LOCUS       NM_028736               5219 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus glutamate receptor interacting protein 1 (Grip1),
            transcript variant 1, mRNA.
ACCESSION   NM_028736
VERSION     NM_028736.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5219)
  AUTHORS   Wang,G., Chen,L., Chen,H., Li,Y., Xu,Y., Xing,Y., Zhang,L. and
            Li,J.
  TITLE     Glutamate Receptor Interacting Protein 1 in the Dorsal CA1 Drives
            Alpha-amino-3-hydroxy-5-methyl-4-Isoxazolepropionic Acid Receptor
            Endocytosis and Exocytosis Bidirectionally and Mediates Forgetting,
            Exploratory, and Anxiety-like Behavior
  JOURNAL   Neuroscience 498, 235-248 (2022)
   PUBMED   35863680
  REMARK    GeneRIF: Glutamate Receptor Interacting Protein 1 in the Dorsal CA1
            Drives Alpha-amino-3-hydroxy-5-methyl-4-Isoxazolepropionic Acid
            Receptor Endocytosis and Exocytosis Bidirectionally and Mediates
            Forgetting, Exploratory, and Anxiety-like Behavior.
REFERENCE   2  (bases 1 to 5219)
  AUTHORS   Longatti,A., Ponzoni,L., Moretto,E., Giansante,G., Lattuada,N.,
            Colombo,M.N., Francolini,M., Sala,M., Murru,L. and Passafaro,M.
  TITLE     Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting
            Hippocampal Glutamatergic Synapses and Cognition in Mice
  JOURNAL   Mol Neurobiol 58 (12), 6092-6110 (2021)
   PUBMED   34455539
REFERENCE   3  (bases 1 to 5219)
  AUTHORS   Kinoshita,A., Ohyama,K., Tanimura,S., Matsuda,K., Kishino,T.,
            Negishi,Y., Asahina,N., Shiraishi,H., Hosoki,K., Tomiwa,K.,
            Ishihara,N., Mishima,H., Mori,R., Nakashima,M., Saitoh,S. and
            Yoshiura,K.I.
  TITLE     Itpr1 regulates the formation of anterior eye segment tissues
            derived from neural crest cells
  JOURNAL   Development 148 (16) (2021)
   PUBMED   34338282
REFERENCE   4  (bases 1 to 5219)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5219)
  AUTHORS   Nakata,A., Ito,T., Nagata,M., Hori,S. and Sekimizu,K.
  TITLE     GRIP1tau, a novel PDZ domain-containing transcriptional activator,
            cooperates with the testis-specific transcription elongation factor
            SII-T1
  JOURNAL   Genes Cells 9 (11), 1125-1135 (2004)
   PUBMED   15507123
  REMARK    GeneRIF: investigated whether there is a link between growth
            inhibitory effect and transcriptional activation of PPARgamma in
            several gastrointestinal tumour cell lines [GRIP1tau]
REFERENCE   6  (bases 1 to 5219)
  AUTHORS   Bladt,F., Tafuri,A., Gelkop,S., Langille,L. and Pawson,T.
  TITLE     Epidermolysis bullosa and embryonic lethality in mice lacking the
            multi-PDZ domain protein GRIP1
  JOURNAL   Proc Natl Acad Sci U S A 99 (10), 6816-6821 (2002)
   PUBMED   11983858
  REMARK    GeneRIF: GRIP1 scaffolding protein is required for the formation
            and integrity of the dermo-epidermal junction and reveal the
            importance of PDZ domains in the organization of supramolecular
            structures essential for mammalian embryonic development.
REFERENCE   7  (bases 1 to 5219)
  AUTHORS   Yamazaki,M., Fukaya,M., Abe,M., Ikeno,K., Kakizaki,T., Watanabe,M.
            and Sakimura,K.
  TITLE     Differential palmitoylation of two mouse glutamate receptor
            interacting protein 1 forms with different N-terminal sequences
  JOURNAL   Neurosci Lett 304 (1-2), 81-84 (2001)
   PUBMED   11335060
REFERENCE   8  (bases 1 to 5219)
  AUTHORS   Torres,R., Firestein,B.L., Dong,H., Staudinger,J., Olson,E.N.,
            Huganir,R.L., Bredt,D.S., Gale,N.W. and Yancopoulos,G.D.
