LOCUS       NM_024478               3338 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus GrpE-like 1, mitochondrial (Grpel1), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_024478
VERSION     NM_024478.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3338)
  AUTHORS   Neupane,N., Rajendran,J., Kvist,J., Harjuhaahto,S., Hu,B.,
            Kinnunen,V., Yang,Y., Nieminen,A.I. and Tyynismaa,H.
  TITLE     Inter-organellar and systemic responses to impaired mitochondrial
            matrix protein import in skeletal muscle
  JOURNAL   Commun Biol 5 (1), 1060 (2022)
   PUBMED   36198903
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3338)
  AUTHORS   Chen,P., Wang,B., Mo,Q., Wu,P., Fang,Y., Tian,Y., Jin,X., Gao,Y.,
            Wu,Y., Cao,Y., Zhang,Y., Xi,L., Wang,S., Hu,J., Ma,D., Zhou,J.,
            Gao,Q. and Chen,G.
  TITLE     The LIV-1-GRPEL1 axis adjusts cell fate during anti-mitotic
            agent-damaged mitosis
  JOURNAL   EBioMedicine 49, 26-39 (2019)
   PUBMED   31636012
  REMARK    GeneRIF: These data demonstrate that LIV-1-GRPEL1 axis dually
            regulates mitotic exit as well as apoptosis by interacting with
            PP2A B55alpha and AIF.
REFERENCE   3  (bases 1 to 3338)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   4  (bases 1 to 3338)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   5  (bases 1 to 3338)
  AUTHORS   Pfisterer,P., Ehlermann,J., Hegen,M. and Schorle,H.
  TITLE     A subtractive gene expression screen suggests a role of
            transcription factor AP-2 alpha in control of proliferation and
            differentiation
  JOURNAL   J Biol Chem 277 (8), 6637-6644 (2002)
   PUBMED   11741941
REFERENCE   6  (bases 1 to 3338)
  AUTHORS   Naylor,D.J., Stines,A.P., Hoogenraad,N.J. and Hoj,P.B.
  TITLE     Evidence for the existence of distinct mammalian cytosolic,
            microsomal, and two mitochondrial GrpE-like proteins, the
            Co-chaperones of specific Hsp70 members
  JOURNAL   J Biol Chem 273 (33), 21169-21177 (1998)
   PUBMED   9694873
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK048732.1.
            
            On Jun 9, 2003 this sequence version replaced NM_024478.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK048732.1, AK050445.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3338
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 19.14 cM"
     gene            1..3338
                     /gene="Grpel1"
                     /gene_synonym="mt-GrpE#1; mt-Grpel1"
                     /note="GrpE-like 1, mitochondrial"
                     /db_xref="GeneID:17713"
                     /db_xref="MGI:MGI:1334417"
     exon            1..71
                     /gene="Grpel1"
                     /gene_synonym="mt-GrpE#1; mt-Grpel1"
                     /inference="alignment:Splign:2.1.0"
     exon            72..234
                     /gene="Grpel1"
                     /gene_synonym="mt-GrpE#1; mt-Grpel1"
                     /inference="alignment:Splign:2.1.0"
     exon            235..316
                     /gene="Grpel1"
                     /gene_synonym="mt-GrpE#1; mt-Grpel1"
                     /inference="alignment:Splign:2.1.0"
     exon            317..3338
                     /gene="Grpel1"
                     /gene_synonym="mt-GrpE#1; mt-Grpel1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      938..943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grpel1"
                     /gene_synonym="mt-GrpE#1; mt-Grpel1"
                     /note="hexamer: AATAAA"
     polyA_site      958
                     /gene="Grpel1"
                     /gene_synonym="mt-GrpE#1; mt-Grpel1"
                     /note="major polyA site"
     regulatory      2078..2083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grpel1"
                     /gene_synonym="mt-GrpE#1; mt-Grpel1"
                     /note="hexamer: AATACA"
     polyA_site      2099
                     /gene="Grpel1"
                     /gene_synonym="mt-GrpE#1; mt-Grpel1"
ORIGIN      
        1 ggggcagtca tggcggctcg gtgtgtgagg ctggcgcgcc gcagcctccc ggctttggca
