LOCUS       NM_008169               4326 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Mus musculus glutamate receptor, ionotropic, NMDA1 (zeta 1)
            (Grin1), transcript variant 1, mRNA.
ACCESSION   NM_008169
VERSION     NM_008169.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4326)
  AUTHORS   Huikang,W., Shiya,C., Di,P., Kiani,F.A., Hao,L., Sha,N., Xuan,L.,
            Abouelfetouh,M.M., Ahmed,Z., Mingxing,D. and Yi,D.
  TITLE     Elucidation of Dexmedetomidine-Induced Analgesic Tolerance
            Mechanisms in Neuropathic Pain With Modulation of SGK1, NR2A, and
            NR2B Expression via the Spinal SGK1/NF-kappaB Signalling Pathway
  JOURNAL   J Cell Mol Med 29 (6), e70372 (2025)
   PUBMED   40099662
REFERENCE   2  (bases 1 to 4326)
  AUTHORS   Ruggiero,A., Heim,L.R., Susman,L., Hreaky,D., Shapira,I.,
            Katsenelson,M., Rosenblum,K. and Slutsky,I.
  TITLE     NMDA receptors regulate the firing rate set point of hippocampal
            circuits without altering single-cell dynamics
  JOURNAL   Neuron 113 (2), 244-259 (2025)
   PUBMED   39515323
REFERENCE   3  (bases 1 to 4326)
  AUTHORS   Borruto,A.M., Calpe-Lopez,C., Spanagel,R. and Bernardi,R.E.
  TITLE     Conditional deletion of the AMPA-GluA1 and NMDA-GluN1 receptor
            subunit genes in midbrain D1 neurons does not alter cocaine reward
            in mice
  JOURNAL   Neuropharmacology 258, 110081 (2024)
   PUBMED   39002853
REFERENCE   4  (bases 1 to 4326)
  AUTHORS   Yuan,B.T., Li,M.N., Zhu,L.P., Xu,M.L., Gu,J., Gao,Y.J. and Ma,L.J.
  TITLE     TFAP2A is involved in neuropathic pain by regulating Grin1
            expression in glial cells of the dorsal root ganglion
  JOURNAL   Biochem Pharmacol 227, 116427 (2024)
   PUBMED   39009095
  REMARK    GeneRIF: TFAP2A is involved in neuropathic pain by regulating Grin1
            expression in glial cells of the dorsal root ganglion.
REFERENCE   5  (bases 1 to 4326)
  AUTHORS   Artimagnella,O., Maftei,E.S., Esposito,M., Sanges,R. and
            Mallamaci,A.
  TITLE     Foxg1 regulates translation of neocortical neuronal genes,
            including the main NMDA receptor subunit gene, Grin1
  JOURNAL   BMC Biol 22 (1), 180 (2024)
   PUBMED   39183266
  REMARK    GeneRIF: Foxg1 regulates translation of neocortical neuronal genes,
            including the main NMDA receptor subunit gene, Grin1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4326)
  AUTHORS   Watanabe,M., Inoue,Y., Sakimura,K. and Mishina,M.
  TITLE     Developmental changes in distribution of NMDA receptor channel
            subunit mRNAs
  JOURNAL   Neuroreport 3 (12), 1138-1140 (1992)
   PUBMED   1493227
REFERENCE   7  (bases 1 to 4326)
  AUTHORS   Ikeda,K., Nagasawa,M., Mori,H., Araki,K., Sakimura,K., Watanabe,M.,
            Inoue,Y. and Mishina,M.
  TITLE     Cloning and expression of the epsilon 4 subunit of the NMDA
            receptor channel
  JOURNAL   FEBS Lett 313 (1), 34-38 (1992)
   PUBMED   1385220
REFERENCE   8  (bases 1 to 4326)
  AUTHORS   Kutsuwada,T., Kashiwabuchi,N., Mori,H., Sakimura,K., Kushiya,E.,
            Araki,K., Meguro,H., Masaki,H., Kumanishi,T., Arakawa,M. et al.
  TITLE     Molecular diversity of the NMDA receptor channel
  JOURNAL   Nature 358 (6381), 36-41 (1992)
   PUBMED   1377365
REFERENCE   9  (bases 1 to 4326)
  AUTHORS   Meguro,H., Mori,H., Araki,K., Kushiya,E., Kutsuwada,T.,
            Yamazaki,M., Kumanishi,T., Arakawa,M., Sakimura,K. and Mishina,M.
  TITLE     Functional characterization of a heteromeric NMDA receptor channel
            expressed from cloned cDNAs
  JOURNAL   Nature 357 (6373), 70-74 (1992)
   PUBMED   1374164
REFERENCE   10 (bases 1 to 4326)
  AUTHORS   Yamazaki,M., Mori,H., Araki,K., Mori,K.J. and Mishina,M.
