LOCUS       NM_010350               4895 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus glutamate receptor, ionotropic, NMDA2C (epsilon 3)
            (Grin2c), transcript variant 1, mRNA.
ACCESSION   NM_010350
VERSION     NM_010350.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4895)
  AUTHORS   Gao,R., Ali,T., Liu,Z., Li,A., He,K., Yang,C., Feng,J. and Li,S.
  TITLE     NMDAR (2C) deletion in astrocytes relieved LPS-induced
            neuroinflammation and depression
  JOURNAL   Int Immunopharmacol 132, 111964 (2024)
   PUBMED   38603856
  REMARK    GeneRIF: NMDAR (2C) deletion in astrocytes relieved LPS-induced
            neuroinflammation and depression.
REFERENCE   2  (bases 1 to 4895)
  AUTHORS   Spirkova,A., Kovarikova,V., Sefcikova,Z., Pisko,J., Ksinanova,M.,
            Koppel,J., Fabian,D. and Cikos,S.
  TITLE     Glutamate can act as a signaling molecule in mouse preimplantation
            embryosdagger
  JOURNAL   Biol Reprod 107 (4), 916-927 (2022)
   PUBMED   35746896
REFERENCE   3  (bases 1 to 4895)
  AUTHORS   Shelkar,G.P., Gandhi,P.J., Liu,J. and Dravid,S.M.
  TITLE     Cocaine preference and neuroadaptations are maintained by
            astrocytic NMDA receptors in the nucleus accumbens
  JOURNAL   Sci Adv 8 (29), eabo6574 (2022)
   PUBMED   35867797
REFERENCE   4  (bases 1 to 4895)
  AUTHORS   Wu,X., Sosunov,A.A., Lado,W., Teoh,J.J., Ham,A., Li,H.,
            Al-Dalahmah,O., Gill,B.J.A., Arancio,O., Schevon,C.A.,
            Frankel,W.N., McKhann,G.M. 2nd, Sulzer,D., Goldman,J.E. and Tang,G.
  TITLE     Synaptic hyperexcitability of cytomegalic pyramidal neurons
            contributes to epileptogenesis in tuberous sclerosis complex
  JOURNAL   Cell Rep 40 (3), 111085 (2022)
   PUBMED   35858542
REFERENCE   5  (bases 1 to 4895)
  AUTHORS   Uemura,T., Suzuki-Kouyama,E., Kawase,S., Kurihara,T., Yasumura,M.,
            Yoshida,T., Fukai,S., Yamazaki,M., Fei,P., Abe,M., Watanabe,M.,
            Sakimura,K., Mishina,M. and Tabuchi,K.
  TITLE     Neurexins play a crucial role in cerebellar granule cell survival
            by organizing autocrine machinery for neurotrophins
  JOURNAL   Cell Rep 39 (1), 110624 (2022)
   PUBMED   35385735
REFERENCE   6  (bases 1 to 4895)
  AUTHORS   Watanabe,M., Mishina,M. and Inoue,Y.
  TITLE     Distinct spatiotemporal expressions of five NMDA receptor channel
            subunit mRNAs in the cerebellum
  JOURNAL   J Comp Neurol 343 (4), 513-519 (1994)
   PUBMED   7518474
REFERENCE   7  (bases 1 to 4895)
  AUTHORS   Watanabe,M., Mishina,M. and Inoue,Y.
  TITLE     Differential distributions of the NMDA receptor channel subunit
            mRNAs in the mouse retina
  JOURNAL   Brain Res 634 (2), 328-332 (1994)
   PUBMED   7510577
REFERENCE   8  (bases 1 to 4895)
  AUTHORS   Watanabe,M., Inoue,Y., Sakimura,K. and Mishina,M.
  TITLE     Developmental changes in distribution of NMDA receptor channel
            subunit mRNAs
  JOURNAL   Neuroreport 3 (12), 1138-1140 (1992)
   PUBMED   1493227
REFERENCE   9  (bases 1 to 4895)
  AUTHORS   Kutsuwada,T., Kashiwabuchi,N., Mori,H., Sakimura,K., Kushiya,E.,
            Araki,K., Meguro,H., Masaki,H., Kumanishi,T., Arakawa,M. et al.
  TITLE     Molecular diversity of the NMDA receptor channel
  JOURNAL   Nature 358 (6381), 36-41 (1992)
   PUBMED   1377365
REFERENCE   10 (bases 1 to 4895)
  AUTHORS   Brilliant,M.H., Gondo,Y. and Eicher,E.M.
