LOCUS       NM_001417964            4172 bp    mRNA    linear   ROD 14-OCT-2024
DEFINITION  Mus musculus glutamate receptor, metabotropic 3 (Grm3), transcript
            variant 2, mRNA.
ACCESSION   NM_001417964
VERSION     NM_001417964.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4172)
  AUTHORS   Roh,W.S., Yoo,J.H., Dravid,S.M., Mannaioni,G., Krizman,E.N.,
            Wahl,P., Robinson,M.B., Traynelis,S.F., Lee,C.J. and Han,K.S.
  TITLE     Astrocytic PAR1 and mGluR2/3 control synaptic glutamate time course
            at hippocampal CA1 synapses
  JOURNAL   Glia 72 (9), 1707-1724 (2024)
   PUBMED   38864289
  REMARK    GeneRIF: Astrocytic PAR1 and mGluR2/3 control synaptic glutamate
            time course at hippocampal CA1 synapses.
REFERENCE   2  (bases 1 to 4172)
  AUTHORS   Busceti,C.L., Di Menna,L., Castaldi,S., D'Errico,G., Taddeucci,A.,
            Bruno,V., Fornai,F., Pittaluga,A., Battaglia,G. and Nicoletti,F.
  TITLE     Adaptive Changes in Group 2 Metabotropic Glutamate Receptors
            Underlie the Deficit in Recognition Memory Induced by
            Methamphetamine in Mice
  JOURNAL   eNeuro 11 (8) (2024)
   PUBMED   38969501
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4172)
  AUTHORS   Dogra,S., Aguayo,C., Xiang,Z., Putnam,J., Smith,J., Johnston,C.,
            Foster,D.J., Lindsley,C.W., Niswender,C.M. and Conn,P.J.
  TITLE     Activation of Metabotropic Glutamate Receptor 3 Modulates
            Thalamo-accumbal Transmission and Rescues Schizophrenia-Like
            Physiological and Behavioral Deficits
  JOURNAL   Biol Psychiatry 96 (3), 230-242 (2024)
   PUBMED   38061467
  REMARK    GeneRIF: Activation of Metabotropic Glutamate Receptor 3 Modulates
            Thalamo-accumbal Transmission and Rescues Schizophrenia-Like
            Physiological and Behavioral Deficits.
REFERENCE   4  (bases 1 to 4172)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 4172)
  AUTHORS   Spirkova,A., Kovarikova,V., Sefcikova,Z., Pisko,J., Ksinanova,M.,
            Koppel,J., Fabian,D. and Cikos,S.
  TITLE     Glutamate can act as a signaling molecule in mouse preimplantation
            embryosdagger
  JOURNAL   Biol Reprod 107 (4), 916-927 (2022)
   PUBMED   35746896
REFERENCE   6  (bases 1 to 4172)
  AUTHORS   Kaupmann,K., Huggel,K., Heid,J., Flor,P.J., Bischoff,S.,
            Mickel,S.J., McMaster,G., Angst,C., Bittiger,H., Froestl,W. and
            Bettler,B.
  TITLE     Expression cloning of GABA(B) receptors uncovers similarity to
            metabotropic glutamate receptors
  JOURNAL   Nature 386 (6622), 239-246 (1997)
   PUBMED   9069281
REFERENCE   7  (bases 1 to 4172)
  AUTHORS   Winder,D.G. and Conn,P.J.
  TITLE     Roles of metabotropic glutamate receptors in glial function and
            glial-neuronal communication
  JOURNAL   J Neurosci Res 46 (2), 131-137 (1996)
   PUBMED   8915890
  REMARK    Review article
REFERENCE   8  (bases 1 to 4172)
  AUTHORS   Bergmann,M., Fox,P.A., Grabs,D., Post,A. and Schilling,K.
  TITLE     Expression and subcellular distribution of glutamate receptor
            subunits 2/3 in the developing cerebellar cortex
  JOURNAL   J Neurosci Res 43 (1), 78-86 (1996)
   PUBMED   8838577
REFERENCE   9  (bases 1 to 4172)
  AUTHORS   Duvoisin,R.M., Zhang,C. and Ramonell,K.
  TITLE     A novel metabotropic glutamate receptor expressed in the retina and
            olfactory bulb
  JOURNAL   J Neurosci 15 (4), 3075-3083 (1995)
   PUBMED   7722646
REFERENCE   10 (bases 1 to 4172)
  AUTHORS   Chavis,P., Shinozaki,H., Bockaert,J. and Fagni,L.
