LOCUS       NM_130455               3281 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus glutamate receptor, ionotropic, NMDA3B (Grin3b), mRNA.
ACCESSION   NM_130455
VERSION     NM_130455.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3281)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3281)
  AUTHORS   Spirkova,A., Kovarikova,V., Sefcikova,Z., Pisko,J., Ksinanova,M.,
            Koppel,J., Fabian,D. and Cikos,S.
  TITLE     Glutamate can act as a signaling molecule in mouse preimplantation
            embryosdagger
  JOURNAL   Biol Reprod 107 (4), 916-927 (2022)
   PUBMED   35746896
REFERENCE   3  (bases 1 to 3281)
  AUTHORS   Patel,T., Hammelman,J., Aziz,S., Jang,S., Closser,M.,
            Michaels,T.L., Blum,J.A., Gifford,D.K. and Wichterle,H.
  TITLE     Transcriptional dynamics of murine motor neuron maturation in vivo
            and in vitro
  JOURNAL   Nat Commun 13 (1), 5427 (2022)
   PUBMED   36109497
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3281)
  AUTHORS   Yang,B., Qu,M., Wang,R., Chatterton,J.E., Liu,X.B., Zhu,B.,
            Narisawa,S., Millan,J.L., Nakanishi,N., Swoboda,K., Lipton,S.A. and
            Zhang,D.
  TITLE     The critical role of membralin in postnatal motor neuron survival
            and disease
  JOURNAL   Elife 4, e06500 (2015)
   PUBMED   25977983
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3281)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 3281)
  AUTHORS   Matsuda,K., Fletcher,M., Kamiya,Y. and Yuzaki,M.
  TITLE     Specific assembly with the NMDA receptor 3B subunit controls
            surface expression and calcium permeability of NMDA receptors
  JOURNAL   J Neurosci 23 (31), 10064-10073 (2003)
   PUBMED   14602821
  REMARK    GeneRIF: NR3B may modulate the function of NMDA receptors in
            somatic motor neurons during adulthood by controlling membrane
            trafficking and by reducing Ca2+ permeability
REFERENCE   7  (bases 1 to 3281)
  AUTHORS   Matsuda,K., Kamiya,Y., Matsuda,S. and Yuzaki,M.
  TITLE     Cloning and characterization of a novel NMDA receptor subunit NR3B:
            a dominant subunit that reduces calcium permeability
  JOURNAL   Brain Res Mol Brain Res 100 (1-2), 43-52 (2002)
   PUBMED   12008020
REFERENCE   8  (bases 1 to 3281)
  AUTHORS   Chatterton,J.E., Awobuluyi,M., Premkumar,L.S., Takahashi,H.,
            Talantova,M., Shin,Y., Cui,J., Tu,S., Sevarino,K.A., Nakanishi,N.,
            Tong,G., Lipton,S.A. and Zhang,D.
  TITLE     Excitatory glycine receptors containing the NR3 family of NMDA
            receptor subunits
  JOURNAL   Nature 415 (6873), 793-798 (2002)
   PUBMED   11823786
  REMARK    GeneRIF: Assembling NMDA receptor subunit NR1 with NR3A or NR3B
            forms glycine-gated cation channels.
REFERENCE   9  (bases 1 to 3281)
  AUTHORS   Nishi,M., Hinds,H., Lu,H.P., Kawata,M. and Hayashi,Y.
  TITLE     Motoneuron-specific expression of NR3B, a novel NMDA-type glutamate
            receptor subunit that works in a dominant-negative manner
  JOURNAL   J Neurosci 21 (23), RC185 (2001)
   PUBMED   11717388
REFERENCE   10 (bases 1 to 3281)
  AUTHORS   Andersson,O., Stenqvist,A., Attersand,A. and von Euler,G.
  TITLE     Nucleotide sequence, genomic organization, and chromosomal
            localization of genes encoding the human NMDA receptor subunits
            NR3A and NR3B
  JOURNAL   Genomics 78 (3), 178-184 (2001)
   PUBMED   11735224
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY062435.1 and AF396649.1.