  TITLE     PDZ proteins bind, cluster, and synaptically colocalize with Eph
            receptors and their ephrin ligands
  JOURNAL   Neuron 21 (6), 1453-1463 (1998)
   PUBMED   9883737
REFERENCE   9  (bases 1 to 5219)
  AUTHORS   Hong,H., Kohli,K., Trivedi,A., Johnson,D.L. and Stallcup,M.R.
  TITLE     GRIP1, a novel mouse protein that serves as a transcriptional
            coactivator in yeast for the hormone binding domains of steroid
            receptors
  JOURNAL   Proc Natl Acad Sci U S A 93 (10), 4948-4952 (1996)
   PUBMED   8643509
REFERENCE   10 (bases 1 to 5219)
  AUTHORS   Brown,K.S., Hetzel,S.C. and Harne,L.C.
  TITLE     Craniofacial consequences of connective tissue disorders in mice
  JOURNAL   Birth Defects Orig Artic Ser 20 (3), 113-136 (1984)
   PUBMED   6391574
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC153493.6, AB051561.1,
            AK043821.1 and AC134326.3.
            
            On Mar 29, 2013 this sequence version replaced NM_028736.1.
            
            Summary: This gene encodes a protein containing multiple PDZ (post
            synaptic density protein, Drosophila disc large tumor suppressor,
            and zonula occludens-1 protein) domains. The encoded protein acts
            as a mediator between cytoskeletal and membrane proteins,
            particularly in neuronal cells, and facilitates complex formation
            at the cell membrane. Mutation of this gene can cause embryonic
            lethality resulting from defects of the dermo-epidermal junction.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Mar 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the isoform (1, also known as 1a-long).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB051561.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AC153493.6         78491-78613
            124-3655            AB051561.1         1-3532
            3656-4974           AK043821.1         338-1656
            4975-5219           AC134326.3         16913-17157         c
FEATURES             Location/Qualifiers
     source          1..5219
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 67.33 cM"
     gene            1..5219
                     /gene="Grip1"
                     /gene_synonym="4931400F03Rik; eb; GRIP"
                     /note="glutamate receptor interacting protein 1"
                     /db_xref="GeneID:74053"
                     /db_xref="MGI:MGI:1921303"
     exon            1..246
                     /gene="Grip1"
                     /gene_synonym="4931400F03Rik; eb; GRIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..3575
                     /gene="Grip1"
                     /gene_synonym="4931400F03Rik; eb; GRIP"
                     /note="isoform 1 is encoded by transcript variant 1; eye
                     blebs"
                     /codon_start=1
                     /product="glutamate receptor-interacting protein 1 isoform
                     1"
                     /protein_id="NP_083012.1"
                     /db_xref="CCDS:CCDS24202.1"
                     /db_xref="GeneID:74053"
                     /db_xref="MGI:MGI:1921303"
                     /translation="MIAVSFKCRCQILRRLTKDESPYTKSASQTKPPDGALAVRRQSI
                     PEEFKGSTVVELMKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIK
                     AVNGINLAKFRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVMFRTVEVTLHKEGN
                     TFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAE
                     AMSILKQCGQEATLLIEYDVSVMDSVATASGPLLVEVAKTPGASLGVALTTSVCCNKQ
                     VIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILP
                     HHQTRLALKGPDHVKIQRSDRQHPWDAWASNQCGVHTNHHHNTYHPDHCRVPALTFPK
                     ALPPNSPPAMVPSSSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSS
