LOCUS       NM_175481               3488 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus glutamate receptor, ionotropic, kainate 4 (Grik4),
            mRNA.
ACCESSION   NM_175481
VERSION     NM_175481.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3488)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3488)
  AUTHORS   Spirkova,A., Kovarikova,V., Sefcikova,Z., Pisko,J., Ksinanova,M.,
            Koppel,J., Fabian,D. and Cikos,S.
  TITLE     Glutamate can act as a signaling molecule in mouse preimplantation
            embryosdagger
  JOURNAL   Biol Reprod 107 (4), 916-927 (2022)
   PUBMED   35746896
REFERENCE   3  (bases 1 to 3488)
  AUTHORS   Kinare,V., Iyer,A., Padmanabhan,H., Godbole,G., Khan,T., Khatri,Z.,
            Maheshwari,U., Muralidharan,B. and Tole,S.
  TITLE     An evolutionarily conserved Lhx2-Ldb1 interaction regulates the
            acquisition of hippocampal cell fate and regional identity
  JOURNAL   Development 147 (20) (2020)
   PUBMED   32994168
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3488)
  AUTHORS   Luo,L., Ambrozkiewicz,M.C., Benseler,F., Chen,C., Dumontier,E.,
            Falkner,S., Furlanis,E., Gomez,A.M., Hoshina,N., Huang,W.H.,
            Hutchison,M.A., Itoh-Maruoka,Y., Lavery,L.A., Li,W., Maruo,T.,
            Motohashi,J., Pai,E.L., Pelkey,K.A., Pereira,A., Philips,T.,
            Sinclair,J.L., Stogsdill,J.A., Traunmuller,L., Wang,J., Wortel,J.,
            You,W., Abumaria,N., Beier,K.T., Brose,N., Burgess,H.A.,
            Cepko,C.L., Cloutier,J.F., Eroglu,C., Goebbels,S., Kaeser,P.S.,
            Kay,J.N., Lu,W., Luo,L., Mandai,K., McBain,C.J., Nave,K.A.,
            Prado,M.A.M., Prado,V.F., Rothstein,J., Rubenstein,J.L.R.,
            Saher,G., Sakimura,K., Sanes,J.R., Scheiffele,P., Takai,Y.,
            Umemori,H., Verhage,M., Yuzaki,M., Zoghbi,H.Y., Kawabe,H. and
            Craig,A.M.
  TITLE     Optimizing Nervous System-Specific Gene Targeting with Cre Driver
            Lines: Prevalence of Germline Recombination and Influencing Factors
  JOURNAL   Neuron 106 (1), 37-65 (2020)
   PUBMED   32027825
REFERENCE   5  (bases 1 to 3488)
  AUTHORS   Kool,M.J., Proietti Onori,M., Borgesius,N.Z., van de Bree,J.E.,
            Elgersma-Hooisma,M., Nio,E., Bezstarosti,K., Buitendijk,G.H.S.,
            Aghadavoud Jolfaei,M., Demmers,J.A.A., Elgersma,Y. and van
            Woerden,G.M.
  TITLE     CAMK2-Dependent Signaling in Neurons Is Essential for Survival
  JOURNAL   J Neurosci 39 (28), 5424-5439 (2019)
   PUBMED   31064859
REFERENCE   6  (bases 1 to 3488)
  AUTHORS   Grove,E.A. and Tole,S.
  TITLE     Patterning events and specification signals in the developing
            hippocampus
  JOURNAL   Cereb Cortex 9 (6), 551-561 (1999)
   PUBMED   10498273
REFERENCE   7  (bases 1 to 3488)
  AUTHORS   Jablonska,B., Smith,A.L., Kossut,M. and Skangiel-Kramska,J.
  TITLE     Development of laminar distributions of kainate receptors in the
            somatosensory cortex of mice
  JOURNAL   Brain Res 791 (1-2), 325-329 (1998)
   PUBMED   9593973
REFERENCE   8  (bases 1 to 3488)
  AUTHORS   Tole,S., Christian,C. and Grove,E.A.
  TITLE     Early specification and autonomous development of cortical fields
            in the mouse hippocampus
  JOURNAL   Development 124 (24), 4959-4970 (1997)
   PUBMED   9362459
REFERENCE   9  (bases 1 to 3488)
  AUTHORS   Zhang,C., Hammassaki-Britto,D.E., Britto,L.R. and Duvoisin,R.M.
