LOCUS       NM_001361125            3734 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus glutamate receptor, metabotropic 8 (Grm8), transcript
            variant 3, mRNA.
ACCESSION   NM_001361125 XM_006504987
VERSION     NM_001361125.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3734)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   2  (bases 1 to 3734)
  AUTHORS   Nabit,B.P., Taylor,A. and Winder,D.G.
  TITLE     Thalamocortical mGlu8 Modulates Dorsal Thalamus Excitatory
            Transmission and Sensorimotor Activity
  JOURNAL   J Neurosci 44 (31), e0119242024 (2024)
   PUBMED   38918065
  REMARK    GeneRIF: Thalamocortical mGlu8 Modulates Dorsal Thalamus Excitatory
            Transmission and Sensorimotor Activity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3734)
  AUTHORS   Woo,M.S., Bal,L.C., Winschel,I., Manca,E., Walkenhorst,M.,
            Sevgili,B., Sonner,J.K., Di Liberto,G., Mayer,C.,
            Binkle-Ladisch,L., Rothammer,N., Unger,L., Raich,L., Hadjilaou,A.,
            Noli,B., Manai,A.L., Vieira,V., Meurs,N., Wagner,I., Pless,O.,
            Cocco,C., Stephens,S.B., Glatzel,M., Merkler,D. and Friese,M.A.
  TITLE     The NR4A2/VGF pathway fuels inflammation-induced neurodegeneration
            via promoting neuronal glycolysis
  JOURNAL   J Clin Invest 134 (16), e177692 (2024)
   PUBMED   39145444
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3734)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3734)
  AUTHORS   Spirkova,A., Kovarikova,V., Sefcikova,Z., Pisko,J., Ksinanova,M.,
            Koppel,J., Fabian,D. and Cikos,S.
  TITLE     Glutamate can act as a signaling molecule in mouse preimplantation
            embryosdagger
  JOURNAL   Biol Reprod 107 (4), 916-927 (2022)
   PUBMED   35746896
REFERENCE   6  (bases 1 to 3734)
  AUTHORS   Linden,A.M., Johnson,B.G., Peters,S.C., Shannon,H.E., Tian,M.,
            Wang,Y., Yu,J.L., Koster,A., Baez,M. and Schoepp,D.D.
  TITLE     Increased anxiety-related behavior in mice deficient for
            metabotropic glutamate 8 (mGlu8) receptor
  JOURNAL   Neuropharmacology 43 (2), 251-259 (2002)
   PUBMED   12213279
  REMARK    GeneRIF: Naive mGlu8 receptor-deficient mice show increased
            anxiety-related behavior in the elevated plus maze in low
            illumination conditions (red light) compared to wild-type mice.
REFERENCE   7  (bases 1 to 3734)
  AUTHORS   Gerlai,R., Adams,B., Fitch,T., Chaney,S. and Baez,M.
  TITLE     Performance deficits of mGluR8 knockout mice in learning tasks: the
            effects of null mutation and the background genotype
  JOURNAL   Neuropharmacology 43 (2), 235-249 (2002)
   PUBMED   12213278
  REMARK    GeneRIF: The role of mGluR8 as a presynaptic autoreceptor and its
            contribution to cognitive processes are hypothesized and the
            utility of gene targeting is discussed as compared to
            pharmacological methods.
REFERENCE   8  (bases 1 to 3734)
  AUTHORS   Zhai,J., Tian,M.T., Wang,Y., Yu,J.L., Koster,A., Baez,M. and
            Nisenbaum,E.S.
  TITLE     Modulation of lateral perforant path excitatory responses by
            metabotropic glutamate 8 (mGlu8) receptors
  JOURNAL   Neuropharmacology 43 (2), 223-230 (2002)
   PUBMED   12213276
REFERENCE   9  (bases 1 to 3734)
  AUTHORS   Kaupmann,K., Huggel,K., Heid,J., Flor,P.J., Bischoff,S.,
            Mickel,S.J., McMaster,G., Angst,C., Bittiger,H., Froestl,W. and
            Bettler,B.
  TITLE     Expression cloning of GABA(B) receptors uncovers similarity to
            metabotropic glutamate receptors
  JOURNAL   Nature 386 (6622), 239-246 (1997)
   PUBMED   9069281
REFERENCE   10 (bases 1 to 3734)
  AUTHORS   Duvoisin,R.M., Zhang,C. and Ramonell,K.
  TITLE     A novel metabotropic glutamate receptor expressed in the retina and
            olfactory bulb
  JOURNAL   J Neurosci 15 (4), 3075-3083 (1995)
   PUBMED   7722646
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079957.5, AC067970.4, AC035247.4, AC121497.15, AC068066.3 and
            AC074223.4.