                     LSLASSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEAD
                     SPAERCGVLQIGDRVMAINGIPTEDSTFEEANQLLRDSSITSKVTLEIEFDVAESVIP
                     SSGTFHVKLPKKHSVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLA
                     IDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGPL
                     GITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQ
                     MAGETVTLKIKKQTDAQSASSPKKFPIPGHSGDLGDGEEDPSPIQKPGKLSDAYPSTV
                     PSVDSAVDSWDGSGIDASYGSQGSTFQTSGYNYNTYDWRSPKQRTSLSPVPKPRSQTY
                     PDVGLSNEDWDRSTASGFVGASDSADAEQEENFWSQALEDLETCGQSGILRELEEKAD
                     RRVSLRNMTLLATIMSGSTMSLNHEAPMARSQLGRQASFQERSSSRPHYSQTTRSNTL
                     PSDVGRKSVTLRKMKQEIKEIMSPTPVELHKVTLYKDSGMEDFGFSVADGLLEKGVYV
                     KNIRPAGPGDVGGLKPYDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLVISRNPLAS
                     QKSIEQPALPSDWSEQNSAFFQQPSHGGNLETREPTNTL"
     exon            247..327
                     /gene="Grip1"
                     /gene_synonym="4931400F03Rik; eb; GRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            328..463
                     /gene="Grip1"
                     /gene_synonym="4931400F03Rik; eb; GRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            464..609
                     /gene="Grip1"
                     /gene_synonym="4931400F03Rik; eb; GRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            610..693
                     /gene="Grip1"
                     /gene_synonym="4931400F03Rik; eb; GRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            694..769
                     /gene="Grip1"
                     /gene_synonym="4931400F03Rik; eb; GRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            770..915
                     /gene="Grip1"
                     /gene_synonym="4931400F03Rik; eb; GRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1063
                     /gene="Grip1"
                     /gene_synonym="4931400F03Rik; eb; GRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1233
                     /gene="Grip1"
                     /gene_synonym="4931400F03Rik; eb; GRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1389
                     /gene="Grip1"
                     /gene_synonym="4931400F03Rik; eb; GRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1542
                     /gene="Grip1"
                     /gene_synonym="4931400F03Rik; eb; GRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1729
                     /gene="Grip1"
                     /gene_synonym="4931400F03Rik; eb; GRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1875
                     /gene="Grip1"
                     /gene_synonym="4931400F03Rik; eb; GRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..1956
                     /gene="Grip1"
                     /gene_synonym="4931400F03Rik; eb; GRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2026
                     /gene="Grip1"
                     /gene_synonym="4931400F03Rik; eb; GRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2172
                     /gene="Grip1"
                     /gene_synonym="4931400F03Rik; eb; GRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2317
                     /gene="Grip1"
                     /gene_synonym="4931400F03Rik; eb; GRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2457
                     /gene="Grip1"
                     /gene_synonym="4931400F03Rik; eb; GRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2652
                     /gene="Grip1"
                     /gene_synonym="4931400F03Rik; eb; GRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..2809
                     /gene="Grip1"
                     /gene_synonym="4931400F03Rik; eb; GRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2810..2921
