LOCUS       NM_001411663            5231 bp    mRNA    linear   ROD 08-AUG-2023
DEFINITION  Mus musculus glutamate receptor interacting protein 2 (Grip2),
            transcript variant 2, mRNA.
ACCESSION   NM_001411663 XM_006506104
VERSION     NM_001411663.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5231)
  AUTHORS   Jo Y, Balmer L, Lee B, Shim JA, Ali LA, Morahan G and Hong C.
  TITLE     Variants of innate CD8+ T cells are associated with Grip2 and Klf15
            genes
  JOURNAL   Cell Mol Immunol 17 (9), 1007-1009 (2020)
   PUBMED   31919398
  REMARK    GeneRIF: Variants of innate CD8(+) T cells are associated with
            Grip2 and Klf15 genes.
REFERENCE   2  (bases 1 to 5231)
  AUTHORS   Mejias R, Chiu SL, Han M, Rose R, Gil-Infante A, Zhao Y, Huganir RL
            and Wang T.
  TITLE     Purkinje cell-specific Grip1/2 knockout mice show increased
            repetitive self-grooming and enhanced mGluR5 signaling in
            cerebellum
  JOURNAL   Neurobiol Dis 132, 104602 (2019)
   PUBMED   31476380
  REMARK    GeneRIF: Results indicate that loss of Grip1/2 in cerebellar
            Purkinje cells contributes to increased repetitive self-grooming, a
            core autism behavior in mice
REFERENCE   3  (bases 1 to 5231)
  AUTHORS   Han M, Mejias R, Chiu SL, Rose R, Adamczyk A, Huganir R and Wang T.
  TITLE     Mice lacking GRIP1/2 show increased social interactions and
            enhanced phosphorylation at GluA2-S880
  JOURNAL   Behav Brain Res 321, 176-184 (2017)
   PUBMED   28063882
  REMARK    GeneRIF: Study performed social behavioral testing on
            neuron-specific Grip1/2-double knockout (DKO) and wild type (WT)
            mice and determined the expression profile of key signaling
            proteins in AMPAR, mGluR, mTOR, and GABA pathways in brain. Data
            Grip1/2-mediated AMPA signaling in regulating social behaviors and
            disturbance of glutamate- and GABA-signaling in specialized brain
            regions in autism-related social behavioral deficits.
REFERENCE   4  (bases 1 to 5231)
  AUTHORS   Tan HL, Queenan BN and Huganir RL.
  TITLE     GRIP1 is required for homeostatic regulation of AMPAR trafficking
  JOURNAL   Proc Natl Acad Sci U S A 112 (32), 10026-10031 (2015)
   PUBMED   26216979
REFERENCE   5  (bases 1 to 5231)
  AUTHORS   Briand LA, Kimmey BA, Ortinski PI, Huganir RL and Pierce RC.
  TITLE     Disruption of glutamate receptor-interacting protein in nucleus
            accumbens enhances vulnerability to cocaine relapse
  JOURNAL   Neuropsychopharmacology 39 (3), 759-769 (2014)
   PUBMED   24126453
  REMARK    GeneRIF: This study demonistrated that deletion of accumbal GRIP2
            increases vulnerability to cue-induced cocaine relapse without
            altering the reinforcing properties of the drug or the response to
            natural rewards
REFERENCE   6  (bases 1 to 5231)
  AUTHORS   Mao L, Takamiya K, Thomas G, Lin DT and Huganir RL.
  TITLE     GRIP1 and 2 regulate activity-dependent AMPA receptor recycling via
            exocyst complex interactions
  JOURNAL   Proc Natl Acad Sci U S A 107 (44), 19038-19043 (2010)
   PUBMED   20956289
  REMARK    GeneRIF: GRIP1 and 2 regulate activity-dependent AMPA receptor
            recycling via exocyst complex interactions.
REFERENCE   7  (bases 1 to 5231)
  AUTHORS   Takamiya K, Mao L, Huganir RL and Linden DJ.
  TITLE     The glutamate receptor-interacting protein family of GluR2-binding
            proteins is required for long-term synaptic depression expression
            in cerebellar Purkinje cells
  JOURNAL   J Neurosci 28 (22), 5752-5755 (2008)
   PUBMED   18509036
REFERENCE   8  (bases 1 to 5231)
  AUTHORS   Vadasz C, Saito M, Gyetvai BM, Oros M, Szakall I, Kovacs KM, Prasad
            VV, Morahan G and Toth R.
