LOCUS       NM_011881               7462 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus G protein-coupled receptor kinase 1 (Grk1), mRNA.
ACCESSION   NM_011881 XM_907847
VERSION     NM_011881.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7462)
  AUTHORS   Ng,L., Liu,H., Liu,Y. and Forrest,D.
  TITLE     Biphasic expression of thyroid hormone receptor TRbeta1 in
            mammalian retina and anterior ocular tissues
  JOURNAL   Front Endocrinol (Lausanne) 14, 1174600 (2023)
   PUBMED   37033230
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7462)
  AUTHORS   Maddala,R., Gao,J., Mathias,R.T., Lewis,T.R., Arshavsky,V.Y.,
            Levine,A., Backer,J.M., Bresnick,A.R. and Rao,P.V.
  TITLE     Absence of S100A4 in the mouse lens induces an aberrant
            retina-specific differentiation program and cataract
  JOURNAL   Sci Rep 11 (1), 2203 (2021)
   PUBMED   33500475
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7462)
  AUTHORS   Merlini,M., Rafalski,V.A., Ma,K., Kim,K.Y., Bushong,E.A., Rios
            Coronado,P.E., Yan,Z., Mendiola,A.S., Sozmen,E.G., Ryu,J.K.,
            Haberl,M.G., Madany,M., Sampson,D.N., Petersen,M.A., Bardehle,S.,
            Tognatta,R., Dean,T. Jr., Acevedo,R.M., Cabriga,B., Thomas,R.,
            Coughlin,S.R., Ellisman,M.H., Palop,J.J. and Akassoglou,K.
  TITLE     Microglial Gi-dependent dynamics regulate brain network
            hyperexcitability
  JOURNAL   Nat Neurosci 24 (1), 19-23 (2021)
   PUBMED   33318667
  REMARK    GeneRIF: Microglial Gi-dependent dynamics regulate brain network
            hyperexcitability.
REFERENCE   4  (bases 1 to 7462)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7462)
  AUTHORS   Kolesnikov,A.V., Chrispell,J.D., Osawa,S., Kefalov,V.J. and
            Weiss,E.R.
  TITLE     Phosphorylation at Serine 21 in G protein-coupled receptor kinase 1
            (GRK1) is required for normal kinetics of dark adaption in rod but
            not cone photoreceptors
  JOURNAL   FASEB J 34 (2), 2677-2690 (2020)
   PUBMED   31908030
  REMARK    GeneRIF: Phosphorylation at Serine 21 in G protein-coupled receptor
            kinase 1 (GRK1) is required for normal kinetics of dark adaption in
            rod but not cone photoreceptors.
REFERENCE   6  (bases 1 to 7462)
  AUTHORS   Zhang,H., Huang,W., Zhang,H., Zhu,X., Craft,C.M., Baehr,W. and
            Chen,C.K.
  TITLE     Light-dependent redistribution of visual arrestins and transducin
            subunits in mice with defective phototransduction
  JOURNAL   Mol Vis 9, 231-237 (2003)
   PUBMED   12802257
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7462)
  AUTHORS   Mendez,A., Lem,J., Simon,M. and Chen,J.
  TITLE     Light-dependent translocation of arrestin in the absence of
            rhodopsin phosphorylation and transducin signaling
  JOURNAL   J Neurosci 23 (8), 3124-3129 (2003)
   PUBMED   12716919
REFERENCE   8  (bases 1 to 7462)
  AUTHORS   Choi,S., Hao,W., Chen,C.K. and Simon,M.I.
  TITLE     Gene expression profiles of light-induced apoptosis in
            arrestin/rhodopsin kinase-deficient mouse retinas
  JOURNAL   Proc Natl Acad Sci U S A 98 (23), 13096-13101 (2001)
   PUBMED   11687607
REFERENCE   9  (bases 1 to 7462)
  AUTHORS   Lyubarsky,A.L., Chen,C., Simon,M.I. and Pugh,E.N. Jr.
  TITLE     Mice lacking G-protein receptor kinase 1 have profoundly slowed
            recovery of cone-driven retinal responses
  JOURNAL   J Neurosci 20 (6), 2209-2217 (2000)
   PUBMED   10704496
REFERENCE   10 (bases 1 to 7462)
  AUTHORS   Chen,C.K., Burns,M.E., Spencer,M., Niemi,G.A., Chen,J.,
            Hurley,J.B., Baylor,D.A. and Simon,M.I.
