LOCUS       NM_008175               2148 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus granulin (Grn), mRNA.
ACCESSION   NM_008175 XM_984981
VERSION     NM_008175.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2148)
  AUTHORS   Root,J., Mendsaikhan,A., Taylor,G., Merino,P., Nandy,S., Wang,M.,
            Araujo,L.T., Ryu,D., Holler,C., Thompson,B.M., Astarita,G.,
            Blain,J.F. and Kukar,T.
  TITLE     Granulins rescue inflammation, lysosome dysfunction, lipofuscin,
            and neuropathology in a mouse model of progranulin deficiency
  JOURNAL   Cell Rep 43 (12), 114985 (2024)
   PUBMED   39565694
REFERENCE   2  (bases 1 to 2148)
  AUTHORS   Tsuji,S., Kudo,U., Takahashi,K., Nakamura,S. and Shimazawa,M.
  TITLE     The role of progranulin in macrophages of a glioblastoma model
  JOURNAL   J Neurooncol 170 (2), 319-329 (2024)
   PUBMED   39141257
REFERENCE   3  (bases 1 to 2148)
  AUTHORS   Wang,S., Weyer,M.P., Hummel,R., Wilken-Schmitz,A., Tegeder,I. and
            Schafer,M.K.E.
  TITLE     Selective neuronal expression of progranulin is sufficient to
            provide neuroprotective and anti-inflammatory effects after
            traumatic brain injury
  JOURNAL   J Neuroinflammation 21 (1), 257 (2024)
   PUBMED   39390556
  REMARK    GeneRIF: Selective neuronal expression of progranulin is sufficient
            to provide neuroprotective and anti-inflammatory effects after
            traumatic brain injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2148)
  AUTHORS   Lin,Y., Zhao,X., Liou,B., Fannin,V., Zhang,W., Setchell,K.D.R.,
            Wang,X., Pan,D., Grabowski,G.A., Liu,C.J. and Sun,Y.
  TITLE     Intrinsic link between PGRN and Gba1 D409V mutation dosage in
            potentiating Gaucher disease
  JOURNAL   Hum Mol Genet 33 (20), 1771-1788 (2024)
   PUBMED   39101473
REFERENCE   5  (bases 1 to 2148)
  AUTHORS   He,M., Hettinghouse,A., Bi,Y., Chen,Y. and Liu,C.
  TITLE     Progranulin mediates the onset of pristane induced systemic lupus
            erythematosus
  JOURNAL   Adv Rheumatol 64 (1), 67 (2024)
   PUBMED   39252120
  REMARK    GeneRIF: Progranulin mediates the onset of pristane induced
            systemic lupus erythematosus.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2148)
  AUTHORS   Bucan,M., Gatalica,B., Baba,T. and Gerton,G.L.
  TITLE     Mapping of Grn, the gene encoding the granulin/epithelin precursor
            (acrogranin), to mouse chromosome 11
  JOURNAL   Mamm Genome 7 (9), 704-705 (1996)
   PUBMED   8703129
REFERENCE   7  (bases 1 to 2148)
  AUTHORS   Zhou,J., Gao,G., Crabb,J.W. and Serrero,G.
  TITLE     Purification of an autocrine growth factor homologous with mouse
            epithelin precursor from a highly tumorigenic cell line
  JOURNAL   J Biol Chem 268 (15), 10863-10869 (1993)
   PUBMED   8496151
REFERENCE   8  (bases 1 to 2148)
  AUTHORS   Baba,T., Nemoto,H., Watanabe,K., Arai,Y. and Gerton,G.L.
  TITLE     Exon/intron organization of the gene encoding the mouse
            epithelin/granulin precursor (acrogranin)
  JOURNAL   FEBS Lett 322 (2), 89-94 (1993)
   PUBMED   8482392
REFERENCE   9  (bases 1 to 2148)
  AUTHORS   Baba,T., Hoff,H.B. 3rd, Nemoto,H., Lee,H., Orth,J., Arai,Y. and
            Gerton,G.L.
