LOCUS       NM_177078               6578 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus G protein-coupled receptor kinase 3 (Grk3), transcript
            variant 1, mRNA.
ACCESSION   NM_177078 XM_913819 XM_922908 XM_922918
VERSION     NM_177078.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6578)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6578)
  AUTHORS   Rabjohns,E.M., Rampersad,R.R., Ghosh,A., Hurst,K., Eudy,A.M.,
            Brozowski,J.M., Lee,H.H., Ren,Y., Mirando,A., Gladman,J.,
            Bowser,J.L., Berg,K., Wani,S., Ralston,S.H., Hilton,M.J. and
            Tarrant,T.K.
  TITLE     Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice
            Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions
            Analogous to Human Paget's Disease of Bone
  JOURNAL   Cells 12 (7), 981 (2023)
   PUBMED   37048054
  REMARK    GeneRIF: Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient
            Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions
            Analogous to Human Paget's Disease of Bone.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6578)
  AUTHORS   Glaser,K.M., Tarrant,T.K. and Lammermann,T.
  TITLE     Combinatorial depletions of G-protein coupled receptor kinases in
            immune cells identify pleiotropic and cell type-specific functions
  JOURNAL   Front Immunol 13, 1039803 (2022)
   PUBMED   36451830
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6578)
  AUTHORS   Brozowski,J.M., Timoshchenko,R.G., Serafin,D.S., Allyn,B.,
            Koontz,J., Rabjohns,E.M., Rampersad,R.R., Ren,Y., Eudy,A.M.,
            Harris,T.F., Abraham,D., Mattox,D., Rubin,C.T., Hilton,M.J.,
            Rubin,J., Allbritton,N.L., Billard,M.J. and Tarrant,T.K.
  TITLE     G protein-coupled receptor kinase 3 modulates mesenchymal stem cell
            proliferation and differentiation through sphingosine-1-phosphate
            receptor regulation
  JOURNAL   Stem Cell Res Ther 13 (1), 37 (2022)
   PUBMED   35093170
  REMARK    GeneRIF: G protein-coupled receptor kinase 3 modulates mesenchymal
            stem cell proliferation and differentiation through
            sphingosine-1-phosphate receptor regulation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6578)
  AUTHORS   Sheng,Y., Chen,L., Ren,X., Jiang,Z. and Yau,K.W.
  TITLE     Molecular determinants of response kinetics of mouse M1
            intrinsically-photosensitive retinal ganglion cells
  JOURNAL   Sci Rep 11 (1), 23424 (2021)
   PUBMED   34873237
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6578)
  AUTHORS   Jaber,M., Koch,W.J., Rockman,H., Smith,B., Bond,R.A., Sulik,K.K.,
            Ross,J. Jr., Lefkowitz,R.J., Caron,M.G. and Giros,B.
  TITLE     Essential role of beta-adrenergic receptor kinase 1 in cardiac
            development and function
  JOURNAL   Proc Natl Acad Sci U S A 93 (23), 12974-12979 (1996)
   PUBMED   8917529
REFERENCE   7  (bases 1 to 6578)
  AUTHORS   Hughes,R.J., Anderson,K.L., Kiel,D. and Insel,P.A.
  TITLE     Cloning of GRK2 cDNA from S49 murine lymphoma cells
  JOURNAL   Am J Physiol 270 (3 Pt 1), C885-C891 (1996)
   PUBMED   8638670
REFERENCE   8  (bases 1 to 6578)
  AUTHORS   Koch,W.J., Rockman,H.A., Samama,P., Hamilton,R.A., Bond,R.A.,
            Milano,C.A. and Lefkowitz,R.J.
  TITLE     Cardiac function in mice overexpressing the beta-adrenergic
            receptor kinase or a beta ARK inhibitor
  JOURNAL   Science 268 (5215), 1350-1353 (1995)
   PUBMED   7761854
REFERENCE   9  (bases 1 to 6578)
  AUTHORS   Haga,T., Haga,K. and Kameyama,K.
  TITLE     G protein--coupled receptor kinases
  JOURNAL   J Neurochem 63 (2), 400-412 (1994)
   PUBMED   8035170
  REMARK    Review article
REFERENCE   10 (bases 1 to 6578)
  AUTHORS   Benovic,J.L., Onorato,J.J., Arriza,J.L., Stone,W.C., Lohse,M.,
            Jenkins,N.A., Gilbert,D.J., Copeland,N.G., Caron,M.G. and
            Lefkowitz,R.J.
