LOCUS       NM_016976               6922 bp    mRNA    linear   ROD 06-FEB-2024
DEFINITION  Mus musculus glutamate receptor, metabotropic 1 (Grm1), transcript
            variant 1, mRNA.
ACCESSION   NM_016976 XM_906685 XM_920008
VERSION     NM_016976.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6922)
  AUTHORS   Qin,Y., Zhang,X.Y., Liu,Y., Ma,Z., Tao,S., Li,Y., Peng,R., Wang,F.,
            Wang,J., Feng,J., Qiu,Z., Jin,L., Wang,H. and Gong,X.
  TITLE     Downregulation of mGluR1-mediated signaling underlying
            autistic-like core symptoms in Shank1 P1812L-knock-in mice
  JOURNAL   Transl Psychiatry 13 (1), 329 (2023)
   PUBMED   37880287
  REMARK    GeneRIF: Downregulation of mGluR1-mediated signaling underlying
            autistic-like core symptoms in Shank1 P1812L-knock-in mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6922)
  AUTHORS   Moreau,M.X., Saillour,Y., Elorriaga,V., Bouloudi,B., Delberghe,E.,
            Deutsch Guerrero,T., Ochandorena-Saa,A., Maeso-Alonso,L.,
            Marques,M.M., Marin,M.C., Spassky,N., Pierani,A. and Causeret,F.
  TITLE     Repurposing of the multiciliation gene regulatory network in fate
            specification of Cajal-Retzius neurons
  JOURNAL   Dev Cell 58 (15), 1365-1382 (2023)
   PUBMED   37321213
REFERENCE   3  (bases 1 to 6922)
  AUTHORS   Ramsakha,N., Ojha,P., Pal,S., Routh,S., Citri,A. and
            Bhattacharyya,S.
  TITLE     A vital role for PICK1 in the differential regulation of
            metabotropic glutamate receptor internalization and synaptic AMPA
            receptor endocytosis
  JOURNAL   J Biol Chem 299 (6), 104837 (2023)
   PUBMED   37209824
  REMARK    GeneRIF: A vital role for PICK1 in the differential regulation of
            metabotropic glutamate receptor internalization and synaptic AMPA
            receptor endocytosis.
REFERENCE   4  (bases 1 to 6922)
  AUTHORS   Mansouri,M., Kremser,L., Nguyen,T.P., Kasugai,Y., Caberlotto,L.,
            Gassmann,M., Sarg,B., Lindner,H., Bettler,B., Carboni,L. and
            Ferraguti,F.
  TITLE     Protein Networks Associated with Native Metabotropic Glutamate 1
            Receptors (mGlu1) in the Mouse Cerebellum
  JOURNAL   Cells 12 (9), 1325 (2023)
   PUBMED   37174725
  REMARK    GeneRIF: Protein Networks Associated with Native Metabotropic
            Glutamate 1 Receptors (mGlu1) in the Mouse Cerebellum.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6922)
  AUTHORS   Harbers,M., Nakao,H., Watanabe,T., Matsuyama,K., Tohyama,S.,
            Nakao,K., Kishimoto,Y., Kano,M. and Aiba,A.
  TITLE     mGluR5 Is Substitutable for mGluR1 in Cerebellar Purkinje Cells for
            Motor Coordination, Developmental Synapse Elimination, and Motor
            Learning
  JOURNAL   Cells 11 (13), 2004 (2022)
   PUBMED   35805089
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6922)
  AUTHORS   Duvoisin,R.M., Zhang,C. and Ramonell,K.
  TITLE     A novel metabotropic glutamate receptor expressed in the retina and
            olfactory bulb
  JOURNAL   J Neurosci 15 (4), 3075-3083 (1995)
   PUBMED   7722646
REFERENCE   7  (bases 1 to 6922)
  AUTHORS   Conquet,F., Bashir,Z.I., Davies,C.H., Daniel,H., Ferraguti,F.,
            Bordi,F., Franz-Bacon,K., Reggiani,A., Matarese,V., Conde,F. et al.