            
            On Jul 25, 2022 this sequence version replaced NM_001361125.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.4681923.1,
                                           SRR17784643.336599.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               AC079957.5         148202-148332       c
            132-942             AC079957.5         138853-139663       c
            943-1159            AC067970.4         140343-140559       c
            1160-1295           AC035247.4         113750-113885       c
            1296-1450           AC035247.4         112594-112748       c
            1451-1588           AC035247.4         111562-111699       c
            1589-1789           AC121497.15        7401-7601
            1790-1926           AC068066.3         137159-137295       c
            1927-2862           AC068066.3         70844-71779         c
            2863-3164           AC074223.4         76358-76659         c
            3165-3734           AC074223.4         65803-66372         c
FEATURES             Location/Qualifiers
     source          1..3734
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 11.97 cM"
     gene            1..3734
                     /gene="Grm8"
                     /gene_synonym="A230002O04; GluR8; Gprc1h; mGluR8"
                     /note="glutamate receptor, metabotropic 8"
                     /db_xref="GeneID:14823"
                     /db_xref="MGI:MGI:1351345"
     exon            1..131
                     /gene="Grm8"
                     /gene_synonym="A230002O04; GluR8; Gprc1h; mGluR8"
                     /inference="alignment:Splign:2.1.0"
     exon            132..942
                     /gene="Grm8"
                     /gene_synonym="A230002O04; GluR8; Gprc1h; mGluR8"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1159
                     /gene="Grm8"
                     /gene_synonym="A230002O04; GluR8; Gprc1h; mGluR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1295
                     /gene="Grm8"
                     /gene_synonym="A230002O04; GluR8; Gprc1h; mGluR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1450
                     /gene="Grm8"
                     /gene_synonym="A230002O04; GluR8; Gprc1h; mGluR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1588
                     /gene="Grm8"
                     /gene_synonym="A230002O04; GluR8; Gprc1h; mGluR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1789
                     /gene="Grm8"
                     /gene_synonym="A230002O04; GluR8; Gprc1h; mGluR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1926
                     /gene="Grm8"
                     /gene_synonym="A230002O04; GluR8; Gprc1h; mGluR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2862
                     /gene="Grm8"
                     /gene_synonym="A230002O04; GluR8; Gprc1h; mGluR8"
                     /inference="alignment:Splign:2.1.0"
     exon            2863..3164
                     /gene="Grm8"
                     /gene_synonym="A230002O04; GluR8; Gprc1h; mGluR8"
                     /inference="alignment:Splign:2.1.0"
     exon            3165..3734
                     /gene="Grm8"
                     /gene_synonym="A230002O04; GluR8; Gprc1h; mGluR8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3714..3719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grm8"
                     /gene_synonym="A230002O04; GluR8; Gprc1h; mGluR8"
                     /note="hexamer: AATAAA"
     polyA_site      3734
                     /gene="Grm8"
                     /gene_synonym="A230002O04; GluR8; Gprc1h; mGluR8"
                     /note="major polyA site"
ORIGIN      
        1 ctcagcccgg agaccagcca caagtgcggc cgtggtgctc gcctctctcg gtggccaagg
       61 cggcggcagc gctgatatgg agctgcgggt cccccgcagg cttcctcacc tcgccctctg
      121 cggggagcag ggaagaattc tgctacaggg ctgaattcaa ggacatgaat tgttgacctc
      181 atcccaacat cagaacctca gatagcattc taatttattt gcaagccaac tttatgtggg
      241 aataaacttg aacggaggat ctgttggaaa ttcactgtga agttcaaatc aagaaaactt
      301 gctgaaatcc ctaaagcctt cccccatggg ccctgatggt agcctccaga aggtgcagcc
      361 tcaggtggtc ccccttcttc tgtggcaaga ataaactttg ggtcgctgac tgcaatacca