                     /gene="Grip1"
                     /gene_synonym="4931400F03Rik; eb; GRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2922..2966
                     /gene="Grip1"
                     /gene_synonym="4931400F03Rik; eb; GRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2967..3200
                     /gene="Grip1"
                     /gene_synonym="4931400F03Rik; eb; GRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3201..3347
                     /gene="Grip1"
                     /gene_synonym="4931400F03Rik; eb; GRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3348..5219
                     /gene="Grip1"
                     /gene_synonym="4931400F03Rik; eb; GRIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5195..5200
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grip1"
                     /gene_synonym="4931400F03Rik; eb; GRIP"
                     /note="hexamer: AATAAA"
     polyA_site      5214
                     /gene="Grip1"
                     /gene_synonym="4931400F03Rik; eb; GRIP"
                     /note="major polyA site"
ORIGIN      
        1 gaaaggcaca gctctgccag atgacatgta gcggacctct gcatcagcca agaggaatta
       61 agctttgtca ctccccactg ggactacctt tctcctggta tgtgcgcaag gaattcacat
      121 gctgccgctc gccgctgcag ccaccagagc agagcccctg tgtacacttt gccagagagc
      181 agagagcaag aatgatagct gtctctttta aatgccgctg tcaaattcta aggcgactta
      241 ccaaagatga gagtccctac actaaatctg ccagccagac aaagccgccc gatggagcat
      301 tggctgtgag gagacagagc atcccagagg aattcaaggg ctccacagtg gtggagttga
      361 tgaagaagga gggaaccact cttggcctga cggtatcggg aggcattgat aaagatggca
      421 agccaagagt gtccaacctg cggcagggag gaatcgctgc cagaagtgac cagctggatg
      481 tgggcgacta catcaaggcg gtgaatggga tcaacctggc caagttccgc cacgatgaga
      541 tcatcagcct gctgaaaaat gtcggggaaa gagtggtcct ggaggtcgag tacgagcttc
      601 caccggtctc tgtacaagga tccagtgtta tgttccgaac tgtggaggtc acgctgcaca
      661 aagaaggcaa cacctttggt tttgtcatcc gagggggagc gcatgatgac aggaacaagt
      721 cccgtccggt tgtgataacc tgtgttcgtc ctggagggcc tgctgacaga gagggcacca
      781 tcaaacctgg agacaggttg ctcagcgtgg atggaattcg gctcctggga accacccatg
      841 ccgaggccat gagcatcctt aaacagtgcg gacaagaagc cacgctgctg atagaatacg
      901 atgtctctgt gatggattct gtggcgacag catccgggcc actactagtt gaagttgcca
      961 aaactccagg tgccagcctt ggggttgccc taactacctc cgtgtgctgt aacaagcagg
     1021 tcattgtcat agacaaaatc aaatctgcaa gcattgcgga cagatgtggc gcgctacacg
     1081 tgggagacca catcctctcc attgacggca cgagtatgga gtactgtacc ctcgcagaag
     1141 cgacccagtt cctggccaat accactgacc aggtcaagct ggagattctc ccacaccatc
     1201 agacccgcct ggccctaaag ggccctgacc atgtgaaaat tcagaggagc gacagacaac
     1261 atccctggga tgcctgggcc agcaaccagt gcggcgttca taccaaccat caccataaca
     1321 cgtaccaccc agaccattgc agagtgccag ccctgacttt cccgaaagcg cttcctccaa
     1381 acagccctcc ggctatggtg ccctcatctt ctcctacctc catgagtgcg tacagtctga
     1441 gttccctgaa catggggact ttacctcgaa gcctctactc caccagccca cgaggaacca
     1501 tgatgaggag gagactgaaa aagaaagact tcaaaagctc actgtcttta gcctccagca
     1561 ctgtggggtt ggctggccag gtcgttcaca ctgaaaccac agaggttgtg ctgacggctg
     1621 accctgtcac gggcttcgga atccaactgc agggcagcgt gtttgccaca gagacgctct
     1681 cctctccgcc tctgatttcc tatattgaag ctgacagccc agcagagaga tgtggtgtgc
     1741 tacagattgg agacagagtc atggccatta atggaatccc aacagaagac agcaccttcg
     1801 aggaagccaa tcaactcctg agagactctt ccatcacgag caaagtcaca ctagaaatcg
     1861 agtttgatgt tgcagagtct gtcatcccaa gtagtggaac atttcatgta aaactgccca
     1921 agaagcacag cgtggaactt ggaataacca tcagttcgcc atccagtaga aaaccggggg
     1981 acccccttgt catttcagat atcaagaaag gcagtgtggc acacagaacc ggaactctgg
     2041 aactgggaga caaactgctt gcgatagata acatccggct ggataactgt tccatggaag
     2101 atgcggtcca gatcctccag cagtgtgaag acctggtgaa gctcaaaatc cgcaaagatg
