LOCUS       NM_001291045            4593 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus glutamate receptor, metabotropic 4 (Grm4), transcript
            variant 1, mRNA.
ACCESSION   NM_001291045 XM_006524317 XM_006524318
VERSION     NM_001291045.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4593)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4593)
  AUTHORS   Martin,R., Suarez-Pinilla,A.S., Garcia-Font,N., Laguna-Luque,M.L.,
            Lopez-Ramos,J.C., Oset-Gasque,M.J., Gruart,A., Delgado-Garcia,J.M.,
            Torres,M. and Sanchez-Prieto,J.
  TITLE     The activation of mGluR4 rescues parallel fiber synaptic
            transmission and LTP, motor learning and social behavior in a mouse
            model of Fragile X Syndrome
  JOURNAL   Mol Autism 14 (1), 14 (2023)
   PUBMED   37029391
  REMARK    GeneRIF: The activation of mGluR4 rescues parallel fiber synaptic
            transmission and LTP, motor learning and social behavior in a mouse
            model of Fragile X Syndrome.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4593)
  AUTHORS   Spirkova,A., Kovarikova,V., Sefcikova,Z., Pisko,J., Ksinanova,M.,
            Koppel,J., Fabian,D. and Cikos,S.
  TITLE     Glutamate can act as a signaling molecule in mouse preimplantation
            embryosdagger
  JOURNAL   Biol Reprod 107 (4), 916-927 (2022)
   PUBMED   35746896
REFERENCE   4  (bases 1 to 4593)
  AUTHORS   Piszczek,L., Constantinescu,A., Kargl,D., Lazovic,J., Pekcec,A.,
            Nicholson,J.R. and Haubensak,W.
  TITLE     Dissociation of impulsive traits by subthalamic metabotropic
            glutamate receptor 4
  JOURNAL   Elife 11, e62123 (2022)
   PUBMED   34982027
  REMARK    GeneRIF: Dissociation of impulsive traits by subthalamic
            metabotropic glutamate receptor 4.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4593)
  AUTHORS   Siddig,S., Aufmkolk,S., Doose,S., Jobin,M.L., Werner,C., Sauer,M.
            and Calebiro,D.
  TITLE     Super-resolution imaging reveals the nanoscale organization of
            metabotropic glutamate receptors at presynaptic active zones
  JOURNAL   Sci Adv 6 (16), eaay7193 (2020)
   PUBMED   32494600
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4593)
  AUTHORS   Snead,O.C. 3rd, Banerjee,P.K., Burnham,M. and Hampson,D.
  TITLE     Modulation of absence seizures by the GABA(A) receptor: a critical
            rolefor metabotropic glutamate receptor 4 (mGluR4)
  JOURNAL   J Neurosci 20 (16), 6218-6224 (2000)
   PUBMED   10934271
REFERENCE   7  (bases 1 to 4593)
  AUTHORS   Masugi,M., Yokoi,M., Shigemoto,R., Muguruma,K., Watanabe,Y.,
            Sansig,G., van der Putten,H. and Nakanishi,S.
  TITLE     Metabotropic glutamate receptor subtype 7 ablation causes deficit
            in fear response and conditioned taste aversion
  JOURNAL   J Neurosci 19 (3), 955-963 (1999)
   PUBMED   9920659
REFERENCE   8  (bases 1 to 4593)
  AUTHORS   Gerlai,R., Roder,J.C. and Hampson,D.R.
  TITLE     Altered spatial learning and memory in mice lacking the mGluR4
            subtype of metabotropic glutamate receptor
  JOURNAL   Behav Neurosci 112 (3), 525-532 (1998)
   PUBMED   9676970
REFERENCE   9  (bases 1 to 4593)
  AUTHORS   Kaupmann,K., Huggel,K., Heid,J., Flor,P.J., Bischoff,S.,
            Mickel,S.J., McMaster,G., Angst,C., Bittiger,H., Froestl,W. and
            Bettler,B.
  TITLE     Expression cloning of GABA(B) receptors uncovers similarity to
            metabotropic glutamate receptors
  JOURNAL   Nature 386 (6622), 239-246 (1997)
   PUBMED   9069281
REFERENCE   10 (bases 1 to 4593)
  AUTHORS   Pekhletski,R., Gerlai,R., Overstreet,L.S., Huang,X.P., Agopyan,N.,
            Slater,N.T., Abramow-Newerly,W., Roder,J.C. and Hampson,D.R.