  TITLE     Expression of glutamate receptor subunit genes during development
            of the mouse retina
  JOURNAL   Neuroreport 8 (1), 335-340 (1996)
   PUBMED   9051806
REFERENCE   10 (bases 1 to 3488)
  AUTHORS   Szpirer,C., Molne,M., Antonacci,R., Jenkins,N.A., Finelli,P.,
            Szpirer,J., Riviere,M., Rocchi,M., Gilbert,D.J., Copeland,N.G. et
            al.
  TITLE     The genes encoding the glutamate receptor subunits KA1 and KA2
            (GRIK4 and GRIK5) are located on separate chromosomes in human,
            mouse, and rat
  JOURNAL   Proc Natl Acad Sci U S A 91 (25), 11849-11853 (1994)
   PUBMED   7527545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK032029.1 and AC136903.6.
            
            [WARNING] On Jul 16, 2024 this sequence was replaced by
            NM_175481.6.
            
            On Aug 28, 2010 this sequence version replaced NM_175481.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032029.1, AK080582.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2820              AK032029.1         2-2821
            2821-3488           AC136903.6         130374-131041       c
FEATURES             Location/Qualifiers
     source          1..3488
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 23.8 cM"
     gene            1..3488
                     /gene="Grik4"
                     /gene_synonym="6330551K01Rik; GluK4; GluRgamma1; KA-1;
                     KA1"
                     /note="glutamate receptor, ionotropic, kainate 4"
                     /db_xref="GeneID:110637"
                     /db_xref="MGI:MGI:95817"
     exon            1..45
                     /gene="Grik4"
                     /gene_synonym="6330551K01Rik; GluK4; GluRgamma1; KA-1;
                     KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            46..150
                     /gene="Grik4"
                     /gene_synonym="6330551K01Rik; GluK4; GluRgamma1; KA-1;
                     KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            151..282
                     /gene="Grik4"
                     /gene_synonym="6330551K01Rik; GluK4; GluRgamma1; KA-1;
                     KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            283..447
                     /gene="Grik4"
                     /gene_synonym="6330551K01Rik; GluK4; GluRgamma1; KA-1;
                     KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            448..545
                     /gene="Grik4"
                     /gene_synonym="6330551K01Rik; GluK4; GluRgamma1; KA-1;
                     KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..711
                     /gene="Grik4"
                     /gene_synonym="6330551K01Rik; GluK4; GluRgamma1; KA-1;
                     KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            712..890
                     /gene="Grik4"
                     /gene_synonym="6330551K01Rik; GluK4; GluRgamma1; KA-1;
                     KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..944
                     /gene="Grik4"
                     /gene_synonym="6330551K01Rik; GluK4; GluRgamma1; KA-1;
                     KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1106
                     /gene="Grik4"
                     /gene_synonym="6330551K01Rik; GluK4; GluRgamma1; KA-1;
                     KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1259
                     /gene="Grik4"
                     /gene_synonym="6330551K01Rik; GluK4; GluRgamma1; KA-1;
                     KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1364
                     /gene="Grik4"
                     /gene_synonym="6330551K01Rik; GluK4; GluRgamma1; KA-1;
                     KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1472
                     /gene="Grik4"
                     /gene_synonym="6330551K01Rik; GluK4; GluRgamma1; KA-1;
                     KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1676
                     /gene="Grik4"
                     /gene_synonym="6330551K01Rik; GluK4; GluRgamma1; KA-1;
                     KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1790
                     /gene="Grik4"
                     /gene_synonym="6330551K01Rik; GluK4; GluRgamma1; KA-1;
                     KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1900
                     /gene="Grik4"
                     /gene_synonym="6330551K01Rik; GluK4; GluRgamma1; KA-1;
                     KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2074