  TITLE     Acrogranin, an acrosomal cysteine-rich glycoprotein, is the
            precursor of the growth-modulating peptides, granulins, and
            epithelins, and is expressed in somatic as well as male germ cells
  JOURNAL   Mol Reprod Dev 34 (3), 233-243 (1993)
   PUBMED   8471244
REFERENCE   10 (bases 1 to 2148)
  AUTHORS   Plowman,G.D., Green,J.M., Neubauer,M.G., Buckley,S.D.,
            McDonald,V.L., Todaro,G.J. and Shoyab,M.
  TITLE     The epithelin precursor encodes two proteins with opposing
            activities on epithelial cell growth
  JOURNAL   J Biol Chem 267 (18), 13073-13078 (1992)
   PUBMED   1618805
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK018744.1, AK152705.1 and AW456643.1.
            
            On Feb 20, 2019 this sequence version replaced NM_008175.4.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049943.1, AK153289.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1763              AK018744.1         27-1789
            1764-2144           AK152705.1         1765-2145
            2145-2148           AW456643.1         16-19               c
FEATURES             Location/Qualifiers
     source          1..2148
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 66.29 cM"
     gene            1..2148
                     /gene="Grn"
                     /gene_synonym="epithelin; GP88; PCDGF; PEPI; Pgrn"
                     /note="granulin"
                     /db_xref="GeneID:14824"
                     /db_xref="MGI:MGI:95832"
     exon            1..34
                     /gene="Grn"
                     /gene_synonym="epithelin; GP88; PCDGF; PEPI; Pgrn"
                     /inference="alignment:Splign:2.1.0"
     exon            35..179
                     /gene="Grn"
                     /gene_synonym="epithelin; GP88; PCDGF; PEPI; Pgrn"
                     /inference="alignment:Splign:2.1.0"
     exon            180..305
                     /gene="Grn"
                     /gene_synonym="epithelin; GP88; PCDGF; PEPI; Pgrn"
                     /inference="alignment:Splign:2.1.0"
     exon            306..390
                     /gene="Grn"
                     /gene_synonym="epithelin; GP88; PCDGF; PEPI; Pgrn"
                     /inference="alignment:Splign:2.1.0"
     exon            391..500
                     /gene="Grn"
                     /gene_synonym="epithelin; GP88; PCDGF; PEPI; Pgrn"
                     /inference="alignment:Splign:2.1.0"
     exon            501..636
                     /gene="Grn"
                     /gene_synonym="epithelin; GP88; PCDGF; PEPI; Pgrn"
                     /inference="alignment:Splign:2.1.0"
     exon            637..746
                     /gene="Grn"
                     /gene_synonym="epithelin; GP88; PCDGF; PEPI; Pgrn"
                     /inference="alignment:Splign:2.1.0"
     exon            747..870
                     /gene="Grn"
                     /gene_synonym="epithelin; GP88; PCDGF; PEPI; Pgrn"
                     /inference="alignment:Splign:2.1.0"
     exon            871..968
                     /gene="Grn"
                     /gene_synonym="epithelin; GP88; PCDGF; PEPI; Pgrn"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1214
                     /gene="Grn"
                     /gene_synonym="epithelin; GP88; PCDGF; PEPI; Pgrn"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1448
                     /gene="Grn"