      421 cctgcggaga aaatggtttg tgagggaaag cgctcaacct cttgcccttg tttcttcctt
      481 ttgactgcca agttctactg gatcctcaca atgatgcaaa gaactcacag ccaggagtat
      541 gcgcattcca tccgcctgga tggggacatc attttggggg gtctttttcc tgttcatgcc
      601 aagggagaaa gaggggtgcc ttgtggggac ctgaagaagg aaaagggcat ccacagactt
      661 gaggccatgc tttatgcaat cgaccagatt aataaggacc ccgatctcct ctccaatatc
      721 actctgggtg tccggatcct tgacacatgt tccagggaca cctatgcttt ggagcagtca
      781 ctaaccttcg tgcaggcact gatagagaaa gacgcgtctg acgtgaagtg tgctaatgga
      841 gacccaccca tattcaccaa gcccgacaag atttctggtg tcataggtgc tgcagcaagc
      901 tccgtgtcca tcatggtggc taacatttta agacttttta agatacctca gattagctat
      961 gcatctacag ccccagagct aagtgacaac accaggtatg atttcttttc tcgggtggtc
     1021 ccgcctgact cctaccaagc ccaagccatg gtggacattg tgacagccct gggatggaat
     1081 tatgtgtcaa cactggcttc cgaggggaac tatggagaga gtggtgttga ggccttcact
     1141 cagatctcaa gggagattgg tggtgtttgc attgctcaat cacagaaaat cccacgtgaa
     1201 ccaagacctg gagaattcga aaaaattatc aaacgcctgc tggagacacc caacgctcgc
     1261 gcagtgatta tgtttgccaa tgaggatgac atcaggagga tattggaagc agcaaaaaaa
     1321 ttaaaccaga gtgggcattt tctatggatt ggctcagata gttggggatc caaaatagca
     1381 cctgtctatc agcaggagga gatcgccgaa ggagctgtga caattttgcc caaaagagca
     1441 tcaattgatg ggtttgaccg atactttaga agccgaactc ttgccaataa tcgaagaaat
     1501 gtgtggtttg cagaattttg ggaggagaat tttggatgca aattaggatc acatgggaag
     1561 aggaacagtc atataaagaa atgcacaggg ctggagcgaa ttgcacggga ttcatcttac
     1621 gaacaagaag gaaaggttca atttgtaatt gatgcagtgt attccatggc ttatgcactg
     1681 cacaacatgc acaaagaact ctgccctggt tacataggcc tttgcccaag gatggttacc
     1741 atcgatggga aagagctact gggttacatc agggccgtga attttaatgg cagcgctggt
     1801 acacctgtca cttttaatga gaatggagat gctccgggac gctacgatat cttccaatat
     1861 cagataaaca acaaaagtac agaatacaaa atcatcggcc actggaccaa tcaacttcac
     1921 ctaaaagtgg aagacatgca gtgggctaat agagagcaca cgcacccagc atctgtctgc
     1981 agcctgccgt gcaagcctgg ggagaggaag aaaaccgtga aaggggtccc ttgctgctgg
     2041 cactgtgaac gctgcgaggg ttataactac caggtggacg aactctcctg tgaactctgc
     2101 cctttggatc agagaccaaa catcaaccgc actggctgcc agaggattcc catcatcaag
     2161 ttggagtggc attcaccctg ggccgtggta cctgtgttca tagcaatatt gggaatcatt
     2221 gccaccacct ttgtgattgt gacctttgtc cgctataatg acacaccaat cgtgagagct
     2281 tctgggcggg aacttagtta tgtgctccta acggggattt ttctctgtta ctcaatcact
     2341 tttttgatga ttgcggcacc tgacacaatc atctgctctt tccgaaggat cttcctggga
     2401 cttggtatgt gtttcagcta tgcagcactt ttgaccaaaa caaaccgtat ccaccgaata
     2461 ttcgagcaag ggaagaaatc tgtcacagca cctaagttca tcagcccagc atcccagctg
     2521 gtgatcacct tcagcctcat ctccgtacag ctccttggag tgtttgtgtg gtttgtcgtg
     2581 gatccccccc acaccatcat tgactatgga gaacagcgaa cactggatcc cgagaacgcc
     2641 aggggagtgc tcaagtgtga catttccgat ctgtcactca tttgttcact gggatacagt
     2701 atcctcctga tggtcacttg tactgtttat gccattaaaa ccagaggggt tccagaaacg
     2761 ttcaatgaag ccaaacctat tggatttacc atgtacacca cgtgcatcat ttggttagct
     2821 ttcattccca tcttttttgg tacagcccag tcagcagaaa agatgtacat ccagacaaca
     2881 acacttactg tctccatgag tttaagtgct tcagtgtctc tgggaatgct ctatatgccc
     2941 aaagtttata ttataatttt tcatccagag cagaacgttc aaaaacgcaa gagaagcttc
     3001 aaggctgtgg tcacggccgc taccatgcaa agcaaactga tccaaaaggg aaatgacaga
     3061 ccaaacggcg aggtgaaaag tgaactctgt gagagtcttg aaaccaacag taagtcatct
     3121 gtagactttc agatggtcaa gagcgggagc acttcctaat agatcttctt ctaccaagac
     3181 aacatacatc agctacagta atcattcaat ctgaacaggg agatggcacc atctgaagga
     3241 aggtgctgta tattcttaaa tactgaacat gagactgcca aaacgtactc tgggagatct
     3301 ccatagacta caatcaatca gatcaatagt ctcgtaagga acaaaaatta gccatgagcc
     3361 aaaagtatca atattgagga gcaaagaagc ccatttttat acaatacaac caatgagtgt
     3421 caagctaaag tattgcttac ttgtgagcag ttaaaaaaaa aatctcaaac ggaaaactaa
     3481 tgttagcttg tggaaaaaaa aatgctgttg aaataaacca tgtctgatgt tattcttgta
     3541 agtatttttc tgtgattgtg agaactcctg ttcctgtccc acactgttca acttgtataa
     3601 gcctctgagt ctgtttcttg taatggctga ctggattgaa gccctgggtt gtgctacaaa
     3661 ataaatgcaa tgattgacgc atgcaatttt tatacaaata atttatttct aataataaag
     3721 gaatgttttg caaa
//