  TITLE     Mapping of QTLs for oral alcohol self-administration in B6.C and
            B6.I quasi-congenic RQI strains
  JOURNAL   Neurochem Res 32 (7), 1099-1112 (2007)
   PUBMED   17273929
REFERENCE   9  (bases 1 to 5231)
  AUTHORS   Monea S, Jordan BA, Srivastava S, DeSouza S and Ziff EB.
  TITLE     Membrane localization of membrane type 5 matrix metalloproteinase
            by AMPA receptor binding protein and cleavage of cadherins
  JOURNAL   J Neurosci 26 (8), 2300-2312 (2006)
   PUBMED   16495457
REFERENCE   10 (bases 1 to 5231)
  AUTHORS   Takamiya K, Kostourou V, Adams S, Jadeja S, Chalepakis G, Scambler
            PJ, Huganir RL and Adams RH.
  TITLE     A direct functional link between the multi-PDZ domain protein GRIP1
            and the Fraser syndrome protein Fras1
  JOURNAL   Nat Genet 36 (2), 172-177 (2004)
   PUBMED   14730302
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC168852.2 and AC162914.2.
            
            On Aug 31, 2022 this sequence version replaced XM_006506104.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.1298524.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               AC168852.2         53244-53465         c
            223-303             AC162914.2         150116-150196       c
            304-439             AC162914.2         149760-149895       c
            440-585             AC162914.2         148936-149081       c
            586-672             AC162914.2         148219-148305       c
            673-748             AC162914.2         147433-147508       c
            749-894             AC162914.2         146437-146582       c
            895-1042            AC162914.2         145576-145723       c
            1043-1212           AC162914.2         145322-145491       c
            1213-1335           AC162914.2         144535-144657       c
            1336-1479           AC162914.2         144068-144211       c
            1480-1666           AC162914.2         142083-142269       c
            1667-1812           AC162914.2         141576-141721       c
            1813-1893           AC162914.2         140887-140967       c
            1894-1960           AC162914.2         140587-140653       c
            1961-2106           AC162914.2         140351-140496       c
            2107-2251           AC162914.2         139117-139261       c
            2252-2391           AC162914.2         137097-137236       c
            2392-2571           AC162914.2         136434-136613       c
            2572-2740           AC162914.2         135545-135713       c
            2741-2846           AC162914.2         134385-134490       c
            2847-2990           AC162914.2         127000-127143       c
            2991-3137           AC162914.2         126448-126594       c
            3138-5231           AC162914.2         123265-125358       c
FEATURES             Location/Qualifiers
     source          1..5231
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 40.8 cM"
     gene            1..5231
                     /gene="Grip2"
                     /note="glutamate receptor interacting protein 2"
                     /db_xref="GeneID:243547"
                     /db_xref="MGI:MGI:2681173"
     exon            1..222
                     /gene="Grip2"
                     /inference="alignment:Splign:2.1.0"
     exon            223..303
                     /gene="Grip2"
                     /inference="alignment:Splign:2.1.0"
     exon            304..439
                     /gene="Grip2"
                     /inference="alignment:Splign:2.1.0"
     exon            440..585
                     /gene="Grip2"
                     /inference="alignment:Splign:2.1.0"
     exon            586..672
                     /gene="Grip2"
                     /inference="alignment:Splign:2.1.0"
     exon            673..748
                     /gene="Grip2"
                     /inference="alignment:Splign:2.1.0"
     exon            749..894
                     /gene="Grip2"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1042
