LOCUS       NM_001160353            3338 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Mus musculus glutamate receptor, metabotropic 2 (Grm2), mRNA.
ACCESSION   NM_001160353 XM_001475814 XM_909627
VERSION     NM_001160353.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3338)
  AUTHORS   Roh,W.S., Yoo,J.H., Dravid,S.M., Mannaioni,G., Krizman,E.N.,
            Wahl,P., Robinson,M.B., Traynelis,S.F., Lee,C.J. and Han,K.S.
  TITLE     Astrocytic PAR1 and mGluR2/3 control synaptic glutamate time course
            at hippocampal CA1 synapses
  JOURNAL   Glia 72 (9), 1707-1724 (2024)
   PUBMED   38864289
  REMARK    GeneRIF: Astrocytic PAR1 and mGluR2/3 control synaptic glutamate
            time course at hippocampal CA1 synapses.
REFERENCE   2  (bases 1 to 3338)
  AUTHORS   Busceti,C.L., Di Menna,L., Castaldi,S., D'Errico,G., Taddeucci,A.,
            Bruno,V., Fornai,F., Pittaluga,A., Battaglia,G. and Nicoletti,F.
  TITLE     Adaptive Changes in Group 2 Metabotropic Glutamate Receptors
            Underlie the Deficit in Recognition Memory Induced by
            Methamphetamine in Mice
  JOURNAL   eNeuro 11 (8) (2024)
   PUBMED   38969501
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3338)
  AUTHORS   Philibert,C.E., Disdier,C., Lafon,P.A., Bouyssou,A.,
            Oosterlaken,M., Galant,S., Pizzoccaro,A., Tuduri,P., Ster,J.,
            Liu,J., Kniazeff,J., Pin,J.P., Rondard,P., Marin,P. and
            Vandermoere,F.
  TITLE     TrkB receptor interacts with mGlu2 receptor and mediates
            antipsychotic-like effects of mGlu2 receptor activation in the
            mouse
  JOURNAL   Sci Adv 10 (4), eadg1679 (2024)
   PUBMED   38277461
REFERENCE   4  (bases 1 to 3338)
  AUTHORS   Ma,J., Hu,Z., Yue,H., Luo,Y., Wang,C., Wu,X., Gu,Y. and Wang,L.
  TITLE     GRM2 Regulates Functional Integration of Adult-Born DGCs by
            Paradoxically Modulating MEK/ERK1/2 Pathway
  JOURNAL   J Neurosci 43 (16), 2822-2836 (2023)
   PUBMED   36878727
  REMARK    GeneRIF: GRM2 Regulates Functional Integration of Adult-Born DGCs
            by Paradoxically Modulating MEK/ERK1/2 Pathway.
REFERENCE   5  (bases 1 to 3338)
  AUTHORS   Spirkova,A., Kovarikova,V., Sefcikova,Z., Pisko,J., Ksinanova,M.,
            Koppel,J., Fabian,D. and Cikos,S.
  TITLE     Glutamate can act as a signaling molecule in mouse preimplantation
            embryosdagger
  JOURNAL   Biol Reprod 107 (4), 916-927 (2022)
   PUBMED   35746896
REFERENCE   6  (bases 1 to 3338)
  AUTHORS   Kaupmann,K., Huggel,K., Heid,J., Flor,P.J., Bischoff,S.,
            Mickel,S.J., McMaster,G., Angst,C., Bittiger,H., Froestl,W. and
            Bettler,B.
  TITLE     Expression cloning of GABA(B) receptors uncovers similarity to
            metabotropic glutamate receptors
  JOURNAL   Nature 386 (6622), 239-246 (1997)
   PUBMED   9069281
REFERENCE   7  (bases 1 to 3338)
  AUTHORS   Yokoi,M., Kobayashi,K., Manabe,T., Takahashi,T., Sakaguchi,I.,
            Katsuura,G., Shigemoto,R., Ohishi,H., Nomura,S., Nakamura,K.,
            Nakao,K., Katsuki,M. and Nakanishi,S.