  TITLE     Impaired cerebellar synaptic plasticity and motor performance in
            mice lacking the mGluR4 subtype of metabotropic glutamate receptor
  JOURNAL   J Neurosci 16 (20), 6364-6373 (1996)
   PUBMED   8815915
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127341.3.
            
            On or before Mar 30, 2020 this sequence version replaced
            XM_006524317.4, NM_001291045.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10662774.793982.1,
                                           SRR7974084.6285.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849377 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-606               AC127341.3         132467-133072       c
            607-1493            AC127341.3         122322-123208       c
            1494-1710           AC127341.3         92583-92799         c
            1711-1846           AC127341.3         74162-74297         c
            1847-2001           AC127341.3         71580-71734         c
            2002-2142           AC127341.3         69800-69940         c
            2143-2343           AC127341.3         58337-58537         c
            2344-2480           AC127341.3         57971-58107         c
            2481-3416           AC127341.3         54208-55143         c
            3417-3663           AC127341.3         51007-51253         c
            3664-4593           AC127341.3         45579-46508         c
FEATURES             Location/Qualifiers
     source          1..4593
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 14.05 cM"
     gene            1..4593
                     /gene="Grm4"
                     /gene_synonym="Gprc1d; mGluR4"
                     /note="glutamate receptor, metabotropic 4"
                     /db_xref="GeneID:268934"
                     /db_xref="MGI:MGI:1351341"
     exon            1..606
                     /gene="Grm4"
                     /gene_synonym="Gprc1d; mGluR4"
                     /inference="alignment:Splign:2.1.0"
     exon            607..1493
                     /gene="Grm4"
                     /gene_synonym="Gprc1d; mGluR4"
                     /inference="alignment:Splign:2.1.0"
     CDS             975..3713
                     /gene="Grm4"
                     /gene_synonym="Gprc1d; mGluR4"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; metabotropic glutamate receptor 4; G
                     protein-coupled receptor GRM4; G protein-coupled receptor,
                     family C, group 1, member D"
                     /codon_start=1
                     /product="metabotropic glutamate receptor 4 isoform 1
                     precursor"
                     /protein_id="NP_001277974.1"
                     /db_xref="CCDS:CCDS70775.1"
                     /db_xref="GeneID:268934"
                     /db_xref="MGI:MGI:1351341"
                     /translation="MSGKGGWAWWWARLPLCLLLSLYGSWVPSSLGKPKGHPHMNSIR
                     IDGDITLGGLFPVHGRGSEGKACGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLG
                     ARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSS
                     VSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKW
                     NYVSTLASEGSYGESGVEAFIQKSRENGGVCIAQSVKIPREPKTGEFDKIIKRLLETS
                     NARAIIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKSAPVLRLEEVAEGAVTI
                     LPKRTSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHIKKCTNRE
                     RIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYI
                     RNVNFSGIAGNPVTFNENGDAPGRYDIYQYQRRNGSAEYKVIGSWTDHLHLRIERMQW
                     PGSGQQLPRSICSLPCQPGERKKTVKGMACCWHCEPCTGYQYQVDRYTCKTCPYDMRP
                     TENRTSCQPIPIVKLEWDSPWAVLPLFLAVVGIAATLFVVVTFVRYNDTPIVKASGRE
                     LSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFE
                     QGKRSVSAPRFISPASQLAITFVLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFA
                     RGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVW
                     LAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKR
                     KRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTYVTYTNHAI"
     exon            1494..1710
                     /gene="Grm4"
                     /gene_synonym="Gprc1d; mGluR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1846
                     /gene="Grm4"
                     /gene_synonym="Gprc1d; mGluR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2001
                     /gene="Grm4"
                     /gene_synonym="Gprc1d; mGluR4"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2142
                     /gene="Grm4"
                     /gene_synonym="Gprc1d; mGluR4"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2343
                     /gene="Grm4"
                     /gene_synonym="Gprc1d; mGluR4"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..2480
                     /gene="Grm4"
                     /gene_synonym="Gprc1d; mGluR4"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..3416
                     /gene="Grm4"
                     /gene_synonym="Gprc1d; mGluR4"
                     /inference="alignment:Splign:2.1.0"
     exon            3417..3663
                     /gene="Grm4"
                     /gene_synonym="Gprc1d; mGluR4"
                     /inference="alignment:Splign:2.1.0"
     exon            3664..4593
                     /gene="Grm4"
                     /gene_synonym="Gprc1d; mGluR4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4568..4573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grm4"
                     /gene_synonym="Gprc1d; mGluR4"
                     /note="hexamer: AATAAA"
     polyA_site      4593
                     /gene="Grm4"
                     /gene_synonym="Gprc1d; mGluR4"
                     /note="major polyA site"
ORIGIN      
        1 gccccgcact cgcggcgcaa acttgcgggc tgggctcgcg cgtgcggtgc ggcagggcgg
       61 tgggcgccgg gagccgtgcg gccccctcgg ccctcggccc gcgctcccgg cgctcgcgcc
      121 cctcccgcgc cgctcggctc cctgtgctag gctcgcacgc tcccattttc tcctcgccgc
      181 cgccgccgcc gtcaggtgcc cgcaccccgg ccggctgcgc tcgctcccca gccccgatcc
      241 tcggcgcacg cagcgccccg caccgcctcg cccgcgctct cgggctccgc ggcggcggcg
      301 gcggcggcag cggcagcagc agcagcacgg gcaccgtggc ggccgctccc agctccagct
      361 tcccgggagc agcagccgag cgccaccgct cgttgctccg aggctccggc caaagcggcc
      421 gccagctcct ccccgccgcg cccgggaccg ccggcggctc ggcgcccggt ttggtccgca
      481 gcgtcagcgc cacccgccgc ggcccgggct cccggcaccg cgagcagcta agagctggcc
      541 gccgcctccc tgcacttccc gggcgcagcc gacccctagc cgtggcgttc acctcgccga
      601 tgcgcggttg gtaggagtga ccgaagctgt tttctccttg attctaatat cggctatcag
      661 gataggagcg cggctccctt tccacagcca gacacggata tctggtcttc aggacacagg
      721 gacaaggatc tgagacctcc tgtatctctg accactggct gttgtctgtg gttttggcct
      781 gtgtgggcct ctgagctcaa ctcaagtatc aaagaggagg aggggagatc tctggaatgg
      841 tccaccccat cggccttcag cagccatcct gttgctgaag ctgcgctgtc catgtacacc
      901 cagatcatgg gacccagggc ctgctagggc taggagtggg gcccgctatt catgggtctc
      961 taagcctttc cgaaatgtcc gggaagggag gctgggcctg gtggtgggcc cggctgcccc
     1021 tctgcctact cctcagcctt tatggctcct gggtgccttc atccctagga aagcccaagg
     1081 gtcaccccca catgaactct atccgtatcg atggagacat caccctggga ggcctgtttc
     1141 ccgtccacgg tcgcggctcc gagggcaagg cctgcggcga gttgaagaag gagaaaggta
     1201 tccaccggct ggaggccatg ctctttgccc tggaccgcat caacaacgac ccggacctac
     1261 tgcccaacat cacgttgggc gcccgcattc tggacacctg ctcaagggat acccacgccc
     1321 tggagcagtc cctgaccttt gtgcaggcgc tcatcgagaa ggacggcacg gaggtccgct
     1381 gcggcagcgg gggcccaccc atcatcacca agcctgaacg agtggtgggt gtcatcggag
     1441 cttcggggag ctccgtctcg atcatggtgg ccaacatcct ccgcctcttc aagatccccc
