LOCUS       NM_023168               1693 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus glutamate receptor, ionotropic, N-methyl
            D-aspartate-associated protein 1 (glutamate binding) (Grina), mRNA.
ACCESSION   NM_023168
VERSION     NM_023168.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1693)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   2  (bases 1 to 1693)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1693)
  AUTHORS   Habib,P., Stamm,A.S., Schulz,J.B., Reich,A., Slowik,A.,
            Capellmann,S., Huber,M. and Wilhelm,T.
  TITLE     EPO and TMBIM3/GRINA Promote the Activation of the Adaptive Arm and
            Counteract the Terminal Arm of the Unfolded Protein Response after
            Murine Transient Cerebral Ischemia
  JOURNAL   Int J Mol Sci 20 (21), 5421 (2019)
   PUBMED   31683519
  REMARK    GeneRIF: GRINA/TMBIM3 plays a crucial role in post-ischemic
            unfolded protein response (UPR).
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1693)
  AUTHORS   Habib,P., Stamm,A.S., Zeyen,T., Noristani,R., Slowik,A., Beyer,C.,
            Wilhelm,T., Huber,M., Komnig,D., Schulz,J.B. and Reich,A.
  TITLE     EPO regulates neuroprotective Transmembrane BAX Inhibitor-1
            Motif-containing (TMBIM) family members GRINA and FAIM2 after
            cerebral ischemia-reperfusion injury
  JOURNAL   Exp Neurol 320, 112978 (2019)
   PUBMED   31211943
REFERENCE   5  (bases 1 to 1693)
  AUTHORS   Rojas-Rivera,D., Armisen,R., Colombo,A., Martinez,G.,
            Eguiguren,A.L., Diaz,A., Kiviluoto,S., Rodriguez,D., Patron,M.,
            Rizzuto,R., Bultynck,G., Concha,M.L., Sierralta,J., Stutzin,A. and
            Hetz,C.
  TITLE     TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene
            that controls apoptosis through the modulation of ER calcium
            homeostasis
  JOURNAL   Cell Death Differ 19 (6), 1013-1026 (2012)
   PUBMED   22240901
REFERENCE   6  (bases 1 to 1693)
  AUTHORS   Nielsen,J.A., Chambers,M.A., Romm,E., Lee,L.Y., Berndt,J.A. and
            Hudson,L.D.
  TITLE     Mouse transmembrane BAX inhibitor motif 3 (Tmbim3) encodes a 38 kDa
            transmembrane protein expressed in the central nervous system
  JOURNAL   Mol Cell Biochem 357 (1-2), 73-81 (2011)
   PUBMED   21614515
  REMARK    GeneRIF: In this study, the authors show that TMBIM3 is expressed
            in the brain including high levels in the hippocampus.
REFERENCE   7  (bases 1 to 1693)
  AUTHORS   Tachikawa,K., Sasaki,S., Maeda,T. and Nakajima,K.
  TITLE     Identification of molecules preferentially expressed beneath the
            marginal zone in the developing cerebral cortex
  JOURNAL   Neurosci Res 60 (2), 135-146 (2008)
   PUBMED   18055048
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC110211.16.
            
            On Nov 17, 2006 this sequence version replaced NM_023168.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010802.2, AF182040.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AC110211.16        176357-176450
            95-421              AC110211.16        177401-177727
            422-531             AC110211.16        177809-177918
            532-732             AC110211.16        177999-178199
            733-861             AC110211.16        178322-178450
            862-1005            AC110211.16        178528-178671
            1006-1693           AC110211.16        178767-179454
FEATURES             Location/Qualifiers
     source          1..1693
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 35.59 cM"
     gene            1..1693
                     /gene="Grina"
                     /gene_synonym="1110025J15Rik; Lag; Tmbim3"
                     /note="glutamate receptor, ionotropic, N-methyl
                     D-aspartate-associated protein 1 (glutamate binding)"
                     /db_xref="GeneID:66168"
                     /db_xref="MGI:MGI:1913418"
     exon            1..94
                     /gene="Grina"
                     /gene_synonym="1110025J15Rik; Lag; Tmbim3"
                     /inference="alignment:Splign:2.1.0"
     exon            95..421
                     /gene="Grina"