  TITLE     Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2
  JOURNAL   Science 273 (5275), 645-647 (1996)
   PUBMED   8662555
REFERENCE   8  (bases 1 to 3338)
  AUTHORS   Bergmann,M., Fox,P.A., Grabs,D., Post,A. and Schilling,K.
  TITLE     Expression and subcellular distribution of glutamate receptor
            subunits 2/3 in the developing cerebellar cortex
  JOURNAL   J Neurosci Res 43 (1), 78-86 (1996)
   PUBMED   8838577
REFERENCE   9  (bases 1 to 3338)
  AUTHORS   Chavis,P., Shinozaki,H., Bockaert,J. and Fagni,L.
  TITLE     The metabotropic glutamate receptor types 2/3 inhibit L-type
            calcium channels via a pertussis toxin-sensitive G-protein in
            cultured cerebellar granule cells
  JOURNAL   J Neurosci 14 (11 Pt 2), 7067-7076 (1994)
   PUBMED   7965099
REFERENCE   10 (bases 1 to 3338)
  AUTHORS   Thomsen,C., Klitgaard,H., Sheardown,M., Jackson,H.C., Eskesen,K.,
            Jacobsen,P., Treppendahl,S. and Suzdak,P.D.
  TITLE     (S)-4-carboxy-3-hydroxyphenylglycine, an antagonist of metabotropic
            glutamate receptor (mGluR) 1a and an agonist of mGluR2, protects
            against audiogenic seizures in DBA/2 mice
  JOURNAL   J Neurochem 62 (6), 2492-2495 (1994)
   PUBMED   8189254
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY290719.1, CK619406.1, BC115866.1, AC152452.3 and BQ174642.1.
            
            On or before May 22, 2009 this sequence version replaced
            XM_909627.3, XM_001475814.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.204019.1,
                                           SRR7652917.547948.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-445               BY290719.1         2-446
            446-461             CK619406.1         407-422
            462-1119            BC115866.1         435-1092
            1120-1330           AC152452.3         170080-170290       c
            1331-1630           BC115866.1         1304-1603
            1631-2464           AC152452.3         166777-167610       c
            2465-2972           BC115866.1         1604-2111
            2973-3161           BQ174642.1         178-366             c
            3162-3162           AC152452.3         164201-164201       c
            3163-3338           BQ174642.1         1-176               c
FEATURES             Location/Qualifiers
     source          1..3338
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 57.98 cM"
     gene            1..3338
                     /gene="Grm2"
                     /gene_synonym="4930441L02Rik; Gprc1b; mGluR2; mGluR7"
                     /note="glutamate receptor, metabotropic 2"
                     /db_xref="GeneID:108068"
                     /db_xref="MGI:MGI:1351339"
     exon            1..84
                     /gene="Grm2"
                     /gene_synonym="4930441L02Rik; Gprc1b; mGluR2; mGluR7"
                     /inference="alignment:Splign:2.1.0"
     exon            85..670
                     /gene="Grm2"
                     /gene_synonym="4930441L02Rik; Gprc1b; mGluR2; mGluR7"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..2839
                     /gene="Grm2"
                     /gene_synonym="4930441L02Rik; Gprc1b; mGluR2; mGluR7"
                     /note="G protein-coupled receptor, family C, group 1,
                     member B; metabotropic glutamate receptor 2"
                     /codon_start=1