                     /gene="Grip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1212
                     /gene="Grip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1335
                     /gene="Grip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1479
                     /gene="Grip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1666
                     /gene="Grip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1812
                     /gene="Grip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1893
                     /gene="Grip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..1960
                     /gene="Grip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2106
                     /gene="Grip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2251
                     /gene="Grip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2391
                     /gene="Grip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..2571
                     /gene="Grip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2572..2740
                     /gene="Grip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2741..2846
                     /gene="Grip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..2990
                     /gene="Grip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2991..3137
                     /gene="Grip2"
                     /inference="alignment:Splign:2.1.0"
     exon            3138..5231
                     /gene="Grip2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagccgctgc tcagccgcgg gcgggcgcgg aagccggagc ggagccggcg gcatctaccg
       61 agccggccgc tcatgccccg tgcgctgggc ccgcggcctc cggagccctg cgctgcgcct
      121 ggcccggcgg gggcgaggcc gggtggggcc gcccggcggc tgcggggatg cggggctggc
      181 gcaggaacct cgcgctctgc ttgcagcggc tgccggacga agatgatggg ccttactcaa
      241 aaggggggaa ggacacagcg ggggccgacg gggctctggt atgccgccgc cagagcattc
      301 cagaggagtt ccggggcatc accatggtgg agttgatcaa acgtgagggc agcactctgg
      361 gcctgaccat ctccggaggg actgacaagg acgggaagcc cagagtctcc aacctgagac
      421 ctgggggcct ggcagccagg agtgatctac tgaatgtggg cgactacatc cgctcagtga
      481 acgggatcca tctgacccgc ctccgacatg acgagatcat cacactgctg aagaatgtgg
      541 gcgagcgcgt ggtgctggag gtggagtatg agctgccccc gcccgctccc gaaaacaacc
      601 caaggatcat ttccaagacg gtggacgtct ccctctacaa ggaaggcaac agctttggct
      661 ttgtcctcag aggaggtgcc catgaggacc tgcacaaatc ccgcccattg gtcctgactt
      721 acgtgagacc tggtggccca gcggacaggg aggggtcctt aaaggtgggc gacaggctgc
      781 tcagcataga tgggatccca ctgcatgggg ccagccatgc tactgcaata gccaccctgc
      841 aacagtgtag ccatgaggcc cttttccaag tggagtatga tgtggccacc ccagacacag
      901 tggccaatgc ttcaggccct ttggtggtag aaatagccaa gaccccagga tctgccctgg
      961 ggatctctct caccactggc tcccaccgga acaagccagc tatcactatc gaccgtatca
     1021 agccagctag cgtggtggac aggagtggtg cgctgcatgc tggagaccac atcctcgcca
     1081 tcgatggcac cagcacagaa cactgctcac tggtcgaggc tactaagctc ctggccagtg
     1141 ttactgagaa agttcgactg gagatcttgc cttcgcccca gagtcgtcgg cccctgaagc
     1201 ccccagaggc agtgagaata cagaggagtg agcagctgca ccgctgggac ccctctgccc
     1261 cttcttgcca cagcccaagg ccaagccact gcagggcacc cacctgggca gctggaggcc
     1321 cggaccagag ccgatctgtg tcctcgactc ccttctcctc accgactatg aaccccgcct
     1381 ttccctgtgc caacgccagc accctgccca gaggacccat gagccccagg acaacagcag
     1441 ggaggagaag gcagcgaagg aaagaacaca ggagctcttt gtcactggcc tccagcacgg
     1501 tagggcccgg cgggcagatt gttcatacgg agaccacgga agttgtgctc tgtggagatc
     1561 ctctcagtgg cttcggcctt cagctgcaag gaggcatctt tgccaccgag accctgtcct
     1621 ccccaccctt ggtgcgattt attgaacctg acagccccgc tgagaggtgt ggtctgctgc
     1681 aggtggggga ccgagtccta gccatcaatg gcattgccac tgaggatggg accatggagg
     1741 aagccaacca gctgttgcgg gatgctgcgc tggcccgcaa agttgttttg gagatcgagt
     1801 ttgatgtggc agagtctgtc atcccaagca gtggaacctt ccacgtgaag ttacccaaaa
     1861 gacgcggtgt ggagctgggc atcaccatta gctcggccag cagaaagcga ggggaacccc
     1921 tgatcatctc cgacatcaag aaaggcagcg tggcgcacag gactggcacc ctcgagccag
