LOCUS       NM_173372               4370 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus glutamate receptor, metabotropic 6 (Grm6), mRNA.
ACCESSION   NM_173372
VERSION     NM_173372.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4370)
  AUTHORS   Brockett,A.T. and Francis,N.A.
  TITLE     Psilocybin decreases neural responsiveness and increases functional
            connectivity while preserving pure-tone frequency selectivity in
            mouse auditory cortex
  JOURNAL   J Neurophysiol 132 (1), 45-53 (2024)
   PUBMED   38810366
REFERENCE   2  (bases 1 to 4370)
  AUTHORS   Miller,M.L., Pindwarawala,M. and Agosto,M.A.
  TITLE     Complex N-glycosylation of mGluR6 is required for trans-synaptic
            interaction with ELFN adhesion proteins
  JOURNAL   J Biol Chem 300 (4), 107119 (2024)
   PUBMED   38428819
  REMARK    GeneRIF: Complex N-glycosylation of mGluR6 is required for
            trans-synaptic interaction with ELFN adhesion proteins.
            Erratum:[J Biol Chem. 2024 Oct;300(10):107782. doi:
            10.1016/j.jbc.2024.107782.. PMID: 39332159]
REFERENCE   3  (bases 1 to 4370)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4370)
  AUTHORS   Kim,J.E., Lee,R.P., Yazigi,E., Atta,L., Feghali,J., Pant,A.,
            Jain,A., Levitan,I., Kim,E., Patel,K., Kannapadi,N., Shah,P.,
            Bibic,A., Hou,Z., Caplan,J.M., Gonzalez,L.F., Huang,J., Xu,R.,
            Fan,J., Tyler,B., Brem,H., Boussiotis,V.A., Jantzie,L.,
            Robinson,S., Koehler,R.C., Lim,M., Tamargo,R.J. and Jackson,C.M.
  TITLE     Soluble PD-L1 reprograms blood monocytes to prevent cerebral edema
            and facilitate recovery after ischemic stroke
  JOURNAL   Brain Behav Immun 116, 160-174 (2024)
   PUBMED   38070624
  REMARK    GeneRIF: Soluble PD-L1 reprograms blood monocytes to prevent
            cerebral edema and facilitate recovery after ischemic stroke.
REFERENCE   5  (bases 1 to 4370)
  AUTHORS   Cao,Y., Fajardo,D., Guerrero-Given,D., Samuel,M.A., Ohtsuka,T.,
            Boye,S.E., Kamasawa,N. and Martemyanov,K.A.
  TITLE     Post-developmental plasticity of the primary rod pathway allows
            restoration of visually guided behaviors
  JOURNAL   Curr Biol 32 (22), 4783-4796 (2022)
   PUBMED   36179691
REFERENCE   6  (bases 1 to 4370)
  AUTHORS   Sugihara,H., Inoue,T., Nakanishi,S. and Fukuda,Y.
  TITLE     A late ON response remains in visual response of the
            mGluR6-deficient mouse
  JOURNAL   Neurosci Lett 233 (2-3), 137-140 (1997)
   PUBMED   9350851
REFERENCE   7  (bases 1 to 4370)
  AUTHORS   Ueda,Y., Iwakabe,H., Masu,M., Suzuki,M. and Nakanishi,S.
  TITLE     The mGluR6 5' upstream transgene sequence directs a cell-specific
            and developmentally regulated expression in retinal rod and ON-type
            cone bipolar cells
  JOURNAL   J Neurosci 17 (9), 3014-3023 (1997)
   PUBMED   9096137
REFERENCE   8  (bases 1 to 4370)
  AUTHORS   Kaupmann,K., Huggel,K., Heid,J., Flor,P.J., Bischoff,S.,
            Mickel,S.J., McMaster,G., Angst,C., Bittiger,H., Froestl,W. and
            Bettler,B.
  TITLE     Expression cloning of GABA(B) receptors uncovers similarity to
            metabotropic glutamate receptors
  JOURNAL   Nature 386 (6622), 239-246 (1997)
   PUBMED   9069281
REFERENCE   9  (bases 1 to 4370)
  AUTHORS   Iwakabe,H., Katsuura,G., Ishibashi,C. and Nakanishi,S.
  TITLE     Impairment of pupillary responses and optokinetic nystagmus in the
            mGluR6-deficient mouse
  JOURNAL   Neuropharmacology 36 (2), 135-143 (1997)
   PUBMED   9144650
REFERENCE   10 (bases 1 to 4370)
  AUTHORS   Masu,M., Iwakabe,H., Tagawa,Y., Miyoshi,T., Yamashita,M.,
            Fukuda,Y., Sasaki,H., Hiroi,K., Nakamura,Y., Shigemoto,R. et al.