                     /gene_synonym="1110025J15Rik; Lag; Tmbim3"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1155
                     /gene="Grina"
                     /gene_synonym="1110025J15Rik; Lag; Tmbim3"
                     /note="glutamate [NMDA] receptor-associated protein 1;
                     NMDA receptor glutamate-binding subunit"
                     /codon_start=1
                     /product="protein lifeguard 1"
                     /protein_id="NP_075657.1"
                     /db_xref="CCDS:CCDS27563.1"
                     /db_xref="GeneID:66168"
                     /db_xref="MGI:MGI:1913418"
                     /translation="MSHEKSFLVSGDSYPPQNIVGPQAPMPPYVQAPYPGAPYPQAPF
                     QPSPYGQPGYPHGPSPYPQGGYPQGPYPQGGYPQGPYPQSPFPPNPYGQPPPFQDPGS
                     PQHGNYQEEGPPSYYDNQDFPAVNWDKNIRQAFIRKVFLVLTLQLSVTLSTVAIFTFV
                     GEVKGFVRENVWTYYVSYAIFFISLIVLSCCGDFRRKHPWNLVALSILTVSLSYMVGM
                     IASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSVVVLFIFAILCIF
                     IRNRILEIVYASLGALLFTCFLAVDTQLLLGNKQLSLSPEEYVFAALNLYTDIINIFL
                     YILTIIGRAKE"
     exon            422..531
                     /gene="Grina"
                     /gene_synonym="1110025J15Rik; Lag; Tmbim3"
                     /inference="alignment:Splign:2.1.0"
     exon            532..732
                     /gene="Grina"
                     /gene_synonym="1110025J15Rik; Lag; Tmbim3"
                     /inference="alignment:Splign:2.1.0"
     exon            733..861
                     /gene="Grina"
                     /gene_synonym="1110025J15Rik; Lag; Tmbim3"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1005
                     /gene="Grina"
                     /gene_synonym="1110025J15Rik; Lag; Tmbim3"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1693
                     /gene="Grina"
                     /gene_synonym="1110025J15Rik; Lag; Tmbim3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcccagcg ggtgcaggtg cggacgcacc ggccatcacc gcgcgcggct gcgcagcggg
       61 caccgtaagc accggtctct ggctcccggg agcggggcag ccacagaacc cgaggccatg
      121 tcccatgaaa agagtttctt ggtgtctggg gacagttatc ctccccaaaa cattgtgggg
      181 ccccaagccc ctatgcctcc ctatgttcag gctccctacc ctggggcccc atacccacag
      241 gcccctttcc agccctctcc ctatggtcag ccaggatatc cccatggtcc cagcccctat
      301 ccacagggtg gttaccctca agggccctac cctcaaggag gctacccaca ggggccatac
      361 ccacagagcc ccttcccgcc caacccctat ggacagccac cacccttcca ggaccctggc
      421 tcacctcagc atgggaacta ccaggaggaa gggcctccat cctactatga caaccaggac
      481 ttccctgctg tcaactggga caagaacatt cgccaggcct ttatcagaaa ggtgttcctg
      541 gtgctgaccc tgcagctgtc ggtgaccctg tccactgtgg ccattttcac ttttgttggg
      601 gaggtgaagg gctttgtccg ggagaatgtc tggacctact atgtctccta cgccatcttc
      661 ttcatctccc tcattgttct cagctgttgt ggggacttcc ggcgaaagca tccctggaac
      721 cttgttgctc tgtcgatcct gaccgtcagc ttgtcctaca tggtgggcat gatagccagc
      781 ttttacaaca cggaggcagt catcatggcc gtgggcatca ccacagctgt ctgcttcacg
      841 gtggtcatct tctccatgca gacccgctat gacttcacct cgtgcatggg cgtgctcctg
      901 gtgagtgttg tggtgctctt catcttcgcc atcctctgca tcttcatccg gaaccgcatc
      961 ctggagattg tatacgcctc gctgggcgct ctgctcttca cctgcttcct ggcagtggac
     1021 acccagctac tcctggggaa caagcagctg tccctgagcc cagaagaata tgtgtttgcg
     1081 gccctgaacc tgtacacgga catcatcaac atcttcctat atattctcac catcattggc
     1141 cgtgccaagg agtagaacaa gccccagctc aggtggcatg gttggctcag acccatgccc
     1201 ctggcatgac aatgccatct gtgcttccct ctctctggtc cccaggcctg gcctggtgca
     1261 gagggagtcc ctctcgccct cttgtatgta cactgcaaat acttaacgtc tggaccctct
     1321 atggccacag catggccccc tttatccctt ttgcccttgc caaggggcga cagggctgca
     1381 tttctgtgcc accttctgtc cactcactgt tgcatgagcc ctgtctgcca gccccatccc
     1441 agggtcaggg accaacacca ggtctcaggg gagaaggatc ataccaagag gtgagggtgc
     1501 acgtcttccc ttctgtcccg gctcccctgg catagagtac ccgtgtcccc tccccaccct
     1561 gccttctgag gggcacgcag ggcggggtct cattcttgcg ctgggcccca agagcagaga
     1621 ggatgtcatg tttcaaggga ggaggctctc tcgtgctgcc attgttaaaa tgccaataaa
     1681 agggtacctt ctg
//