       61 ctgtcgttca ggccttctcc tcgcttgttg tgcacagcta cgaaacagaa gaacaatggc
      121 cagaacctgg acgaggactt gggtcattgt gagccaaaga cagatccacc ctctgcagac
      181 aagaccctcc tggaagagaa ggcaaagctg gaagagcagc tgagagagac catggaaaaa
      241 tacaaacgtg ctttggcaga tactgagaat ctacggcaga gaagccagaa gctggtagag
      301 gaggccaagt tatatggcat ccagggtttc tgcaaggact tgctggaggt tgcagacatc
      361 ctggagaagg caacccagag tgttccaaag gaggagatca gcaacaacaa ccctcacctg
      421 aagagtcttt atgaagggct cgtgatgact gaagtccaga ttcagaaggt gttcacaaaa
      481 cacggcttgc tcaggcttga cccaattggg gccaagttcg acccttacga acatgaggcc
      541 ttgttccaca cccctgtgga ggggaaagaa ccaggcactg tggcactagt tagtaaggtg
      601 ggctacaagc tgcacggacg caccctgagg ccagctttgg tgggggtggt gaaggacgct
      661 tagctccctc cctcaggctc tggactttgt aggtcacttg ctagaactcg aagggcgggc
      721 ttgtaatttc tcatctgtga attcatctga cccttgccca gccttgttgg aaatcttaag
      781 taagctaagc agaacatgaa gctgcttgca cagtcaggga ctctgggagt ctggtcactg
      841 aatttagcat tacctacttc agaagagggc catcaggacc tcgggagtag tatgctaaca
      901 ttgtatctgt tccacctggt gattagtact ttacacaaat aaaaggtctt tggctatatc
      961 tatgctgcac agtctacctc tgagtaccaa ggcactggaa gggaagagcc agagcaggaa
     1021 cacttgttgc cagcgaaaat aagaccttca agagtgcata ttcctttaca agtcagtgta
     1081 aaagtcctga gatttggaca cctgccctgg ctctgaaatg acacggagtc ctggtatact
     1141 tagtgatgag ctgcttgcac tatacctggg cagggttctt tcttatctct tctaacccga
     1201 ccatgctgcc taccacccag tcatgtgccc agttacctgc tatcttagtc ttgccctggc
     1261 tgctcctgct ccgttcaacc tcatagtgac actctgccca ctttctggcc agccattggc
     1321 tgatcaggtg acagaaagcg attttacaca acacagacgg gagatgcttg atgatgccag
     1381 catctgggct acaaccagat ctccagcaca gtagtcagca tctgaacaca gttcacaact
     1441 gttccccatc agacagtatt cagctattgt gaatgttagc cttcagacag ggaaaagaag
     1501 ccatgaattt gaacatgttt agctctttcc ctgtttatac tcttaagctg taactaagta
     1561 gttgctaagg acatcaagcc ctatccagat agaccatatt gactgtaaag ctgcatggct
     1621 ggcatgctta aacattgcca cttgggaggt tgtggtcaag gggattagaa ggctcgtctt
     1681 ttatcttccc actttctggt actggatttt gtcatctaat ggagatctgg taggctcctg
     1741 aggagaaacc ctggcttact cagctcacag ctcttcaagc ttggggctgc agaagcctgg
     1801 gctctacgct ggccttacat acagttataa tacagctcat gggagaaagc caggcagcca
     1861 aagccacgac acacatgaga agctgacttt aggctcccac cagccaaaag attcttccct
     1921 gttattgcaa gctcagaaaa gctgatgaaa tggtgatgta aaggaagcca tgcgacagca
     1981 gtgagtacgg ccttgagtat acccttgtgt agaagccagg gcagaacagg caaagccaca
     2041 gaggtagggg tattctgttt tgttactaaa tttgaacaat acaagtaatt ttccccaaat
     2101 tcaagcttcc atcatcaccg agtttcttcc tttaagctgc cttgaactat tgaaacaaaa
     2161 caatagccag gtggagggca gcctgacagc agaggcagtg ccttcacatt gcataagtga
     2221 atacaccatt agactccttt tcagctaaag ctgctgaaca gcacagagct ctgcaaggtc
     2281 tcgtcagctc catgtcagac tgaagacaat ctttcagagg ccagcaagat tactcagcca
     2341 ggaaaggtgc ccgctgccaa gcctaatgac ctgagttcag tctctggaaa cccatgcagg
     2401 gagaggagtc ccactaaacc acaataatga agtctcagaa tggttgacag caaacatgaa
     2461 gaggactttt aagtttgtat ggcattatgg agactgcaca gatccatgga gacagtgcct
     2521 gctgttttgt aggagccact tgcatactct ggttttggtg acctggcacc atcatgacta
     2581 acctagatgt gatatttgta agttaatcag tcaacactaa caggagttgt gcacacattt
     2641 cccctggaaa ttcaggtctt gctccgccac atgcaagcct agtgactgga agcagcaagg
     2701 tcatagctgg caaagttgtt gagtttggct agccagaggc agctggaaat gggccctgct
     2761 ccatggaaat catctttggc actttgagga tcagactcac cgtgatgtgt agctgcatgg
     2821 tcctcaagac cttctgctat gctacagcag cttgtcacct tgggtcagaa gctggtttaa
     2881 cagcagagtg tgctgagaag ttggaggatc aagaagcaaa cagacacaac tctgttctca
     2941 acaatttaat gtaaaagaag aataaaaatg gtagggtttc agttcttcat acattcttgg
     3001 aatgttggcc tcccagagag cattatttca aacagttgaa gaattatcta acttttctga
     3061 ctcaaagaca atttgttgaa atttgaaaag acttggttcc atggggttgt agtagctaat
     3121 ttatcaagag aattaaatac aaacatgtca atgtctcagc taacaaaaaa taatatgcca
     3181 gaaacagctg gggcagacag gagagcaaac aatcctaata ttacttttcc cttgtaacaa
     3241 tattaatact tgaacataaa ttaattatac attcattatg gtgttttaaa acagtcacgc
     3301 ccaaataaat ttatatcatc gaaagatgta cacacact
//