  TITLE     Motor deficit and impairment of synaptic plasticity in mice lacking
            mGluR1
  JOURNAL   Nature 372 (6503), 237-243 (1994)
   PUBMED   7969468
REFERENCE   8  (bases 1 to 6922)
  AUTHORS   Aiba,A., Kano,M., Chen,C., Stanton,M.E., Fox,G.D., Herrup,K.,
            Zwingman,T.A. and Tonegawa,S.
  TITLE     Deficient cerebellar long-term depression and impaired motor
            learning in mGluR1 mutant mice
  JOURNAL   Cell 79 (2), 377-388 (1994)
   PUBMED   7954803
REFERENCE   9  (bases 1 to 6922)
  AUTHORS   Aiba,A., Chen,C., Herrup,K., Rosenmund,C., Stevens,C.F. and
            Tonegawa,S.
  TITLE     Reduced hippocampal long-term potentiation and context-specific
            deficit in associative learning in mGluR1 mutant mice
  JOURNAL   Cell 79 (2), 365-375 (1994)
   PUBMED   7954802
REFERENCE   10 (bases 1 to 6922)
  AUTHORS   Thomsen,C., Klitgaard,H., Sheardown,M., Jackson,H.C., Eskesen,K.,
            Jacobsen,P., Treppendahl,S. and Suzdak,P.D.
  TITLE     (S)-4-carboxy-3-hydroxyphenylglycine, an antagonist of metabotropic
            glutamate receptor (mGluR) 1a and an agonist of mGluR2, protects
            against audiogenic seizures in DBA/2 mice
  JOURNAL   J Neurochem 62 (6), 2492-2495 (1994)
   PUBMED   8189254
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ129468.1, BC067057.1, AK132901.1, AC100149.12 and AI835246.1.
            
            [WARNING] On Mar 14, 2024 this sequence was replaced by
            NM_016976.4.
            
            On Dec 1, 2010 this sequence version replaced NM_016976.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (alpha).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF320126.2, SRR1660815.5760.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                CJ129468.1         2-27
            27-2920             BC067057.1         1-2894
            2921-4140           AK132901.1         1151-2370
            4141-6898           AC100149.12        172874-175631       c
            6899-6922           AI835246.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..6922
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 3.44 cM"
     gene            1..6922
                     /gene="Grm1"
                     /gene_synonym="4930455H15Rik; Gm10828; Gprc1a; mGluR1;
                     nmf373; rcw; wobl"
                     /note="glutamate receptor, metabotropic 1"
                     /db_xref="GeneID:14816"
                     /db_xref="MGI:MGI:1351338"
     exon            1..83
                     /gene="Grm1"
                     /gene_synonym="4930455H15Rik; Gm10828; Gprc1a; mGluR1;
                     nmf373; rcw; wobl"
                     /inference="alignment:Splign:2.1.0"
     exon            84..1101
                     /gene="Grm1"
                     /gene_synonym="4930455H15Rik; Gm10828; Gprc1a; mGluR1;
                     nmf373; rcw; wobl"
                     /inference="alignment:Splign:2.1.0"
     CDS             402..4001
                     /gene="Grm1"
                     /gene_synonym="4930455H15Rik; Gm10828; Gprc1a; mGluR1;
                     nmf373; rcw; wobl"
