LOCUS       NM_001290818            3379 bp    mRNA    linear   ROD 29-MAY-2023
DEFINITION  Mus musculus G protein-coupled receptor kinase 2 (Grk2), transcript
            variant 1, mRNA.
ACCESSION   NM_001290818 XM_006531633
VERSION     NM_001290818.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3379)
  AUTHORS   Zhang J, Zhang X, Shi X, Liu Y, Cheng D, Tian Q, Lin N, Wei W and
            Wu H.
  TITLE     CXCL9, 10, 11/CXCR3 Axis Contributes to the Progress of Primary
            Sjogren's Syndrome by Activating GRK2 to Promote T Lymphocyte
            Migration
  JOURNAL   Inflammation 46 (3), 1047-1060 (2023)
   PUBMED   36801996
  REMARK    GeneRIF: CXCL9, 10, 11/CXCR3 Axis Contributes to the Progress of
            Primary Sjogren's Syndrome by Activating GRK2 to Promote T
            Lymphocyte Migration.
REFERENCE   2  (bases 1 to 3379)
  AUTHORS   Yano H, Onoue K, Tokinaga S, Ioka T, Ishihara S, Hashimoto Y,
            Nakada Y, Nakagawa H, Ueda T, Seno A, Nishida T, Watanabe M and
            Saito Y.
  TITLE     Overexpression of GRK2 in vascular smooth muscle leads to
            inappropriate hypertension and acute heart failure as in clinical
            scenario 1
  JOURNAL   Sci Rep 13 (1), 7707 (2023)
   PUBMED   37173348
  REMARK    GeneRIF: Overexpression of GRK2 in vascular smooth muscle leads to
            inappropriate hypertension and acute heart failure as in clinical
            scenario 1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3379)
  AUTHORS   Thapaliya M and Ali H.
  TITLE     GRK2 differentially regulates FcepsilonRI and MRGPRB2-mediated
            responses in mast cells
  JOURNAL   Front Immunol 14, 1155777 (2023)
   PUBMED   37063868
  REMARK    GeneRIF: GRK2 differentially regulates FcepsilonRI and
            MRGPRB2-mediated responses in mast cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3379)
  AUTHORS   Fu L, Adu-Amankwaah J, Sang L, Tang Z, Gong Z, Zhang X, Li T and
            Sun H.
  TITLE     Gender differences in GRK2 in cardiovascular diseases and its
            interactions with estrogen
  JOURNAL   Am J Physiol Cell Physiol 324 (2), C505-C516 (2023)
   PUBMED   36622065
  REMARK    GeneRIF: Gender differences in GRK2 in cardiovascular diseases and
            its interactions with estrogen.
            Review article
REFERENCE   5  (bases 1 to 3379)
  AUTHORS   Glaser KM, Tarrant TK and Lammermann T.
  TITLE     Combinatorial depletions of G-protein coupled receptor kinases in
            immune cells identify pleiotropic and cell type-specific functions
  JOURNAL   Front Immunol 13, 1039803 (2022)
   PUBMED   36451830
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3379)
  AUTHORS   Koch WJ, Rockman HA, Samama P, Hamilton RA, Bond RA, Milano CA and
            Lefkowitz RJ.
  TITLE     Cardiac function in mice overexpressing the beta-adrenergic
            receptor kinase or a beta ARK inhibitor
  JOURNAL   Science 268 (5215), 1350-1353 (1995)
   PUBMED   7761854
REFERENCE   7  (bases 1 to 3379)
  AUTHORS   Tsukada S, Simon MI, Witte ON and Katz A.
  TITLE     Binding of beta gamma subunits of heterotrimeric G proteins to the
            PH domain of Bruton tyrosine kinase
  JOURNAL   Proc Natl Acad Sci U S A 91 (23), 11256-11260 (1994)
   PUBMED   7972043
REFERENCE   8  (bases 1 to 3379)
  AUTHORS   Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg
            JR, Trask BJ, de Jong P, Reed RR, Simon MI et al.
  TITLE     Evolution of the mammalian G protein alpha subunit multigene family
  JOURNAL   Nat Genet 1 (2), 85-91 (1992)
   PUBMED   1302014
  REMARK    Review article
REFERENCE   9  (bases 1 to 3379)
  AUTHORS   Benovic JL, Onorato JJ, Arriza JL, Stone WC, Lohse M, Jenkins NA,
            Gilbert DJ, Copeland NG, Caron MG and Lefkowitz RJ.