  TITLE     Cloning, expression and modulation of a mouse NMDA receptor subunit
  JOURNAL   FEBS Lett 300 (1), 39-45 (1992)
   PUBMED   1532151
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD355382.1, BC039157.1, AW494928.1, CD363997.1 and AI844150.1.
            
            On Mar 13, 2014 this sequence version replaced NM_008169.2.
            
            Transcript Variant: This variant (1) encodes isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D10028.1, SRR7974084.1991.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                CD355382.1         1-84
            85-2491             BC039157.1         1-2407
            2492-3040           AW494928.1         13-561              c
            3041-3432           CD363997.1         306-697
            3433-4305           BC039157.1         2882-3754
            4306-4326           AI844150.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..4326
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 17.14 cM"
     gene            1..4326
                     /gene="Grin1"
                     /gene_synonym="GluN1; GluRdelta1; GluRzeta1; M100174;
                     NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174"
                     /note="glutamate receptor, ionotropic, NMDA1 (zeta 1)"
                     /db_xref="GeneID:14810"
                     /db_xref="MGI:MGI:95819"
     exon            1..559
                     /gene="Grin1"
                     /gene_synonym="GluN1; GluRdelta1; GluRzeta1; M100174;
                     NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174"
                     /inference="alignment:Splign:2.1.0"
     CDS             302..3118
                     /gene="Grin1"
                     /gene_synonym="GluN1; GluRdelta1; GluRzeta1; M100174;
                     NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; glutamate [NMDA] receptor subunit zeta-1;
                     N-methyl-D-aspartate receptor subunit NR1; glutamate
                     receptor ionotropic, NMDA 1"
                     /codon_start=1
                     /product="glutamate receptor ionotropic, NMDA 1 isoform 1
                     precursor"
                     /protein_id="NP_032195.1"
                     /db_xref="CCDS:CCDS15764.1"
                     /db_xref="GeneID:14810"
                     /db_xref="MGI:MGI:95819"
                     /translation="MSTMHLLTFALLFSCSFARAACDPKIVNIGAVLSTRKHEQMFRE
                     AVNQANKRHGSWKIQLNATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHF
                     TPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYNW
                     NHIILLVSDDHEGRAAQKRLETLLEERESKAEKVLQFDPGTKNVTALLMEARDLEARV
                     IILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGIIGLQLINGKN
                     ESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGV
                     TGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGY
                     QMSTRLKIVTIHQEPFVYVKPTMSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHT
                     VPQCCYGFCVDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSG
                     QADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLV
                     GLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAP
                     RSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYA
                     TVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA
                     SQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQEC
                     DSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVN
                     VWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDTSTGGGRGALQNQKD
                     TVLPRRAIEREEGQLQLCSRHRES"
     exon            560..694
                     /gene="Grin1"
                     /gene_synonym="GluN1; GluRdelta1; GluRzeta1; M100174;
                     NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174"
                     /inference="alignment:Splign:2.1.0"
     exon            695..871
                     /gene="Grin1"
                     /gene_synonym="GluN1; GluRdelta1; GluRzeta1; M100174;
                     NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174"
                     /inference="alignment:Splign:2.1.0"
     exon            872..972
                     /gene="Grin1"
                     /gene_synonym="GluN1; GluRdelta1; GluRzeta1; M100174;
                     NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1094