  TITLE     Abnormal photoresponses and light-induced apoptosis in rods lacking
            rhodopsin kinase
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3718-3722 (1999)
   PUBMED   10097103
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC096611.1, AC130818.3 and BC030304.1.
            
            On Nov 15, 2007 this sequence version replaced NM_011881.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096611.1, SRR9219383.83395.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1439              BC096611.1         1-1439
            1440-1440           AC130818.3         45526-45526         c
            1441-3060           BC096611.1         1441-3060
            3061-7462           BC030304.1         301-4702
FEATURES             Location/Qualifiers
     source          1..7462
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 5.93 cM"
     gene            1..7462
                     /gene="Grk1"
                     /gene_synonym="Gprk1; Rhok; Rk"
                     /note="G protein-coupled receptor kinase 1"
                     /db_xref="GeneID:24013"
                     /db_xref="MGI:MGI:1345146"
     exon            1..736
                     /gene="Grk1"
                     /gene_synonym="Gprk1; Rhok; Rk"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1732
                     /gene="Grk1"
                     /gene_synonym="Gprk1; Rhok; Rk"
                     /EC_number="2.7.11.14"
                     /note="G-protein receptor kinase 1"
                     /codon_start=1
                     /product="rhodopsin kinase GRK1"
                     /protein_id="NP_036011.3"
                     /db_xref="CCDS:CCDS22112.1"
                     /db_xref="GeneID:24013"
                     /db_xref="MGI:MGI:1345146"
                     /translation="MDFGSLETVVANSAFIAARGSFDGSSTPSSRDKKYLAKLRLPPL
                     SKCEGLRDNLSLEFESLCSEQPIGKRLFQQFLKTDERHVPALELWKDIEDYDTADDDL
                     RPQKAQAILAEYLDPQGTLFCNFLDQGMVTRVKEGPTGSQDGLFQPLLQATMEHLSQA
                     PFQEYLESLYFLRFLQWKWLEAQPIGEDWFLDFRVLGKGGFGEVSACQMKATGKMYAC
                     KKLNKKRLKKRKGYQGAIVEKRILTKVHSRFIVSLAYAFETKTDLCLVMTIMNGGDVR
                     YHIYNVDEDNPGFSEPRAIYYTAQIISGLEHLHQRRIVYRDLKPENVLLDNDGNIRIS
                     DLGLAVELKEGQNKTKGYAGTPGFMAPELLRGEEYDFSVDYFALGVTLYEMIAARGPF
                     RARGEKVENKELKQRIISEPVKYPEKFSQASKDFCEQLLEKDPEKRLGFRDGTCDALR
                     ANVLFKDISWRQLEAGMLIPPFIPDSRTVYAKNIQDVGAFSTVKGVVFDKADTEFFQE
                     FASGNCSIPWQEEMIETGLFGDLNVWRADGQMPDDMKGITTEEAAPTAKSGMCLIS"
     exon            737..864
                     /gene="Grk1"
                     /gene_synonym="Gprk1; Rhok; Rk"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1022
                     /gene="Grk1"
                     /gene_synonym="Gprk1; Rhok; Rk"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1106
                     /gene="Grk1"
                     /gene_synonym="Gprk1; Rhok; Rk"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1231
                     /gene="Grk1"
                     /gene_synonym="Gprk1; Rhok; Rk"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1433
                     /gene="Grk1"
                     /gene_synonym="Gprk1; Rhok; Rk"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..7431
                     /gene="Grk1"