  TITLE     Cloning, expression, and chromosomal localization of
            beta-adrenergic receptor kinase 2. A new member of the receptor
            kinase family
  JOURNAL   J Biol Chem 266 (23), 14939-14946 (1991)
   PUBMED   1869533
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ104587.1, AK134672.1, AK076533.1 and AI851927.1.
            
            On Oct 23, 2013 this sequence version replaced NM_177078.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134672.1, SRR10223970.7809.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                CJ104587.1         2-25
            25-1015             AK134672.1         2-992
            1016-1016           AK076533.1         914-914
            1017-4787           AK134672.1         994-4764
            4788-6557           AK134672.1         4766-6535
            6558-6578           AI851927.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..6578
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 55.29 cM"
     gene            1..6578
                     /gene="Grk3"
                     /gene_synonym="4833444A01Rik; Adrbk-2; Adrbk2; Bark-2"
                     /note="G protein-coupled receptor kinase 3"
                     /db_xref="GeneID:320129"
                     /db_xref="MGI:MGI:87941"
     exon            1..172
                     /gene="Grk3"
                     /gene_synonym="4833444A01Rik; Adrbk-2; Adrbk2; Bark-2"
                     /inference="alignment:Splign:2.1.0"
     exon            173..249
                     /gene="Grk3"
                     /gene_synonym="4833444A01Rik; Adrbk-2; Adrbk2; Bark-2"
                     /inference="alignment:Splign:2.1.0"
     exon            250..323
                     /gene="Grk3"
                     /gene_synonym="4833444A01Rik; Adrbk-2; Adrbk2; Bark-2"
                     /inference="alignment:Splign:2.1.0"
     exon            324..425
                     /gene="Grk3"
                     /gene_synonym="4833444A01Rik; Adrbk-2; Adrbk2; Bark-2"
                     /inference="alignment:Splign:2.1.0"
     exon            426..500
                     /gene="Grk3"
                     /gene_synonym="4833444A01Rik; Adrbk-2; Adrbk2; Bark-2"
                     /inference="alignment:Splign:2.1.0"
     exon            501..562
                     /gene="Grk3"
                     /gene_synonym="4833444A01Rik; Adrbk-2; Adrbk2; Bark-2"
                     /inference="alignment:Splign:2.1.0"
     exon            563..614
                     /gene="Grk3"
                     /gene_synonym="4833444A01Rik; Adrbk-2; Adrbk2; Bark-2"
                     /inference="alignment:Splign:2.1.0"
     exon            615..706
                     /gene="Grk3"
                     /gene_synonym="4833444A01Rik; Adrbk-2; Adrbk2; Bark-2"
                     /inference="alignment:Splign:2.1.0"
     exon            707..806
                     /gene="Grk3"
                     /gene_synonym="4833444A01Rik; Adrbk-2; Adrbk2; Bark-2"
                     /inference="alignment:Splign:2.1.0"
     exon            807..885
                     /gene="Grk3"
                     /gene_synonym="4833444A01Rik; Adrbk-2; Adrbk2; Bark-2"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1016
                     /gene="Grk3"
                     /gene_synonym="4833444A01Rik; Adrbk-2; Adrbk2; Bark-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1111
                     /gene="Grk3"