  TITLE     Cloning, expression, and chromosomal localization of
            beta-adrenergic receptor kinase 2. A new member of the receptor
            kinase family
  JOURNAL   J Biol Chem 266 (23), 14939-14946 (1991)
   PUBMED   1869533
REFERENCE   10 (bases 1 to 3379)
  AUTHORS   Benovic,J.L., Strasser,R.H., Caron,M.G. and Lefkowitz,R.J.
  TITLE     Beta-adrenergic receptor kinase: identification of a novel protein
            kinase that phosphorylates the agonist-occupied form of the
            receptor
  JOURNAL   Proc Natl Acad Sci U S A 83 (9), 2797-2801 (1986)
   PUBMED   2871555
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK155691.1 and AA014484.1.
            
            [WARNING] On Nov 29, 2023 this sequence was replaced by
            NM_001290818.2.
            
            On Mar 20, 2014 this sequence version replaced XM_006531633.1.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155691.1, BC003196.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3376              AK155691.1         2-3377
            3377-3379           AA014484.1         410-412
FEATURES             Location/Qualifiers
     source          1..3379
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 3.98 cM"
     gene            1..3379
                     /gene="Grk2"
                     /gene_synonym="Adrbk-1; Adrbk1; Bark-1; beta ARK;
                     betaARK1"
                     /note="G protein-coupled receptor kinase 2"
                     /db_xref="GeneID:110355"
                     /db_xref="MGI:MGI:87940"
     exon            1..321
                     /gene="Grk2"
                     /gene_synonym="Adrbk-1; Adrbk1; Bark-1; beta ARK;
                     betaARK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..2278
                     /gene="Grk2"
                     /gene_synonym="Adrbk-1; Adrbk1; Bark-1; beta ARK;
                     betaARK1"
                     /EC_number="2.7.11.15"
                     /note="isoform 1 is encoded by transcript variant 1;
                     beta-adrenergic receptor kinase 1; beta-AR kinase-1;
                     adrenergic receptor kinase, beta 1"
                     /codon_start=1
                     /product="beta-adrenergic receptor kinase 1 isoform 1"
                     /protein_id="NP_001277747.1"
                     /db_xref="CCDS:CCDS70915.1"
                     /db_xref="GeneID:110355"
                     /db_xref="MGI:MGI:87940"
                     /translation="MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQ
                     KYLEDRGEVTFEKIFSQKLGYLLFRDFCLNHLEEAKPLVEFYEEIKKYEKLETEEERV
                     VRSREIFDSYIMKELLACSHPFSKNATEHVQGHLVKKQVPPDLFQPYIEEICQNLRGD
                     VFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYA
                     MKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNG
                     GDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRIS
                     DLGLACDFSKKRPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFR
                     QHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKES
                     PFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRN
                     FPLTISERWQQEVAETVFDTINAETDRLEARKKAKNKQLGHEEDYALGKDCIVHGYMS
                     KMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKI
                     RGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQ
                     RGSANGL"
     exon            322..398
                     /gene="Grk2"
                     /gene_synonym="Adrbk-1; Adrbk1; Bark-1; beta ARK;
                     betaARK1"
                     /inference="alignment:Splign:2.1.0"
     exon            399..472
                     /gene="Grk2"
                     /gene_synonym="Adrbk-1; Adrbk1; Bark-1; beta ARK;
                     betaARK1"
                     /inference="alignment:Splign:2.1.0"