                     /gene_synonym="Gprk1; Rhok; Rk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3039..3044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grk1"
                     /gene_synonym="Gprk1; Rhok; Rk"
                     /note="hexamer: AATAAA"
     polyA_site      3060
                     /gene="Grk1"
                     /gene_synonym="Gprk1; Rhok; Rk"
                     /note="major polyA site"
     regulatory      7409..7414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grk1"
                     /gene_synonym="Gprk1; Rhok; Rk"
                     /note="hexamer: ATTAAA"
     polyA_site      7431
                     /gene="Grk1"
                     /gene_synonym="Gprk1; Rhok; Rk"
                     /note="major polyA site"
ORIGIN      
        1 gtcttaatac ttgaagtgga cacagggcat cagcaggatg gatttcgggt ccttggagac
       61 cgtggtggcc aactctgcct tcatcgctgc ccggggcagt tttgacggaa gcagcacacc
      121 gtcttcccga gacaagaaat atctggccaa gctccggttg cccccactgt ccaagtgtga
      181 gggtctccgt gacaacctca gcttggagtt tgagagcctg tgctcagagc aacccatcgg
      241 caagaggctc ttccaacagt tcttgaagac agacgagaga catgtgccag ctctggagct
      301 ctggaaggac attgaggact atgacactgc tgatgatgac ctgaggccac agaaggcaca
      361 agccatcctg gctgagtacc tggacccaca gggcacactc ttctgcaact ttctggacca
      421 gggcatggtg acaagggtga aagaagggcc aactgggagc caggacggcc tcttccagcc
      481 tttgctccag gccacaatgg agcacttgag ccaggcgccc ttccaggagt acctagaaag
      541 cttgtatttc ctgcggtttc ttcagtggaa gtggttggaa gcccagccca taggtgaaga
      601 ctggttcttg gacttcaggg tcctgggaaa ggggggcttc ggggaagtgt ctgcctgtca
      661 gatgaaggcg actggcaaga tgtatgcctg caagaagctc aacaagaaac ggctgaagaa
      721 gaggaagggc taccagggcg ccattgttga gaagaggatt ctgactaaag tacacagcag
      781 gttcattgtg tctctggcct atgcgttcga gaccaagacg gacctctgtc tggtgatgac
      841 catcatgaac ggaggtgacg tgaggtacca catctacaat gtggatgagg ataaccccgg
      901 cttctcagaa ccacgggcca tctattacac agcacagatc atcagtggcc tggagcacct
      961 gcatcagaga cgcattgtct accgtgacct caagccagag aatgtgctat tggacaatga
     1021 tggcaatatc cgaatttctg accttggact ggctgtggag ctgaaggaag ggcagaataa
     1081 gaccaagggc tacgcaggga ccccaggttt catggcccct gagctcctgc gaggtgaaga
     1141 atacgacttc tctgtggact actttgccct gggggtcaca ttgtacgaga tgatcgcagc
     1201 cagaggaccc ttccgagccc gaggagagaa ggtagagaac aaggagctta agcaacgtat
     1261 catctcagag cctgtgaagt acccagagaa gttcagccag gccagcaagg acttctgtga
     1321 gcagctgttg gagaaggacc cggagaagcg cctgggcttc cgggatggaa cctgtgatgc
     1381 gcttcgggca aacgtcctct tcaaagatat cagctggagg cagctcgaag ccgggatgct
     1441 cattcctcca ttcatcccag actctaggac tgtctatgcc aagaacattc aggacgtggg
     1501 tgccttttcc acagtcaagg gtgtggtttt tgacaaagcg gacacagagt tcttccaaga
     1561 attcgcctct ggcaactgct ccattccctg gcaggaggag atgatcgaga ctgggctctt
     1621 tggggaccta aatgtgtggc gcgcagatgg tcagatgccg gatgacatga agggaatcac
     1681 cacggaggag gcagccccta cagccaagtc gggaatgtgt ctcatctcct agctaagtgt
     1741 cagaggaaag catggagctg gttgtataaa gagaggaaag tgtacagagc ccaggggaag
     1801 agagtgaccc tggtatccca ctccaaccag gtcaccatgc aactgtgtct ccatgtggag
     1861 caagcaagac tttcggtcta gaccctacag acatgacagt cctatttgtc ctatttcatt
     1921 caaaagagac aaaaaaggcc acagatggaa taataaggtg aaggtgtaaa tgctcaaaga
     1981 acttctatgt atagatgtgc ggccaggcca ggagcttggt gatcagactc acattcaatg
     2041 tcaatctcct ggtacttgga cttaatattt cagggcagac ctgtttgctc ctggtcagct
