LOCUS       NM_175012                905 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus gastrin releasing peptide (Grp), mRNA.
ACCESSION   NM_175012
VERSION     NM_175012.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 905)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 905)
  AUTHORS   Yang,N.D., Mellor,R.L., Hermanstyne,T.O. and Nerbonne,J.M.
  TITLE     Effects of NALCN-Encoded Na+ Leak Currents on the Repetitive Firing
            Properties of SCN Neurons Depend on K+-Driven Rhythmic Changes in
            Input Resistance
  JOURNAL   J Neurosci 43 (28), 5132-5141 (2023)
   PUBMED   37339878
REFERENCE   3  (bases 1 to 905)
  AUTHORS   Shirey,K.A., Lai,W., Sunday,M.E., Cuttitta,F., Blanco,J.C.G. and
            Vogel,S.N.
  TITLE     Novel neuroendocrine role of gamma-aminobutyric acid and
            gastrin-releasing peptide in the host response to influenza
            infection
  JOURNAL   Mucosal Immunol 16 (3), 302-311 (2023)
   PUBMED   36965691
  REMARK    GeneRIF: Novel neuroendocrine role of gamma-aminobutyric acid and
            gastrin-releasing peptide in the host response to influenza
            infection.
REFERENCE   4  (bases 1 to 905)
  AUTHORS   Gutierrez-Mecinas,M., Kokai,E., Polgar,E., Quillet,R.,
            Titterton,H.F., Weir,G.A., Watanabe,M. and Todd,A.J.
  TITLE     Antibodies Against the Gastrin-releasing Peptide Precursor
            Pro-Gastrin-releasing Peptide Reveal Its Expression in the Mouse
            Spinal Dorsal Horn
  JOURNAL   Neuroscience 510, 60-71 (2023)
   PUBMED   36581131
  REMARK    GeneRIF: Antibodies Against the Gastrin-releasing Peptide Precursor
            Pro-Gastrin-releasing Peptide Reveal Its Expression in the Mouse
            Spinal Dorsal Horn.
REFERENCE   5  (bases 1 to 905)
  AUTHORS   Liau,E.S., Jin,S., Chen,Y.C., Liu,W.S., Calon,M., Nedelec,S.,
            Nie,Q. and Chen,J.A.
  TITLE     Single-cell transcriptomic analysis reveals diversity within
            mammalian spinal motor neurons
  JOURNAL   Nat Commun 14 (1), 46 (2023)
   PUBMED   36596814
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 905)
  AUTHORS   King,K.A., Torday,J.S. and Sunday,M.E.
  TITLE     Bombesin and [Leu8]phyllolitorin promote fetal mouse lung branching
            morphogenesis via a receptor-mediated mechanism
  JOURNAL   Proc Natl Acad Sci U S A 92 (10), 4357-4361 (1995)
   PUBMED   7753811
REFERENCE   7  (bases 1 to 905)
  AUTHORS   Wilkie,T.M., Chen,Y., Gilbert,D.J., Moore,K.J., Yu,L., Simon,M.I.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     Identification, chromosomal location, and genome organization of
            mammalian G-protein-coupled receptors
  JOURNAL   Genomics 18 (2), 175-184 (1993)
   PUBMED   8288218
REFERENCE   8  (bases 1 to 905)
  AUTHORS   Justice,M.J., Gilbert,D.J., Kinzler,K.W., Vogelstein,B.,
            Buchberg,A.M., Ceci,J.D., Matsuda,Y., Chapman,V.M., Patriotis,C.,
            Makris,A. et al.
  TITLE     A molecular genetic linkage map of mouse chromosome 18 reveals
            extensive linkage conservation with human chromosomes 5 and 18
  JOURNAL   Genomics 13 (4), 1281-1288 (1992)
   PUBMED   1354644
REFERENCE   9  (bases 1 to 905)
  AUTHORS   Detera-Wadleigh,S.D., Anderson,S. and Spindel,E.R.
  TITLE     A frequent Pvu II RFLP of the human gastrin releasing peptide gene
  JOURNAL   Nucleic Acids Res 15 (1), 375 (1987)
   PUBMED   2881252
REFERENCE   10 (bases 1 to 905)
  AUTHORS   Spindel,E.R., Chin,W.W., Price,J., Rees,L.H., Besser,G.M. and
            Habener,J.F.
