LOCUS       NM_008172               5395 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus glutamate receptor, ionotropic, NMDA2D (epsilon 4)
            (Grin2d), mRNA.
ACCESSION   NM_008172
VERSION     NM_008172.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5395)
  AUTHORS   Doyle,M.A., Salimando,G.J., Altemus,M.E., Badt,J.K.,
            Bedenbaugh,M.N., Vardy,A.S., Adank,D.N., Park,A.S. and Winder,D.G.
  TITLE     BNST GluN2D-containing NMDARs contribute to ethanol intake but not
            negative affective behaviors in female mice
  JOURNAL   Alcohol Clin Exp Res (Hoboken) 48 (10), 1876-1891 (2024)
   PUBMED   39179522
REFERENCE   2  (bases 1 to 5395)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5395)
  AUTHORS   Vinnakota,C., Schroeder,A., Du,X., Ikeda,K., Ide,S., Mishina,M.,
            Hudson,M., Jones,N.C., Sundram,S. and Hill,R.A.
  TITLE     Understanding the role of the NMDA receptor subunit, GluN2D, in
            mediating NMDA receptor antagonist-induced behavioral disruptions
            in male and female mice
  JOURNAL   J Neurosci Res 102 (1), e25257 (2024)
   PUBMED   37814998
  REMARK    GeneRIF: Understanding the role of the NMDA receptor subunit,
            GluN2D, in mediating NMDA receptor antagonist-induced behavioral
            disruptions in male and female mice.
REFERENCE   4  (bases 1 to 5395)
  AUTHORS   Sharma,R., Neupane,C., Pham,T.L., Lee,M., Lee,S., Lee,S.Y.,
            Nam,M.H., Kim,C.S. and Park,J.B.
  TITLE     Tonic Activation of NR2D-Containing NMDARs Exacerbates Dopaminergic
            Neuronal Loss in MPTP-Injected Parkinsonian Mice
  JOURNAL   J Neurosci 43 (46), 7730-7744 (2023)
   PUBMED   37726169
REFERENCE   5  (bases 1 to 5395)
  AUTHORS   Vinnakota,C., Hudson,M.R., Jones,N.C., Sundram,S. and Hill,R.A.
  TITLE     Potential Roles for the GluN2D NMDA Receptor Subunit in
            Schizophrenia
  JOURNAL   Int J Mol Sci 24 (14), 11835 (2023)
   PUBMED   37511595
  REMARK    GeneRIF: Potential Roles for the GluN2D NMDA Receptor Subunit in
            Schizophrenia.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5395)
  AUTHORS   Watanabe,M., Mishina,M. and Inoue,Y.
  TITLE     Distinct distributions of five NMDA receptor channel subunit mRNAs
            in the brainstem
  JOURNAL   J Comp Neurol 343 (4), 520-531 (1994)
   PUBMED   7518475
REFERENCE   7  (bases 1 to 5395)
  AUTHORS   Watanabe,M., Mishina,M. and Inoue,Y.
  TITLE     Distinct spatiotemporal expressions of five NMDA receptor channel
            subunit mRNAs in the cerebellum
  JOURNAL   J Comp Neurol 343 (4), 513-519 (1994)
   PUBMED   7518474
REFERENCE   8  (bases 1 to 5395)
  AUTHORS   Watanabe,M., Mishina,M. and Inoue,Y.
  TITLE     Differential distributions of the NMDA receptor channel subunit
            mRNAs in the mouse retina
  JOURNAL   Brain Res 634 (2), 328-332 (1994)
   PUBMED   7510577
REFERENCE   9  (bases 1 to 5395)
  AUTHORS   Watanabe,M., Inoue,Y., Sakimura,K. and Mishina,M.
  TITLE     Developmental changes in distribution of NMDA receptor channel
            subunit mRNAs
  JOURNAL   Neuroreport 3 (12), 1138-1140 (1992)
   PUBMED   1493227
REFERENCE   10 (bases 1 to 5395)
  AUTHORS   Ikeda,K., Nagasawa,M., Mori,H., Araki,K., Sakimura,K., Watanabe,M.,
            Inoue,Y. and Mishina,M.