                     /note="isoform alpha precursor is encoded by transcript
                     variant 1; G protein-coupled receptor, family C, group 1,
                     member A; metabotropic glutamate receptor 1"
                     /codon_start=1
                     /product="metabotropic glutamate receptor 1 isoform alpha
                     precursor"
                     /protein_id="NP_058672.1"
                     /db_xref="CCDS:CCDS23696.1"
                     /db_xref="GeneID:14816"
                     /db_xref="MGI:MGI:1351338"
                     /translation="MVRLLLIFFPMIFLEMSILPRMPDRKVLLAGASSQRSVARMDGD
                     VIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLG
                     SEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGLNRCLPDGQTLPPGRTKKPIAGVI
                     GPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDI
                     VKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRK
                     LRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEA
                     NGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKK
                     VCTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGYVGLCDAMKPIDGRKL
                     LDFLIKSSFVGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNID
                     DYKIQMNKSGMVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEFVQDEFTCRACD
                     LGWWPNAELTGCEPITIRYLEWSDIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVK
                     SSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRI
                     ARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIK
                     EVYLICNTSNLGVVAPVGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIW
                     LAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVV
                     RMHVGDGKLPCRSNTFLNIFRRKKPGAGNANSNGKSVSWSEPGGRQAPKGQHVWQRLS
                     VHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDASTKTLYNVEEEDNTPSTHFSPPS
                     SPSMVVHRRGPPVATTPPLPPHLSAEETPLFLADSVIPKGLPPPLPQQQQQPPPQPPP
                     QQPKSLMDQLQGVVTNFGSGIPDFHAVLAGPGTPGNGLRSLYPPPPPPQHLQMLPLQL
                     STFREEPISPPGEDDDDDSSERFKLLQEFVYEREGNTEEDDLEEEEDLPAASKLTPED
                     SPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVTYASVILRDYKQSSSTL"
     exon            1102..1351
                     /gene="Grm1"
                     /gene_synonym="4930455H15Rik; Gm10828; Gprc1a; mGluR1;
                     nmf373; rcw; wobl"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1587
                     /gene="Grm1"
                     /gene_synonym="4930455H15Rik; Gm10828; Gprc1a; mGluR1;
                     nmf373; rcw; wobl"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1834
                     /gene="Grm1"
                     /gene_synonym="4930455H15Rik; Gm10828; Gprc1a; mGluR1;
                     nmf373; rcw; wobl"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..2003
                     /gene="Grm1"
                     /gene_synonym="4930455H15Rik; Gm10828; Gprc1a; mGluR1;
