LOCUS       NM_019497               2408 bp    mRNA    linear   ROD 04-FEB-2024
DEFINITION  Mus musculus G protein-coupled receptor kinase 4 (Grk4), transcript
            variant 1, mRNA.
ACCESSION   NM_019497
VERSION     NM_019497.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2408)
  AUTHORS   Xia,X., Zeng,Y., Li,Z., Luo,H., Wang,W., He,Y., Lu,B., Guo,J.,
            Chen,K. and Xu,X.
  TITLE     Effect of GRK4 on renal gastrin receptor regulation in hypertension
  JOURNAL   Clin Exp Hypertens 45 (1), 2245580 (2023)
   PUBMED   37641972
  REMARK    GeneRIF: Effect of GRK4 on renal gastrin receptor regulation in
            hypertension.
REFERENCE   2  (bases 1 to 2408)
  AUTHORS   Tao,Y., Luo,W., Chen,Y., Chen,C., Chen,S., Li,X., Chen,K. and
            Zeng,C.
  TITLE     Exercise ameliorates skeletal muscle insulin resistance by
            modulating GRK4-mediated D1R expression
  JOURNAL   Clin Sci (Lond) 137 (17), 1391-1407 (2023)
   PUBMED   37622333
  REMARK    GeneRIF: Exercise ameliorates skeletal muscle insulin resistance by
            modulating GRK4-mediated D1R expression.
REFERENCE   3  (bases 1 to 2408)
  AUTHORS   Yang,D., Tang,M., Zhang,M., Ren,H., Li,X., Zhang,Z., He,B.,
            Peng,S., Wang,W., Fang,D., Song,Y., Xiong,Y., Liu,Z.Z., Liang,L.,
            Shi,W., Fu,C., Hu,Y., Jose,P.A., Zhou,L., Han,Y. and Zeng,C.
  TITLE     Downregulation of G protein-coupled receptor kinase 4 protects
            against kidney ischemia-reperfusion injury
  JOURNAL   Kidney Int 103 (4), 719-734 (2023)
   PUBMED   36669643
  REMARK    GeneRIF: Downregulation of G protein-coupled receptor kinase 4
            protects against kidney ischemia-reperfusion injury.
REFERENCE   4  (bases 1 to 2408)
  AUTHORS   Li,X., Wu,Z., Yang,J. and Zhang,D.
  TITLE     LncRNA 148400 Promotes the Apoptosis of Renal Tubular Epithelial
            Cells in Ischemic AKI by Targeting the miR-10b-3p/GRK4 Axis
  JOURNAL   Cells 11 (24), 3986 (2022)
   PUBMED   36552750
  REMARK    GeneRIF: LncRNA 148400 Promotes the Apoptosis of Renal Tubular
            Epithelial Cells in Ischemic AKI by Targeting the miR-10b-3p/GRK4
            Axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2408)
  AUTHORS   Banna,F.K.E., Otto,J.M., Mulloy,S.M., Tsai,W., McElroy,S.M.,
            Wong,A.L., Cutts,G., Vrieze,S.I. and Lee,A.M.
  TITLE     Back-translating GWAS findings to animal models reveals a role for
            Hgfac and Slc39a8 in alcohol and nicotine consumption
  JOURNAL   Sci Rep 12 (1), 9336 (2022)
   PUBMED   35661789
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2408)
  AUTHORS   Wang,L., Gesty-Palmer,D., Fields,T.A. and Spurney,R.F.
  TITLE     Inhibition of WNT signaling by G protein-coupled receptor (GPCR)
            kinase 2 (GRK2)
  JOURNAL   Mol Endocrinol 23 (9), 1455-1465 (2009)
   PUBMED   19556343
  REMARK    GeneRIF: GRK2 inhibits WNT signaling in osteoblasts
REFERENCE   7  (bases 1 to 2408)
  AUTHORS   Usui,I., Imamura,T., Babendure,J.L., Satoh,H., Lu,J.C.,
            Hupfeld,C.J. and Olefsky,J.M.