     exon            473..574
                     /gene="Grk2"
                     /gene_synonym="Adrbk-1; Adrbk1; Bark-1; beta ARK;
                     betaARK1"
                     /inference="alignment:Splign:2.1.0"
     exon            575..649
                     /gene="Grk2"
                     /gene_synonym="Adrbk-1; Adrbk1; Bark-1; beta ARK;
                     betaARK1"
                     /inference="alignment:Splign:2.1.0"
     exon            650..711
                     /gene="Grk2"
                     /gene_synonym="Adrbk-1; Adrbk1; Bark-1; beta ARK;
                     betaARK1"
                     /inference="alignment:Splign:2.1.0"
     exon            712..763
                     /gene="Grk2"
                     /gene_synonym="Adrbk-1; Adrbk1; Bark-1; beta ARK;
                     betaARK1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..855
                     /gene="Grk2"
                     /gene_synonym="Adrbk-1; Adrbk1; Bark-1; beta ARK;
                     betaARK1"
                     /inference="alignment:Splign:2.1.0"
     exon            856..955
                     /gene="Grk2"
                     /gene_synonym="Adrbk-1; Adrbk1; Bark-1; beta ARK;
                     betaARK1"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1034
                     /gene="Grk2"
                     /gene_synonym="Adrbk-1; Adrbk1; Bark-1; beta ARK;
                     betaARK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1165
                     /gene="Grk2"
                     /gene_synonym="Adrbk-1; Adrbk1; Bark-1; beta ARK;
                     betaARK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1260
                     /gene="Grk2"
                     /gene_synonym="Adrbk-1; Adrbk1; Bark-1; beta ARK;
                     betaARK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1368
                     /gene="Grk2"
                     /gene_synonym="Adrbk-1; Adrbk1; Bark-1; beta ARK;
                     betaARK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1435
                     /gene="Grk2"
                     /gene_synonym="Adrbk-1; Adrbk1; Bark-1; beta ARK;
                     betaARK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1536
                     /gene="Grk2"
                     /gene_synonym="Adrbk-1; Adrbk1; Bark-1; beta ARK;
                     betaARK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1603
                     /gene="Grk2"
                     /gene_synonym="Adrbk-1; Adrbk1; Bark-1; beta ARK;
                     betaARK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1699
                     /gene="Grk2"
                     /gene_synonym="Adrbk-1; Adrbk1; Bark-1; beta ARK;
                     betaARK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1862
                     /gene="Grk2"
                     /gene_synonym="Adrbk-1; Adrbk1; Bark-1; beta ARK;
                     betaARK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1999
                     /gene="Grk2"
                     /gene_synonym="Adrbk-1; Adrbk1; Bark-1; beta ARK;
                     betaARK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2113
                     /gene="Grk2"
                     /gene_synonym="Adrbk-1; Adrbk1; Bark-1; beta ARK;
                     betaARK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..3379
                     /gene="Grk2"
                     /gene_synonym="Adrbk-1; Adrbk1; Bark-1; beta ARK;
                     betaARK1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcccggcg ggagcggagc gcgagccggg ccgggcccga gccggcgcca tggggcggcg
       61 ccgcctgtga gccggcgacg agcgaggacc gggcggggcg gcggcggcgc cgaggcccac
      121 aagccgcgcg ggccgggccg ggccgagcga gcgggagcgg agcggagcct cgggcggcgg
      181 gaggaacagc gccgccgccg ccgccaagat ggccgacctg gaggcggtgc tggccgatgt
      241 gagctacctg atggccatgg agaagagcaa ggccacgccg gccgcgcgcg ccagcaagaa