  TITLE     Specific deficit of the ON response in visual transmission by
            targeted disruption of the mGluR6 gene
  JOURNAL   Cell 80 (5), 757-765 (1995)
   PUBMED   7889569
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG293080.1, BC152480.1 and BC041684.1.
            
            On Aug 29, 2008 this sequence version replaced NM_173372.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               BG293080.1         1-238
            239-2083            BC152480.1         19-1863
            2084-4370           BC041684.1         1093-3379
FEATURES             Location/Qualifiers
     source          1..4370
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 30.93 cM"
     gene            1..4370
                     /gene="Grm6"
                     /gene_synonym="Gm3; Gprc1f; mGluR6; nerg1; nob2; nob3;
                     nob4"
                     /note="glutamate receptor, metabotropic 6"
                     /db_xref="GeneID:108072"
                     /db_xref="MGI:MGI:1351343"
     exon            1..155
                     /gene="Grm6"
                     /gene_synonym="Gm3; Gprc1f; mGluR6; nerg1; nob2; nob3;
                     nob4"
                     /inference="alignment:Splign:2.1.0"
     exon            156..652
                     /gene="Grm6"
                     /gene_synonym="Gm3; Gprc1f; mGluR6; nerg1; nob2; nob3;
                     nob4"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..2782
                     /gene="Grm6"
                     /gene_synonym="Gm3; Gprc1f; mGluR6; nerg1; nob2; nob3;
                     nob4"
                     /note="G protein-coupled receptor, family C, group 1,
                     member F; G protein-coupled receptor GRM6; metabotropic
                     glutamate receptor 6"
                     /codon_start=1
                     /product="metabotropic glutamate receptor 6 precursor"
                     /protein_id="NP_775548.2"
                     /db_xref="CCDS:CCDS48785.1"
                     /db_xref="GeneID:108072"
                     /db_xref="MGI:MGI:1351343"
                     /translation="MGRLRVLLLWLAWWLSQAGIAHGAGSVRLAGGLTLGGLFPVHAR
                     GAAGRACGTLKKEQGVHRLEAMLYALDRINADPELLPGVRLGARLLDTCSRDTYALEQ
                     ALSFVQALIRGRGDGEEASVRCPGGVPPLRAAPPERVVAVVGASASSVSIMVANVLRL
                     FAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGN
                     YGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFHKVIRRLMETPNARGIIIFANE
                     DDIRRVLEATRQANLTGHFLWVGSDSWGSKISPILNLEEEAVGAITILPKRASIDGFD
                     QYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGGQSDDSTRKCTGEERIGQDSTYEQE
                     GKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRTLLHYIRAVRFNGSAGT
                     PVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAEALRLDMEALQWSGDPHEVP
                     PSQCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGHMRPTPNHTGCR
                     PTPVVRLTWSSPWAALPLLLAVLGIMATTTIIATFMRHNDTPIVRASGRELSYVLLTG
                     IFLIYAITFLMVAEPCAAVCASRRLLLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTP
                     PPFISPTSQLVITFGLTSLQVVGVIAWLGAQPPHSVIDYEEQRTVDPEQARGVLKCDM
                     SDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFF
                     GTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKKTS
                     TMAAPPKSENSEDAK"
     exon            653..869
                     /gene="Grm6"
                     /gene_synonym="Gm3; Gprc1f; mGluR6; nerg1; nob2; nob3;
                     nob4"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1005
                     /gene="Grm6"