  TITLE     G protein-coupled receptor kinase 2 mediates endothelin-1-induced
            insulin resistance via the inhibition of both Galphaq/11 and
            insulin receptor substrate-1 pathways in 3T3-L1 adipocytes
  JOURNAL   Mol Endocrinol 19 (11), 2760-2768 (2005)
   PUBMED   15994203
  REMARK    GeneRIF: The role of GRK2 in chronic ET-1-induced insulin
            resistance was investigated.
REFERENCE   8  (bases 1 to 2408)
  AUTHORS   Naf,D., Wilson,L.A., Bergstrom,R.A., Smith,R.S., Goodwin,N.C.,
            Verkerk,A., van Ommen,G.J., Ackerman,S.L., Frankel,W.N. and
            Schimenti,J.C.
  TITLE     Mouse models for the Wolf-Hirschhorn deletion syndrome
  JOURNAL   Hum Mol Genet 10 (2), 91-98 (2001)
   PUBMED   11152656
REFERENCE   9  (bases 1 to 2408)
  AUTHORS   Premont,R.T., Macrae,A.D., Aparicio,S.A., Kendall,H.E., Welch,J.E.
            and Lefkowitz,R.J.
  TITLE     The GRK4 subfamily of G protein-coupled receptor kinases.
            Alternative splicing, gene organization, and sequence conservation
  JOURNAL   J Biol Chem 274 (41), 29381-29389 (1999)
   PUBMED   10506199
REFERENCE   10 (bases 1 to 2408)
  AUTHORS   Grosson,C.L., MacDonald,M.E., Duyao,M.P., Ambrose,C.M.,
            Roffler-Tarlov,S. and Gusella,J.F.
  TITLE     Synteny conservation of the Huntington's disease gene and
            surrounding loci on mouse Chromosome 5
  JOURNAL   Mamm Genome 5 (7), 424-428 (1994)
   PUBMED   7919654
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132685.1 and BY719486.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_019497.3.
            
            On Jan 23, 2007 this sequence version replaced NM_019497.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132685.1, BC150691.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-570               AK132685.1         2-571
            571-571             BY719486.1         443-443
            572-2408            AK132685.1         573-2409
FEATURES             Location/Qualifiers
     source          1..2408
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.91 cM"
     gene            1..2408
                     /gene="Grk4"
                     /gene_synonym="A830025H08Rik; Gprk2l; Gprk4; GRK"
                     /note="G protein-coupled receptor kinase 4"
                     /db_xref="GeneID:14772"
                     /db_xref="MGI:MGI:95801"
     exon            1..626
                     /gene="Grk4"
                     /gene_synonym="A830025H08Rik; Gprk2l; Gprk4; GRK"
                     /inference="alignment:Splign:2.1.0"
     CDS             575..2299
                     /gene="Grk4"
                     /gene_synonym="A830025H08Rik; Gprk2l; Gprk4; GRK"
                     /EC_number="2.7.11.16"
                     /note="isoform 1 is encoded by transcript variant 1; g
                     protein-coupled receptor kinase GRK4; G protein-coupled
                     receptor kinase 2, groucho gene related"
                     /codon_start=1
                     /product="G protein-coupled receptor kinase 4 isoform 1"
                     /protein_id="NP_062370.2"
                     /db_xref="CCDS:CCDS19219.1"
                     /db_xref="GeneID:14772"
                     /db_xref="MGI:MGI:95801"
