LOCUS       NP_001153825             872 aa            linear   ROD 07-OCT-2024
DEFINITION  metabotropic glutamate receptor 2 precursor [Mus musculus].
ACCESSION   NP_001153825 XP_001475864 XP_914720
VERSION     NP_001153825.1
DBSOURCE    REFSEQ: accession NM_001160353.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 872)
  AUTHORS   Roh,W.S., Yoo,J.H., Dravid,S.M., Mannaioni,G., Krizman,E.N.,
            Wahl,P., Robinson,M.B., Traynelis,S.F., Lee,C.J. and Han,K.S.
  TITLE     Astrocytic PAR1 and mGluR2/3 control synaptic glutamate time course
            at hippocampal CA1 synapses
  JOURNAL   Glia 72 (9), 1707-1724 (2024)
   PUBMED   38864289
  REMARK    GeneRIF: Astrocytic PAR1 and mGluR2/3 control synaptic glutamate
            time course at hippocampal CA1 synapses.
REFERENCE   2  (residues 1 to 872)
  AUTHORS   Busceti,C.L., Di Menna,L., Castaldi,S., D'Errico,G., Taddeucci,A.,
            Bruno,V., Fornai,F., Pittaluga,A., Battaglia,G. and Nicoletti,F.
  TITLE     Adaptive Changes in Group 2 Metabotropic Glutamate Receptors
            Underlie the Deficit in Recognition Memory Induced by
            Methamphetamine in Mice
  JOURNAL   eNeuro 11 (8) (2024)
   PUBMED   38969501
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 872)
  AUTHORS   Philibert,C.E., Disdier,C., Lafon,P.A., Bouyssou,A.,
            Oosterlaken,M., Galant,S., Pizzoccaro,A., Tuduri,P., Ster,J.,
            Liu,J., Kniazeff,J., Pin,J.P., Rondard,P., Marin,P. and
            Vandermoere,F.
  TITLE     TrkB receptor interacts with mGlu2 receptor and mediates
            antipsychotic-like effects of mGlu2 receptor activation in the
            mouse
  JOURNAL   Sci Adv 10 (4), eadg1679 (2024)
   PUBMED   38277461
REFERENCE   4  (residues 1 to 872)
  AUTHORS   Ma,J., Hu,Z., Yue,H., Luo,Y., Wang,C., Wu,X., Gu,Y. and Wang,L.
  TITLE     GRM2 Regulates Functional Integration of Adult-Born DGCs by
            Paradoxically Modulating MEK/ERK1/2 Pathway
  JOURNAL   J Neurosci 43 (16), 2822-2836 (2023)
   PUBMED   36878727
  REMARK    GeneRIF: GRM2 Regulates Functional Integration of Adult-Born DGCs
            by Paradoxically Modulating MEK/ERK1/2 Pathway.
REFERENCE   5  (residues 1 to 872)
  AUTHORS   Spirkova,A., Kovarikova,V., Sefcikova,Z., Pisko,J., Ksinanova,M.,
            Koppel,J., Fabian,D. and Cikos,S.
  TITLE     Glutamate can act as a signaling molecule in mouse preimplantation
            embryosdagger
  JOURNAL   Biol Reprod 107 (4), 916-927 (2022)
   PUBMED   35746896
REFERENCE   6  (residues 1 to 872)
  AUTHORS   Kaupmann,K., Huggel,K., Heid,J., Flor,P.J., Bischoff,S.,
            Mickel,S.J., McMaster,G., Angst,C., Bittiger,H., Froestl,W. and
            Bettler,B.
  TITLE     Expression cloning of GABA(B) receptors uncovers similarity to
            metabotropic glutamate receptors
  JOURNAL   Nature 386 (6622), 239-246 (1997)
   PUBMED   9069281
REFERENCE   7  (residues 1 to 872)
  AUTHORS   Yokoi,M., Kobayashi,K., Manabe,T., Takahashi,T., Sakaguchi,I.,
            Katsuura,G., Shigemoto,R., Ohishi,H., Nomura,S., Nakamura,K.,
            Nakao,K., Katsuki,M. and Nakanishi,S.
  TITLE     Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2
  JOURNAL   Science 273 (5275), 645-647 (1996)
   PUBMED   8662555
REFERENCE   8  (residues 1 to 872)
  AUTHORS   Bergmann,M., Fox,P.A., Grabs,D., Post,A. and Schilling,K.
  TITLE     Expression and subcellular distribution of glutamate receptor
            subunits 2/3 in the developing cerebellar cortex
  JOURNAL   J Neurosci Res 43 (1), 78-86 (1996)
   PUBMED   8838577
REFERENCE   9  (residues 1 to 872)
  AUTHORS   Chavis,P., Shinozaki,H., Bockaert,J. and Fagni,L.
  TITLE     The metabotropic glutamate receptor types 2/3 inhibit L-type
            calcium channels via a pertussis toxin-sensitive G-protein in
            cultured cerebellar granule cells
  JOURNAL   J Neurosci 14 (11 Pt 2), 7067-7076 (1994)
   PUBMED   7965099
REFERENCE   10 (residues 1 to 872)
  AUTHORS   Thomsen,C., Klitgaard,H., Sheardown,M., Jackson,H.C., Eskesen,K.,
            Jacobsen,P., Treppendahl,S. and Suzdak,P.D.