     2101 cagggttgca ggcacttgtg taccccaaag agggctgtac ttagagtacc cacatgaccc
     2161 ctccttgcct ggttcctgcc tcctaagctg cctttactgg tcactgcctg ctctcaggga
     2221 ccccaatgtg gggatgttaa gtctttagag aatggaaagg atggaagggc ctctctcaag
     2281 aagcagagac agctacctct ggcagctacg gtctccgtca tcagtcgaca ttacatgcgg
     2341 tgtatatcca aattgtcaca gtcacatcac atgtgatggg gggcccaagt ccttacatgt
     2401 tttttttttt ccatttttta ttaggtattt aactcattta catttccaat gctataccaa
     2461 aagtccccca tatccaccca cccccactcc cctgcccacc cactccccct ttttggccct
     2521 ggtgttcccc tgtactgggg catataaagt ttgcaagtcc aatgagcctc tctttccagt
     2581 gatggccgac taggccatct tttgatatat atgcagctag agtcaagagc tccggggtac
     2641 tggttagttc ataatgttgt tccacctata gggttgcaga tccctttagc tccttggcta
     2701 ctttctctag ctcctccatt gggagcccta tgatccatcc attagctgac tgtaagtcct
     2761 tacatgttaa tgacatgtgt ggtggatgcc tgagcaaagc catggccata tgtggctatt
     2821 gcctgagtcc ttacatggcc attgcacctg taatgagtgt ctgtgttctc aggccatctt
     2881 tgtacccccc agcctccaga gctttttggg aaggaaggcg ccctacacat accccaaatt
     2941 tttgaaagat tgctggatga agccaatact ggaacacaac actggaccag tgtccctaaa
     3001 ttgtatgggg cacaagcaac tgtcaagaat atgtcatcaa taaaacccag gccagctgta
     3061 ttgtggaagg ttccagatgt tgctatagag gtgccttgca cacacggata tcctggggac
     3121 taatgctgga tgctaaagaa gtccacacta gattcctgct cttcccagag aatcaaacac
     3181 tgtgcaattt ggcgcgctct ggaagggcct tggggaggtg actacacctc ctggaccatg
     3241 gtctgggaat ctttgggacc cagtagtcat gtggctaatt agtgctgaga actgtagata
     3301 agacaaatct tccgtcctcc ctttctactt cactccgtcc tctagcccca ggcagcacac
     3361 atgtatcaaa tacttggatg tatatttcat ttcaatgtgt tctggagctc aaattaatgt
     3421 gctctgggtt gaagaccctc gaagattggt ggtctcatcc tgggcttcac tggggcacgg
     3481 ggtatgtgtg tgaaaaggtg aattccagca gccatagctg gtttcaggaa ggcctggtcc
     3541 ttgttataca ccagccctca tccctgcttg gtttgcctag aactcctggc atcgatgatg
     3601 gggcctggtg actacatagg ctcagagtca ggttccccaa ccctgcactg tagataaaag
     3661 agcaagatag tccagtttaa atttcagaca aatagcgaat actttgacag tgtaaggtct
     3721 cagcagtatt tggggacaga cttatactaa aaccattcat tgtttgttgg aaattcagat
     3781 ttcaccagat gatctgtagg tctttttaaa atctaaatct agccggccca ctgcagattc
     3841 accaacaagc agggatgaaa ttgttggggg caatgctgct ttgcttctgt gtctcttagg
     3901 gtctaatcag gagaggtctt ttctcactct ggcccattca cagacgtaag ctcgagtgtt
     3961 actcagagag actcactttg ggacctccag ctgccctgtg cctggttgta cctgcaggtc
     4021 actgctggct tcatcagagg tgatgctgag aggagaaggg tgagttgctt gctctgtgtt
     4081 ctctgggtgg aaattttagc caactcctca tcctagaggt ttcttggact gtttttgggg
     4141 ctccgctgta ggtattctct cagggacagt aaccctttgc ctgaagagat gtccccatca
     4201 ctactgtctc tcctcacacc tagagcttat agactcctag gtcctagagc tcaagtcttg
     4261 cctggacact gaccccacgg aacttcaatg tgcccacttt gattctggca cttgttggcc
     4321 accttggtta taatctctcc caggaagaca gagagcagag agtcatcacc aattacagga
     4381 caccatggat gctgctgtac aggtctgttc tagtacctct gccaaagagg acctcctgaa
     4441 catggggagt tatccctagg actggaagcc aacttgggag ctctgtgaga tgtaggttga
     4501 cttgtatcct ggtcaccagt gagctgtaaa atggcttcac ttatgatcag agatatataa
     4561 ctatggtaag cttcatttct gcaatgactc taataattct tcatcttcaa gagggacccg
     4621 tcagagaggc acctcagata gacagagatg actctgggag ttgaaggtca tctaatgaaa
     4681 ggcaggaaca tgctatgaac agtagggtgt gtcagcttct gccgtacatt ggtcaactgg
     4741 atttggactt tattcctata atcaagggtg atgaaattct ccagcaggcc ttggagctct