  TITLE     The mouse pink-eyed unstable mutation: a DNA duplication revealed
            by genome scanning
  JOURNAL   Pigment Cell Res Suppl 2, 271-274 (1992)
   PUBMED   1409429
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603828.9 and D10694.1.
            
            On Sep 15, 2005 this sequence version replaced NM_010350.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: D10694.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMN00849374,
                                    SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-254               AL603828.9         67906-68159         c
            255-426             AL603828.9         67336-67507         c
            427-661             AL603828.9         66995-67229         c
            662-773             AL603828.9         62049-62160         c
            774-4493            D10694.1           1-3720
            4494-4895           AL603828.9         50085-50486         c
FEATURES             Location/Qualifiers
     source          1..4895
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.8 cM"
     gene            1..4895
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /note="glutamate receptor, ionotropic, NMDA2C (epsilon 3)"
                     /db_xref="GeneID:14813"
                     /db_xref="MGI:MGI:95822"
     exon            1..254
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            255..426
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            427..661
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            662..1172
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     CDS             774..4493
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /note="glutamate [NMDA] receptor subunit epsilon-3;
                     N-methyl D-aspartate receptor subtype 2C; GluRepsilon3;
                     glutamate receptor ionotropic, NMDA 2C"
                     /codon_start=1
                     /product="glutamate receptor ionotropic, NMDA 2C
                     precursor"
                     /protein_id="NP_034480.2"
                     /db_xref="CCDS:CCDS25624.1"
                     /db_xref="GeneID:14813"
                     /db_xref="MGI:MGI:95822"
                     /translation="MGGALGPALLLTSLLGAWAGLGAGQGEQAVTVAVVFGSSGPLQA
                     QARTRLTPQNFLDLPLEIQPLTIGVNNTNPSSILTQICGLLGAARVHGIVFEDNVDTE
                     AVAQLLDFVSSQTHVPILSISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEY
                     DWSAFAVITSLHPGHALFLEGVRAVADASYLSWRLLDVLTLELGPGGPRARTQRLLRQ
                     VDAPVLVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNLALGSTDAPPAAFPVGLISV
                     VTESWRLSLRQKVRDGVAILALGAHSYRRQYGTLPAPAGDCRSHPGPVSPAREAFYRH
                     LLNVTWEGRDFSFSPGGYLVQPTMVVIALNRHRLWEMVGRWDHGVLYMKYPVWPRYST
                     SLQPVVDSRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDITPYT
                     KLCCKGFCIDILKKLAKVVKFSYDLYLVTNGKHGKRVRGVWNGMIGEVYYKRADMAIG
                     SLTINEERSEIIDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTV
                     VAITVFMFEYFSPVSYNQNLTKGKKSGGPSFTIGKSVWLLWALVFNNSVPIENPRGTT
                     SKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGT
                     VPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKD
                     EGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLSGIC
                     HNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPSSSQLDFL
                     LAFSRGIYSCFNGVQSLPSPARPPSPDLTAGSAQANVLKMLQAARDMVSTADVSGSLD
                     RATRTIENWGNNRRAPAPTTSGPRSCTPGPPGQPSPSGWRPPGGGRTPLARRAPQPPA
                     RPATCAGSPQPDVSRASCRHAWDARWPVRVGHQGSHLSASERRALPERSLLHAHCHYS
