LOCUS       NM_001402847            4563 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus glutamate receptor, ionotropic, kainate 5 (gamma 2)
            (Grik5), transcript variant 3, mRNA.
ACCESSION   NM_001402847 XM_017321983
VERSION     NM_001402847.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4563)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4563)
  AUTHORS   Spirkova,A., Kovarikova,V., Sefcikova,Z., Pisko,J., Ksinanova,M.,
            Koppel,J., Fabian,D. and Cikos,S.
  TITLE     Glutamate can act as a signaling molecule in mouse preimplantation
            embryosdagger
  JOURNAL   Biol Reprod 107 (4), 916-927 (2022)
   PUBMED   35746896
REFERENCE   3  (bases 1 to 4563)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4563)
  AUTHORS   Iida,I., Konno,K., Natsume,R., Abe,M., Watanabe,M., Sakimura,K. and
            Terunuma,M.
  TITLE     A comparative analysis of kainate receptor GluK2 and GluK5 knockout
            mice in a pure genetic background
  JOURNAL   Behav Brain Res 405, 113194 (2021)
   PUBMED   33631192
REFERENCE   5  (bases 1 to 4563)
  AUTHORS   Jang,S., Yang,E., Kim,D., Kim,H. and Kim,E.
  TITLE     Clmp Regulates AMPA and Kainate Receptor Responses in the Neonatal
            Hippocampal CA3 and Kainate Seizure Susceptibility in Mice
  JOURNAL   Front Synaptic Neurosci 12, 567075 (2020)
   PUBMED   33408624
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4563)
  AUTHORS   Jablonska,B., Smith,A.L., Kossut,M. and Skangiel-Kramska,J.
  TITLE     Development of laminar distributions of kainate receptors in the
            somatosensory cortex of mice
  JOURNAL   Brain Res 791 (1-2), 325-329 (1998)
   PUBMED   9593973
REFERENCE   7  (bases 1 to 4563)
  AUTHORS   Zhang,C., Hammassaki-Britto,D.E., Britto,L.R. and Duvoisin,R.M.
  TITLE     Expression of glutamate receptor subunit genes during development
            of the mouse retina
  JOURNAL   Neuroreport 8 (1), 335-340 (1996)
   PUBMED   9051806
REFERENCE   8  (bases 1 to 4563)
  AUTHORS   Hirano,T., Kasono,K., Araki,K. and Mishina,M.
  TITLE     Suppression of LTD in cultured Purkinje cells deficient in the
            glutamate receptor delta 2 subunit
  JOURNAL   Neuroreport 6 (3), 524-526 (1995)
   PUBMED   7766857
REFERENCE   9  (bases 1 to 4563)
  AUTHORS   Szpirer,C., Molne,M., Antonacci,R., Jenkins,N.A., Finelli,P.,
            Szpirer,J., Riviere,M., Rocchi,M., Gilbert,D.J., Copeland,N.G. et
            al.
  TITLE     The genes encoding the glutamate receptor subunits KA1 and KA2
            (GRIK4 and GRIK5) are located on separate chromosomes in human,
            mouse, and rat
  JOURNAL   Proc Natl Acad Sci U S A 91 (25), 11849-11853 (1994)
   PUBMED   7527545
REFERENCE   10 (bases 1 to 4563)
  AUTHORS   Sakimura,K., Morita,T., Kushiya,E. and Mishina,M.
  TITLE     Primary structure and expression of the gamma 2 subunit of the
            glutamate receptor channel selective for kainate
  JOURNAL   Neuron 8 (2), 267-274 (1992)
   PUBMED   1310861
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125468.5.