                     /product="metabotropic glutamate receptor 2 precursor"
                     /protein_id="NP_001153825.1"
                     /db_xref="CCDS:CCDS52914.1"
                     /db_xref="GeneID:108068"
                     /db_xref="MGI:MGI:1351339"
                     /translation="MESLLRFLALLLLRGAVAEGPAKKVLTLEGDLVLGGLFPVHQKG
                     GPAEECGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQA
                     LDFVRASLSRGADGSRHICPDGSYATLSDAPTAITGVIGGSYSDVSIQVANLLRLFQI
                     PQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGE
                     TGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDAR
                     ELLAATQRLNASFTWVASDGWGALESVVAGSERAAEGAITIELASYPISDFASYFQNL
                     DPWNNSRNPWFREFWEERFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHAL
                     HNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTDDEVRFDRFGDGI
                     GRYNIFTYLRAGNGRYRYQKVGYWAEGLTLDTSIIPWASPSAGTLPASRCSEPCLQNE
                     VKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDA
                     WAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFI
                     AKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAI
                     CLALISGQLLIVAAWLVVEAPGIGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIA
                     LCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSV
                     SLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAPRASANLGQGSGSQLVP
                     TVCNGREVVDSTTSSL"
     exon            671..1508
                     /gene="Grm2"
                     /gene_synonym="4930441L02Rik; Gprc1b; mGluR2; mGluR7"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..2584
                     /gene="Grm2"
                     /gene_synonym="4930441L02Rik; Gprc1b; mGluR2; mGluR7"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2765
                     /gene="Grm2"
                     /gene_synonym="4930441L02Rik; Gprc1b; mGluR2; mGluR7"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..3323
                     /gene="Grm2"
                     /gene_synonym="4930441L02Rik; Gprc1b; mGluR2; mGluR7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3303..3308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grm2"
                     /gene_synonym="4930441L02Rik; Gprc1b; mGluR2; mGluR7"
                     /note="hexamer: AATAAA"
     polyA_site      3323
                     /gene="Grm2"
                     /gene_synonym="4930441L02Rik; Gprc1b; mGluR2; mGluR7"
                     /note="major polyA site"
ORIGIN      
        1 agggcgggcc ggcggagagc gcagagccag cgagagagcc agcaagcggg aaccggagcc
       61 ccgcgccaga gctgggagcg ccaggagctg gcccccttct catctctctt cctgtctgtc
      121 ctttcccggc ccctgtttgc tcctttcttt gcctttgccg cttctgtcct cacccctcga
      181 agaccccagt ctgctggacc tagccgtccc ttggggggcc atggaatccc tgcttaggtt
      241 cctggcactg ctgctgctgc ggggtgctgt ggccgagggc ccggccaaga aggtgctgac
      301 cctggagggg gacctggtgc tgggtgggct gttcccagtg caccagaagg gtggcccagc
      361 agaggagtgt ggacctgtta atgagcaccg tggcatacag cgcctagagg ccatgctttt
      421 tgcactggac cgcatcaacc gcgaccccca tctgctgcct ggggtgcgtt tgggcgcgca
      481 catcctcgac agctgctcca aggatacaca cgccctggag caggccctgg actttgtgcg
      541 tgcctcactc agccgtgggg ctgatggctc acgccacatc tgtcctgacg gctcctatgc
      601 tactctcagt gatgctccca cagctatcac cggtgtcatt ggcggctcct acagtgatgt