     1501 agatcagcta cgcctccacg gctcccgact tgagtgataa cagccgctat gacttcttct
     1561 cccgggtcgt gccctcggac acataccagg cccaggccat ggtggacatc gtccgggccc
     1621 tcaagtggaa ctatgtgtcc acgctggcct cagagggtag ctacggcgag agcggcgtgg
     1681 aggcctttat ccagaagtcc cgagagaacg gaggcgtgtg cattgcccag tcggtgaaga
     1741 ttccacggga acccaagacc ggggagtttg acaagatcat caaacgcctt ctggaaacgt
     1801 ccaatgccag agccatcatc atctttgcca acgaggatga tatcaggagg gtgctggagg
     1861 cagcgcgcag ggccaaccag accggccact tcttttggat gggttctgat agctggggct
     1921 ccaagagcgc ccccgtgctg cgccttgagg aagtggctga aggtgcagtc accattcttc
     1981 ccaagaggac gtctgtgcga gggtttgacc gatacttctc cagccgcacg cttgacaaca
     2041 acaggcgcaa catctggttt gctgagttct gggaggacaa cttccattgc aagttgagcc
     2101 gccacgcgct caagaaggga agccacatca agaagtgcac caaccgagag cgcatcgggc
     2161 aggactcggc ctacgaacag gaggggaagg tgcagtttgt gatcgacgcc gtgtacgcca
     2221 tgggccatgc tctgcacgcc atgcatcgtg acctgtgtcc cggccgcgta ggactctgcc
     2281 ctcgaatgga ccctgtggat ggcacccagc tgcttaagta catcagaaac gtcaacttct
     2341 caggcatcgc cgggaacccg gtgaccttca acgagaacgg agacgcgcca gggcgttatg
     2401 acatctacca gtaccaacgt cgcaacggct cggctgagta caaggtcatc ggctcatgga
     2461 cagaccactt gcacctcaga atagagcgga tgcagtggcc agggagtggc cagcagctgc
     2521 cacgctccat ctgcagcctg ccctgccagc caggcgagcg gaagaagacg gtgaagggca
     2581 tggcttgctg ctggcactgc gagccctgca cggggtacca gtaccaggtg gaccgctaca
     2641 cctgtaagac ctgcccctat gacatgcggc ccacggagaa ccgcacgagc tgccagccca
     2701 tacccattgt caagttggag tgggactcac cctgggctgt gctgcccctc ttcctggctg
     2761 tggtgggcat tgctgccacg ctgttcgtgg tggtcacttt tgtgcgctac aacgacactc
     2821 cgatcgtcaa ggcctcgggc cgggagctga gctacgtcct gctggcgggc atctttctct
     2881 gctatgccac caccttcctc atgatcgcag agcctgacct ggggacctgt tcactccgcc
     2941 gcatcttcct ggggcttggc atgagcatca gctacgcggc cctgctgacc aagaccaacc
     3001 gcatctaccg catctttgag cagggcaagc ggtcggtcag cgccccacgg ttcatcagcc
     3061 ccgcctcgca gctggccatc accttcgtcc tcatctcgct gcagttgctt ggcatctgcg
     3121 tgtggttcgt ggtggacccc tcccactcgg tggtggactt ccaggaccag cggacacttg
     3181 acccccgctt cgcccggggt gtgctcaagt gtgacatctc ggacctgtcg ctcatctgcc
     3241 tcctgggcta cagcatgctg ctgatggtca cgtgtactgt gtatgccatc aagactcgag
     3301 gcgtgcctga gaccttcaat gaggccaagc ccatcggctt caccatgtac accacctgca
     3361 tcgtctggct ggccttcatc cccatctttt ttggcacctc gcagtcggct gacaagctgt
     3421 acatccagac aaccacactg acggtctctg tgagtctgag cgcttcagtg tccctgggga
     3481 tgctctacat gcccaaagtc tacatcatcc tcttccaccc ggagcagaac gtgcccaagc
     3541 gcaagcgcag cctcaaagcc gttgtcaccg ccgccaccat gtccaacaag ttcacacaga
     3601 agggcaactt caggcctaat ggggaagcca agtcagagct gtgtgagaac ctggaggccc
     3661 cagcactggc caccaaacag acctacgtca cttacaccaa ccatgcaatc tagccgggct
     3721 gcggacagag ccaagcaggc tgaagagcca caacctctga ggatggtgca tccggccagg
     3781 gccattcccg agggccctgc tgatgtctgc ctgcctcgtg ggcatccacg aatgtggctt
     3841 ggtgctgagg acagtagaat ccccagccat cactgctggg cgagccatgg tgggcaactg
     3901 gaggaggcta agtggctggg gcagctccag gttgtgccac acaggccttc cttccagacg
     3961 gatgttgtgt cctactccaa agcacagggg ctcggtctcg agagcccagt cctggctttt
     4021 tctccctcct tctgcctccg tctgtcttgt tggtgaccca gttggtcccc accctgtctt
     4081 tgcgtttctc ttctgtctct gctctgcatg tgttgtctgt ttgggctctc tactcctgta
     4141 tttttctttc tgctcccgcc ctttccccgc catctgccct gctccctgag ttgccccaac
     4201 cctaccactg tcattttctc ttctgcacca ctggacctca tttccttcca gcctctcccc
     4261 ctctttgctt catctaccaa ctctttcaca tcacaaaaga gaaaaaaagg ggggaatcaa
     4321 ccccccaaaa aagcccaaac aaaaactaat cttgagtgtg tttcgaagtg ctcgaagtgc
     4381 tgcgtcctcc tggtggcctg tgtgtccctg tggcctgcag cctgctcgcc caccctaccc
     4441 gtctgccatg tgtcctgccc gcctgtccgc cttgcccttc ctgccaacga cacggagttc
     4501 agtgcctgag tgtttggtga tggtctctga tgtgtagcat gactgttttt ataccgagaa
     4561 catttctaat aaagagaaac acatggtttt gca
//