  TITLE     The metabotropic glutamate receptor types 2/3 inhibit L-type
            calcium channels via a pertussis toxin-sensitive G-protein in
            cultured cerebellar granule cells
  JOURNAL   J Neurosci 14 (11 Pt 2), 7067-7076 (1994)
   PUBMED   7965099
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162520.7 and AC157555.9.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10662774.1946313.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-711               AC162520.7         42802-43512
            712-858             AC162520.7         87363-87509
            859-1467            AC162520.7         178458-179066
            1468-2323           AC157555.9         13977-14832
            2324-3390           AC157555.9         72227-73293
            3391-3565           AC157555.9         79852-80026
            3566-4172           AC157555.9         98910-99516
FEATURES             Location/Qualifiers
     source          1..4172
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 3.69 cM"
     gene            1..4172
                     /gene="Grm3"
                     /gene_synonym="0710001G23Rik; Gprc1c; mGlu3; mGluR3"
                     /note="glutamate receptor, metabotropic 3"
                     /db_xref="GeneID:108069"
                     /db_xref="MGI:MGI:1351340"
     exon            1..711
                     /gene="Grm3"
                     /gene_synonym="0710001G23Rik; Gprc1c; mGlu3; mGluR3"
                     /inference="alignment:Splign:2.1.0"
     exon            712..858
                     /gene="Grm3"
                     /gene_synonym="0710001G23Rik; Gprc1c; mGlu3; mGluR3"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1467
                     /gene="Grm3"
                     /gene_synonym="0710001G23Rik; Gprc1c; mGlu3; mGluR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             1000..3639
                     /gene="Grm3"
                     /gene_synonym="0710001G23Rik; Gprc1c; mGlu3; mGluR3"
                     /note="G protein-coupled receptor, family C, group 1,
                     member C; metabotropic glutamate receptor 3"
                     /codon_start=1
                     /product="metabotropic glutamate receptor 3 precursor"
                     /protein_id="NP_001404893.1"
                     /db_xref="GeneID:108069"
                     /db_xref="MGI:MGI:1351340"
                     /translation="MKMLTRLQVLMLALFSKGFLVSLGDHNFMRREIKIEGDLVLGGL
                     FPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRD
                     TYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANL
                     LRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRYFNWTYVSTVAS
                     EGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFM
                     RSDDSRELIAAASRVNASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFD
                     RYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRQICDKHLAIDSSNYEQESKIMF
                     VVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKGA
                     DSIVKFDTYGDGMGRYNVFNFQHIGGKYSYLKVGHWAETLYLDVDSIHWSRNSVPTSQ
                     CSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLP
                     EDYIRWEDAWAIGPVTIACLGFMCTCIVITVFIKHNNTPLVKASGRELCYILLFGVSL
                     SYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALLTKTNCIARIFDGVKNGAQRPKF
                     ISPSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLPEKRETVILKCNVKDSSMLIS
                     LTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRV
                     QTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQKNVVTHRLHLNRFSVSGTATTYSQS
                     SASTYVPTVCNGREVLDSTTSSL"
     exon            1468..2323
                     /gene="Grm3"
                     /gene_synonym="0710001G23Rik; Gprc1c; mGlu3; mGluR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..3390
                     /gene="Grm3"
                     /gene_synonym="0710001G23Rik; Gprc1c; mGlu3; mGluR3"
                     /inference="alignment:Splign:2.1.0"
     exon            3391..3565
                     /gene="Grm3"
                     /gene_synonym="0710001G23Rik; Gprc1c; mGlu3; mGluR3"
                     /inference="alignment:Splign:2.1.0"
     exon            3566..4172
                     /gene="Grm3"
                     /gene_synonym="0710001G23Rik; Gprc1c; mGlu3; mGluR3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4067..4072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grm3"
                     /gene_synonym="0710001G23Rik; Gprc1c; mGlu3; mGluR3"
                     /note="hexamer: ATTAAA"
     polyA_site      4088
                     /gene="Grm3"
                     /gene_synonym="0710001G23Rik; Gprc1c; mGlu3; mGluR3"
                     /note="major polyA site"
     regulatory      4111..4116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grm3"
                     /gene_synonym="0710001G23Rik; Gprc1c; mGlu3; mGluR3"
                     /note="hexamer: AATAAA"
     polyA_site      4137
                     /gene="Grm3"
                     /gene_synonym="0710001G23Rik; Gprc1c; mGlu3; mGluR3"
                     /note="major polyA site"
     regulatory      4147..4152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grm3"
                     /gene_synonym="0710001G23Rik; Gprc1c; mGlu3; mGluR3"
                     /note="hexamer: AATAAA"
     polyA_site      4172
                     /gene="Grm3"
                     /gene_synonym="0710001G23Rik; Gprc1c; mGlu3; mGluR3"
                     /note="major polyA site"
ORIGIN      
        1 aacctttgta tgcattgcct aaggactgca aaccttgggg cagagaagct ctcaaccccg
       61 ccaggctttc tgtattgtaa cctttgggtc taggtacagt agctcactga agactctgca
      121 gctacacccc tataaacgga gggaagaagg gggaagggaa aggaggagaa aggaaaggag
      181 aagaatgagg aggagaggat gtcagaaggt ccgtgcctct ctgcctgagt cccagttaga
      241 tgcgactgtt tctgcctggc caaggtgaag gaaagttgct tgtgagccca ggaagtgggt
      301 ttggctgcaa agaggaggag ggcgcctggg ctctaaagct cccctccctt ctgctgaaga
      361 ccactgggtc cccttcttcc caacctcctc ctgctcttct cctctagccc tcccttttcc
      421 cactcctcct tgactcggag gcctggatgc tgggccaccg ggcagtggtc cagcgcgcag
      481 ccgggcgggg gcgggggcag ggggcactgt gacaggaagc ttcgcgcaca agttggccat
      541 ttcaggggca aaataagttc tcccttggat ttagaaagga caaaggcagc aagctccctc
      601 ttttgtgtcg gatgaagagg accaaccatg agccagagct tgggtgcagg ctcaccgctg
      661 ccgctaccac cgcggtcagc ttcagttcct gccaggagtt gaccgtgcga gcaacattag
      721 caacgtatct ggcatggctg tgagaacaga gagagacttt attacaggag catgaaaaac
      781 tatggcacaa tatttcagca ccttcagact ggacagattc atcagagaag agcagaaaac
      841 aagagcagtt ctcagcagga attcagtgac gggctctttt agccctatcc tcccttatct
      901 gaaggacaga ccaaagatcc tacttggaaa tgagaggata ctagcaggaa acattggacc
      961 cactcagtga tatctccaag agatacagaa ccaggattca tgaagatgtt gacaagacta
     1021 caagttctta tgttagcttt gttttcaaag ggatttttag tctctttagg agatcacaac
     1081 tttatgagga gagaaattaa aatagaagga gaccttgttt tagggggctt atttcctatt
     1141 aatgaaaaag gcactggaac tgaagagtgt ggacgaatca atgaagacag aggtatccaa
     1201 cgcctggagg ccatgttgtt tgccattgat gaaatcaaca aagacaatta cttgcttcca
     1261 ggagtgaagc tgggggttca cattttggat acatgttcaa gagacaccta tgcattagag