                     SFPRAERSGRPFLPLFPEPPEPDDLPLLGPEQLARREALLRAAWARGPRPRHASLPSS
                     VAEAFTRSNPLPARCTGHACACPCPQSRPSCRHVAQTQSLRLPSYREACVEGVPAGVA
                     ATWQPRQHVCLHTHTHLPFCWGTVCRHPPPCSSHSPWLIGTWEPPSHRGRTLGLGTGY
                     RDSGVLEEVSREACGTQGFPRSCTWRRISSLESEV"
     exon            1173..1771
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1886
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2098
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2264
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2418
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2544
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..2774
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2935
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            2936..3123
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            3124..3356
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            3357..4895
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4872..4877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /note="hexamer: ATTAAA"
     polyA_site      4895
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NMDAR2C; NR2C"
                     /note="major polyA site"
ORIGIN      
        1 agtcggctgg tgagccccga gagcgggagg cgcgcctttg cgcagcccgg gacacagccc
       61 cgccgcgggg cgcgggccgg gcgcgggggc gggcggcatt caggccgcgc tacccgtact
      121 ggtcccgccg cgcccggctc cggtgcccgc cgagctcgca gccagcgtgc cagctcacgg
      181 gggctggctc tgggaagagc accgcgcggg agacggccgc gggctctggg cgtgggtgca
      241 gcgccccttc cccggtagaa gcctgcaagg aacccggcaa aggccaagaa ccagggccga
      301 ggctaggttt gaccagagcg cggggagctg gaaaggacac agagctctcg gagagctgta
      361 gcagttggcg agctggtccc tgctgggtac ctgctgcgcg catctgccta ctaccgaccc
      421 attagggatt tccccaaacg ctgacccccc cacacacacc acggcttggt tcccctcggc
      481 tctgagggct ccaaaagcag agtgggagga agaggctacg gtagagcctg cgctccggtg
      541 cctgggcccc ggaagcaccc tttggcagct gtggtctcct ggggctgcaa ccaggatccc
      601 cgacggctga gaggagacgc ctgagcctct agctgccgaa ggcgttttgt gcttggacta
      661 ggaaggttct ctgtactctg gctgtctgtg tgttctctgg cccttacctt ctgtttgtcc
      721 atctacctct ctctgtgcct gctctgattt ctctgcagga ccctccagtg gacatgggtg
      781 gagccctggg gcccgccctg cttctcactt cactccttgg tgcttgggca gggctgggcg
      841 cagggcaggg agaacaggcc gtgaccgtgg cggtggtgtt tggcagctct gggccactgc
      901 aggcccaggc ccggactcgt ctcaccccgc agaacttcct ggacttgcct ctggagatcc
      961 agccactcac catcggggtc aacaatacca accccagcag catcctcacc caaatctgtg
     1021 ggctcctggg tgccgcccga gtccacggca tcgtctttga ggacaacgtg gacactgagg
     1081 ccgtggctca gctgctggat ttcgtctcct ctcagaccca cgtgcccatc ctcagcatca
     1141 gtggaggttc tgctgtggtc ctcaccccca aggagccagg ctccgccttt ctacagctgg
     1201 gcgtgtccct ggagcagcag ctgcaggtgc tgttcaaggt gctggaggaa tacgactgga
     1261 gcgcgttcgc tgtcatcacc agcctgcacc cgggccacgc gctcttcctc gagggcgtgc
     1321 gcgccgtcgc cgacgccagc tacctgagct ggcggctgct ggacgtgctc acgctggagc
     1381 tgggccccgg tgggccgcga gcgcgcactc agcgcttact gcgccaggtc gacgccccgg
     1441 tgctggtggc ctactgctcc cgtgaagagg cggaggtgct cttcgcggag gctgcacagg
     1501 ctggcttggt gggacccggt cacgtgtggt tagtacctaa tctggcgctg ggaagcaccg
     1561 acgctccccc tgcagccttc ccagtgggcc tcatcagtgt ggtcaccgag agttggcgcc
     1621 ttagcctacg ccagaaagtc cgcgacggtg tagccattct ggccctcggt gcccacagct
     1681 accgacgcca gtacggtacc cttccagccc cggctggaga ctgccgaagc cacccaggac
     1741 ccgtcagccc tgccagggag gctttctaca ggcatctgct gaatgtcacc tgggaaggcc
     1801 gagacttctc ttttagccct ggtgggtacc tggtccagcc cacaatggtt gtgatcgctc
     1861 tcaaccggca tcgcctctgg gagatggtgg gacggtggga tcatggggtc ctgtacatga
     1921 agtatccagt atggcctcgc tacagcactt ctctgcagcc tgtggtggac agccggcacc