  TITLE     Cloning and expression of the epsilon 4 subunit of the NMDA
            receptor channel
  JOURNAL   FEBS Lett 313 (1), 34-38 (1992)
   PUBMED   1385220
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149053.3.
            
            On Sep 30, 2022 this sequence version replaced NM_008172.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AB154245.1, D12822.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMN00849374,
                                    SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               AC149053.3         90723-90924
            203-500             AC149053.3         91698-91995
            501-982             AC149053.3         95113-95594
            983-1602            AC149053.3         99143-99762
            1603-1717           AC149053.3         103142-103256
            1718-1929           AC149053.3         103622-103833
            1930-2098           AC149053.3         104060-104228
            2099-2252           AC149053.3         104813-104966
            2253-2378           AC149053.3         107007-107132
            2379-2608           AC149053.3         107249-107478
            2609-2769           AC149053.3         108343-108503
            2770-2957           AC149053.3         126880-127067
            2958-3190           AC149053.3         127225-127457
            3191-5395           AC149053.3         127619-129823
FEATURES             Location/Qualifiers
     source          1..5395
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.54 cM"
     gene            1..5395
                     /gene="Grin2d"
                     /gene_synonym="GluN2D; NMDAR2D; NR2D"
                     /note="glutamate receptor, ionotropic, NMDA2D (epsilon 4)"
                     /db_xref="GeneID:14814"
                     /db_xref="MGI:MGI:95823"
     exon            1..202
                     /gene="Grin2d"
                     /gene_synonym="GluN2D; NMDAR2D; NR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            203..500
                     /gene="Grin2d"
                     /gene_synonym="GluN2D; NMDAR2D; NR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            501..982
                     /gene="Grin2d"
                     /gene_synonym="GluN2D; NMDAR2D; NR2D"
                     /inference="alignment:Splign:2.1.0"
     CDS             527..4498
                     /gene="Grin2d"
                     /gene_synonym="GluN2D; NMDAR2D; NR2D"
                     /note="glutamate [NMDA] receptor subunit epsilon-4; glur
                     epsilon 4; ionotropic NMDA glutamate receptor epsilon 4
                     subunit type 2; N-methyl D-aspartate receptor subtype 2D;
                     GluRepsilon4; glutamate receptor ionotropic, NMDA 2D"
                     /codon_start=1
                     /product="glutamate receptor ionotropic, NMDA 2D
                     precursor"
                     /protein_id="NP_032198.2"
                     /db_xref="CCDS:CCDS21267.1"
                     /db_xref="GeneID:14814"
                     /db_xref="MGI:MGI:95823"
                     /translation="MRGAGGPRGPRGPAKMLLLLALACASPFPEEVPGPGAAGGGTGG
                     ARPLNVALVFSGPAYAAEAARLGPAVAAAVRSPGLDVRPVALVLNGSDPRSLVLQLCD
                     LLSGLRVHGVVFEDDSRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEKGSTFLQ
                     LGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLTDGSLVGWEHRGAL
                     TLDPGAGEAVLGAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGPGYVWFMVGPQL
                     AGGGGSGVPGEPLLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRD
                     YGFLPELGHDCRAQNRTHRGESLHRYFMNITWDNRDYSFNEDGFLVNPSLVVISLTRD
                     RTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIVEPADPISG
                     TCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNG
                     KHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSN
                     GTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTF
                     TIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEE
                     YVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEE
                     ALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKR
                     PIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLS
                     LLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGMYSCCSAEAAPPPAKPPPPPQPLPS
                     PAYPAARPPPGPAPFVPRERAAADRWRRAKGTGPPGGAALADGFHRYYGPIEPQGLGL
                     GEARAAPRGAAGRPLSPPTTQPPQKPPPSYFAIVREQEPAEPPAGAFPGFPSPPAPPA
                     AAAAAVGPPLCRLAFEDESPPAPSRWPRSDPESQPLLGGGAGGPSAGAPTAPPPRRAA
                     PPPCAYLDLEPSPSDSEDSESLGGASLGGLEPWWFADFPYPYAERLGPPPGRYWSVDK
                     LGGWRAGSWDYLPPRGGPAWHCRHCASLELLPPPRHLSCSHDGLDGGWWAPPPPPWAA
                     GPPPRRRARCGCPRPHPHRPRASHRAPAAAPHHHRHRRAAGGWDLPPPAPTSRSLEDL
                     SSCPRAAPTRRLTGPSRHARRCPHAAHWGPPLPTASHRRHRGGDLGTRRGSAHFSSLE
                     SEV"
     exon            983..1602
                     /gene="Grin2d"
                     /gene_synonym="GluN2D; NMDAR2D; NR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1717
                     /gene="Grin2d"
                     /gene_synonym="GluN2D; NMDAR2D; NR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1929
                     /gene="Grin2d"
                     /gene_synonym="GluN2D; NMDAR2D; NR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2098
                     /gene="Grin2d"
                     /gene_synonym="GluN2D; NMDAR2D; NR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2252
                     /gene="Grin2d"
                     /gene_synonym="GluN2D; NMDAR2D; NR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2378
                     /gene="Grin2d"
                     /gene_synonym="GluN2D; NMDAR2D; NR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2608
                     /gene="Grin2d"
                     /gene_synonym="GluN2D; NMDAR2D; NR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            2609..2769
                     /gene="Grin2d"
                     /gene_synonym="GluN2D; NMDAR2D; NR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..2957
                     /gene="Grin2d"
                     /gene_synonym="GluN2D; NMDAR2D; NR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            2958..3190
                     /gene="Grin2d"
                     /gene_synonym="GluN2D; NMDAR2D; NR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            3191..5395
                     /gene="Grin2d"
                     /gene_synonym="GluN2D; NMDAR2D; NR2D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5368..5373
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grin2d"
                     /gene_synonym="GluN2D; NMDAR2D; NR2D"
                     /note="hexamer: AATAAA"
     polyA_site      5395
