LOCUS       NP_036011                564 aa            linear   ROD 29-JUL-2024
DEFINITION  rhodopsin kinase GRK1 [Mus musculus].
ACCESSION   NP_036011 XP_912940
VERSION     NP_036011.3
DBSOURCE    REFSEQ: accession NM_011881.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 564)
  AUTHORS   Ng,L., Liu,H., Liu,Y. and Forrest,D.
  TITLE     Biphasic expression of thyroid hormone receptor TRbeta1 in
            mammalian retina and anterior ocular tissues
  JOURNAL   Front Endocrinol (Lausanne) 14, 1174600 (2023)
   PUBMED   37033230
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 564)
  AUTHORS   Maddala,R., Gao,J., Mathias,R.T., Lewis,T.R., Arshavsky,V.Y.,
            Levine,A., Backer,J.M., Bresnick,A.R. and Rao,P.V.
  TITLE     Absence of S100A4 in the mouse lens induces an aberrant
            retina-specific differentiation program and cataract
  JOURNAL   Sci Rep 11 (1), 2203 (2021)
   PUBMED   33500475
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 564)
  AUTHORS   Merlini,M., Rafalski,V.A., Ma,K., Kim,K.Y., Bushong,E.A., Rios
            Coronado,P.E., Yan,Z., Mendiola,A.S., Sozmen,E.G., Ryu,J.K.,
            Haberl,M.G., Madany,M., Sampson,D.N., Petersen,M.A., Bardehle,S.,
            Tognatta,R., Dean,T. Jr., Acevedo,R.M., Cabriga,B., Thomas,R.,
            Coughlin,S.R., Ellisman,M.H., Palop,J.J. and Akassoglou,K.
  TITLE     Microglial Gi-dependent dynamics regulate brain network
            hyperexcitability
  JOURNAL   Nat Neurosci 24 (1), 19-23 (2021)
   PUBMED   33318667
  REMARK    GeneRIF: Microglial Gi-dependent dynamics regulate brain network
            hyperexcitability.
REFERENCE   4  (residues 1 to 564)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 564)
  AUTHORS   Kolesnikov,A.V., Chrispell,J.D., Osawa,S., Kefalov,V.J. and
            Weiss,E.R.
  TITLE     Phosphorylation at Serine 21 in G protein-coupled receptor kinase 1
            (GRK1) is required for normal kinetics of dark adaption in rod but
            not cone photoreceptors
  JOURNAL   FASEB J 34 (2), 2677-2690 (2020)
   PUBMED   31908030
  REMARK    GeneRIF: Phosphorylation at Serine 21 in G protein-coupled receptor
            kinase 1 (GRK1) is required for normal kinetics of dark adaption in
            rod but not cone photoreceptors.
REFERENCE   6  (residues 1 to 564)
  AUTHORS   Zhang,H., Huang,W., Zhang,H., Zhu,X., Craft,C.M., Baehr,W. and
            Chen,C.K.
  TITLE     Light-dependent redistribution of visual arrestins and transducin
            subunits in mice with defective phototransduction
  JOURNAL   Mol Vis 9, 231-237 (2003)
   PUBMED   12802257
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 564)
  AUTHORS   Mendez,A., Lem,J., Simon,M. and Chen,J.
  TITLE     Light-dependent translocation of arrestin in the absence of
            rhodopsin phosphorylation and transducin signaling
  JOURNAL   J Neurosci 23 (8), 3124-3129 (2003)
   PUBMED   12716919
REFERENCE   8  (residues 1 to 564)
  AUTHORS   Choi,S., Hao,W., Chen,C.K. and Simon,M.I.
  TITLE     Gene expression profiles of light-induced apoptosis in
            arrestin/rhodopsin kinase-deficient mouse retinas
  JOURNAL   Proc Natl Acad Sci U S A 98 (23), 13096-13101 (2001)
   PUBMED   11687607
REFERENCE   9  (residues 1 to 564)
  AUTHORS   Lyubarsky,A.L., Chen,C., Simon,M.I. and Pugh,E.N. Jr.
  TITLE     Mice lacking G-protein receptor kinase 1 have profoundly slowed
            recovery of cone-driven retinal responses
  JOURNAL   J Neurosci 20 (6), 2209-2217 (2000)
   PUBMED   10704496
REFERENCE   10 (residues 1 to 564)
  AUTHORS   Chen,C.K., Burns,M.E., Spencer,M., Niemi,G.A., Chen,J.,
            Hurley,J.B., Baylor,D.A. and Simon,M.I.