                     /gene_synonym="epithelin; GP88; PCDGF; PEPI; Pgrn"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1673
                     /gene="Grn"
                     /gene_synonym="epithelin; GP88; PCDGF; PEPI; Pgrn"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..2148
                     /gene="Grn"
                     /gene_synonym="epithelin; GP88; PCDGF; PEPI; Pgrn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2125..2130
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grn"
                     /gene_synonym="epithelin; GP88; PCDGF; PEPI; Pgrn"
                     /note="hexamer: AATAAA"
     polyA_site      2148
                     /gene="Grn"
                     /gene_synonym="epithelin; GP88; PCDGF; PEPI; Pgrn"
                     /note="major polyA site"
ORIGIN      
        1 agatgcctcc cagggagccc ggaccccgac gcaggcagac catgtgggtc ctgatgagct
       61 ggctggcctt cgcggcaggg ctggtagccg gaacacagtg tccagatggg cagttctgcc
      121 ctgttgcctg ctgccttgac cagggaggag ccaactacag ctgctgtaac cctcttctgg
      181 acacatggcc tagaataacg agccatcatc tagatggctc ctgccagacc catggccact
      241 gtcctgctgg ctattcttgt cttctcactg tgtctgggac ttccagctgc tgcccgttct
      301 ctaagggtgt gtcttgtggt gatggctacc actgctgccc ccagggcttc cactgtagtg
      361 cagatgggaa atcctgcttc cagatgtcag ataacccctt gggtgctgtc cagtgtcctg
      421 ggagccagtt tgaatgtcct gactctgcca cctgctgcat tatggttgat ggttcgtggg
      481 gatgttgtcc catgccccag gcctcttgct gtgaagacag agtgcattgc tgtccccatg
      541 gggcctcctg tgacctggtt cacacacgat gcgtttcacc cacgggcacc cacaccctac
      601 taaagaagtt ccctgcacaa aagaccaaca gggcagtgtc tttgcctttt tctgtcgtgt
      661 gccctgatgc taagacccag tgtcccgatg attctacctg ctgtgagcta cccactggga
      721 agtatggctg ctgtccaatg cccaatgcca tctgctgttc cgaccacctg cactgctgcc
      781 cccaggacac tgtatgtgac ctgatccaga gtaagtgcct atccaagaac tacaccacgg
      841 atctcctgac caagctgcct ggatacccag tgaaggaggt gaagtgcgac atggaggtga
      901 gctgccctga aggatatacc tgctgccgcc tcaacactgg ggcctggggc tgctgtccat
      961 ttgccaaggc cgtgtgttgt gaggatcaca ttcattgctg cccggcaggg tttcagtgtc
     1021 acacagagaa aggaacctgc gaaatgggta tcctccaagt accctggatg aagaaggtca
     1081 tagcccccct ccgcctgcca gacccacaga tcttgaagag tgatacacct tgtgatgact
     1141 tcactaggtg tcctacaaac aatacctgct gcaaactcaa ttctggggac tggggctgct
     1201 gtcccatccc agaggctgtc tgctgctcag acaaccagca ttgctgccct cagggcttca
     1261 catgtctggc tcaggggtac tgtcagaagg gagacacaat ggtggctggc ctggagaaga
     1321 tacctgcccg ccagacaacc ccgctccaaa ttggagatat cggttgtgac cagcatacca
     1381 gctgcccagt agggcaaacc tgctgcccaa gcctcaaggg aagttgggcc tgctgccagc
     1441 tgccccatgc tgtgtgctgt gaggaccggc agcactgttg cccggccggg tacacctgca
     1501 atgtgaaggc gaggacctgt gagaaggatg tcgattttat ccagcctccc gtgctcctga
     1561 ccctcggccc taaggttggg aatgtggagt gtggagaagg gcatttctgc catgataacc
     1621 agacctgttg taaagacagt gcaggagtct gggcctgctg tccctaccta aagggtgtct
     1681 gctgtagaga tggacgtcac tgttgccccg gtggcttcca ctgttcagcc aggggaacca
     1741 agtgtttgcg aaagaagatt cctcgctggg acatgttttt gagggatccg gtcccaagac
     1801 cgctactgta aggaagggct acagacttaa ggaactccac agtcctggga accctgttcc
     1861 gagggtaccc actactcagg cctccctagc gcctcctccc ctaacgtctc cccggcctac
     1921 tcatcctgag tcaccctatc accatgggag gtggagcctc aaactaaaac cttcttttat
     1981 ggaaagaagg ctgtggccaa aagccccgta tcaaactgcc atttcttccg gtttctgtgg
     2041 accttgtggc caggtgctct tcccgagcca caggtgttct gtgagcttgc ttgtgtgtgt
     2101 gtgcgcgtgt gcgtgtgttg ctccaataaa gtttgtacac tttctgaa
//