     1321 cagtcactgg agtttgtcag agcatcgttg actaaagtgg atgaagctga atatatgtgt
     1381 cctgatggat catatgctat tcaagaaaac atcccactac tcattgcagg agtcattggc
     1441 ggttcgtaca gcagtgtttc catacaggtg gcaaacctgc tgaggctctt ccagatccct
     1501 cagataagct acgcctccac cagtgccaaa ctcagcgaca aatcgcgcta tgattatttt
     1561 gccaggaccg tgccccctga cttctaccag gccaaagcca tggccgagat cttgcgctac
     1621 tttaactgga cctatgtgtc cactgttgcc tctgaaggtg actatgggga gacagggatt
     1681 gaggccttcg agcaggaagc aaggctacgc aacatctgca tcgccactgc tgaaaaggtg
     1741 gggcgctcca acatccgcaa gtcctacgac agcgtgatcc gtgagctcct gcagaaacct
     1801 aacgcgcgag ttgtggtcct gttcatgcgc agtgatgact cacgagagtt gatcgctgca
     1861 gccagccgcg tgaatgcttc cttcacctgg gtggccagcg atggctgggg tgcacaggag
     1921 agcattgtca agggcagtga gcacgtcgcc tatggagcca tcaccctgga gctggcgtcc
     1981 caccctgttc gtcagtttga tcgctacttc cagagcctca acccctacaa caatcatcgt
     2041 aacccctggt tccgagactt ctgggagcag aagttccagt gcagcctcca gaacaagaga
     2101 aaccacagac agatttgtga caagcacctg gccattgaca gcagcaacta tgaacaagaa
     2161 tccaagatca tgtttgtggt gaatgcagtg tatgccatgg cgcatgcgct gcacaaaatg
     2221 caacgcaccc tctgtcccaa caccaccaag ctctgtgatg caatgaagat cctggatgga
     2281 aagaagttgt acaaagatta tttgctgaaa atcaacttca cagctccatt caacccaaat
     2341 aaaggagcag acagcattgt gaagtttgac acttacggag acgggatggg aagatacaac
     2401 gtgttcaact tccagcatat aggtggaaag tattcctact taaaagttgg ccactgggca
     2461 gaaactttat atctagatgt ggactctatt cattggtccc ggaactcagt ccccacttcc
     2521 cagtgcagtg atccctgtgc ccccaatgaa atgaaaaaca tgcagccagg agatgtttgc
     2581 tgctggatct gcatcccatg tgagccctat gaatacctgg ttgatgagtt cacctgcatg
     2641 gattgtggcc ctggccagtg gcccactgca gacctatctg gatgctacaa ccttccagag
     2701 gattacatca ggtgggaaga tgcctgggca ataggcccag tcactattgc ctgcctgggt
     2761 tttatgtgta catgcatagt cataactgtt tttatcaagc acaacaacac acccttggtc
     2821 aaagcatcag gccgagaact ctgctacatc ttgttatttg gagttagcct gtcctattgc
     2881 atgacattct tcttcattgc taagccatcg cctgtcatct gtgcattgcg ccgacttggg
     2941 cttgggacct cctttgccat ctgttattca gctctcctga ccaagacaaa ctgcatcgct
     3001 cgcatctttg atggggtcaa gaatggcgct cagaggccaa aattcatcag ccccagttct
     3061 caggttttta tctgcctggg tttgatactg gtgcaaattg tgatggtgtc tgtgtggctt
     3121 atcttggaga ctccaggtac tagaagatac accctgccag agaagcggga aacagtcatc
     3181 ctaaaatgca atgtcaaaga ttccagcatg ttgatctctc tgacctatga cgtggttctg
     3241 gtgattctat gcactgtgta tgccttcaaa acaaggaagt gtcctgaaaa cttcaatgaa
     3301 gccaagttca taggcttcac catgtacacc acctgcatca tctggttggc attcctccct
     3361 atattttatg tgacatcaag tgactacaga gtgcagacga caacaatgtg catctccgtt
     3421 agcttgagtg gtttcgtggt cttgggctgt ttgtttgccc ccaaggtgca cattgtcctg
     3481 ttccaacccc agaagaatgt ggtcacacac agacttcacc tcaacaggtt cagtgtcagt
     3541 ggaactgcga ccacatattc tcagtcctct gcaagcacat atgtcccgac agtgtgcaac
     3601 ggaagggaag tcctggactc caccacctca tctctgtgat tgtgactcgc agttcagttc
     3661 tgtttatagg ctgttagacg aagtgctcac atgctgctcc agaatatgga aacagaacaa
     3721 aaacaacaac cctagtacct tctttttttt tttttttttt ttagaaacag taaaataaat
     3781 tatttttgag gactgtatgg tatatagtga tgtgctacaa ctttctaggc tgattttagt
     3841 gcccctatta acagcccctc cccaggacat ggaaataacc attgtttaca gagctgagca
     3901 ttggtgacag ggtctgacag ggtcagtcta ctaaaagaaa acaaaacaaa acaaaaaaaa
     3961 caaaaacaaa aaaataatac agtggcaata ttaggtaacc tttttcctat gaagtctttt
     4021 gtaggttctt gttgtaacta atatagggtg agtttctacg ttgtatatta aagttacatt
     4081 gcgtgtaaca gaacgttttt ctcagtacaa aataaaatgc atctgtatta atgtaaagat
     4141 aaccagaata aaaccttcaa ggttttcaag ca
//