                     /gene_synonym="4833444A01Rik; Adrbk-2; Adrbk2; Bark-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1219
                     /gene="Grk3"
                     /gene_synonym="4833444A01Rik; Adrbk-2; Adrbk2; Bark-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1286
                     /gene="Grk3"
                     /gene_synonym="4833444A01Rik; Adrbk-2; Adrbk2; Bark-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1387
                     /gene="Grk3"
                     /gene_synonym="4833444A01Rik; Adrbk-2; Adrbk2; Bark-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1454
                     /gene="Grk3"
                     /gene_synonym="4833444A01Rik; Adrbk-2; Adrbk2; Bark-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1550
                     /gene="Grk3"
                     /gene_synonym="4833444A01Rik; Adrbk-2; Adrbk2; Bark-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1713
                     /gene="Grk3"
                     /gene_synonym="4833444A01Rik; Adrbk-2; Adrbk2; Bark-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1850
                     /gene="Grk3"
                     /gene_synonym="4833444A01Rik; Adrbk-2; Adrbk2; Bark-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1964
                     /gene="Grk3"
                     /gene_synonym="4833444A01Rik; Adrbk-2; Adrbk2; Bark-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..6561
                     /gene="Grk3"
                     /gene_synonym="4833444A01Rik; Adrbk-2; Adrbk2; Bark-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6535..6540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grk3"
                     /gene_synonym="4833444A01Rik; Adrbk-2; Adrbk2; Bark-2"
                     /note="hexamer: AATAAA"
     polyA_site      6558
                     /gene="Grk3"
                     /gene_synonym="4833444A01Rik; Adrbk-2; Adrbk2; Bark-2"
                     /note="major polyA site"
ORIGIN      
        1 ggggtcgcgc gtcgggcgcg ccgtggcccc gtcggggcgg cgggagctgc ggagccgcca
       61 tggcggacct ggaggccgtg ctggccgacg tcagctacct gatggccatg gagaagagca
      121 agacggcgcc ggccgcgcgc gccagcaaga aggtcgtcct gccggagccc agtatccgga
      181 gtgtgatgca gaggtatctg gcagagagaa acgaaataac ctttgacaag attttcaatc
      241 agaaaatcgg cttcctacta tttaaagact tctgcttgaa tgaaattggg gaagcagtgc
      301 ctcaggtgaa attttatgaa gagataaaag aatatgagaa gctggacaac gaagaggata
      361 ggctacgccg gagccggcag atgtacgacg cctacatcat gagggagctc ctatccagca
      421 cacaccaatt ctcaaagcaa gctgtagaac atgtccagag ccatctctcc aagaaacagg
      481 tgacggctac acttttccag ccatacatag aagaaatctg tgaaagcctt cgtggggata
      541 ttttccaaaa gtttatggaa agcgataaat tcactagatt ctgtcagtgg aagaacgtgg
      601 agttgaatat tcacctgagc atgaacgact tcagtgtgca caggatcatc ggccgaggag
      661 ggtttgggga agtttatggc tgcaggaaag cagacaccgg taaaatgtat gccatgaagt
      721 gcttagacaa gaaaagggtg aagatgaagc agggggagac tctggctttg aacgagagga
      781 tcatgctgtc tctcgttagc actggggatt gtccctttat tgtctgcatg acctacgcct
      841 tccacacgcc ggacaaactc tgcttcatcc tggacctgat gaacgggggc gacatgcact
      901 accatctctc tcaacacggg gtgttttctg agaaggagat gcggttttat gccagcgaga
      961 tcatcctggg cctcgagcac atgcacacct gcttcgtagt ctacagagac ctgaagcctg
     1021 cgaacatcct cctagatgaa tatgggcacg tgaggatatc ggatctcggc cttgcctgcg
     1081 atttctccaa aaagaagcct catgccagcg tgggcaccca tgggtacatg gctcccgagg