                     /gene="Grin1"
                     /gene_synonym="GluN1; GluRdelta1; GluRzeta1; M100174;
                     NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1269
                     /gene="Grin1"
                     /gene_synonym="GluN1; GluRdelta1; GluRzeta1; M100174;
                     NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1414
                     /gene="Grin1"
                     /gene_synonym="GluN1; GluRdelta1; GluRzeta1; M100174;
                     NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1498
                     /gene="Grin1"
                     /gene_synonym="GluN1; GluRdelta1; GluRzeta1; M100174;
                     NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1640
                     /gene="Grin1"
                     /gene_synonym="GluN1; GluRdelta1; GluRzeta1; M100174;
                     NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1768
                     /gene="Grin1"
                     /gene_synonym="GluN1; GluRdelta1; GluRzeta1; M100174;
                     NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1933
                     /gene="Grin1"
                     /gene_synonym="GluN1; GluRdelta1; GluRzeta1; M100174;
                     NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2052
                     /gene="Grin1"
                     /gene_synonym="GluN1; GluRdelta1; GluRzeta1; M100174;
                     NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2165
                     /gene="Grin1"
                     /gene_synonym="GluN1; GluRdelta1; GluRzeta1; M100174;
                     NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2314
                     /gene="Grin1"
                     /gene_synonym="GluN1; GluRdelta1; GluRzeta1; M100174;
                     NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2472
                     /gene="Grin1"
                     /gene_synonym="GluN1; GluRdelta1; GluRzeta1; M100174;
                     NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2634
                     /gene="Grin1"
                     /gene_synonym="GluN1; GluRdelta1; GluRzeta1; M100174;
                     NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174"
                     /inference="alignment:Splign:2.1.0"
     exon            2635..2744
                     /gene="Grin1"
                     /gene_synonym="GluN1; GluRdelta1; GluRzeta1; M100174;
                     NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2890
                     /gene="Grin1"
                     /gene_synonym="GluN1; GluRdelta1; GluRzeta1; M100174;
                     NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174"
                     /inference="alignment:Splign:2.1.0"
     exon            2891..3001
                     /gene="Grin1"
                     /gene_synonym="GluN1; GluRdelta1; GluRzeta1; M100174;
                     NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174"
                     /inference="alignment:Splign:2.1.0"
     exon            3002..4309
                     /gene="Grin1"
                     /gene_synonym="GluN1; GluRdelta1; GluRzeta1; M100174;
                     NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4305
                     /gene="Grin1"
                     /gene_synonym="GluN1; GluRdelta1; GluRzeta1; M100174;
                     NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174"
                     /note="major polyA site"
ORIGIN      
        1 ggaagcgggg gcggtgggag gggtagaacg cgtaggtccc gctcacgact ccgcagctgc
       61 tgcagtcgcc gcagcatcgg gaccagtcgc acagtccagg cagctgtctt tttcgccttt
      121 tccgcgcggg tgttcgagca gcgcccaata cgcttcagca cctcggacag cacccgccgc
      181 gctcgccctg ggctcctgaa gaatccgcgg gtgcttgacc gcgcgggggc ccgggggtcc
      241 gtacatcgcg aggtggtcgc gctcgcgcaa cccagaacca ggcccgctgt gcccgaggct
      301 catgagcacc atgcacctgc tgacattcgc cctgcttttc tcctgctcct tcgcccgcgc
      361 tgcctgcgac cccaagattg tcaacatcgg cgcggtgctg agcacgcgca agcacgagca
      421 gatgttccgc gaggcagtaa accaggccaa taagcgacac ggctcttgga agatacagct
      481 caacgccact tctgtcaccc acaagcccaa cgccatacag atggccctgt cagtgtgtga
      541 ggacctcatc tctagccagg tctacgctat cctagttagt cacccgccta ctcccaacga
      601 ccacttcact cccacccctg tctcctacac agctggcttc tacagaatcc ccgtcctggg
      661 gctgactacc cgaatgtcca tctactctga caagagcatc cacctgagct tccttcgcac
      721 cgtaccaccc tactcccacc agtccagcgt ctggtttgag atgatgcgcg tctacaactg