            
            On Oct 4, 2004 this sequence version replaced NM_130455.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF396649.1, AY062435.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3262              AY062435.1         1-3262
            3263-3281           AF396649.1         3272-3290
FEATURES             Location/Qualifiers
     source          1..3281
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="ICR"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..3281
                     /gene="Grin3b"
                     /gene_synonym="GluN3B; NR3B"
                     /note="glutamate receptor, ionotropic, NMDA3B"
                     /db_xref="GeneID:170483"
                     /db_xref="MGI:MGI:2150393"
     exon            1..602
                     /gene="Grin3b"
                     /gene_synonym="GluN3B; NR3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..3188
                     /gene="Grin3b"
                     /gene_synonym="GluN3B; NR3B"
                     /note="glutamate [NMDA] receptor subunit 3B; nr4; NMDAR3B;
                     NMDA receptor 4; N-methyl-D-aspartate receptor subunit
                     NR3B; glutamate receptor ionotropic, NMDA 3B"
                     /codon_start=1
                     /product="glutamate receptor ionotropic, NMDA 3B
                     precursor"
                     /protein_id="NP_569722.1"
                     /db_xref="CCDS:CCDS24001.1"
                     /db_xref="GeneID:170483"
                     /db_xref="MGI:MGI:2150393"
                     /translation="MECVQTLWLSLALALARGSWVVRGHPQPCGVPTRAGASVRLAAL
                     LPRAPAARARVLAALATPSPRLPHNLSLELVAVASPTRDPASLARGLCQVLAPPGVVA
                     SITFPEARPELRLLQFLAAATETPVLSVLRREVRAPLGAPTPFHLQLDWASPLETILD
                     VLVSLVRAHAWEDIALVLCRVRDPSGLVTLWTSRASQAPKFVLDLSQLDSGNDSLRAT
                     LALLGTLEGGGTPVSAAVLLGCSTAHAHEVLEAAPPGPQWLLGTPLPAEALPKTGLPP
                     GVLVLGETGQPSLEAAVHDMVELVARALSSMALMHPERALLPAAVNCEDLKTGGSEST
                     ARTLARFLSNTSFQGRTGAVWVAGSSQVHVSRHFKVWSLRRDPLGAPAWATVGSWQDG
                     QLDFQPGAAALRVPSPSGTQARPKLRVVTLVEHPFVFTRESDEDGQCPAGQLCLDPGT
                     NDSARLDALFTALENGSVPRTLRRCCYGYCIDLLERLAEDLAFDFELYIVGDGKYGAL
                     RDGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRTRDTASPI
                     GAFMWPLHWSMWVGVFAALHLTALFLTLYEWRSPYGLTPRGRNRGTVFSYSSALNLCY
                     AILFGRTVSSKTPKCPTGRFLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHD
                     PKLHHPSQGFRFGTVWESSAEAYIKASFPEMHAHMRRHSAPTTPHGVAMLTSDPPKLN
                     AFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSG
                     FIDLLHDKWYKMVPCGKRVFAVTETLQMGVYHLSGLFVLLCLGLGSALLTSLGEHVFY
                     RLVLPRIRRGNKLQYWLHTSQKIHRALNTGPPEGQQERAEQECSGPKEEQPAADGAGR
                     WRRVRRAVVERERRVRFLLEPGEAGGDHPWLCSNGPGVQAELRELELRIEAARERLRS
                     ALLRRGELRAQLGDGTRLRPLRLLHAAPAES"
     exon            603..1195
                     /gene="Grin3b"
                     /gene_synonym="GluN3B; NR3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..2228
                     /gene="Grin3b"
                     /gene_synonym="GluN3B; NR3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2374
                     /gene="Grin3b"
                     /gene_synonym="GluN3B; NR3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2490
                     /gene="Grin3b"
                     /gene_synonym="GluN3B; NR3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2491..2642
                     /gene="Grin3b"
                     /gene_synonym="GluN3B; NR3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2807
                     /gene="Grin3b"
                     /gene_synonym="GluN3B; NR3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2808..2875
                     /gene="Grin3b"
                     /gene_synonym="GluN3B; NR3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2876..3274
                     /gene="Grin3b"
                     /gene_synonym="GluN3B; NR3B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3255..3260
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grin3b"
                     /gene_synonym="GluN3B; NR3B"
                     /note="hexamer: ATTAAA"
