LOCUS       NM_018869               3182 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus G protein-coupled receptor kinase 5 (Grk5), mRNA.
ACCESSION   NM_018869 XM_907344
VERSION     NM_018869.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3182)
  AUTHORS   Sun,X., Zhang,B., Yuan,P., Ye,H. and Shi,P.
  TITLE     Irg1 regulates bone homeostasis via regulating the Grk5 expression
  JOURNAL   Biochem Biophys Res Commun 734, 150786 (2024)
   PUBMED   39383830
  REMARK    GeneRIF: Irg1 regulates bone homeostasis via regulating the Grk5
            expression.
REFERENCE   2  (bases 1 to 3182)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3182)
  AUTHORS   Sasaki,S., Nian,C., Xu,E.E., Pasula,D.J., Winata,H., Grover,S.,
            Luciani,D.S. and Lynn,F.C.
  TITLE     Type 2 diabetes susceptibility gene GRK5 regulates physiological
            pancreatic beta-cell proliferation via phosphorylation of HDAC5
  JOURNAL   iScience 26 (8), 107311 (2023)
   PUBMED   37520700
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3182)
  AUTHORS   Nagasaka,A., Terawaki,T., Noda,M., Takashima,M., Fujino,M.,
            Yamauchi,Y., Arawaka,S., Kato,T. and Nakaya,M.
  TITLE     GRK5-mediated inflammation and fibrosis exert cardioprotective
            effects during the acute phase of myocardial infarction
  JOURNAL   FEBS Open Bio 13 (2), 380-391 (2023)
   PUBMED   36633120
  REMARK    GeneRIF: GRK5-mediated inflammation and fibrosis exert
            cardioprotective effects during the acute phase of myocardial
            infarction.
REFERENCE   5  (bases 1 to 3182)
  AUTHORS   Xu,M., Shao,Y., Lin,K., Liu,Y., Lin,Y., Lin,Y., Yang,R., Liu,L.,
            Yin,M., Liao,S., Jiang,S. and He,J.
  TITLE     Genetic Arg-304-His substitution in GRK5 protects against sepsis
            progression by alleviating NF-kappaB-mediated inflammation
  JOURNAL   Int Immunopharmacol 115, 109629 (2023)
   PUBMED   36584571
  REMARK    GeneRIF: Genetic Arg-304-His substitution in GRK5 protects against
            sepsis progression by alleviating NF-kappaB-mediated inflammation.
REFERENCE   6  (bases 1 to 3182)
  AUTHORS   Fong,A.M., Premont,R.T., Richardson,R.M., Yu,Y.R., Lefkowitz,R.J.
            and Patel,D.D.
  TITLE     Defective lymphocyte chemotaxis in beta-arrestin2- and
            GRK6-deficient mice
  JOURNAL   Proc Natl Acad Sci U S A 99 (11), 7478-7483 (2002)
   PUBMED   12032308
REFERENCE   7  (bases 1 to 3182)
  AUTHORS   Gainetdinov,R.R., Bohn,L.M., Walker,J.K., Laporte,S.A.,
            Macrae,A.D., Caron,M.G., Lefkowitz,R.J. and Premont,R.T.
  TITLE     Muscarinic supersensitivity and impaired receptor desensitization
            in G protein-coupled receptor kinase 5-deficient mice
  JOURNAL   Neuron 24 (4), 1029-1036 (1999)
   PUBMED   10624964
REFERENCE   8  (bases 1 to 3182)
  AUTHORS   Premont,R.T., Macrae,A.D., Aparicio,S.A., Kendall,H.E., Welch,J.E.
            and Lefkowitz,R.J.
  TITLE     The GRK4 subfamily of G protein-coupled receptor kinases.
            Alternative splicing, gene organization, and sequence conservation
  JOURNAL   J Biol Chem 274 (41), 29381-29389 (1999)
   PUBMED   10506199
REFERENCE   9  (bases 1 to 3182)
  AUTHORS   Cho,M.C., Rao,M., Koch,W.J., Thomas,S.A., Palmiter,R.D. and
            Rockman,H.A.
  TITLE     Enhanced contractility and decreased beta-adrenergic receptor
            kinase-1 in mice lacking endogenous norepinephrine and epinephrine
  JOURNAL   Circulation 99 (20), 2702-2707 (1999)
   PUBMED   10338466
REFERENCE   10 (bases 1 to 3182)
  AUTHORS   Jaber,M., Koch,W.J., Rockman,H., Smith,B., Bond,R.A., Sulik,K.K.,
            Ross,J. Jr., Lefkowitz,R.J., Caron,M.G. and Giros,B.