      781 gaaccatatc atcctgctgg tcagcgatga ccacgagggc cgggcagcgc agaagcgcct
      841 ggagacgttg ctggaggagc gtgagtccaa ggcagagaag gtgctgcagt ttgacccagg
      901 aaccaagaat gtgacggctc tgctgatgga agcccgggac ctggaagccc gggtcatcat
      961 cctttctgca agcgaggacg acgctgccac cgtataccgc gcagccgcga tgctgaacat
     1021 gactggctct gggtacgtgt ggctcgtcgg ggagcgcgag atctctggga atgccctgcg
     1081 ctacgctcct gacggcatca tcggacttca gctaatcaac ggcaagaacg agtcggccca
     1141 catcagtgac gctgtgggcg tggtggcaca ggcagtccac gagctcctag aaaaggagaa
     1201 catcactgat ccaccgcggg gttgcgtggg caacaccaac atctggaaga caggaccact
     1261 gttcaagagg gtgctgatgt cttccaagta tgcagatgga gtgactggcc gtgtggaatt
     1321 caatgaggat ggggaccgga agtttgccaa ctatagtatc atgaacctgc agaaccgcaa
     1381 gctggtgcaa gtgggcatct acaatggtac ccatgtcatc ccaaatgaca ggaagatcat
     1441 ctggccagga ggagagacag agaagcctcg aggataccag atgtccacca gactaaagat
     1501 agtgacaatc caccaagaac ccttcgtgta tgtcaagccc acaatgagtg atggcacatg
     1561 caaagaggag ttcacagtca atggtgaccc tgtcaagaag gtgatctgta cggggcctaa
     1621 tgacacatcc ccaggaagcc cacgtcacac agtgccccag tgctgttatg gcttctgcgt
     1681 tgacctgctc atcaagctgg cacggaccat gaattttacc tacgaggtgc accttgtggc
     1741 agatggcaag tttggcacac aggagcgggt aaacaacagc aacaaaaagg agtggaacgg
     1801 aatgatggga gagctgctca gtggtcaagc agacatgatc gtggctccac tgaccattaa
     1861 caatgagcgt gcgcagtaca tagagttctc caagcccttc aagtaccagg gcctgaccat
     1921 tctggtcaag aaggagatcc ctcggagcac actggactca ttcatgcagc cctttcagag
     1981 cacactgtgg ctgctggtgg ggctgtcagt tcatgtggtg gccgtgatgc tgtacctgct
     2041 ggaccgcttc agtccctttg gccgatttaa ggtgaacagc gaggaggagg aggaggatgc
     2101 actgaccctg tcctctgcca tgtggttttc ctggggcgtc ctgctcaact ctggcattgg
     2161 ggaaggtgcc ccccggagtt tctctgctcg tatcctaggc atggtgtggg ctggttttgc
     2221 catgatcatc gtggcttcct acactgccaa cctggcagcc ttcctggtgc tggataggcc
     2281 tgaggagcgc atcacaggca tcaatgaccc caggctcaga aacccctcag acaagttcat
     2341 ctatgcaact gtaaaacaga gctctgtgga tatctacttc cggaggcagg tggagttgag
     2401 caccatgtac cggcacatgg agaagcacaa ttatgagagt gcagctgagg ccatccaggc
     2461 tgtgcgggac aacaagctcc atgccttcat ctgggactca gctgtgctgg agtttgaggc
     2521 ttcacagaag tgcgatctgg tgaccacggg tgagctgttc ttccgctccg gctttggcat
     2581 cggcatgcgc aaggacagcc cctggaagca aaatgtgtcc ctgtccatac tcaagtccca
     2641 tgagaatggc ttcatggaag acctggataa gacatgggtt cggtatcaag aatgtgactc
     2701 ccgcagcaat gcccctgcca ccctcacttt tgagaacatg gcaggggtct tcatgctggt
     2761 ggctggaggc atcgtagctg ggatcttcct cattttcatc gagatcgcct acaagcgaca
     2821 caaggatgcc cgtaggaagc agatgcagct ggcttttgca gccgtgaacg tgtggaggaa
     2881 gaacctgcag gatagaaaga gtggtagagc agagcccgac cctaaaaaga aagccacatt
     2941 tagggctatc acctccaccc tggcctccag cttcaagaga cgtaggtcct ccaaagacac
     3001 gagcaccggg ggtggacgcg gcgctttgca aaaccaaaaa gacacagtgc tgccgcgacg
     3061 cgctattgag agggaggagg gccagctgca gctgtgttcc cgtcataggg agagctgaga
     3121 cgccccgccc gccctcctct gcccctcccc cgcagacaga cgcacgggac agcggcctgg
     3181 cccacgcaga gccccggagc acgacggggt cgggggagga gcacccccag cctcccccag
     3241 gccgtgcccg cctgcccgcc ggtcggccgg ctggccggtc caccctgtcc cggccccgcg
     3301 cgtgcccccg acgtcggagc taacgggccg ccttgtctgt gtatttctat tttacagcag
     3361 taccatccca ctgatatcac gggcccgctc aacctctcag atccctcggt cagcaccgtg
     3421 gtgtgaggcc cccggaggcg cccacctgcc cagttagccc ggccaaggac actgatgagt
     3481 cctgctgctc gggaaggcct gagggaagcc cacccgcccc agagactgcc caccctgggc
     3541 ctcccgtcct cctgctctgc tgcctggcgg gcagcccctg caggaccaag gtgcggacca
     3601 gagcggctga ggatgggcca gagctgagcc ggctgggcag ggccacaggg cgctccggca
     3661 gaggcagggc cctgaggtct ctgagcagtg gggtgagggg cctaagtggc cccggtcgga
     3721 ggagcctgga gcagaaatgg cagccccatc cttcctccag ccactacccc aagctacagt
     3781 gggggcccat ggccccagct tgctaggtca ccctccaccc ctcctccagc gcctgctctc
     3841 tgcaacctga cttccacctc tatctctctt tctctcctgc tgcacaatcc tcccacgacc
     3901 cttcccaccc cattcactgg gctggctccg acctttccca gggctagcct tcactgccct
     3961 agtggcagcg cttcccaggg gtgctctctg gctcccagat gtctagggct ccagactcca
     4021 agagggctga gccttctctt ctgtctgcag ccacaatagg cttcctcaga cgctggcttg
     4081 agaggagccc cgcaccttgg gcaccaggga gtgccatccg cctcccagtc cggtgtcact
     4141 cacccaacct tgtacatgac tagctctccc agtgtccaag cgcgtgcctt ccccgagcca
     4201 ctggggcgca gcagcgcgct gcccctctgc cccagggaca ccgggcgcgc ataaccaccc
     4261 ctaatcccgg tattcagtgg tgatgcctaa aggaatgtca gaaaatttca aaaaaaaaaa
     4321 aaaaaa
//