                     /gene_synonym="Gm3; Gprc1f; mGluR6; nerg1; nob2; nob3;
                     nob4"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1160
                     /gene="Grm6"
                     /gene_synonym="Gm3; Gprc1f; mGluR6; nerg1; nob2; nob3;
                     nob4"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1301
                     /gene="Grm6"
                     /gene_synonym="Gm3; Gprc1f; mGluR6; nerg1; nob2; nob3;
                     nob4"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1502
                     /gene="Grm6"
                     /gene_synonym="Gm3; Gprc1f; mGluR6; nerg1; nob2; nob3;
                     nob4"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1648
                     /gene="Grm6"
                     /gene_synonym="Gm3; Gprc1f; mGluR6; nerg1; nob2; nob3;
                     nob4"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..2272
                     /gene="Grm6"
                     /gene_synonym="Gm3; Gprc1f; mGluR6; nerg1; nob2; nob3;
                     nob4"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2584
                     /gene="Grm6"
                     /gene_synonym="Gm3; Gprc1f; mGluR6; nerg1; nob2; nob3;
                     nob4"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..4332
                     /gene="Grm6"
                     /gene_synonym="Gm3; Gprc1f; mGluR6; nerg1; nob2; nob3;
                     nob4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4310..4315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grm6"
                     /gene_synonym="Gm3; Gprc1f; mGluR6; nerg1; nob2; nob3;
                     nob4"
                     /note="hexamer: AATAAA"
     polyA_site      4331
                     /gene="Grm6"
                     /gene_synonym="Gm3; Gprc1f; mGluR6; nerg1; nob2; nob3;
                     nob4"
                     /note="major polyA site"
ORIGIN      
        1 gcagagagag aagagagccc ttcctccact ctcaagctct ggagggggtc tctgccctca
       61 ccctcatccc tccccagaat ccttaaatcc tctagactgt agctctgatt ttacagctgt
      121 cacagactcg tcctactagc cagaggttgg ctcagtccag gagcagatgg ggcggctccg
      181 agtgctgctg ctgtggctag cctggtggct gtcgcaggcg ggcatagctc acggtgcggg
      241 ctcggtgcgc ctggcaggcg gcctgacgct gggcggcctc ttcccggtgc acgcccgggg
      301 cgccgcaggg cgtgcgtgcg ggacgctgaa gaaggagcag ggagtgcacc ggctggaggc
      361 gatgctctac gcgctggacc gcatcaacgc cgacccggag ctcctgcccg gtgtgcgact
      421 aggcgcgcgg ctgctcgaca cctgctcgcg ggacacctac gctctggagc aggcgctgag
      481 cttcgtgcag gcgctcatcc gaggccgcgg agacggcgaa gaggccagcg tgcgctgccc
      541 tgggggcgtc cccccgctgc gcgccgcgcc tcctgaacgc gtcgtggcgg tggtgggcgc
      601 ctcagctagc tccgtgtcca tcatggtcgc caatgtcttg cgcctgtttg cgatacccca
      661 gatcagctat gcctccacag ccccagagct cagtgactcc acacgctatg acttcttctc
      721 ccgagtggtg cctcctgact cctaccaggc gcaggccatg gtggacattg tgcgggcact
      781 gggatggaat tacgtgtcta cactggcctc tgagggcaac tatggtgaaa gcggggttga
      841 ggcctttgtg cagatctccc gtgaggctgg aggtgtctgt attgcccaat caataaagat
      901 tcccagggaa ccaaagccag gagaattcca caaagtgatc cggaggctca tggagacacc
      961 caacgcccgg ggcatcatca tctttgccaa tgaagatgac atcaggaggg tcttggaggc
     1021 aacacgccag gcaaacctga ctggccactt cctgtgggtt ggctcagaca gctggggatc
     1081 caagatctct cccatcttga acctagagga agaggctgtg ggggccatca ccatcttgcc
     1141 caaaagggct tcaatcgacg gatttgacca atactttatg actcgttccc tggagaacaa
     1201 ccgcagaaac atctggtttg ctgagttctg ggaagagaat tttaactgca aactaaccag
     1261 ctcaggtggc cagtcagatg attccacccg gaaatgcaca ggcgaggaac gcatcggcca
     1321 ggactccacc tatgaacagg aggggaaggt gcagttcgtg atagatgctg tgtatgccat
     1381 cgctcatgct ctgcacagca tgcaccaagc actctgccca ggccacacag gtctgtgccc