                     /translation="MELENFVANNLLLKARLGFNKQTGRSKKWRELLKFPPVSMCTEL
                     RWSIEKDFSSLCDKQPIGRLLFRQFCDTKPDLKRCIEFLDAVAEYEVTIEEEQREFGL
                     AIFSRFFKEKSEVPLPEIPPDIVKECKWNLKQNSPSQNVFEECAGIVCKYLSETPFEE
                     YQESTYFNRFLQWKWLERRPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLE
                     KKRIKKRKGEAMALNEKRILEKLHSRFVVSLAYTYETKDALCLVLTIMNGGDLKYHIY
                     NLGDPGFEEPRAVFYAAELCCGLEDLQRKRIVYRDLKPENILLDDHGHIRISDLGLAM
                     EVPEGEMVRGRVGTVGYMAPEIINHEKYTFSPDWWGLGCLIYEMIAGHSPFRKYKEKV
                     NREELERRVKNETEEYSERFSEDAKSICSMLLIKDPSKRLGCQRDGVSAVKQHPIFKD
                     INFSRLEANMLDPPFIPDPQAIYCRNILDIGQFSVVKGVNLDTNDEIFYAEFATGSVT
                     IPWQNEMIESGCFKDLNENEDDLSSLEKYKMCSSILRPKRNFFRRLFRRTGCLNIALS
                     EEREPTEH"
     exon            627..719
                     /gene="Grk4"
                     /gene_synonym="A830025H08Rik; Gprk2l; Gprk4; GRK"
                     /inference="alignment:Splign:2.1.0"
     exon            720..832
                     /gene="Grk4"
                     /gene_synonym="A830025H08Rik; Gprk2l; Gprk4; GRK"
                     /inference="alignment:Splign:2.1.0"
     exon            833..907
                     /gene="Grk4"
                     /gene_synonym="A830025H08Rik; Gprk2l; Gprk4; GRK"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1014
                     /gene="Grk4"
                     /gene_synonym="A830025H08Rik; Gprk2l; Gprk4; GRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1107
                     /gene="Grk4"
                     /gene_synonym="A830025H08Rik; Gprk2l; Gprk4; GRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1171
                     /gene="Grk4"
                     /gene_synonym="A830025H08Rik; Gprk2l; Gprk4; GRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1312
                     /gene="Grk4"
                     /gene_synonym="A830025H08Rik; Gprk2l; Gprk4; GRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1503
                     /gene="Grk4"
                     /gene_synonym="A830025H08Rik; Gprk2l; Gprk4; GRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1541
                     /gene="Grk4"
                     /gene_synonym="A830025H08Rik; Gprk2l; Gprk4; GRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1631
                     /gene="Grk4"
                     /gene_synonym="A830025H08Rik; Gprk2l; Gprk4; GRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1840
                     /gene="Grk4"
                     /gene_synonym="A830025H08Rik; Gprk2l; Gprk4; GRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1978
                     /gene="Grk4"
                     /gene_synonym="A830025H08Rik; Gprk2l; Gprk4; GRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2116
                     /gene="Grk4"
                     /gene_synonym="A830025H08Rik; Gprk2l; Gprk4; GRK"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2248
                     /gene="Grk4"
                     /gene_synonym="A830025H08Rik; Gprk2l; Gprk4; GRK"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2408
                     /gene="Grk4"
                     /gene_synonym="A830025H08Rik; Gprk2l; Gprk4; GRK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2388..2393