     4801 tcccaaattc aaagtcatgt cacaagtggt cttggagact aagcattcaa gtccctggct
     4861 atggtttgag gaaggtttag tgctttcctg aaagtctatg ttttgcaagt tgtacctcca
     4921 gtgaggtagt gtgggtagtg gtgggaacag agcccaggaa cagagccttg gtcttcaggg
     4981 aagtgatttg gaaagactta gctatttctg tggggctgtg tctggtctga aagagagtag
     5041 gttcctctac aggcctgagt ctgacctcca agccccttgc ctccctgtct gtccacctct
     5101 tacacagctg tgtgagctct cagctgagcc tgtgatgcta aggctgtcac tagaggccaa
     5161 acaaatgggg ccactcatct cagctaccca acctccaaac tgtgggggta aataagcctt
     5221 ttcacaaatt accctgctga ggcattttgt tatagcaatg gaaagtgact gtcaacttta
     5281 gaatcttaaa ccgattcaaa gtagacttct gtttccagac aagatggtat atacacatat
     5341 tgtcgtggtt caataggaat ggtctccata ggctcatata tttgaatggt tattagggag
     5401 tggagttcct tgagagttac ttgatgggga ttaggaggtg tggtcttatt aaaggaggtg
     5461 tggccttgtt agagggagtg tattactggg catggtcttg gggtttcaaa tactcaggac
     5521 agacccaatg gctctctctt cctgctgcct gtggatccag atgtagaact ctgaactatt
     5581 tctccagatt catgtctgcc tctatgctgt catgcctcct gccatgacaa tagtggacta
     5641 gacctctgaa actacaagca agctccaggg aaatgttttc ctttctaagc gttgtcatag
     5701 tcttagtgtc tcctcacagc aatagaacac tcactaagag agaaggaagt tggtgccagg
     5761 gagcagggtg tcgctatgat aggctggact gtgctgcttg taggcagaat gtgaagtttg
     5821 gattagaaaa gccgtggaac gcttttgggg tttaatgggc catactcgta gaaacatgga
     5881 agacagggtg ctgagggcaa tctagattct gattcccagg tcaagagctt ccagaggaga
     5941 agaatattag taagtggcct agagactgct cttgtaatat tttggcaaag aatgtggctg
     6001 ctttttgccc ttgtctgaag agtctgcccg aggctaaata taagcatttt ggattgatgg
     6061 cattggcaga ggagagttaa aacagcctag tattgactgt gttgccagtc agtcttatgc
     6121 agatctataa ggaagagggg caagttgagc aaggaaaagt taaaaacgca cagtttgagg
     6181 agaaaggggc cccagaaagt gtgatggagt cagatggaat aaaaggaggg gcgacctcag
     6241 gacaagaccc cgcccagctc agcttccaac ttgtaaaaag gaattaaaga aactccgagg
     6301 caccgaagga aatggtcaac aacagaaagc cggtgcagat gtaatcgaat gaggagccat
     6361 gttccagccc cagcaatcag cagcagaaga actcggcagc ttctgccgca cggtttggct
     6421 ttagggtcaa ggatacaaga aagatacaag gatacatgaa atcctcctcc aaaattaagg
     6481 gaagccactg aggcaaggcg tgcatcaagg gtgtcccttc gaggagaccc agagagtcca
     6541 tggcttgaag ctgtgaaggt gaagcctggg ttgccttgga aaccccaaga gcttggggct
     6601 gccagagcca tggggtacct gccaaggaaa gctctcacat ggagtggagc cagcccacaa
     6661 gggagaagtg tgtgtagtca acaaagctgg aaggagttgg agatctgaag aacgcgttga
     6721 cgtcagccat agagatgcag actttggagc ttgtccgcct ggttgtctgt ctgtctgtct
     6781 tgctttggta ttttctcact atgcttccct tcctcccttt tggaatggtg atgtatattt
     6841 ttgtgccatt gtatgttgca agtatgtgat ctcctttttg gttttgaatt ttatagggga
     6901 ttaccgttaa gagattgcca tgagtctcag aagagacttt gacctttgga cttttaggca
     6961 gtgttgagac tgtaatagac tgtagggact tttgaaggtg gactgaatgc atttttgcac
     7021 tatagctata catctatggg ggtcagggag tggaatgtgg tggtttgagt aggaatggcc
     7081 cccataggct caatatttga atgtttggtc attaaggagt agctacttga gagagattac
     7141 gaggtatggt cttggagtga gtgtgacctt tttggagtgg atgtgtcctt gttggagtgg
     7201 gtgtggcctt gttggaggaa gtgtgtcatt ggggatgggc tttgggggtt tcaaatgctc
     7261 aagccaggcc cagtgtcatt ctcttcctgc tgcctgcgta tctggatgta gaactctcag
     7321 ctacctctcc agcaccacat ctacctgcac gctgtcatac ttcccaccat gataatggac
     7381 taaacctctg aactgtaagc tagccccaat taaatgcttt cctttataaa aaaaaaaaaa
     7441 aaaaaaaaaa aaaaaaaaaa aa
//