     1441 agccatggag cctactgatg gccggaccct gctgcactac atccgagcag tccgcttcaa
     1501 tggtagcgca ggaaccccag tgatgttcaa tgagaatggg gatgcccccg ggcgctatga
     1561 catcttccag taccaagcaa ccaatggaag tgccagcagt ggcgggtacc aggctgtggg
     1621 ccaatgggca gaggccctta gactggatat ggaagctcta cagtggtcag gcgaccccca
     1681 tgaggtgccc ccttctcaat gcagcctccc ctgtgggcct ggtgaacgga aaaagatggt
     1741 gaagggtgtg ccctgctgtt ggcactgtga ggcctgcgac gggtaccgct tccaggtgga
     1801 cgagttcacg tgtgaggcct gtccagggca catgagaccg acacccaacc acactggctg
     1861 ccgtcccact cccgtggtgc gcctgacctg gtcctctccg tgggccgctc tgccccttct
     1921 cctggctgtc ctgggcatca tggccaccac aactatcatt gctaccttca tgcgacacaa
     1981 cgacactccc atagtccgcg cctctggccg tgagcttagc tatgtgctgc tcaccggcat
     2041 cttcctgatc tacgccatca ccttcctcat ggtagccgag ccttgtgcag ccgtctgtgc
     2101 ttcccgaaga ctcttgctcg gcttgggtac cacgctcagc tactctgccc tgctcaccaa
     2161 gaccaaccgc atctaccgca ttttcgagca agggaagcgc tctgtcacgc cgccaccctt
     2221 catcagcccc acctcgcagc tagtcatcac cttcggcctt acctccctgc aggtagtggg
     2281 agtgatagcg tggttggggg cccaacctcc acacagcgtg attgactatg aggaacagag
     2341 gacggtggac cctgagcaag ccaggggtgt gctcaagtgt gacatgtctg atctgtccct
     2401 cattggctgc ctggggtaca gtctcctgct catggtcacg tgtacggtgt atgccatcaa
     2461 ggcccgaggt gtgccagaga ccttcaatga agccaagccc atcggcttca ccatgtacac
     2521 cacctgtatt atctggctgg ctttcgtccc catcttcttt ggcaccgccc agtcagctga
     2581 gaagatctac atccaaacga ccacactgac tgtgtccctg agcctgagcg cgtcggtgtc
     2641 cctcggcatg ctctatgtgc ccaaaaccta cgtcatcctg ttccatccag agcagaacgt
     2701 gcagaagcgg aagcgcagcc tcaagaagac ctccacgatg gcggccccgc ccaagagcga
     2761 gaactcagag gacgccaagt agcaaggttg agtgtgggtg ccacaggttg ctccctgccc
     2821 ttcctttgct gttcgtggct tcaaagagga agctgtgaaa gatcctcaga gaccatcgga
     2881 ggccaggact gtgtaaagat catgcccagc atggatgggc gtgcctccag aaagagctaa
     2941 accatgatcc acgctggact tgtgctttcc tgggcaggct ggcctcatca gcccttcctt
     3001 cttacccaca gtaggaaata cttgcttcca gcattcttcc tgaagacaga gactaaattg
     3061 acaccgtctg ggcgggcatt caaacccgtg gtaaagtcag ggcttgccca agtttgataa
     3121 gatttatctt gatccaacac cgtaacctag gggctggcca gggtgtccgc cagaatgtga
     3181 aaaccccaac aagaaatcca ggattagagc tgaggaggtt cagttgccac aataggaaac
     3241 ctggggaaat atcgtttccc tgagcagagc ctgtaggagg gcgctgggaa ccgggtttgg
     3301 gcctgcagca cagagaggaa ccatacaggg aactggggca ggcttctgtg atgtcgcttc
     3361 ccttttgctc ttttccccag ggtcatccaa atggtttggc agtttttctt tgctgtgtat
     3421 gtttttctag attgttccaa gctgaagaaa tggcaacaca atagtgtggg taagagatga
     3481 taaagtatag ctgggctttg gtcagggggt ccgtgaattg tcttgttgct gcacttcacc
     3541 atcatcatca tctagagtga gggtctccct atgtaactct ggctgtcctg gaattcacta
     3601 tgtagatcag gctggccatg aactcacaga gatctgctgg cttctgcttc ccaagtgttg
     3661 ggatcaaagg tgtgtgtcac tatgcccagc ttaattttta atgatcagaa tgagaataaa
     3721 agctcgccgg catatattct tggagcacca acatgaaagg tgggtgtgag gcacatggag
     3781 gaagttattg gaagaccgtg catggactta atttatttca ctgtttttgt ttttgttttt
     3841 gtttttttta aacagatttt ttaaaattag ggaactctct tttccttgtt tttgttttaa
     3901 tgcattgagt taagtgcttt aatttattat gaattctcca gaatttaagg tacagaactc
     3961 atttttgaaa gggagctgcc cttcaatgga cagatgctcc aagctataat gagttttgac
     4021 cttgagatat aatactttat ttagcatttt aaagacaaca ggcttctctt tagaatgttt
     4081 gtgctgttta gagagtcctc ccttggtgtg ttcccagttt cccatggtgc agagcaccgg
     4141 tctacattta ctgccgagtg cgatccaatg ctctggactg aggcttctgt cctgtttgag
     4201 tcctcaaaag tgtgaaatgt gttctcttgg caaagccttg tctataggac tgttttcatg
     4261 gtggttttct cctctgtgac ctcttctaga gtcagttagc catggtctga ataaaggttt
     4321 tcttgcactt acaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