                     /gene="Grin2d"
                     /gene_synonym="GluN2D; NMDAR2D; NR2D"
                     /note="major polyA site"
ORIGIN      
        1 aatcgcatcc tgagtgagtg tgcgggaaca gcgagtgtgc gagtccctcc cgctctggct
       61 cctgcaagcc gtggccgctg ccgccagcca ccctccgcct gcgcccacag cctcctcggc
      121 cagcagcgcc ctgttgaggg gtaccagcct gggtgggtcc gcctggcccc caggggtctc
      181 tcgtgctaca gccatctgct agcgcaacat gtgtagcctc atccttgcct agtctggtgg
      241 ccgcaacctt gggggacagg gcagggcagg accaagaaga ggagggacag agccgggaca
      301 ggcaaaaggt ccccgccact gccgcctgcg ctgctactgc tgctgctgct gctgctgctg
      361 ctactgctac tgcctccgct gccgccctgg gcctggcccc caaccagctc cccagcactc
      421 cacggaatct ttgggtctct ggacgctggt tccggtcctg gcccccagca atttccccca
      481 aagaacaggg tcatgaaaag aggccgcccg gcggggcccg caggcgatgc gcggcgccgg
      541 tggcccccgc ggccctcggg gccccgctaa gatgctgttg ctgctggcgc tggcgtgcgc
      601 cagcccgttc ccggaggagg tgccggggcc gggcgcggcc ggcgggggca cgggcggggc
      661 gcggccgctc aacgtggcgc tggtcttctc tggcccggcg tacgcggccg aggcggcgcg
      721 cttgggcccg gccgtggcgg cggcagtgcg cagcccgggc ctggacgtac ggcccgtggc
      781 gctggtgctc aacggctccg accctcgcag ccttgtgctg cagctctgcg acctgctgtc
      841 ggggctgcgc gtgcacggcg tggtgttcga ggacgactcg cgcgcgcccg ccgtcgcgcc
      901 cattctcgac ttcctgtcgg cgcagacctc gctgcccatc gtggccgtgc acggcggcgc
      961 cgcgctcgta ctcacaccca aggagaaggg ctccaccttc ctgcagcttg gctcctccac
     1021 agagcaacag ctgcaggtca tttttgaggt gctggaggag tacgactgga catcctttgt
     1081 ggcagtgact acgcgtgccc caggccatcg agccttcttg tcatacatcg aggtgctgac
     1141 tgatggcagc ctggtgggct gggagcatcg aggagcgctg acactggacc ccggagcggg
     1201 tgaggccgtc ctgggcgcac agctccgtag tgtcagtgcg cagatccgcc tgctcttctg
     1261 cgcccgcgag gaggcagagc ctgttttccg ggcggcagaa gaggctggtc tcactgggcc
     1321 tggctacgtc tggttcatgg tgggacctca gctggccgga ggtgggggct ccggggtccc
     1381 tggggaacca cttcttctgc caggaggtgc cccactgcct gctgggctgt ttgcagtgcg
     1441 ctctgctggc tggcgtgacg acttggcacg tcgagtggct gctggtgtgg cggtggtggc
     1501 cagaggtgcc caggccctgc tgcgagacta tggcttcctg cctgagctgg gccatgactg
     1561 tcgcgcccag aatcgcaccc accgcgggga gagtctgcac aggtatttca tgaacatcac
     1621 ctgggataac cgagactact ccttcaatga ggatggcttt ctggtaaacc cgtcactggt
     1681 agtcatctcc ctcaccagag acaggacgtg ggaagtggtg ggcagctggg aacagcagac
     1741 cctccgcctc aagtaccctc tatggtcccg ctatggccgc ttcctgcagc cggtggatga
     1801 cacgcagcac ctcactgtgg ccacgctgga ggagagacct tttgtcattg tagagcctgc
     1861 agaccccatc agcggcactt gcatcagaga ctcggttccc tgccggagcc agctcaaccg
     1921 tacccacagc cctccgcctg acgctccccg cccggagaag agatgctgca agggtttctg
     1981 cattgacatt ttgaagaggc tggcgcacac catcggtttc agctatgacc tctacctggt
     2041 taccaacggc aagcatggca agaagatcga tggcgtctgg aatggcatga ttggtgaggt
     2101 gttctatcag cgtgcggaca tggccatcgg ctccctcacc atcaatgagg agcggtcaga
     2161 gatcgtggac ttctccgtcc cttttgtaga gacaggcatc agcgtcatgg tggcacgcag
     2221 caatggcact gtgtccccct ctgccttcct cgagccctac agccccgctg tgtgggtgat
     2281 gatgttcgtc atgtgcctca ccgtggtcgc cgtcacagtt ttcatctttg agtacctcag
     2341 tcctgtgggc tataaccgaa gcctggccac gggcaaacgc cccggaggct ctaccttcac
     2401 cattgggaaa tccatctggc tgctgtgggc cctggtgttc aacaactccg tgccagtgga
     2461 gaatcctcgg ggcaccacca gcaagatcat ggtgctggtg tgggccttct ttgccgtcat
     2521 ctttcttgcc agctatacag ccaatctggc tgccttcatg atccaggagg agtacgtgga
     2581 caccgtgtct gggctcagcg accggaagtt ccagcggccc caggagcaat acccacccct