     1141 tgttgcagaa gggaacgtgc tatgacagca gcgccgactg gttctccctg ggctgtatgc
     1201 tcttcaagct tctgcggggc cacagcccct tcaggcagca taaaaccaaa gacaagcatg
     1261 agatagaccg aatgaccctg accgtgaacg tgcagcttcc agatgccttc tcccctgagc
     1321 tgaggtccct cttagagggt ttgctccagc gggacgtgag ccagcggctg ggctgcggag
     1381 gaggaggggc acgagagttg aaggagcaca tcttcttcaa gggcattgac tggcagcatg
     1441 tgtacttacg gaagtacccg ccacccctaa tccctcctcg gggagaggtc aacgctgcag
     1501 atgccttcga tatcggctcc ttcgatgagg aagacaccaa aggcattaag ctgttggact
     1561 gtgaccagga cctctataag aacttcccac tggtgatctc cgagcgctgg cagcaagaag
     1621 tggtggagac catctatgac gccgtcaatg ctgatactga taaaatcgag gccaggagga
     1681 aggctaaaaa taagcaactt ggtcaagagg aagattacgc tatggggaag gactgcatca
     1741 tgcacgggta catgctgaag ctggggaacc cctttctcac acagtggcaa agacgctatt
     1801 tttacctgtt ccccaacaga ctggagtgga gaggagaggg cgagtctcgg caaagtctac
     1861 tgaccatgga acagatcatg tctgtggagg agacccagat taaagacaga aagtgcatct
     1921 tactcaggat aaagggaggg aagcaatttg tcttgcaatg tgagagtgac cccgagtttg
     1981 cacagtggct gaaggagctg acctgcacct tcaatgaggc ccagagactg ctgcgccgtg
     2041 cccccaaatt cctcaacaaa ccacgggccg ccatcctgga gttctccaag ccaccactgt
     2101 gtcacagaaa tagcagcggc ctctgaacca cagagcagcg gggcctgaag gaggggcccc
     2161 agctcttcag cccaggagtg gaacgaagcc acggggaacc gtgtggggct aagacacagt
     2221 gtttctgagc actgacgggg ctgctccaag ccgaggaggc tcaggacacc agggcggcct
     2281 tctgggagct gggacatcct cggggctgtc ctatccacac tcgaaattac tgaagaagca
     2341 gaggcattct gctgtgcaac tctctcactt tggtatccag ggacccagaa cgtaaaatgg
     2401 tccttacttc tcaagctttt atgtctggca gggagcatat ctggggtgga agcacggtct
     2461 ctgggactat ggtggcctgt tctaggcatt gctgtgtccg agtgcctgcc tgaggtgtag
     2521 gggttgaggc tccagacact ggaggagggt ctctgtaggt cagggctgac tccttgctgt
     2581 ccctgaggcg atgaggtaac cctgagtatc gtgtgcactt ccttcctctg atgacttctt
     2641 tccagggatg cccctcgagg aaacttcgcg gcatccatca cagccatttc tggtgggcac
     2701 agacttcaag caggacctag gtaacccacc agacagtgcc cccaatgcat ggcgtgcata
     2761 aacttggagt caccatcaat ggttaggtat gacagagtcc tcctgatccc ccagtttgac
     2821 ctggggagca tctgaggatg tgcccaagat agacaagagt tgctgccttg tctttcagta
     2881 tagcttataa tgatctcaca ctggtgggtg acagtgtcca gcggtcggtc ccctatgcgc
     2941 cctggcatgc cccataccct ctgtcactaa tgcactgtgc gctgagttat tctgatgggg
     3001 gcagcagttt gcccagcccc cttcccctta aaagtgggtt tctctgctgc tgcctggccc
     3061 catgtcacac aatgagaagt cctgcaaggt ctcggtggac ttgtccaatt cctgaggcct
     3121 tgggggcggg ggcagtatgg tagtgttact gggtctctag atgaagtccc gagcacataa
     3181 cctgacagca gaattctttg tgttctgtcc tggatcttcc tgacagtccc cagtgtgtat
     3241 tatgttcttg tgctggggaa aatgaggtgt ttatttattg atatctatgg ggtttttttt
     3301 ttaattgcaa ctaccttttg agaatttgga agataattta ctgagagggt ccattactcg
     3361 gcaggtgcat gagggacctg tgagactcag ggcctgtctc accgcacatg aattctgggt
     3421 tcatgatcac gcacagggcc gctgttcact gcctccaggg tgggaatgtg gcgtcacctg
     3481 gcagggacac cctgcttgct taaaagacta atattcagat tcttctactt ctactactac
     3541 tactactact actactacta ctactactac tactactact acacacacac acacttaagc
     3601 gttgtggtta ctgtgtaggc atggttagta tggacagctc acacatgctc agtcagacct
     3661 gcagggaggg gtaggagctg tatctctggt ctctttagca catatagaga cctcccccca
     3721 ccccttccac attgggaggg aacttgaccc cagcaggtgc tgggctagct gtaacagtct
     3781 cttatcgggg ttatagctat accaaagtct ttcaagatgg cacaggatca tgggatcctg