     polyA_site      3274
                     /gene="Grin3b"
                     /gene_synonym="GluN3B; NR3B"
                     /note="major polyA site"
ORIGIN      
        1 agcttcagtc tgagcagtgg aaggcatcac ccaactctgc cctgcgtggc acagcaaacc
       61 taggcagcgg cccagctcct cctcctgtgg acacccggac cggcaggagg aacgagagcg
      121 gggctggctg ggatgtctcc ttaccctcgc acagcacagt ggtaacttcc atcgggatgg
      181 agtgtgtgca gacgctgtgg ctcagcctgg ccctggcgct ggcgcgaggg tcctgggtgg
      241 tgcgcggtca ccctcagccc tgcggggttc ccacgcgcgc cggggcctcc gtgcgcctgg
      301 ctgcgctcct accccgggcg cccgccgccc gcgcccgcgt cctagccgcc ctggccaccc
      361 cttccccgcg gctgccgcac aacctgagtc tggagctagt ggccgtcgcg tccccaaccc
      421 gggaccccgc gtcgctggcc cgaggtctgt gccaggttct ggcaccgccc ggcgtggtgg
      481 cctctataac ctttcccgag gcgcggcctg agctacggct attgcagttc ctggcagctg
      541 ccacagagac cccggtgctg agcgtcctac ggagggaggt gcgcgcgccc ctcggagctc
      601 cgaccccgtt ccacctgcag ctggactggg ctagtcccct ggagaccatc ctggatgtgc
      661 tggtgtccct ggtacgggca cacgcctggg aggacattgc tctagtgctc tgtcgtgtcc
      721 gggaccccag tggcctggtg acactctgga ccagccgtgc tagccaggct ccaaagtttg
      781 tgctggacct gagccagttg gacagcggga atgacagcct tcgggctaca ctggccctgc
      841 tggggacgct ggaaggaggg ggaacccccg tgtctgcagc cgtcctcctg ggctgcagca
      901 ctgcccatgc acatgaggtc ctagaggcag caccaccggg tccccagtgg ctgctgggca
      961 caccactgcc cgccgaggca ctgcccaaaa ccggtctgcc ccctggggtg ttggtgctgg
     1021 gggaaaccgg gcagccttcc ctggaagctg ccgtccacga catggtggag cttgtggctc
     1081 gggcactcag cagcatggcc ctcatgcacc cagagcgggc cctgcttcca gcggcagtaa
     1141 attgtgagga cctgaaaacg ggcggctctg agtcaacagc acgcaccttg gctaggtttc
     1201 tgagcaacac ctcatttcag ggccgcacag gggctgtgtg ggtggcaggc tcctctcagg
     1261 tgcatgtgtc tcggcatttc aaggtatgga gcttacgcag ggacccgctg ggtgccccag
     1321 cctgggcaac agtaggcagc tggcaggatg gacagctgga cttccagcca ggggcggctg
     1381 ctctccgagt tccatctcca tctggcaccc aggcccggcc aaagctgcga gtggtaactc
     1441 tggtggaaca cccatttgtg ttcaccaggg aatctgatga agatgggcag tgcccggctg
     1501 ggcagctgtg tctagaccca ggcaccaatg actcggccag gctggatgcg ctcttcactg
     1561 cattggagaa tggctccgtg cctcgcaccc tgagaagatg ctgttatggc tactgcattg
     1621 acctgctgga gcggctggcc gaggacctgg cctttgactt tgagctctat attgtggggg
     1681 atggcaagta cggggccctg cgtgatggac gctggacagg cctggtgggt gacctgctgg
     1741 ccggtcgggc acacatggcc gtgaccagct tcagtatcaa ctcggctcgc tcccaggtgg
     1801 tggatttcac cagccctttc ttctccacca gcctgggcat catggtgcgc acgcgagata
     1861 cagcctcacc cattggggct ttcatgtggc ccctgcactg gtccatgtgg gtgggtgtgt
     1921 ttgctgccct gcacctcaca gcgctcttcc ttactctgta cgaatggcgg agtccctacg
     1981 ggctcacgcc acgcggccgc aaccgtggta ccgtcttctc ctactcctcc gctctcaacc
     2041 tctgctacgc cattctcttc ggacgcactg tctccagtaa gacacccaag tgtcctaccg
     2101 gacgcttcct catgaatctc tgggcaatct tctgcctgct ggtgctatcc agttacacag
     2161 ccaacctggc agctgtcatg gtcggggaca agacatttga ggagctgtct ggaatccatg
     2221 atcccaagct gcaccaccct tcccaaggct tccgctttgg caccgtgtgg gagagcagcg
     2281 cggaggccta catcaaggcg agcttccccg agatgcacgc acacatgcgt cgccacagcg
     2341 cacctaccac tccacacgga gtggccatgc tcacgagcga cccgcccaag ctcaacgcct
     2401 tcatcatgga taaatcacta ctggattatg aggtgtccat agatgcggac tgcaagctgc
     2461 tcaccgtggg caaacccttt gcgatcgagg gctacggcat agggctgccc caaaattcgc
     2521 cgctcacctc caacctgtca gagttcatca gtaggtacaa gtcctcaggc ttcattgatc
     2581 tgctccatga caagtggtac aagatggtgc cttgcgggaa gcgggtgttc gccgtgacgg
     2641 agacgctgca gatgggggtc taccacttgt cagggttgtt tgtcctgctg tgcctcgggc
     2701 tgggcagtgc acttctcacc tcgctgggtg agcacgtctt ctaccgcctg gtgctgccgc
     2761 gcatccgcag gggcaataag ctgcagtatt ggcttcacac gagccagaag atccaccgag
     2821 ccctcaacac agggccacca gaggggcaac aggagagggc agagcaggag tgcagcggcc
     2881 ccaaggagga gcaacctgca gccgacggtg cggggcgctg gaggcgggtg cgccgggccg
     2941 tggtggaacg ggaacggcgc gtgcgtttcc tgctggaacc tggggaggct ggcggggacc
     3001 atccgtggct ctgctccaat gggcccgggg tgcaagcaga actgcgggag ctggagctgc
     3061 gcattgaggc tgcacgggag cggctgcgta gtgcgctgct gcggcgaggg gaactgcggg
     3121 cccagcttgg ggatggcacc cggctcaggc cactgcgcct gctgcatgcg gcgcccgccg
     3181 agagctgagg aactacacgg ccacactgtc cacgacagtt tattctatat acaaacacga
     3241 ctctgtacac tgcaattaaa tagcgtggaa cgtgaaaaaa a
//