  TITLE     (S)-4-carboxy-3-hydroxyphenylglycine, an antagonist of metabotropic
            glutamate receptor (mGluR) 1a and an agonist of mGluR2, protects
            against audiogenic seizures in DBA/2 mice
  JOURNAL   J Neurochem 62 (6), 2492-2495 (1994)
   PUBMED   8189254
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY290719.1, CK619406.1, BC115866.1, AC152452.3 and BQ174642.1.
            
            On or before May 22, 2009 this sequence version replaced
            XP_914720.1, XP_001475864.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.204019.1,
                                           SRR7652917.547948.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..872
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 57.98 cM"
     Protein         1..872
                     /product="metabotropic glutamate receptor 2 precursor"
                     /note="G protein-coupled receptor, family C, group 1,
                     member B; metabotropic glutamate receptor 2"
                     /calculated_mol_wt=93919
     sig_peptide     1..18
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1987
     mat_peptide     19..872
                     /product="Metabotropic glutamate receptor 2.
                     /id=PRO_0000306249"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14BI2.2)"
                     /calculated_mol_wt=93919
     Region          26..480
                     /region_name="PBP1_mGluR_groupII"
                     /note="ligand binding domain of the group II metabotropic
                     glutamate receptor; cd06375"
                     /db_xref="CDD:380598"
     Site            order(57,61,144..145,166..168,216,295,377)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:380598"
     Site            order(96,99,150,153,176,240)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:380598"
     Site            203
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q14BI2.2)"
     Site            286
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q14BI2.2)"
     Site            338
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q14BI2.2)"
     Site            402
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q14BI2.2)"
     Region          496..546
                     /region_name="NCD3G"
                     /note="Nine Cysteines Domain of family 3 GPCR; pfam07562"
                     /db_xref="CDD:462210"
     Site            547
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q14BI2.2)"
     Region          566..819
                     /region_name="7tmC_mGluR2"
                     /note="metabotropic glutamate receptor 2 in group 2,
                     member of the class C family of seven-transmembrane G
                     protein-coupled receptors; cd15447"
                     /db_xref="CDD:320563"
     Region          566..591
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320563"
     Site            order(569,572..573,576..577,579..580,614,618,621..622,630,
                     634)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:320563"
     Site            569..589
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14BI2.2)"
     Region          603..624
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320563"
     Site            605..625
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14BI2.2)"
     Site            order(623,635..636,639..640,643,723,728,731..732,735,769,
                     772..773,776,780,790..791,794,797,801)
                     /site_type="other"
                     /note="putative allosteric modulator binding site
                     [chemical binding]"
                     /db_xref="CDD:320563"
     Region          633..657
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320563"
     Site            634..651
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14BI2.2)"
     Region          677..685
                     /region_name="Important for interaction with HTR2A.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14BI2.2)"
     Region          679..699
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320563"
     Site            680..700
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14BI2.2)"
     Region          724..750
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320563"
     Site            727..747
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14BI2.2)"
     Region          758..781
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320563"
     Site            761..781
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14BI2.2)"
     Region          788..813
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320563"
     Site            799..819
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14BI2.2)"
     CDS             1..872
                     /gene="Grm2"
                     /gene_synonym="4930441L02Rik; Gprc1b; mGluR2; mGluR7"
                     /coded_by="NM_001160353.1:221..2839"
                     /db_xref="CCDS:CCDS52914.1"
                     /db_xref="GeneID:108068"
                     /db_xref="MGI:MGI:1351339"
ORIGIN      
        1 mesllrflal lllrgavaeg pakkvltleg dlvlgglfpv hqkggpaeec gpvnehrgiq
       61 rleamlfald rinrdphllp gvrlgahild scskdthale qaldfvrasl srgadgsrhi
      121 cpdgsyatls daptaitgvi ggsysdvsiq vanllrlfqi pqisyastsa klsdksrydy
      181 fartvppdff qakamaeilr ffnwtyvstv asegdygetg ieafeleara rnicvatsek
      241 vgramsraaf egvvrallqk psarvavlft rsedarella atqrlnasft wvasdgwgal
      301 esvvagsera aegaitiela sypisdfasy fqnldpwnns rnpwfrefwe erfrcsfrqr
      361 dcaahslrav pfeqeskimf vvnavyamah alhnmhralc pnttrlcdam rpvngrrlyk
      421 dfvlnvkfda pfrpadtdde vrfdrfgdgi gryniftylr agngryryqk vgywaegltl
      481 dtsiipwasp sagtlpasrc sepclqnevk svqpgevccw lcipcqpyey rldeftcadc
      541 glgywpnasl tgcfelpqey irwgdawavg pvtiaclgal atlfvlgvfv rhnatpvvka
      601 sgrelcyill ggvflcycmt fifiakpsta vctlrrlglg tafsvcysal ltktnriari
      661 fggaregaqr prfispasqv aiclalisgq llivaawlvv eapgigketa perrevvtlr
      721 cnhrdasmlg slaynvllia lctlyafktr kcpenfneak figftmyttc iiwlaflpif
      781 yvtssdyrvq tttmcvsvsl sgsvvlgclf apklhiilfq pqknvvshra ptsrfgsaap
      841 rasanlgqgs gsqlvptvcn grevvdstts sl
//