     3841 cacctgcact aaatcacgcc agactggcac aaatatcatg tgttattatt ggccaagtta
     3901 attttaaggc ccctttcctt ttagaaaaag aagtgtgtgt gggtgtgtgt atggtggggt
     3961 ctcctgccct caaccccatt tccctcgggg acaggaatga gagagagtgc agatggcctc
     4021 tggcatagtc ctaaagattc atatatgggc tggtggtgga tctgctagcg ccatctcaaa
     4081 ggccatcttt ccaccctggc atgtggctag ggtgtgtcct ggatccatag ggtgggagga
     4141 ggagccagat gggtttatga tacatggctg tttgagagtt cccatcatgc aggcaagtcc
     4201 ctagatgcct cttgtactca gactgttaac agggcgagtc atgagtacta gtgacctggg
     4261 tttctggcct ggatcactta tcatgatgga ggatgttcca cttattgctg tttttacaca
     4321 gctatactct acataggcgt ggtttcataa ggcaagaatc aatgcacaaa gtccaagaat
     4381 atcagataat tttagagcca ctatgtgaca cacaccaaat taaaaccttt ggcaagcccc
     4441 agtttgttta ttatttattt taatctaaac taccctcttg tccttagggc tccctgcttt
     4501 tcctctgggt cataattaaa tgtgtgggtt ttttgttttt gtttttgttt tttgtttttg
     4561 tttttaaaca aagcctgtgg aaattgtcac actgtagtgg ttgacagagg aacctgtctt
     4621 gctactgata ctcaagtgtg cacattgaaa ggcccattgg ctgacattac aaactgtcca
     4681 tgtaaaacca gcaatgaagg atggatggtg acctacaggg gaaagacact gcaggttcac
     4741 aagcccagcc ttgattggca gaggcaggag gcttatgagt ttgaggctag cctggcctac
     4801 atggcaagtc tctgcctcca gaacaccaag ggctatggca gtagctctgg gccaaggtct
     4861 tgccttacat ctccaagatt ctgggtttaa ttcccagagg gtgtggacag cgggcagcag
     4921 actgttagcc aactaataag atttatctct agtggccgcc ttgaccttgg ctatgtgtct
     4981 gtgagaagca gctgttctga ggccccacta gccaggattg ttcaccagtg gtcagtgtga
     5041 cagagaggca gagcaactcg gtacaggaac tcaccgtttc agtggtaggg taaggacaga
     5101 gggagaaggc ttggttggct gatggaagcc acacacttgg catgatgacc caccaaggag
     5161 ggaatgaggg gagctcaagg gacacgccct cagaatcccc caaggatttt tgcaagactt
     5221 gcttcgttcc tgaggccgag ttgccccgtc atgaaggtgc cgccacgtgt tcttctatgg
     5281 acattcccag gaaggtccct catcagtggt acatccccgg acactgagtc tgtcacctga
     5341 gactgtggct gtgtcgccca ggcagtgtga ggctgtgacc tagtcactgt ccatgaatgg
     5401 gctgtggagg ggtgcgtgtc caacttagat gtggtgaacc tcagaatggc atcaccgcct
     5461 tcctacatgt ttgattccac ttctacttgg aacttccata atttaaattt aaaaaaaaaa
     5521 atcgtttctc ttcctaagtg aggtttactc gaaagtctca attgctcaca ttcatgttaa
     5581 taggacctct tgctttaact tcattggttg gttcaaggcc tcttttcctt tatttgttgc
     5641 tatgggaatg aagaaggatg agcccaaagc ctcttctcca ttcttggtgg acattagcat
     5701 tttctctgtt ggttgctttt gtcaacttag acaaataaga gagaacgcag cacagcacct
     5761 cagactggca gccccaggat tcaggacact gagacaggag aatgataagt cctgggacgt
     5821 cctgggctac agctacaggg gaaaccctgc cttaggaaca aatcaactaa cagacggagt
     5881 tgtttcctga cacaggtgtg aacactccta caagccaccc gaaggtgcca tgttcccaaa
     5941 gtgggaaacc acgcacttta aatggccttc aattgaaaag cagccacaga gacttggttc
     6001 gaaatgttcg cctttcatga aggacagaag tcgttacagc taattcaaat ccatagcgta
     6061 gagttaggtc tcggcttcta atagtctgag tccttccagg aaacagaaac ctatgccatc
     6121 cctttttatt ttgccctaaa tgtaaaacat ctttgacagc agcttgggag tggagccatc
     6181 attctgatta tcaactgtga tttttttttc cctccatttc cttggatttt tcacctgccc
     6241 tgtggttata tgtattgtat gtggtttata aattcaacac tggctttttt ttagttctgt
     6301 tattaaatta tatttttcta tgttctaagt aatagcagat ctggcttctt ctggtaacag
     6361 agatggatgg acctgtaact aggagacaag agttctattt tagcacaaaa gcattttata
     6421 ttatttattg aatccgtatg tgcgttccca tggaaaccat ctgtatttct gcttcttgtg
     6481 atctgtatag tttgttattt aaagagagat ggcagccttt tgtgttgctg aaacaataaa
     6541 accaagctcc tacaagcagt gaaaaaaaaa aaaaaaaa
//