      301 gatcctgctg ccagagccca gcatccgcag cgtcatgcag aagtatctgg aggaccgagg
      361 agaagtgacc tttgaaaaga tcttttcgca gaagttaggg tacctgcttt tccgggactt
      421 ctgcctgaac catctggaag aggccaagcc cttggtggag ttctacgaag agatcaagaa
      481 atatgagaag ctggagacag aggaggaacg tgtggtccgc agccgagaga tctttgactc
      541 ctatattatg aaagaactgc tggcctgctc acatcccttt tcaaagaatg ctacggagca
      601 tgtccagggc cacctggtga agaagcaggt gcctccagat ctcttccagc catacattga
      661 ggagatttgt cagaacctcc gaggggacgt gttccagaag ttcatagaga gtgacaagtt
      721 cacacggttc tgccagtgga agaatgttga gctcaacatc cacctgacca tgaatgactt
      781 cagtgtgcat cgaatcatcg ggcgtggggg cttcggtgag gtctatgggt gccggaaagc
      841 agacacaggc aagatgtacg ccatgaagtg tctggacaag aaacgcatca agatgaagca
      901 gggagagacc ctggctctga acgagcggat catgctttcc ctcgtcagca ccggggactg
      961 ccccttcatc gtgtgcatgt catatgcatt ccacacacca gacaagctca gcttcatcct
     1021 ggacctcatg aacggtgggg acctgcacta ccacctgtct cagcatggag tcttctctga
     1081 agccgacatg cgcttctacg ccgctgagat catcctgggc cttgaacaca tgcacaatcg
     1141 ctttgtagtc tacagggacc tgaagccagc caacattctc ctggatgaac atggccatgt
     1201 gagaatctcg gacctgggcc tagcctgtga cttctccaag aagaggcctc atgccagtgt
     1261 gggcacacac gggtacatgg cccccgaagt cctacagaag ggcgtggcct atgacagcag
     1321 tgcagactgg ttctccctgg gctgcatgct cttcaagttg ttgcggggac acagcccctt
     1381 ccggcagcac aagaccaaag acaagcatga gattgaccgc atgacgttga cgatggctgt
     1441 agagctgcct gactccttct cccctgaact ccgatccctg ctggaaggtt tgttgcagag
     1501 ggacgtcaat cggagactag gctgtctggg ccgtggggct caggaggtaa aagaaagtcc
     1561 tttctttcgt tccctggact ggcagatggt cttcttacag aagtaccctc ctccactgat
     1621 ccccccacgt ggggaggtga atgcagctga cgctttcgac attggctcct ttgatgagga
     1681 ggacacaaaa ggaatcaagt tactggacag tgaccaggaa ctgtaccgca acttccctct
     1741 caccatctct gagcggtggc aacaggaggt ggcagagact gtctttgata ccatcaatgc
     1801 tgaaacagac cggctggagg cacgaaagaa ggccaaaaac aaacagctgg gccacgagga
     1861 ggactatgcc ctgggtaagg actgcatcgt gcatggctac atgtccaaga tgggcaaccc
     1921 cttcctgacc cagtggcagc ggcgatactt ctacttgttc cccaaccggc tcgagtggag
     1981 gggtgaaggc gaggctccgc agagcctcct gaccatggag gagatccagt cagtggaaga
     2041 gacacagatc aaggaacgca agtgtctcct gcttaagatc cgaggtggca agcagtttgt
     2101 cctgcagtgt gatagtgatc cagagctggt gcaatggaaa aaggagctgc gtgatgccta
     2161 ccgcgaggcc cagcagctgg tacagcgagt acccaagatg aagaacaagc cacgctcgcc
     2221 tgtggtggag ctgagcaagg tgccgctgat ccagcgtggc agtgccaacg gcctctgatc
     2281 cacccatgtg ctgcccgcct gcccacccgc cttttataaa cctctaattt attttgttga
     2341 atttttatta tttgttttcc cgcaaagcgg aaaatgtttt attttgtaat tattgtgatc
     2401 tcctgtggcc ccagcctggc ccagccccca gggaggggcc cgcttgcctc agctcctgct
     2461 gccaccaacc cagccactgt ctagcacccc tcccctgtcc ccactcccac cccctagggt
     2521 ccttgctccc agtatcttcc tacagggaag aagagcaacc ctcagcagcc ctcttgcccc
     2581 tccatggggt gaagccacac tcagtgggtg tgtcacttca ggctctgtgg gctgtgctca
     2641 gtctgtggcc cagcacccct gccctagaaa ggggcaacac agggtactac ttgaactttc
     2701 ctatcacagc tcccatgcca cagagggaca gacccctgct gtcctgccct cttgccactg
     2761 gtgagagaag gcccttgtct cctcagacta ggaggtctcc cacagtgaca gctcctgggt
     2821 ccttgttcag gaaaagcctg tgtgttacca ctgcctcatc aggaggctgc cattggcagt
     2881 ggctgctgct ggcctccctg caagtcccct cttcttcctg ttgcgtgcct ggactcagga
     2941 gcatagaaaa gacaattgtg gattgggcca cactggccta gcctgaacct agatccctaa
     3001 ccctgggctg ggtgaggctc acctgcccag gaccacagtg ggacagcctg ggcaggtggg
     3061 tggcacagca taagaaccca gctggggcca gccctccctg tcctggctgg tcagtgtgcc
     3121 cccacccaca ctgtccagcc ccttagccca tgtcatgtca gtggccactg cccacaggtg
     3181 ccaccttgcc caccgcatga ccccttgtgc cagtcgcgca gctgtgtgtg gtgtcgcgcc
     3241 ctctcccctt gggggctggg tgggcacacc ctcccctctt gtctactcac tcctagggcg
     3301 tttctttgcc gatttttgaa tgtgatttta aagagtggaa aatgagacta tgcgttttta
     3361 taaaaaatgg tgcctgact
//