      661 ctccatccag gtggccaatc tcctgcggct gttccagatc ccacagatca gctatgcctc
      721 caccagcgcc aagctgagcg acaagtcccg ttatgattac tttgctcgca ccgtgccccc
      781 agacttcttc caagccaagg ccatggctga gattctccgc tttttcaact ggacgtatgt
      841 gtctacggtg gcatctgagg gtgactatgg agagacaggc attgaggcct tcgagctcga
      901 ggctcgggca cgcaacatct gcgtggccac ttcggagaag gtgggccgtg ccatgagccg
      961 cgcagccttc gagggtgtgg tgcgagccct gttgcagaag cccagcgccc gtgtggctgt
     1021 gctcttcacc cggtcagagg atgcccgtga gctgcttgca gccacccagc gtctcaacgc
     1081 cagcttcacc tgggtagcca gcgacggctg gggggcccta gagagcgtgg tggcaggcag
     1141 tgaaagggct gccgagggcg ccatcaccat tgagctggcc tcctacccca tcagtgactt
     1201 tgcctcctac ttccagaact tggatccctg gaacaacagc aggaaccctt ggttccgtga
     1261 gttctgggag gagaggttcc gttgcagctt ccggcagcga gactgcgccg cccactctct
     1321 gcgggccgta ccctttgaac aggagtcaaa gatcatgttt gtggtcaatg ccgtgtatgc
     1381 catggcccac gctctgcaca acatgcaccg tgccctctgt cccaacacca cccgcctctg
     1441 cgatgccatg agacctgtca atgggcgccg cctctacaag gacttcgtgc tcaatgtcaa
     1501 gtttgatgcc cccttccgcc cagcagatac cgacgacgag gtccgctttg accgctttgg
     1561 agatggtatt ggccgctaca acatcttcac ctatctgcgg gcaggcaatg ggcgctatcg
     1621 ctaccagaag gtaggctact gggcagaagg tctgactctg gatactagca tcatcccatg
     1681 ggcctcccca tcagctggca ccctccctgc ctctcgctgt agcgagccct gccttcagaa
     1741 tgaggtgaag agcgtgcagc ccggcgaggt ctgctgctgg ctctgcatcc cctgtcagcc
     1801 ctatgagtac aggctggatg agttcacctg tgctgactgt ggcctgggct actggcctaa
     1861 tgccagtctg actggatgct ttgagctgcc ccaggagtac atccgctggg gcgacgcctg
     1921 ggcggtggga cctgtcacca tcgcctgcct aggtgccctg gccaccctct ttgtgttggg
     1981 tgtcttcgtg cggcataacg ccacacccgt ggtcaaggcc tcggggcggg agctttgcta
     2041 cattctgctg ggaggcgtct tcctctgcta ctgcatgacc ttcatcttca tcgccaagcc
     2101 ctccacggcc gtctgcacct taaggcgcct cgggttgggg accgccttct ctgtctgcta
     2161 ctcagccctc ctcaccaaga ccaatcgcat cgctcgcatc tttggcgggg cccgggaggg
     2221 tgcccagcgg ccgcgcttca tcagtcccgc ctcacaggtg gccatctgcc tggcacttat
     2281 ctcgggccag ctgctcattg ttgctgcctg gctggtggtg gaggcacctg gcataggcaa
     2341 ggagacagcc cctgagcggc gggaagtggt gaccttgcgc tgtaaccacc gtgacgcaag
     2401 catgcttggc tcgctggcct acaacgtgct cctcatcgct ctctgcacgc tctatgcctt
     2461 caagacccgc aagtgcccgg agaacttcaa cgaggccaag ttcatcggct ttaccatgta
     2521 caccacctgt atcatctggc tggctttcct tcccatcttc tacgtcacct ccagtgatta
     2581 tcgggtgcag accactacga tgtgcgtgtc cgtcagcctc agtggctctg tggtgctcgg
     2641 ctgcctcttt gcacccaagc tgcacattat cctcttccag ccacagaaga acgtggtgag
     2701 ccaccgggca cctaccagcc gctttggcag tgctgccccc agggccagcg ccaaccttgg
     2761 tcaagggtct ggatcccagc ttgttcctac tgtttgcaat ggccgtgagg tggtagactc
     2821 aacaacatcg tcgctttgaa gatcccacac tcctgccctg acatggctgc tcccgaaccc
     2881 agcgtagacc ctcttccatg gccaggagga agttggctgg agccttgcaa taacacctac
     2941 cccatgcctg cccccaaagt cacctaccca cctcctggat tccccagccc tttaggccag
     3001 aagtcagagt ccttagctgg gagtctctgc attggccagt aactatcctt gtagctatgc
     3061 cccgtgtttg ccaggcctgg gaatcagagg ggagaaattc agtgtctacc gtgttttaga
     3121 acagcgtggc tgaggacgac aggcccaacc cccatgcaaa ggtgcttcca gtccagcccc
     3181 tgccccaggc ctttttaatt ttttataagt tactctgggt tagagaggaa ggttattgtg
     3241 gggaccagtc cctccctcct tacccagtag tttgtcccgt ggtttatttt gtattacctg
     3301 taaataaagt gtctttattt aaaaaaaaaa aaaaaaaa
//