  TITLE     Cloning and characterization of cDNAs encoding human
            gastrin-releasing peptide
  JOURNAL   Proc Natl Acad Sci U S A 81 (18), 5699-5703 (1984)
   PUBMED   6207529
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK139345.1, AK133508.1 and
            BE944748.1.
            
            On Aug 7, 2015 this sequence version replaced NM_175012.3.
            
            Summary: This gene encodes a neuropeptide hormone that affects
            various biological processes such as neuroendocrine regulation,
            gastrointestinal secretion, nociception, cell proliferation and
            inflammation. The encoded protein undergoes proteolytic processing
            to generate multiple mature peptides with biological activity.
            [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133508.1, BC024515.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AK139345.1         3-4
            3-869               AK133508.1         2-868
            870-905             BE944748.1         1-36                c
FEATURES             Location/Qualifiers
     source          1..905
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 38.98 cM"
     gene            1..905
                     /gene="Grp"
                     /gene_synonym="BLP"
                     /note="gastrin releasing peptide"
                     /db_xref="GeneID:225642"
                     /db_xref="MGI:MGI:95833"
     exon            1..266
                     /gene="Grp"
                     /gene_synonym="BLP"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..562
                     /gene="Grp"
                     /gene_synonym="BLP"
                     /codon_start=1
                     /product="gastrin-releasing peptide preproprotein"
                     /protein_id="NP_778177.1"
                     /db_xref="CCDS:CCDS29310.1"
                     /db_xref="GeneID:225642"
                     /db_xref="MGI:MGI:95833"
                     /translation="MRGSELSLLLLALVLCQAPRGPAAPVSTGAGGGTVLAKMYPRGS
                     HWAVGHLMGKKSTDESPSLYAADRDGLKEQLRGYVRWEEAARDLLDLLEAAGNQSHQP
                     PQHPPLSLQPTWDPEDGSYFNDVQTAKLVDSLLQVLKEKGGTAS"
     exon            267..508
                     /gene="Grp"
                     /gene_synonym="BLP"
                     /inference="alignment:Splign:2.1.0"
     exon            509..888
                     /gene="Grp"
                     /gene_synonym="BLP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      854..859
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grp"
                     /gene_synonym="BLP"
                     /note="hexamer: AATAAA"
     polyA_site      885
                     /gene="Grp"
                     /gene_synonym="BLP"
                     /note="major polyA site"
ORIGIN      
        1 gcagcagtgg ctctcgaagc ggcagtggca gagctcctga gaaccgtcct cctgtcgctg
       61 ctccgtcggg acaacgcact ctcagcctag tcgagagctc tgagggtttc cctccaggac
      121 catgcgcggc tcggagctct cgctcttgct gttggctctg gtcctctgcc aggcgccccg
      181 ggggccagct gccccggtgt cgacaggcgc aggtggaggc acggtcctgg ctaagatgta
      241 tccgcgcggc agtcactggg ctgtgggaca cttaatggga aaaaagagca cggatgaatc
      301 cccgtccctg tatgcggctg acagagacgg cctgaaggag cagctgaggg ggtacgtccg
      361 ctgggaagaa gctgcaaggg atttgctgga cctcctagaa gctgctggga accaaagcca
      421 ccagccacct cagcatccgc ctctcagtct ccagcctact tgggatcccg aggacggcag
      481 ctactttaac gacgttcaaa ccgctaagtt ggtagactct ctgctccagg ttctcaagga
      541 aaagggagga actgccagct gaagggacaa cgacaagggc ggcttccaag gagcaaaaca
      601 aaacccttca aagactgcct tctgcaaacg tcaactctac tggaccatca acaagatttc
      661 ctttgtgcaa tttacttaac tattctcctt atctttcaac cgcaactaaa ctcgtgattt
      721 ttcgagcagc atcttctggt ttgaacttgt ttctgtgaac cactcactac ttagaaagag
      781 ctttccaatg aacgcttttt ccagctaggc tttttgttga ttagattcag ggctccaatt
      841 tgctaccatt cacaataaaa agcttccgtg atcacgctgt ccaaagggaa aaaaaaaaaa
      901 aaaaa
//