                     nmf373; rcw; wobl"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2130
                     /gene="Grm1"
                     /gene_synonym="4930455H15Rik; Gm10828; Gprc1a; mGluR1;
                     nmf373; rcw; wobl"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..3061
                     /gene="Grm1"
                     /gene_synonym="4930455H15Rik; Gm10828; Gprc1a; mGluR1;
                     nmf373; rcw; wobl"
                     /inference="alignment:Splign:2.1.0"
     exon            3062..6905
                     /gene="Grm1"
                     /gene_synonym="4930455H15Rik; Gm10828; Gprc1a; mGluR1;
                     nmf373; rcw; wobl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatttggagc tgaggtgtct gcgaaccgag ggcggctgca gtcctctgac ctgagaccaa
       61 tagctctgtc tacccggact cagcgtccag cttatggcca ctaacgcgcc gctcattgca
      121 cacctgattc acacaccttc gggcaccagt gaaaaaaccg cgacttgatt ttctggaaga
      181 acacccctag ggtttgggag cggtcgtgga ggaccagcag gaagaagcgg aggggagagg
      241 ggcggtggtg gagactgaga agctttgaac cagctgtgtt ggccaaaggc acgaagcggc
      301 aaaagacagc ggcgggcgtc agggtggttc gcgctgggaa cctgcaggcg ggaccggcgt
      361 gggaacgtgg cttgccggcg gtcgaccgcg tcttcgccac aatggtccgg ctcctcttga
      421 ttttcttccc aatgatcttt ttggagatgt ccattttgcc caggatgcct gacagaaaag
      481 tactgctggc aggtgcctcg tcccagcgct ctgtggcgag aatggacgga gatgtcatca
      541 tcggagccct cttctcagtc catcaccagc ctccagccga aaaggtaccg gaaaggaagt
      601 gtggggagat cagagaacag tatggtatcc agagagtgga ggccatgttc cacacattag
      661 ataagattaa tgcggacccg gtgctcctgc ccaacatcac tctgggcagt gagatccggg
      721 actcctgctg gcactcttct gtggctctgg aacagagcat tgagttcatc agagactccc
      781 tgatttccat ccgagatgag aaggatggac tgaaccgctg cctgcctgat ggccagaccc
      841 tacccccagg caggactaag aagcctattg ctggagtgat cggccctggc tccagctctg
      901 tggccattca agtccagaat cttctgcagc tgttcgacat cccacaaatc gcctattctg
      961 ccacgagcat agacctgagc gacaaaactt tgtacaaata cttcctgagg gtggtccctt
     1021 ctgacacttt gcaggcaagg gcgatgcttg atatcgtcaa gcggtacaac tggacctatg
     1081 tctctgcagt ccacacagaa gggaattacg gcgagagtgg aatggatgct ttcaaagagt
     1141 tggctgccca ggaaggactc tgcatcgcac actcggacaa aatctacagc aatgctggcg
     1201 agaagagctt tgatcggctt ctgcgcaagc tccgagagcg gcttcccaag gccagggttg
     1261 tggtctgctt ctgcgagggc atgacagtgc gggggttact gagtgccatg cgccgccttg
     1321 gcgtcgtggg agagttctca ctcattggaa gtgatggatg ggcagacaga gatgaagtca
     1381 tcgaaggcta tgaggtggaa gccaatgggg gaatcacaat aaagctgcag tctccagagg
     1441 tcaggtcgtt tgatgactac tttctgaagc tgaggctgga caccaacacg aggaatcctt
     1501 ggttccctga gttctggcaa catcgcttcc agtgtcgcct acctggacac ctcttggaaa
     1561 accccaactt taaaaaagtc tgcacaggaa atgaaagctt ggaagaaaat tatgtccagg
     1621 acagcaaaat gggatttgtc atcaacgcca tctatgccat ggcacacggc ctacagaaca
     1681 tgcaccatgc tctatgtcct ggctacgtgg gcctttgtga tgccatgaag cccattgacg
     1741 gcaggaagct cctggatttc ctcatcaaat cctcttttgt tggagtgtct ggagaggagg
     1801 tctggttcga tgagaagggg gatgcacctg gaaggtatga cattatgaat ctgcagtaca
     1861 cagaggctaa tcgctatgac tatgtccatg tgggaacctg gcatgaaggt gtgctgaata