  TITLE     Essential role of beta-adrenergic receptor kinase 1 in cardiac
            development and function
  JOURNAL   Proc Natl Acad Sci U S A 93 (23), 12974-12979 (1996)
   PUBMED   8917529
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK135076.1, BY289760.1, AK161821.1 and AW456000.1.
            
            On Nov 2, 2007 this sequence version replaced NM_018869.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK135076.1, AK161821.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-730               AK135076.1         3-732
            731-973             BY289760.1         183-425
            974-3158            AK135076.1         976-3160
            3159-3165           AK161821.1         2639-2645
            3166-3182           AW456000.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..3182
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 56.52 cM"
     gene            1..3182
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /note="G protein-coupled receptor kinase 5"
                     /db_xref="GeneID:14773"
                     /db_xref="MGI:MGI:109161"
     exon            1..883
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     CDS             832..2604
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /EC_number="2.7.11.16"
                     /note="g protein-coupled receptor kinase GRK5"
                     /codon_start=1
                     /product="G protein-coupled receptor kinase 5"
                     /protein_id="NP_061357.3"
                     /db_xref="CCDS:CCDS29945.1"
                     /db_xref="GeneID:14773"
                     /db_xref="MGI:MGI:109161"
                     /translation="MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCED
                     LRRTIDRDYYSLCDKQPIGRLLFRQFCETRPGLECYIQFLDLVAEYEITPDENLGAKG
                     KEIMTKYLTPKSPVFIAQVGQDLVSQTEKKLLQSPCKELFSACAQSVHDYLKGDPFHE
                     YLDSMYFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLE
                     KKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIY
                     NMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAV
                     KIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKV
                     KREEVDRRVLETEEVYSSKFSEEAKSICNMLLTKDSKQRLGCQEEGAAEVKRHPFFRN
                     MNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVP
                     IPWQNEMIETECFKELNVFGPNGTLSPDLNRSQPPEPPKKGLFHRLFRRQHQSNSKSS
                     PTPKTSCNHRINSNHINSNSTGSS"
     exon            884..979
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1092
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1170
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1271
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1364
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1428
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1569
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1760
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1798
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1888
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2097
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2235
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2373
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2505
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     exon            2506..3168
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2954
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /note="major polyA site"
     regulatory      3132..3137
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
                     /note="hexamer: ATTAAA"
     polyA_site      3148
                     /gene="Grk5"
                     /gene_synonym="Gprk5"
ORIGIN      
        1 gcggccgcca ggtcgccccg ggctggccga accccttgct gcccggaaac aaagtgcacc
       61 tttgtcagag acctggcgcg tgtgagcggc agacggcggg ccgcgcggaa ccccaggagc