     1981 tgacagtggc cacactggaa gaaaggcctt ttgtcattgt ggagagccct gaccctggca
     2041 caggtggctg tgttcccaac actgtgccct gccgtagaca gagcaaccac accttcagca
     2101 gcggggatat aaccccctac accaagctct gttgtaaggg cttctgcatc gacatcctca
     2161 agaagctggc caaggtggtc aagttctcct acgacttgta cctggtgacc aacggcaagc
     2221 acggcaagag ggttcgtggt gtgtggaatg gtatgatcgg tgaggtatac tacaagcggg
     2281 cagacatggc catcggctcc ctcaccatca atgaagagcg ctcagagatt atagacttct
     2341 ctgtgccttt tgtggagacc ggcatcagtg tgatggtggc aaggagcaac ggcaccgtct
     2401 ccccctcggc ttttctggag ccctacagcc ctgccgtgtg ggtgatgatg tttgtaatgt
     2461 gcctcacggt ggttgccatc actgtcttca tgttcgagta tttcagccct gtcagctaca
     2521 accagaatct caccaagggc aagaagtcag gtggaccatc cttcaccatt ggcaagtccg
     2581 tgtggttgct gtgggcactg gtcttcaaca actctgttcc catcgagaac ccccggggca
     2641 ccaccagcaa gatcatggtc ctggtgtggg ccttcttcgc tgtcatcttc ctcgctagct
     2701 acacggccaa tctggcagcc ttcatgatcc aggaacaata catcgacact gtgtcgggcc
     2761 ttagtgacaa gaagtttcag cggcctcaag accaataccc acccttccgt tttggcacgg
     2821 tacctaatgg cagcacagag aggaacattc gtagcaacta tcgtgacatg cacactcaca
     2881 tggtcaagtt caaccagcgc tcggtggagg atgctctcac aagcctgaag atggggaagc
     2941 tggacgcctt catctatgat gccgccgtcc tcaactacat ggcgggcaag gacgaaggct
     3001 gcaagctggt caccattggg tctggcaaag tctttgccac cactggctat ggcattgcca
     3061 tgcagaaaga ctcccactgg aagcgggcca tagacctggc gctcctgcag ttcctggggg
     3121 atggggagac acagaagttg gagacagtgt ggctctcagg gatctgccat aacgagaaga
     3181 acgaggtgat gagcagcaag ctggacattg acaacatggc gggcgtcttc tacatgctgt
     3241 tggtggccat ggggctggcc cttctggtct ttgcctggga gcacctggtc tactggaaac
     3301 ttcgacactc agtgcccagc tcatcccagc tggacttcct gctggctttc agcaggggca
     3361 tctacagctg cttcaacggg gtacagagcc ttccgagccc tgcgcggccg cccagcccgg
     3421 accttacagc aggctcagcc caggccaatg tgctgaagat gctgcaggcg gctcgagaca
     3481 tggtgagcac agcggacgtg agcggctctt tggaccgcgc cactcgtacc atcgagaact
     3541 ggggcaacaa tcgccgcgcg cctgctccca ccacctccgg cccgcggtca tgcaccccgg
     3601 gtcctccggg acaaccgagt cccagcggct ggcggcctcc cggtgggggc cgcaccccgc
     3661 tagcgcgccg ggccccgcag cctcccgctc gccccgcgac ctgcgcaggg tcgcctcagc
     3721 ccgacgtgtc ccgagcatcc tgcaggcacg cttgggatgc gcggtggcca gtgcgagtcg
     3781 ggcatcaggg atcgcacctc tcggcctccg agcggcgcgc gctcccggag cgctccctgt
     3841 tgcacgcgca ctgccactac agttccttcc ctcgagcaga gaggtcaggg cgcccatttc
     3901 tcccgctatt cccggagccc ccggagcccg acgacctgcc gctgctcggg ccggaacagc
     3961 tggctcggcg ggaggctctg ctgcgcgcgg cctgggccag gggcccgcgc cctcggcacg
     4021 cttccctgcc cagctccgtg gcagaagcct tcactcgatc caaccctctg cctgccaggt
     4081 gtaccggtca cgcctgcgct tgcccatgtc cccaaagccg gccatcctgc cggcacgtgg
     4141 ctcaaacaca gtcgttgcgg ctgccatcct accgggaggc ctgtgtggag ggcgtgccag
     4201 caggggtggc cgccacctgg cagcccagac agcatgtctg cctgcacacc catacccacc
     4261 tgccgttctg ctgggggact gtctgccgtc accctccacc ctgttccagc cacagtccct
     4321 ggctcattgg aacttgggag cctccatcac acagaggcag gaccctgggg ctaggtacag
     4381 gctacaggga cagtggggtg ctagaagagg tcagcaggga agcttgtggg acacaagggt
     4441 ttccaaggtc ctgcacctgg aggcggatct ccagcctgga atcagaagtg tgaggtaccg
     4501 gcagctctgg ttcctgctgg actggattct gtggctggtc ttggccaagt ttgggggaca
     4561 gacaagcttt gactcctctg ccttcttctt tgaaattctg gccatgagac cccagtgaaa
     4621 aggatatctt ccatggccag cttatgacct tagcagctta ggtcttggtg tgggctggga
     4681 tcttgctcat cacgtgaagt cttgcagtcc cagggagtaa aaatgtgtcc ctgtcctggc
     4741 gtcagccatt tcctagttgt ggttgctgtg gccttgggtt ggggacacaa aattggaaac
     4801 ggaggttgag tggggccaac tcaccttttg ctccaattgg ttggaatttc ttttcatagg
     4861 aacattggga cattaaagca acgttttaca accca
//