     1921 tcgatgatta caaaatccag atgaacaaaa gcggaatggt acgatctgtg tgcagcgagc
     1981 cttgcttaaa gggtcagatt aaggtcatac ggaaagggga agtgagctgc tgctggatct
     2041 gcacagcctg caaagagaat gagtttgtgc aagatgagtt tacctgcaga gcctgtgacc
     2101 tggggtggtg gcccaatgca gagctcacag gctgtgagcc cattactatc cgttacctcg
     2161 agtggagtga catagaatcc atcatagcca tcgccttttc ttgcctgggc atcctcgtga
     2221 cgctatttgt caccctcatc tttgtgctgt accgggacac acctgtggtc aaatcctcca
     2281 gtagagagct ctgctatatc attctggctg gtattttcct cggctacgta tgccctttca
     2341 ccctcatcgc caaacctact accacatcct gctacctcca gcgcctccta gttggcctct
     2401 cttctgccat gtgctactct gctcttgtga ccaaaaccaa tcgtattgca cgcatcctgg
     2461 ctggcagcaa gaagaagatc tgtacccgga agcccaggtt catgagcgct tgggcccaag
     2521 tgatcatagc ctccattctg attagtgtac agctgacact agtggtgacc ttgatcatca
     2581 tggagcctcc catgcccatt ttgtcctacc cgagcatcaa ggaagtctat cttatctgca
     2641 ataccagcaa cctgggtgta gtggcacctg tgggttacaa cggacttctc atcatgagct
     2701 gtacctacta tgccttcaag acccgcaacg tgccggccaa tttcaatgag gctaaataca
     2761 tcgccttcac tatgtacacc acctgcatca tctggctggc ttttgttccc atttactttg
     2821 ggagcaacta caagattatc actacctgct tcgcagtgag cctcagtgtg acggtggccc
     2881 tgggctgcat gttcactccc aagatgtaca tcattattgc caaacccgag aggaatgtcc
     2941 gcagtgcctt caccacctct gatgtagtgc gcatgcacgt cggtgacggc aagctgccat
     3001 gccgctccaa caccttcctc aacattttcc ggagaaagaa gcctggggca gggaacgcca
     3061 attctaacgg caagtctgtg tcatggtctg aaccaggtgg aagacaggcg cccaagggac
     3121 agcatgtgtg gcagcgcctc tctgtgcacg tgaagaccaa tgagacggcc tgtaaccaaa
     3181 cagccgtaat taaacccctc actaaaagtt accaaggctc tggcaagagt ctgacctttt
     3241 cagacgccag caccaagacc ctttacaacg tggaggaaga ggacaatacc ccttcaactc
     3301 acttcagccc tcccagcagc ccttccatgg tggtgcaccg acgcgggcca cccgtggcca
     3361 ccacgccacc tctgccaccc caccttagcg cagaagagac gcccttgttc ctggctgatt
     3421 ctgtcatccc caagggcttg cctcctcctc tcccgcagca gcaacagcag ccgccccctc
     3481 agccgcctcc gcagcagccc aaatccctga tggaccagct gcaaggcgtg gtcaccaact
     3541 ttggctctgg gattccagac ttccacgcgg tgctggcagg cccggggaca ccagggaacg
     3601 ggctgcgctc cctgtacccg cccccgcctc caccgcaaca cctgcagatg ttgcccctgc
     3661 agctgagcac cttccgagag gagcccatct cccctccggg ggaggacgac gatgatgaca
     3721 gcagcgagag gttcaagctc ctgcaggagt tcgtgtatga gcgtgaaggg aacacggagg
     3781 aagacgatct ggaagaggag gaggacctgc ctgcagccag caagctgacg cctgaggatt
     3841 cgcctgccct gacgccccct tctcctttcc gagattccgt ggcctctggc agctcagtgc
     3901 ccagttcccc agtgtctgag tcagtgctct gcacccctcc aaatgtgacc tatgcctctg
     3961 tcattctgag ggactacaag caaagctctt ccactctgta gtaagggggg agtatgcgtg
     4021 gagaagccag agatgccaag gagtgtcaac cctttcagaa atgtgtagaa agcaaggggg
     4081 tggggtggga tggaggacca cagtctgcag ggaagaaaaa aaagaaaaga aaaggaaagg
     4141 aaaggaaagg aaaggaaagg aaaggaaagg aaaggaaagg aaaggaaagg aaaggaaagg
     4201 aaaggaaaaa agatgcggct gccttaaaga gggagaggga agatgccaac tgaacagtgg
     4261 tcccggccag gactgtgact cttgaattat tcaaaaacct tctctagaaa gaaagggaat
     4321 tatgacaaag cacaattcca tatggtatgt aacttttatc gaaaaaaata ataaaacgta
     4381 aaaataaaat caacaaaaat aatctcttcg tttgctcagt cgtgcataca tatatctgcc