      121 gcgccttcgc tcgggtctca gctcactcct gggcctccca cagcagcgtt ctgccgcctt
      181 ggcttgtgct ttccgctttc tcggatcttg gcgggacagg aaagggactc tgcgctccag
      241 gagtgggggt ttcgttttgg ctgagtcgtt tttgactcct gccggcgagg ctgggccgcc
      301 tgggctcagc gccataccgg cagcagtcct gctccacagt cccggtgcaa tagagccctc
      361 gccccgtcag acgcgggact acaattccca gcactcctcg cgttcagagc gcgcggtggg
      421 agttgcctcc gggcagacgc ctgcgcgctg cagcggctcg agcctggagt accacacccc
      481 cgggagggga acgaggggag gctgaagcat ccgaagcatt aaagcatccg agggagccgg
      541 aggggaggag aatggagtga cagagacgcg cggagggtgg ggggtggggg ggaaagtgtt
      601 gagggagggg ggagggggga cacagaggga ggaagaagcg gcggcggcgt ctcttcggtg
      661 cagaggggga aactccgcgg gctccgagaa agaataatgc ggtagcaggc aggctgcttg
      721 ctctggggtt tggcagcagc ggcggcagct cgagcagtgg cagcggcagc ggcatcaccc
      781 cagacgctga cagcacagcc ggccggctcc ctcgctgact gccgactgtc aatggagctg
      841 gaaaacatcg tggccaacac ggtcttgctg aaagcccggg aagggggtgg aggaaagcgc
      901 aaagggaaaa gcaagaagtg gaaggaaatc ctgaagtttc ctcacatcag ccagtgtgaa
      961 gacctccgaa ggaccataga cagagattac tacagtctat gtgacaagca accaattggg
     1021 agactgcttt ttcgacagtt ctgtgaaacc aggcctgggc tggagtgcta cattcagttc
     1081 ctggacttag tggcagaata tgaaattact ccagatgaaa accttggggc gaaggggaag
     1141 gaaataatga ccaagtacct cactccaaag tccccagtct tcattgccca agttggacag
     1201 gacctggtct cccagacaga gaagaagctc ctgcagagcc cctgcaaaga actcttctct
     1261 gcttgtgctc agtctgtcca tgactacttg aagggagacc ccttccacga gtacctggat
     1321 agcatgtatt ttgaccgttt tctgcagtgg aaatggttag aaagacaacc agtgaccaaa
     1381 aacactttcc ggcagtaccg agtgctgggc aaagggggct ttggagaggt ctgtgcctgc
     1441 caggttcggg ccactggtaa aatgtatgct tgtaaacgct tagagaagaa gaggatcaaa
     1501 aagaggaaag gcgaatccat ggcactcaac gaaaagcaga ttcttgagaa ggtcaacagc
     1561 cagtttgtgg tcaacctggc ctatgcctat gaaaccaaag atgcactatg cctggttctg
     1621 accattatga atggtggtga cctgaagttt cacatctaca atatggggaa tcctggcttt
     1681 gaggaagagc gagccttatt ttatgcagct gagatcctct gtggcctaga agacttacac
     1741 cgtgagaaca ctgtctatag agatctaaaa cccgaaaaca tcttgctgga tgattatggc
     1801 cacataagga tctcagacct cggactggcc gtgaagatcc ccgagggaga ccttatccgt
     1861 ggccgggtag gcactgttgg ctacatggcc ccagaagttc tgaacaacca gcgatatgga
     1921 ctgagccctg actactgggg cctgggctgc ctcatctatg agatgattga aggccagtca
     1981 ccatttcgag gtcgcaagga gaaggttaag cgggaagagg tggatcgccg ggtgctggag
     2041 actgaggaag tgtattcctc caagttctct gaagaggcca agtccatctg caacatgctg
     2101 ctcaccaaag actcgaagca gaggctgggc tgccaggagg agggggccgc cgaggtcaag
     2161 aggcaccctt tcttcaggaa catgaacttt aagcgcctgg aggctgggat gttggaccct
     2221 cccttcgttc cagatccccg ggctgtatac tgcaaggatg tgctggacat tgagcagttc
     2281 tccactgtga aaggtgtcaa cctggaccat acggacgatg atttttactc aaagttctct
     2341 acaggctctg tgccaattcc atggcaaaat gagatgatag aaacagaatg tttcaaggag
     2401 ctgaatgtgt tcggacctaa cggtaccctc tcaccagacc tgaacagaag tcagcctcca
     2461 gaaccgccaa agaaagggct gttccacaga ctcttcaggc gtcagcatca aagcaattcc
     2521 aagagttcac ctactcctaa gaccagttgt aaccaccgaa taaattcaaa ccacatcaat
     2581 tcaaactcca ctggaagcag ctagtttcgg ctctggcctt gaagtcaaaa gtggaaccag
     2641 ctcagagcct tctacttgga agcagaactt gtagccaggg gagcttccac tgtggctcag
     2701 tggccagcaa agctccagtg ggaactaaga taggagaccg ttcccccaat aacaaacctc
     2761 caagtttctc aaagaaattt ccactcaggt ctgttttcca aggtggcccc aagctggggt
     2821 ggactagaat tttccttgtt gaacattgca atagaaaccc aatgggatat gacagcttgc
     2881 acggatttta atagcatcct aactagaact gaattttgtc tttattattt ttaaaggaaa
     2941 gttttgtaaa tttctctatt gtctctgttt acattttgta tatttgtatt taagtgaaag
     3001 tcagactttg agggtgtata ttttctgtgc agccactgtt aagccatgtg ttttaagaca
     3061 ttttagattg gagggggggt tacaaaaatg tgactctaga cttccagagc ctcaaaagag
     3121 ataatgtttt tattaaatat agaaaatatc tcacttttta cctttaaaaa aaaaaaaaaa
     3181 aa
//