     2161 aagataactc agacgagcaa gagagttccg gagcgattat ttacacggtg gagctgaagc
     2221 gctatggggg gccccttggc atcacaattt ctggaactga agagccgttt gatcctatta
     2281 tcatctcgag cctcactaaa gggggattag ctgaaaggac tggagcgatc cacatcggag
     2341 atagaatcct agccatcaat agcagcagct tgaaggggaa gcctctgagt gaagccatcc
     2401 acttgctcca gatggcagga gagactgtca ccctgaaaat taagaaacag acagatgccc
     2461 aatctgcatc aagtcccaag aagttcccca tccctggcca ctcgggggac ctaggagatg
     2521 gtgaggagga cccctcccca atacagaaac ctggcaagct ctccgatgcg tacccctcca
     2581 cggtgcccag cgtggacagt gctgtggact cctgggatgg gtctggaata gatgccagct
     2641 atgggagtca aggctcaact tttcagactt caggatacaa ttacaacacc tatgattgga
     2701 ggagtccaaa gcaaagaacc agcctgtccc cagtccccaa gcctcgaagc cagacgtacc
     2761 cagatgtggg cctgagtaat gaagactggg atcgatccac agccagtggc tttgtagggg
     2821 cttctgacag tgcagatgct gaacaagagg aaaacttctg gtctcaagca ttggaggacc
     2881 tggagacctg cggccagtcg gggatcctga gagagcttga ggagaaagct gacaggcgtg
     2941 tgtcattgag aaacatgacc ctcttggcaa caatcatgtc ggggagtact atgagtttga
     3001 atcatgaggc tccaatggct cgcagtcagc tggggcgaca ggccagcttc caggaacgga
     3061 gcagttcacg gccacactat agccaaacaa ctcgcagcaa caccctgccc tcagacgtgg
     3121 gcagaaagtc tgtaaccctg cggaaaatga agcaagaaat aaaggagatc atgtccccaa
     3181 ctccggtgga gctacacaag gtgaccttat acaaggactc tggcatggag gacttcgggt
     3241 tcagtgtggc agatggcctg ctggagaaag gcgtgtatgt caaaaatatc cgcccagctg
     3301 ggccaggtga tgttgggggc ttgaagccct acgacaggct cttacaggta aatcacgtgc
     3361 ggacgagaga ctttgactgc tgcctggtgg tgcctctcat agctgaatct ggcaacaagc
     3421 tggacctggt tattagcaga aatccactgg cctcccagaa gtcgatagaa cagccggctc
     3481 tgcccagcga ctggagcgaa cagaacagcg ctttcttcca gcaacccagc cacggtggta
     3541 atctagagac acgagaaccc actaacacac tatagcagta cttttataaa gcaggacaaa
     3601 agacaatatc tacatggtgc taaacaaaaa caaaaacaaa aacaaaaaca aaaaacaaaa
     3661 aaacaaaaac aaaacaaaaa cccattaaga tttctgtgac agctgaagca cagagaatca
     3721 cgtggcatta atgcaagcac aggggtcttt taaatctccc tcatggctca tgttctcgtc
     3781 ccttcccaac tagaagaggt ttcttaaaag agtggccact ccggtagctg gtgagtcctt
     3841 ctctcctggg gcccagtggt agggaataaa gcagaaggca gcccatccct tccccccagt
     3901 taagatcaga ggaaactttt tacaattcac ctttactgtc actttttaca gagaaaaaca
     3961 tcggtttgaa aatattctct atggtaattt cctgaatgac atacgtttct tcctataacg
     4021 tcattagtgt aaggacatga tcaacatgga tttacagaca gctggctcgg ctaggggagc
     4081 taaggagggg tgactggcca ggcctgccgc agtgggaggg gcgcaggtat agcattaggc
     4141 tttcttaaaa tatttccgca acaatgcacg taggagacct taataggtgg tggtaaatgt
     4201 tttgcccaaa tataggaatg attttaacta agatgtatgc tattccctat gcaacagatg
     4261 atcaaacagg atatgtcttg tgacctgttt tgtttttgtt ttgttctcct tccccttaag
     4321 gacacatttt tttttccttt ttttaaaata gctgaaaaaa aaatctctga taatgaatta
     4381 gagtgtgtag taacactgag aattagtgat atgatcctat tttttaaatc caaggctaag
     4441 aatttaagga gtgaagagtc ttaatgagat gagattcact ttatgggtag gcaaatagaa
     4501 ctcagccagg tcagatggct gcagacggct tccccgaggg gtgcaccgca tggtacttac
     4561 tgccggcgtt tgttctgagc catgccactt gcttaacttg taaatacatt ttcacaaagc
     4621 tcattgccaa tcactgtccc cccgaagcaa taaaccgtga cagttgcttt aaatgtttgt
     4681 gggcaactgc tttcatctgt tcacatattt tgaatagcta cactaataac tgttatttgg
     4741 taaatattta aaggaaaaaa aatagatctg tatattgatg gtagaatgtc aagacaattc
     4801 ttttccaaac atgttcattt tggtcactaa tacaactgcg caggcaaaac atcgaaacac
     4861 tgtgtccttt gtttaaggga aatgattcat ctttcttttt tgtgcaaaga aatatatgat
     4921 ttcaaacaca tttctgaact gccagggcaa gaaagtatag aacagaatca tgttaagaaa
     4981 aaaaaaaaaa aagatcatga gtcacttaaa tatgtatttt tgtttgtaac aaacaagtat
     5041 taaactgtaa agtatttttg tacaaattta atactttaat agcatggtat ttatcgtcta
     5101 tgtatggttt tggggaattc aaaattgttg caaatatttg tatggaaaaa aaaatcctct
     5161 accaaatgga ataaacggtg attttaaaag ccaaaataaa aaaaaaagaa atgacctgc
//
