto,Y., Miwa,H., Katayama,K.I., Watanabe,A., Yamada,K.,
            Ito,T., Nakagawa,S. and Aruga,J.
  TITLE     Slitrk4 is required for the development of inhibitory neurons in
            the fear memory circuit of the lateral amygdala
  JOURNAL   Front Mol Neurosci 17, 1386924 (2024)
   PUBMED   38736483
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2582)
  AUTHORS   Li,H., Wang,X., Hu,C., Cui,J., Li,H., Luo,X. and Hao,Y.
  TITLE     IL-6 Enhances the Activation of PI3K-AKT/mTOR-GSK-3beta by
            Upregulating GRPR in Hippocampal Neurons of Autistic Mice
  JOURNAL   J Neuroimmune Pharmacol 19 (1), 12 (2024)
   PUBMED   38536552
  REMARK    GeneRIF: IL-6 Enhances the Activation of PI3K-AKT/mTOR-GSK-3beta by
            Upregulating GRPR in Hippocampal Neurons of Autistic Mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2582)
  AUTHORS   Quillet,R., Gutierrez-Mecinas,M., Polgar,E., Dickie,A.C.,
            Boyle,K.A., Watanabe,M. and Todd,A.J.
  TITLE     Synaptic circuits involving gastrin-releasing peptide
            receptor-expressing neurons in the dorsal horn of the mouse spinal
            cord
  JOURNAL   Front Mol Neurosci 16, 1294994 (2023)
   PUBMED   38143564
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2582)
  AUTHORS   Weber,H.C., Jensen,R.T. and Battey,J.F.
  TITLE     Molecular organization of the mouse gastrin-releasing peptide
            receptor gene and its promoter
  JOURNAL   Gene 244 (1-2), 137-149 (2000)
   PUBMED   10689196
REFERENCE   5  (bases 1 to 2582)
  AUTHORS   King,K.A., Torday,J.S. and Sunday,M.E.
  TITLE     Bombesin and [Leu8]phyllolitorin promote fetal mouse lung branching
            morphogenesis via a receptor-mediated mechanism
  JOURNAL   Proc Natl Acad Sci U S A 92 (10), 4357-4361 (1995)
   PUBMED   7753811
REFERENCE   6  (bases 1 to 2582)
  AUTHORS   Zhou,E., Favor,J., Silvers,W. and Stambolian,D.
  TITLE     Exclusion of three candidate genes, Grpr, Cxn33, and Pdha1, for the
            X-linked cataract gene on the distal region of the mouse chromosome
            X
  JOURNAL   Mamm Genome 6 (5), 357-359 (1995)
   PUBMED   7626887
REFERENCE   7  (bases 1 to 2582)
  AUTHORS   Kusano,K., Gainer,H., Battey,J.F., Fathi,Z. and Wada,E.
  TITLE     Receptor-activated currents in mouse fibroblasts expressing
            transfected bombesin receptor subtype cDNAs
  JOURNAL   Am J Physiol 265 (4 Pt 1), C869-C876 (1993)
   PUBMED   8238311
REFERENCE   8  (bases 1 to 2582)
  AUTHORS   Giladi,E., Nagalla,S.R. and Spindel,E.R.
  TITLE     Molecular cloning and characterization of receptors for the
            mammalian bombesin-like peptides
  JOURNAL   J Mol Neurosci 4 (1), 41-54 (1993)
   PUBMED   8391296
REFERENCE   9  (bases 1 to 2582)
  AUTHORS   Battey,J.F., Way,J.M., Corjay,M.H., Shapira,H., Kusano,K.,
            Harkins,R., Wu,J.M., Slattery,T., Mann,E. and Feldman,R.I.
  TITLE     Molecular cloning of the bombesin/gastrin-releasing peptide
            receptor from Swiss 3T3 cells
  JOURNAL   Proc Natl Acad Sci U S A 88 (2), 395-399 (1991)
   PUBMED   1671171
REFERENCE   10 (bases 1 to 2582)
  AUTHORS   Spindel,E.R., Giladi,E., Brehm,P., Goodman,R.H. and Segerson,T.P.
  TITLE     Cloning and functional characterization of a complementary DNA
            encoding the murine fibroblast bombesin/gastrin-releasing peptide
            receptor
  JOURNAL   Mol Endocrinol 4 (12), 1956-1963 (1990)
   PUBMED   1707129
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL670292.9 and AK033473.1.
            
            On May 8, 2015 this sequence version replaced NM_008177.2.
            
            Summary: This gene encodes a multipass membrane protein that
            functions as a receptor for gastrin releasing peptide. Signalling
            through this receptor is important in a variety of physiological
            processes, including responses to itching, satiety, and fear.