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grk4"
                     /gene_synonym="A830025H08Rik; Gprk2l; Gprk4; GRK"
                     /note="putative"
ORIGIN      
        1 agccggggcc cagctgtctt gcgagttaac tggcggctgc ggctgccgct gctggagctg
       61 tcgccgtcgc cgctggagac cgctctcgag tttgtaagct cctcggtagg gtagggcgcg
      121 gcgaaggttg agtgctgccc aggacccggc gctgaggaga gagttacgcg ccctgggcct
      181 gggcgatgat gctgagagga gctcgagcta ccgcgcgccg gcgccgatag cggaagcccc
      241 ttgccgggac agcaacagag ctggaacccg tagcgagcct acccgtgtcc catctccgcg
      301 gcgaccgcga cggcgacagc gacggcgacg acggcagcgc tcctgttggc agttgtggcg
      361 accccggagg aggcggagga agaagcgaca gagacggtcg ctgtcgcgga gggccaccgt
      421 ccagaagccg cgttcctcaa aggacaaggg atgccccgag gcttctgccg cgggtttagg
      481 atctccttcc ccgcagcctt ccccgtctcc attgcctcga ctccgaaaag ttcgacgtcg
      541 gaaaccgcgg cagcgacggc gcaggacagc gatcatggaa ctcgagaact tcgtggccaa
      601 caatctgttg ctgaaggccc gtctaggatt taacaaacag actggtcgta gtaaaaaatg
      661 gagagagctc ctgaagtttc ccccagtcag catgtgcact gaattaagat ggtccatcga
      721 aaaggatttt agcagtcttt gcgacaaaca gccaattgga agacttcttt ttagacaatt
      781 ctgtgataca aaaccagatc taaaaaggtg cattgaattc ttggatgcag tggcagagta
      841 cgaagttacc attgaagagg aacaaagaga atttggacta gccatcttca gtagattctt
      901 caaagagaag tcagaagtcc ccttaccaga gatacctcca gatattgtga aagagtgtaa
      961 atggaatctg aagcagaatt ctccctctca aaatgttttc gaagaatgtg ctggaattgt
     1021 ctgtaagtat ttgagtgaaa caccatttga agaataccaa gaaagtacct actttaatcg
     1081 atttttacaa tggaaatggc tagaaaggcg tccagtaaca aagaacacat tcagacaata
     1141 tagagttcta ggaaaaggcg gatttggaga ggtttgtgcc tgtcaagtac gagctacagg
     1201 aaaaatgtat gcctgcaaaa aactagaaaa aaaaagaata aagaagagga aaggtgaagc
     1261 catggctctg aatgaaaaaa gaatcttaga aaaattgcat agtagatttg tagttagttt
     1321 agcctacact tatgaaacca aggatgcttt gtgtttggtg ctaaccataa tgaatggagg
     1381 ggatttgaag taccacattt acaacctggg tgatcctggc tttgaggagc cgagagctgt
     1441 gttctatgct gcagagctgt gctgtggctt ggaagattta cagaggaaaa gaattgtata
     1501 cagagaccta aagccagaga atatcctcct tgatgatcat ggacacatcc gaatttcaga
     1561 tcttggtcta gctatggaag tcccagaagg ggagatggta cgaggaagag ttggtactgt
     1621 tggctacatg gctccagaaa ttatcaatca tgaaaagtat acatttagtc ctgactggtg
     1681 gggacttggc tgtttgatat atgaaatgat tgcgggacat tctccattca gaaaatataa
     1741 agaaaaagtc aaccgggagg aattggaaag aagagtgaag aatgaaactg aggagtactc
     1801 tgagaggttt tcagaggatg ccaagtccat ctgcagcatg ttactcatca aagatccaag
     1861 taagagactg ggctgccaga gggatggagt ctctgctgta aagcagcacc caatattcaa
     1921 ggatataaac ttcagcaggc tggaagcaaa tatgttagat ccacctttca ttcctgatcc
     1981 tcaggccatt tattgtagga acatcttgga tattgggcag ttctctgtgg tgaaaggagt
     2041 caacctggat accaatgatg aaatcttcta cgctgaattt gcgacagggt ctgtcaccat
     2101 cccctggcag aatgagatga ttgaatctgg atgtttcaag gatctcaatg aaaatgaaga
     2161 cgatttgtca tcacttgaaa aatacaagat gtgttcctcc attctcagac caaagagaaa
     2221 cttcttccgt agactcttca gaagaacggg ctgcctgaac attgccctca gtgaggagag
     2281 ggagccaaca gaacactgac cattcactgt gcagaccaca gagcaagacc ttggtgttaa
     2341 gaaggaatct atcacatact cagtgtcttg tcctttccat aaattgtaat aaactgtctg
     2401 taacactg
//