            
            On Mar 23, 2022 this sequence version replaced XM_017321983.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10662773.53763.1,
                                           SRR10662772.2706480.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1050              AC125468.5         180281-181330       c
            1051-1179           AC125468.5         176685-176813       c
            1180-1344           AC125468.5         176251-176415       c
            1345-1442           AC125468.5         173614-173711       c
            1443-1608           AC125468.5         173370-173535       c
            1609-1787           AC125468.5         171119-171297       c
            1788-1841           AC125468.5         168971-169024       c
            1842-2003           AC125468.5         168711-168872       c
            2004-2156           AC125468.5         167182-167334       c
            2157-2261           AC125468.5         166735-166839       c
            2262-2369           AC125468.5         166525-166632       c
            2370-2573           AC125468.5         154415-154618       c
            2574-2690           AC125468.5         131524-131640       c
            2691-2800           AC125468.5         131227-131336       c
            2801-2974           AC125468.5         130682-130855       c
            2975-3140           AC125468.5         124049-124214       c
            3141-3366           AC125468.5         123546-123771       c
            3367-3495           AC125468.5         122031-122159       c
            3496-3617           AC125468.5         121827-121948       c
            3618-4563           AC125468.5         118090-119035       c
FEATURES             Location/Qualifiers
     source          1..4563
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 13.73 cM"
     gene            1..4563
                     /gene="Grik5"
                     /gene_synonym="GluK5; GluRgamma2; KA2"
                     /note="glutamate receptor, ionotropic, kainate 5 (gamma
                     2)"
                     /db_xref="GeneID:14809"
                     /db_xref="MGI:MGI:95818"
     exon            1..1050
                     /gene="Grik5"
                     /gene_synonym="GluK5; GluRgamma2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1179
                     /gene="Grik5"
                     /gene_synonym="GluK5; GluRgamma2; KA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             1101..4043
                     /gene="Grik5"
                     /gene_synonym="GluK5; GluRgamma2; KA2"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; gluR gamma-2; glutamate receptor KA-2;
                     glutamate receptor gamma-2; glutamate receptor ionotropic,
                     kainate 5"
                     /codon_start=1
                     /product="glutamate receptor ionotropic, kainate 5 isoform
                     3 precursor"
                     /protein_id="NP_001389776.1"
                     /db_xref="GeneID:14809"
                     /db_xref="MGI:MGI:95818"
                     /translation="MPAELLLLLIVAFANPSCQVLSSLRMAAILDDQTVCGRGERLAL
                     ALAREQINGIIEVPAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPAS
                     ASTVSHICGEKEIPHIKVGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPS
                     ASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDA
                     NASISHLVLRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPF
                     YPEFVRSLNMSWRENCEASTYPGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLAC
                     TSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWY
                     SNRTLAMNATTLDINLSQTLANKTLVVTTILENPYVMRRPNFQALSGNERFEGFCVDM
                     LRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRQKADLAVAAFTITAERE
                     KVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAA
                     RLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGV
                     WWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNS
                     RYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQI
                     GGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAK
                     GLGMENIGGIFVVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVSC
                     RKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAGAHGGPQRLLDDPG
                     PPGGPRPQAPTPCTHVRVCQECRRIQALRASGAGAPPRGLGTPAEATSPPRPRPGPTG
                     PRELTEHE"
     exon            1180..1344
                     /gene="Grik5"
                     /gene_synonym="GluK5; GluRgamma2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1442
                     /gene="Grik5"
                     /gene_synonym="GluK5; GluRgamma2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1608
                     /gene="Grik5"
                     /gene_synonym="GluK5; GluRgamma2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1787
                     /gene="Grik5"
                     /gene_synonym="GluK5; GluRgamma2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1841
                     /gene="Grik5"
                     /gene_synonym="GluK5; GluRgamma2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..2003
                     /gene="Grik5"
                     /gene_synonym="GluK5; GluRgamma2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2156
                     /gene="Grik5"
                     /gene_synonym="GluK5; GluRgamma2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2261
                     /gene="Grik5"
                     /gene_synonym="GluK5; GluRgamma2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2369
                     /gene="Grik5"
                     /gene_synonym="GluK5; GluRgamma2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2573
                     /gene="Grik5"
                     /gene_synonym="GluK5; GluRgamma2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2574..2690
                     /gene="Grik5"
                     /gene_synonym="GluK5; GluRgamma2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2800
                     /gene="Grik5"
                     /gene_synonym="GluK5; GluRgamma2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..2974
                     /gene="Grik5"
                     /gene_synonym="GluK5; GluRgamma2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2975..3140
                     /gene="Grik5"
                     /gene_synonym="GluK5; GluRgamma2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3141..3366
                     /gene="Grik5"
                     /gene_synonym="GluK5; GluRgamma2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3367..3495
                     /gene="Grik5"
                     /gene_synonym="GluK5; GluRgamma2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3496..3617
                     /gene="Grik5"
                     /gene_synonym="GluK5; GluRgamma2; KA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3618..4563
                     /gene="Grik5"
                     /gene_synonym="GluK5; GluRgamma2; KA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4537..4542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grik5"
                     /gene_synonym="GluK5; GluRgamma2; KA2"
                     /note="hexamer: AATAAA"
     polyA_site      4563
                     /gene="Grik5"
                     /gene_synonym="GluK5; GluRgamma2; KA2"
                     /note="major polyA site"
ORIGIN      
        1 ctccctccct tcatctctcc cctccaccac caccaccacc accatcacca ccaccaccac
       61 caccaccacc accccacccc cccgcgctcc aggactcagc gcgggcgggc gggcaggcgg
      121 cggcctagga ggggagaagg agcagtggcg gcagcggtag tagcggccgg cagcaaggag
      181 gcaggcccgg ctggggacac ggagccgcca gcggctgccg ctcacagggg accagagtgt
      241 gcggccaggc cctcccaccg agagccggcg ggccccggga caccccaccc tcctccgcct
      301 tcccgttcca cctgcttctc tccatcctct cctcccacct catctcgcca cctcgtctgc
      361 ctcccttctt ggtctcacca gggctgccag ttgctctgtc ctcgctagcc ccttcattga
      421 ccggcctctc ctggccctca agcatgtttt tcccgtgggg actgaggggt tgaggactcc
      481 cggccctagc ctcatccagg gcagggccaa ggctctgggg ggaggggggg gaagggggcg
      541 gccccctccc ccccagcagg ccctcccctc ccccacttcc ccccgatggc tggctttctt
      601 ttctccaccc agtcctcacc cccagtgccc cccccaggcc ggcccggcta ggggaggggg
      661 cgggggccct ttcctgggcc ggcttccccc tcccccggct ttgcctgtgc ccccctccct
      721 tccgttttca ccttcctctc ctcctttcct ccctccttcc cctccgtttg ctccttcccc
      781 ctctcctctc tccccttctc tcctccattt tctcctttcc ccttcctccc ctcctggccc
      841 gccctttgct tttccacctg tccttcctcc ccgctgctgg ggagacaccg ttttggatta
      901 gttgggggcc accgccggcg gcgggggagg gggcccagtg gactgccctc tcccccggcc
      961 ccagcctcac cagcacccag catcggagca cctcctggtt gtcgttcctc gggcctcgag