     1981 gcgacaagct gctggccatt gacaatatcc gcctggacca ctgtcccatg gaggatgccg
     2041 tgcagatcct gcgtcaatgt gaggacctgg tgaagctgaa gatccggaaa gatgaggaca
     2101 actcagatga gcaggagagc tctggcgcag tcagctacac agtggaactg aagcgctatg
     2161 gcggaccact gggcatcacc atctctggta cagaggaacc ttttgacccc atcattatct
     2221 ctggcctcac caagcggggt ctagccgaaa ggactggtgc catccatgtc ggggaccgga
     2281 tactggccat caacagcgtg agcctcaagg gccggcccct gagtgaggcc atccaccttc
     2341 tgcaggtggc cggggagacg gtcacactga agatcaagaa gcagctagac cgtcccctcc
     2401 tcccccgcca gtcaggcagc ctcagtgagg ccagtgatgt ggatgaggac ccccctgagg
     2461 ccctcaaggg aggcttgctg gcaacgcgct tctcacctgc tgtacccagc gtggacagtg
     2521 ctgtggagtc ctggggcagc tctgccacag atggtggctt tgggggcaca ggctcctaca
     2581 ctccgcaggt ggcagtccgg agtgtgactc cccaggagtg gcgtcctagc agactgaaga
     2641 gtagcccccc accccttgag ccccggagga cgagctacac accgggtccc tctgacgaaa
     2701 gcttcccaga ggaagagggg gactgggagc caccaatgag cccagccccc ggccccgccc
     2761 gagaggaggg tttctggaga gtgcttggag aggctcttga agacctggag tcctgtggtc
     2821 agtctgaact gctaagggag ctggaggctt ccatcatgac aggcactgta cactccgtgg
     2881 ctgtggatgg caggcctggc tctcgaccct ggcgccggag ccgggaggtc cgaacatccc
     2941 ctgaagacct gcaggagctg ctgctgccga cacccctgga gatgcacagg gtgaccctgc
     3001 acaaagaccc ggtgaggaac gactttggtt tcagcgtctc agatggcctc ctggagaagg
     3061 gtgtctatgt ccacactgtg cgcattgacg gaccagctca gcttggaggc ctgcagccct
     3121 ttgaccgtct cctgcaggtc aaccatgttc gcactcggga ctttgactgc tgtctggcgg
     3181 taccactcct ggcggaggct ggggacatcc tggagctggt ggtcagccgt aacccactgg
     3241 cacagagccg caggacacca ggagcaccag gccccagtag tccccagatg ctctgaggtc
     3301 attatgaagc tcagctggag gagtggcccc cagtcatcca cttatggtct gcagattcca
     3361 catccataga atggcatctt caagttggat ctcagagaac cccacgggaa aggtgccgtc
     3421 cctgctgctc agtcagaaga gtccagctcc ctgcacagtc atctcagagc agcaagaggt
     3481 gtggggaaag cccagctcag tgtgggaact cgactgagct accagtgttt cccatcttgg
     3541 gaagtgaata agcagaaggt ggacaatcct ggtctgtggc aggaggcatt cggcaaccca
     3601 gctgtataga tggcacccag tgcacaggca tcctgccacc aggaaagata tggcacaaga
     3661 acagtgtcct cccttctccc aaatggtggt gttttgagag cctccagcat cagtgaccac
     3721 accgaggaac cccagttagg aagatctggg gtaccagaga atgcttgccc tttccttcag
     3781 gttggccata caatcatttc tgtttcgtgg gtgattctga accccagagc agagccgtgg
     3841 tcatcattac cctcctgcgc cacaaaacct tagcccaagg acccgtccag agaagggcac
     3901 tgctcgagtc aaaaggtcca ggagcatcta ctcacctggc attccaacag ataccatgga
     3961 aaataaggct gagccacggc tgtgcccctg atcccatcca tggaaaaggg gaagaagaaa
     4021 gaagctgaga tggagggagg ttggctgaag gacaagacag taatgagagg gagcagtgtc
     4081 cagagaggct actcaaggaa gtccccagca tcccttaact cggggttcct ccatctctgc
     4141 caagcagaac ccttccagct tcaagcagga ctcaagacac ctcccagtgg tctgggctgg
     4201 tctgacaatt ggcttcctgt ttgcccagct caaggtccca aggacccagg ggcctccaac
     4261 cctaccccgt cacccctctc tgcccttgaa gctcattgcc caaaagaact ccctgttgaa
     4321 gaggacagac agggccctaa gaagccattc ctttccctag tttccttctt ggctgagtaa
     4381 ccttgtgtga atctgacaga cacagggcga gctccagctg cccactcaga cgcttcagct
     4441 ctctgcgttt cctcagcttc ccccataccc tgcccttcat gatggcctct ccagggaccc
     4501 ttatgcctgg gtccaggtaa cccggtgtct ctactttcac tgcccatcca tcatgggcac
     4561 caaacgaact aagaccttca acttccaggg caggcgaatg gcacagcaga gaggagactc
     4621 ctggctacca gcacaccgga tgctgtgtga ccatgggcag atggctcagc ctctctggat
     4681 ttctggtgtg tggcatggct gactgtacct tgaaagcctc ttagcttggg aaatctgtat
     4741 cccacttaaa gactccaggt tctgaaaatg caaccactgc cctcccctcg ggctgaggct
     4801 ctcccatcct cccagatgta tgcaactagg ccaatcggtg gacctcctgg ccgtggcctg
     4861 aggccttctc atatgcaata tcccccctgg cttctcccag gggtgtttgc cccacacaat
     4921 attcctagcc ccctccccag tgagcatcct gcctgcctat gcattttggg tacctcccct
     4981 gtgacaccca cccccagagc tgtatttttc tctggctaag attagaacat attccttgta
     5041 aagtattttt ctatgccggt tttcttaggg ctcccaggga gcacccagca cacccatggc
     5101 accactgtac aggctgttcc tagtctgtct ggggcccacg tataaatctt atgtcccacc
     5161 aggcatcgca gtgactgggg ggaggttgag tgctattggg gtaatttttg taataaaatt
     5221 ggttaaatgc a
//