  TITLE     Abnormal photoresponses and light-induced apoptosis in rods lacking
            rhodopsin kinase
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3718-3722 (1999)
   PUBMED   10097103
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC096611.1, AC130818.3 and BC030304.1.
            
            On Nov 15, 2007 this sequence version replaced NP_036011.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096611.1, SRR9219383.83395.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..564
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 5.93 cM"
     Protein         1..564
                     /product="rhodopsin kinase GRK1"
                     /EC_number="2.7.11.14"
                     /note="G-protein receptor kinase 1"
                     /calculated_mol_wt=63734
     mat_peptide     1..561
                     /product="Rhodopsin kinase GRK1. /id=PRO_0000024377"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WVL4.1)"
                     /calculated_mol_wt=63552
     Region          1..189
                     /region_name="N-terminal"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WVL4.1)"
     Region          1..15
                     /region_name="Interaction with RCVRN.
                     /evidence=ECO:0000250|UniProtKB:P28327"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WVL4.1)"
     Site            5
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P28327; propagated from
                     UniProtKB/Swiss-Prot (Q9WVL4.1)"
     Site            8
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P28327; propagated from
                     UniProtKB/Swiss-Prot (Q9WVL4.1)"
     Site            21
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKA and autocatalysis.
                     /evidence=ECO:0000305|PubMed:21504899; propagated from
                     UniProtKB/Swiss-Prot (Q9WVL4.1)"
     Region          42..179
                     /region_name="RGS"
                     /note="Regulator of G protein signaling (RGS) domain
                     superfamily; cl02565"
                     /db_xref="CDD:470619"
     Region          188..475
                     /region_name="STKc_GRK1"
                     /note="Catalytic domain of the Serine/Threonine Kinase, G
                     protein-coupled Receptor Kinase 1; cd05608"
                     /db_xref="CDD:270759"
     Site            order(196..200,204,217,219,251,267..268,270,274,276,317,
                     319,321..322,324,334..335,338,352..357,384,390,393)
                     /site_type="active"
                     /db_xref="CDD:270759"
     Site            order(196..200,204,217,219,267..268,270,324,335)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270759"
     Site            order(200,274,276,317,319,321,338,352..357,384,390,393)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270759"
     Site            334..357
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270759"
     Region          456..564
                     /region_name="C-terminal"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WVL4.1)"
     Site            491
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P28327; propagated from
                     UniProtKB/Swiss-Prot (Q9WVL4.1)"
     Site            492
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P28327; propagated from
                     UniProtKB/Swiss-Prot (Q9WVL4.1)"
     Site            561
                     /site_type="methylation"
                     /note="Cysteine methyl ester.
                     /evidence=ECO:0000250|UniProtKB:P28327; propagated from
                     UniProtKB/Swiss-Prot (Q9WVL4.1)"
     CDS             1..564
                     /gene="Grk1"
                     /gene_synonym="Gprk1; Rhok; Rk"
                     /coded_by="NM_011881.3:38..1732"
                     /db_xref="CCDS:CCDS22112.1"
                     /db_xref="GeneID:24013"
                     /db_xref="MGI:MGI:1345146"
ORIGIN      
        1 mdfgsletvv ansafiaarg sfdgsstpss rdkkylaklr lpplskcegl rdnlslefes
       61 lcseqpigkr lfqqflktde rhvpalelwk diedydtadd dlrpqkaqai laeyldpqgt
      121 lfcnfldqgm vtrvkegptg sqdglfqpll qatmehlsqa pfqeylesly flrflqwkwl
      181 eaqpigedwf ldfrvlgkgg fgevsacqmk atgkmyackk lnkkrlkkrk gyqgaivekr
      241 iltkvhsrfi vslayafetk tdlclvmtim nggdvryhiy nvdednpgfs epraiyytaq
      301 iisglehlhq rrivyrdlkp envlldndgn irisdlglav elkegqnktk gyagtpgfma
      361 pellrgeeyd fsvdyfalgv tlyemiaarg pfrargekve nkelkqriis epvkypekfs
      421 qaskdfceql lekdpekrlg frdgtcdalr anvlfkdisw rqleagmlip pfipdsrtvy
      481 akniqdvgaf stvkgvvfdk adteffqefa sgncsipwqe emietglfgd lnvwradgqm
      541 pddmkgitte eaaptaksgm clis
//