     1021 ggagcccagc cctccgtccc accaggatcc gtggcgagtg ggggccgcgg cagctgcgtc
     1081 cccatgagga ggggaggaag atgccggctg agctgctgct gctgctgata gtcgccttcg
     1141 ccaatcccag ctgccaggtg ctgtcatcac tgcgcatggc tgcaatcctg gacgaccaga
     1201 ccgtgtgtgg ccgtggtgag cgtctggccc tggccctggc ccgagagcag atcaatggga
     1261 tcatcgaggt cccagccaag gccagagtgg aagtagacat ctttgagctg cagcgggaca
     1321 gccagtacga gaccacggac accatgtgtc agatcctgcc caagggggtt gtatctgtct
     1381 tgggaccctc ctccagccca gcttctgcct ccaccgtgag ccatatctgt ggggagaagg
     1441 agattcccca catcaaggtg ggtcctgagg agacgccccg ccttcagtac cttcgcttcg
     1501 catctgtcag cctgtacccc agtaatgaag atgtcagcct ggcagtctcc cgaatcctca
     1561 agtcctttaa ctacccctca gctagcctca tctgcgccaa ggctgagtgc ctgctgcggc
     1621 tagaagaact ggtgcgaggc ttcctcatct ccaaggagac actgtccgtg aggatgcttg
     1681 atgacagccg ggaccccacg ccgctactca aggagatccg agatgacaaa gtgtccacca
     1741 tcatcattga tgccaatgcg tccatctccc accttgtcct ccgtaaggct tcggagctgg
     1801 gaatgacctc agcgttttac aagtacatcc tcaccaccat ggactttccc atcctgcatc
     1861 tggatggtat cgtggaggac tcctccaaca tcctgggctt ttccatgttc aacacctccc
     1921 accccttcta cccagagttt gtgcgcagcc tcaacatgtc ctggagggag aactgtgaag
     1981 ccagcaccta tcctggccct gcgctgtccg cagccctgat gtttgacgct gtgcacgtgg
     2041 tggtaagcgc tgtccgagaa ctgaaccgaa gccaggagat tggcgtcaag ccactggcct
     2101 gcacttcggc caacatttgg ccccatggga ccagccttat gaactacctt cgaatggtag
     2161 agtatgacgg gctgaccggg cgggttgagt tcaacagcaa agggcagagg accaactaca
     2221 cactacgcat cctggagaag tcccgccagg gccaccgtga gataggggtg tggtactcta
     2281 accggaccct ggccatgaat gccaccaccc tggacatcaa cctgtcacag actctagcca
     2341 acaagactct ggtggtcaca actatcctgg agaacccgta tgttatgcgc cggcccaact
     2401 tccaggcctt gtcagggaat gagcgcttcg agggcttctg cgtggacatg ctcagggagc
     2461 tggccgagct gctgcgcttc cgataccgcc tgcggttggt agaggacgga ctctacgggg
     2521 cacctgagcc caacggttcc tggacaggca tggttggaga actcatcaac cggcagaagg
     2581 cagacctggc tgtggcagcc ttcaccatca ccgccgagag ggagaaggtc atcgacttct
     2641 ccaagccctt catgaccctg gggatcagca tcctctacag ggtgcacatg ggccgcaagc
     2701 ctggctactt ctccttcctg gaccccttct cccctgccgt gtggctcttc atgcttcttg
     2761 cctacctggc tgtcagctgt gtcttgttcc tggctgccag gctgagccct tatgagtggt
     2821 acaacccaca cccgtgtctc cgggcgcgtc cccatatcct ggagaaccag tacacgctgg
     2881 gcaacagcct ctggttcccc gtgggtggct tcatgcagca gggctcggag atcatgccgc
     2941 gggcactgtc cacacgctgt gtcagcggag tctggtgggc cttcaccttg atcatcatct
     3001 cctcctacac ggccaacctg gctgccttcc tcacggtgca gcgcatggag gtgccggtgg
     3061 agtcggctga cgacctggcg gatcagacca acattgagta cggcactatc cacgctggct
     3121 ccaccatgac cttcttccag aactcgcggt accagacgta ccagcggatg tggaactaca
     3181 tgcaatcgaa gcagcccagc gtgtttgtca agagcacaga ggagggaatc gcccgcgtcc
     3241 tcaactcccg ctatgccttc ctgctggagt ccaccatgaa cgagtaccac aggcgcctca
     3301 attgcaacct cacccagatc gggggcctcc tcgacaccaa gggctacggc atcggcatgc
     3361 cgctgggctc ccctttccgg gatgagatca cactggccat cctgcagctc caggagaaca
     3421 acaggctgga gatcctgaag cgcaagtggt gggagggcgg ccggtgcccc aaggaggagg
     3481 accacagggc caaaggtttg ggcatggaga acattggcgg catttttgtc gtgctgatct
     3541 gtggcctcat cattgctgtc ttcgtggcgg tcatggagtt catctggtcc acgcggaggt
     3601 cagcggagtc cgaggaggtg tcggtgtgcc aggagatgct gcaggagcta cgccacgccg
     3661 tgtcttgccg aaagacctcg cgttcccgcc ggcgccggcg ccctggtggc ccgagccggg
     3721 ccctgctgtc gctgcgcgca gtccgcgaga tgcgactcag caacggcaag ctctactcgg
     3781 ccggcgcggg cggggacgcg ggcgcgcacg ggggtccgca gcgcctcctg gacgaccccg
     3841 gacctcctgg gggaccccgg ccccaggctc ccacgccctg cacgcacgtg cgcgtctgcc
     3901 aggagtgcag gcgcatccag gcgctgcgag cttcgggggc cggggcgccc ccacgtggcc
     3961 tgggcacccc agccgaagcc accagcccgc ctcggccgcg gccaggcccc accggacccc
     4021 gcgagctgac cgagcacgaa tgaccgtgga cggggccggg cgtgcgcccc gactgactgc
     4081 agggacgcga tgcgccccag acggacagga cgccgcgatt ttgccttcaa ttcctggtga
     4141 agtccgagcc cggctccgga gcaggcctgc gcctcctagt ggacttgagc aagggtgtcg
     4201 cggacgcccg cattctatcc cgcaccgtgg acgggaggag cgcagagacc gaggactcta
     4261 agggccacgg actgtggggg ctgctcccgg agttggaaag cggtccgcgg ggaggacccc
     4321 aacctgggac tgcccagatg ccccaagact tgacacggct ctccacactt ctggaggtgg
     4381 ggagggcctc tggacatgtg ggtgtcccct ggtgcccctc tcttctcttt ctctcttttt
     4441 tggggggaga aacctcagaa atttctatga gacgccccca gggagagggt ctcttgggcc
     4501 cctatacctc cccctgccac atcccagtcc tgttggaata aaaaaaagaa caaaacccca
     4561 aaa
//