     4441 cacactctcg tggtgaaact agagacggag cgggccctgc catggcgcca gctgaatcat
     4501 aaattcgtca tcccagtgag tggatgaaga gagggcagga catggggatt ggttcggact
     4561 acagttccca tctcagacct tgtctgtgct gagcctgcag actcctggac taaggaagac
     4621 ccaggaactg acctcatgag ggtcccgttc cactgctgtg atccagtgcc agcctttagt
     4681 tgcccgggat aaaggcacag taaccttttg catttctgtg attccctgtg tttaggaaaa
     4741 tgaaagtctg agcaaagtca tctccaaaat gagcttcatc agaagtgcta tggggagtaa
     4801 agagagaagc gagacgatat gtacgcacag ggccatgaac gaggtgaggt accagcttct
     4861 tcacagattc catacttgtg tactgatact tttggagagg agtgtcagaa gccgtttgtg
     4921 aactcacttg cactgtgcca accaggttct ccactgccct ccagcagaag aggacaagcc
     4981 gcattaccat gttttacctt ccatttactg tagcaaataa taccaaccag ttgaacttct
     5041 aagattcagt ttcagtacaa tgcggtgccg ctgtttctcc catgtgctat ggaaatgaat
     5101 ctatctttga acttaatggt gtattcatag caactattac tggtttagat tttcccccta
     5161 ttgtcacagg agtccctgga actagcaact gaatgtgttt tcctgtgttc cttgtataca
     5221 tgtgattatg aaatttgtgc catttaatgt caatctagct gccactagaa aatcgtcttt
     5281 cagatatagt ataaatgttt ttatgtacca gtgaggtacc agtgtctctc tggaggttgg
     5341 atctgtggtc tgatgtttct cacatgcagc ttcgatggga aatcttctaa gtgaaaatta
     5401 tttttcagat attttatgaa acgagaatgt tattaatgaa gaagtttgaa agggcattgt
     5461 ttaaaaagat caccaagcag tgggtgacag taaagggtcc attttttata acttgcacac
     5521 attgttatta aaatgtaagg ttgaaagggc aatatttaga atacttcaga tatattttta
     5581 aaaagttttt ccacagatac ttgagtttca cggtcttcta gtatgtaata acactcaagt
     5641 ccacccagag tgtctcaact atctgcttgt caatcatgct taatttttta ttttcatgca
     5701 ttttaatttt tatatttttg ttagtgtctc tttcttaaat cctcacattt actactatgt
     5761 aatagccaca gacatgtaat ccagttattc catcttgacc ctgccttttc taacccaaaa
     5821 gaaaaagatt gttcctgtta tttttatttc ttctgttatt tgtgggatga atcaaatccc
     5881 tttaaatatc tttgtttatg ccttatgttc agtcacttta atttgcttcc ttcatgtcga
     5941 agctgctgat ttctcagcca aaaagcatca ttttagaatc tccaaatgcc taaagcatca
     6001 taagttcaga atttaacatc aactcctatg tcagagttgt gtttcttgtg tgttgccaca
     6061 tcctactgcc cagtttagtg aattcctttg caagaatttt tggcttctat tttaaagtta
     6121 tttttaagca tctttattgc aaagacctca agaatttaaa cattagcttc tgtgttttca
     6181 ctgtgaagaa acagaatggg aaataacagt acagagctgg acatgggggt ccatgtcttt
     6241 aagcccagca cttgggaggc agaggcaggt ggagctttgt aagtttgagg ccagcctgct
     6301 ttatccaaga aattctaagc ctaaatagag ataccctgtt tcaaaaacca aaacacacaa
     6361 caaagatgac tcagtgctaa aaagatgggt tcccaccagt tgagaaacct gtgaaagaat
     6421 tcatccttcc cctgctcttt taaacttgaa gcacttacat gcatccttca ttattgtggg
     6481 acttgtgcag tcagggcttt ttgttgttgt tgttattgtt gttgttattg ttgtttggca
     6541 agaatagatg aggcaatgtt tgcctattta aatgctgtaa caggcaagtt aactctaggg
     6601 ttttggtctg agacatttga tgaacacctt caacactgat taaaatatta ctgaatgcct
     6661 actcttatcc tgattataaa ttttccagaa taaatagatt attagctcat ataattgttc
     6721 agaattggag atgtacacat acataccctg tacctaaagg gcaaaatatc ttcactgtaa
     6781 cgtgtgtgct tctacaaggt gttttgcttc ttgtaaaagt gttttccttt ggcttgttac
     6841 tgccttttgt caaataatct taatgatgct gtatcataat aaatattttc tatttattaa
     6901 atgtgaaaaa aaaaaaaaaa aa
//