            [provided by RefSeq, May 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033473.1, BC113145.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 5' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                AL670292.9         175130-175209       c
            81-1790             AK033473.1         3-1712
            1791-2582           AL670292.9         139377-140168       c
FEATURES             Location/Qualifiers
     source          1..2582
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 75.63 cM"
     gene            1..2582
                     /gene="Grpr"
                     /gene_synonym="GRP-R"
                     /note="gastrin releasing peptide receptor"
                     /db_xref="GeneID:14829"
                     /db_xref="MGI:MGI:95836"
     exon            1..855
                     /gene="Grpr"
                     /gene_synonym="GRP-R"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1207
                     /gene="Grpr"
                     /gene_synonym="GRP-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..2582
                     /gene="Grpr"
                     /gene_synonym="GRP-R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2417..2422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grpr"
                     /gene_synonym="GRP-R"
                     /note="hexamer: ATTAAA"
     polyA_site      2443
                     /gene="Grpr"
                     /gene_synonym="GRP-R"
                     /note="major polyA site"
ORIGIN      
        1 ctacaaatca gggaagacgg gaaatgctgt gtgaaaatag caatccaaaa gttcttagta
       61 aactgcagcc agagagactc agtctaggat ggaggtagga agagctgaga caaagtgggc
      121 ttaattctaa gcttttcttc aggctgagtt tctgttgctt gttaacttag tgaatgtaca
      181 gatgtattgc ttgctggtgg tgtgaaggct gggacagaac caacatcaac aaactgagct
      241 agagtttgga ataccagtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtga
      301 attcagagtg ttttaaagag agatcaagag gctcacacag atcagcgagc ctaactgaca
      361 aaccttcagc gcctaactga aaaacccaga agttacaaag cagcatcttg aaggcgcatt
      421 tgaagagaga agctttgaga tggctccaaa taattgttcc cacctgaact tggacgtgga
      481 ccctttcctg tcctgcaacg acaccttcaa tcaaagtctg agtcccccca agatggacaa
      541 ctggtttcac ccgggcttca tctatgtcat ccctgcagtt tatgggctta tcatcgtgat
      601 aggtcttatt ggcaacatca cgctcatcaa gatcttctgc acggtcaagt ccatgcgaaa
      661 cgtgccaaac ctgttcatct ctagcctggc tttgggagac ctgctgctgc tggtgacatg
      721 cgcccctgtg gatgccagca agtacctggc tgacaggtgg ctatttggca gaattggctg
      781 caaactgatc ccctttatac aacttacttc agtgggggtg tctgtcttca cacttacggc
      841 actgtcagct gacaggtaca aagccattgt acggccaatg gatatccagg catcccatgc
      901 cctgatgaag atctgtctca aagctgcttt gatctggatt gtctctatgt tgttggccat
      961 cccagaggct gtgttttctg acctccaccc cttccatgtg aaagatacca accaaacctt
     1021 cattagttgt gccccctacc cacactccaa tgagctacac cctaaaatcc attccatggc
     1081 ttcctttctg gttttctacg ttatcccact ggcgatcatc tctgtctact actacttcat
     1141 tgcccgaaat ctgattcaga gtgcctacaa tcttcccgtg gaaggcaata tacatgtcaa
     1201 gaagcagatc gaatcccgga agcggcttgc caagacagta ctggtgtttg tgggcctctt
     1261 tgccttctgc tggctcccca accatgtcat ctacctgtac cgttcctacc actactctga
     1321 agtggacacc tccatgctcc actttgtcac cagcatctgt gcccgcctcc tggccttcac
     1381 caactcctgt gtgaacccct ttgctcttta tctgctgagc aagagcttca ggaagcagtt
     1441 caacactcaa cttctctgct gccagcctgg cctgatgaac aggtcccaca gcacaggcag
     1501 aagtaccacc tgcatgacct ccttcaagag cactaacccc tcggctacct ttagcctcat
     1561 caacagaaat atctgtcatg aggggtatgt ctagactaaa cttcaacctt gcctctaaag
     1621 gaactcctgg tattgttcta cagatgtcca ggggccctga gattgattgt tgtctctata
     1681 tcttctgaag actcttcagg gggatgagtg atacagacgg atgggaaaga tgtccaaatg
     1741 caccaatcac cattgtatct caaagtaagc ctgcaggctt cattttccat ctcagttgtg
     1801 agggcttctt ctgatggaga tgaaatcttc ctttaaaaaa caaggaacaa attggaaatt
     1861 attattcaaa gcaccaagcc ccactaggca agtatggtca attaagtctt agaaattata
     1921 tgaaaaaaaa aaaagagaga gagagagccg agaaaccatg cattggttat ctgctctgtg
     1981 agttattttc tttaaacaga agctggttgc ttgcaaaaca tggcttggct cctttttttt
     2041 ccagaaatat ctataatatg taaaccaagg gacaacttgt atttacattc ctaaaatgaa
     2101 aagccaactc taaaaaagag tcccatgtgt gaggaatgga ctccatttat aacattggaa
     2161 gccagtgtaa tataaaacaa actgctaaat attgactttt tcagagatgt tgctgaggac
     2221 acagaagaaa cactcaatag aaaatgttaa ggcgaaaagc aaccaaatgt agacccatgt
     2281 atggctatgg agcaatggct tatgcccaga tttcccattt catagaaatt ctgattcttg
     2341 ttaatccaat tttggtcatt atagtgtcat tctaccatag aagagagatc ttttttgtgg
     2401 gaaaaatgct cattttatta aagtattaac tattacaaat gtataaagga tggcatttat
     2461 tcttgatata catgttttga atcaagtgta tttgcttagg gttaactgtc tttgtaaagc
     2521 agtagtttca atacaagaaa gataattttt ttctgtgcag aaataaaatc atgtttatat
     2581 tg
//