     2641 gaagtttgga acggtgccca atgggtccac ggagaagaat atccgaagca actaccctga
     2701 tatgcacagc tacatggtgc gatacaacca gccaagagtg gaggaggcgc tcactcagct
     2761 caaggcaggg aaactggacg ccttcatcta tgacgcagca gtgctcaact acatggcccg
     2821 aaaggatgag ggctgcaagc tggtcaccat cggctcaggc aaggtcttcg ccaccactgg
     2881 ttatggcatc gccctacaca agggctcccg ctggaagagg cccatcgacc tggcgctgct
     2941 gcagttcctg ggggacgatg agattgagat gctggagcgg ctgtggcttt cagggatctg
     3001 ccacaacgac aaaatcgagg tgatgagcag caagctggat atcgacaaca tggcaggtgt
     3061 cttctacatg ctcctcgtgg ccatgggcct ctccttgctg gtcttcgcct gggaacacct
     3121 tgtgtactgg cgactgcggc actgtctggg gcccacccac cgcatggatt tcctactggc
     3181 cttctccagg ggtatgtaca gctgctgcag cgctgaggct gctccgccgc cggccaaacc
     3241 cccgccaccg ccgcagccgc tgcccagtcc ggcgtatccc gccgctcgcc caccccctgg
     3301 ccccgcaccc ttcgtgcccc gagagcgcgc agccgccgac cgctggcgcc gggccaaggg
     3361 cacagggccc ccggggggcg cagcgctagc cgacggcttc caccgatact acggccccat
     3421 cgagccgcag gggctgggcc tcggcgaggc gcgcgcggca ccgagaggcg cagccggacg
     3481 cccactgtcc ccacccacca cacagccccc acagaagcca ccaccttcct acttcgccat
     3541 cgtgcgcgag caagagccgg ccgagccccc cgccggcgcc ttcccgggct tcccatctcc
     3601 gcccgctccg cctgccgccg cagccgccgc cgtcgggccg ccactgtgcc gcctggcttt
     3661 cgaggacgag agcccgcccg cgccctcgcg ctggccgcgt tctgaccccg agagccagcc
     3721 gctgttgggt gggggcgcgg gcggcccgag cgctggggcc ccgaccgcac caccgccgcg
     3781 ccgcgccgcg ccaccaccgt gcgcctacct ggacctcgag ccttcgcctt cggactccga
     3841 ggattcggag agcctgggcg gagcgtcgct cggtggcctg gagccctggt ggttcgccga
     3901 cttcccctac ccgtatgcgg agcgcctcgg gccgccgccc ggccgctact ggtcggttga
     3961 caagctcggg ggctggcgcg ctggtagctg ggactacctg cccccgcgcg gcggccccgc
     4021 atggcactgc cgccactgcg ccagcctgga gctgctaccg ccaccacgcc atctcagctg
     4081 ctcgcacgac ggcctagacg gtggctggtg ggcgcctccg cctccaccct gggctgcggg
     4141 gccaccgccc cggcgccggg cgcgctgtgg ttgtccgcga ccgcacccgc accgcccccg
     4201 ggcttcgcac cgtgcgcccg ccgccgcacc gcaccaccac cgacacaggc gcgcggcggg
     4261 tggctgggac ctcccgccgc ccgcgcccac ctcgcgttcg ctggaggacc tgagctcctg
     4321 cccacgggcg gcccccacgc gcaggctcac cgggccctcg cgccacgcgc gccgctgtcc
     4381 gcacgctgcg cattgggggc cgcccctgcc caccgcatct caccggagac accggggcgg
     4441 ggacctgggc acacgcaggg gctctgcgca cttctccagc ctggagtccg aggtatgacg
     4501 cggctcgggc cccccacccc cgccgccccc tcggtcagcg caggccacga cccgagggga
     4561 cgcgctaagt ggacaagacc ctcatgggtt gggaaggaca gaaacggacc tggctggacc
     4621 tcgcctggag cagcgtcctg cgccccaccc ccttgccttg ggggaactat gagccagagg
     4681 ggactcggtc gcccaaatct cacccatcct gagagcaagg gggcggggtt cttggagccc
     4741 accgactctt ttttaaaccc gaaaagggct ttttaacgtc acctgattgg cgggaggtgt
     4801 gggggggtca cgccgcgccc cacccctacg ctccgggcca tggccctcac atcactgtgc
     4861 agctccctag ccccagacac acctctaggg gagcctgttt ttaacctttc attcatcagg
     4921 actcaaaact gtgagacgcg tatgccaaac tgtgactcca gaccttggcc ccgccacaca
     4981 gaaacccctg accccagact gtgacttcca acacctaaaa tgatcatctg accccagact
     5041 gtgccccgac cagactgtga cccttcatgt cagacctcaa tgacccctcc cttttagatc
     5101 cttgttggct ctgacctatg acctctcctc cacgaaagtc ctacctttac ctgtctcccc
     5161 ccactcacct accaccccag atgccaccaa tcacatcttc aagtccagcc cttatttgtg
     5221 acccttcagt gataatccag cagacactcc acccccaggt ctcctttccc agatttcagc
     5281 agggtctgag gctgggctga gaggagggtc tgggagccca cacctgacct ttcctcccct
     5341 ctcccgctcc tacactgcag tgtttggaat aaaaccatgt ttttacgcct cctca
//