                     /gene="Grik4"
                     /gene_synonym="6330551K01Rik; GluK4; GluRgamma1; KA-1;
                     KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2240
                     /gene="Grik4"
                     /gene_synonym="6330551K01Rik; GluK4; GluRgamma1; KA-1;
                     KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2466
                     /gene="Grik4"
                     /gene_synonym="6330551K01Rik; GluK4; GluRgamma1; KA-1;
                     KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2595
                     /gene="Grik4"
                     /gene_synonym="6330551K01Rik; GluK4; GluRgamma1; KA-1;
                     KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..2714
                     /gene="Grik4"
                     /gene_synonym="6330551K01Rik; GluK4; GluRgamma1; KA-1;
                     KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2715..3488
                     /gene="Grik4"
                     /gene_synonym="6330551K01Rik; GluK4; GluRgamma1; KA-1;
                     KA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3451..3456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grik4"
                     /gene_synonym="6330551K01Rik; GluK4; GluRgamma1; KA-1;
                     KA1"
                     /note="hexamer: ATTAAA"
     polyA_site      3456
                     /gene="Grik4"
                     /gene_synonym="6330551K01Rik; GluK4; GluRgamma1; KA-1;
                     KA1"
                     /note="major polyA site"
     polyA_site      3472
                     /gene="Grik4"
                     /gene_synonym="6330551K01Rik; GluK4; GluRgamma1; KA-1;
                     KA1"
ORIGIN      
        1 aacgtcgggt ccccagcttg gcgcccggag tgcggagccg cccagatacc gtgtgagtac
       61 ctactatgtg ccagtctgtg ccaggcactg gggacacagg tggaaaagtc cgagttgttc
      121 cctgcttttc tggttctcat tgtcccggag cgttatgtca tgcccagacc agcagagggc
      181 tccatgagga gttatagaag atgccccgtg tctccgctcc tctggtgctg cttcctgctt
      241 ggctcttgat ggtggcctgt agcccacact ccctgaggat tgctgctatc ttggatgacc
      301 ccatggagtg cagcagaggg gaacggctct ccatcaccct ggccaagaac cgtatcaacc
      361 gcgcaccaga gaggctgggc aaggccaagg tcgaagtgga catctttgag cttctcagag
      421 acagcgagta cgaaactgca gaaaccatgt gtcagatcct ccccaagggt gtggtcgctg
      481 tcctgggacc atcgtccagc ccagcctcca gctccatcat cagcaacatc tgtggagaga
      541 aggaggtccc tcatttcaag gtggccccag aggaatttgt caggttccaa ctccagagat
      601 tcaccaccct gaaccttcac cccagcaaca ccgacatcag cgtggctgtg gctgggatcc
      661 tgaacttctt caactgcacc accgcctgcc tcatctgtgc caaagcagaa tgccttttaa
      721 acctggagaa gctgctccga caattcctta tctccaagga cacactctcg gtccggatgt
      781 tggacgacac acgggacccc actccactcc tcaaggagat ccgggatgac aagacagcta
      841 ctatcatcat ccacgccaac gcctccatgt cgcacaccat cctcctgaag gcagctgaac
      901 tggggatggt gtcagcctat tacacataca tcttcaccaa tctggagttc tccctccaga
      961 gaatggacag ccttgtggat gatagagtca acatcttagg attttccatt ttcaaccaat
     1021 cccatgcatt cttccaagag ttctcccaga gcctcaacca atcctggcag gagaactgtg
     1081 accatgtgcc cttcaccggc cctgcgttgt cctcagccct gctgtttgac gctgtctatg
     1141 ctgtggtgac agcggtacag gaactgaacc ggagccaaga gattggtgtg aagcccctgt
     1201 cctgtggctc agcccagatc tggcagcatg gcaccagcct catgaactac cttcgcatgg
     1261 tagaattgga aggtcttacc ggccacattg aattcaacag caaaggccag aggtccaact
     1321 atgccttgaa aatcttacag ttcaccagga atgggtttca gcagattggc cagtggcatg
     1381 tggcagaggg cctcagcatg gacagccgcc tctacgcctc caacatctct gacagtctct
     1441 tcaacaccac cctggtcgtc accaccatcc tggaaaaccc atacttaatg ctgaagggga
     1501 accaccagga gatggaaggc aatgaccgat atgagggatt ctgtgtggac atgctcaagg
     1561 agttggctga gatcctacgg ttcaactaca agatccgcct tgttggggat ggtgtttacg
     1621 gcgtacctga ggccaacggc acctggacag gcatggttgg ggagctgatc gctcggaaag
     1681 cggatctggc tgtggcgggc ctcaccatca cagcggaacg tgagaaagtg atcgatttct
     1741 ccaagccatt catgacgctg ggaattagta ttctttacag agttcatatg ggacgcagac
     1801 cgggctattt ctccttcctg gatccctttt ctccaggagt ctggctcttc atgcttctag
     1861 cttatctggc ggtcagctgt gtcctcttcc tggtggctcg gttgactcct tatgagtggt
     1921 acagtccaca tccttgtgcg cagggccggt gtaatctcct ggtcaaccag tactccctgg
     1981 gcaacagcct ctggtttccg gttggaggct tcatgcagca aggctccact attgcccctc
     2041 gagctttgtc tacccgctgt gtcagtggtg tctggtgggc attcacgttg atcatcatct
     2101 cctcctacac ggccaacctg gcagccttcc tgactgtgca gcgcatggag gtgcccattg
     2161 agtctgtgga tgacctggct gaccagactg ccattgagta tggcacgatt catggaggct
     2221 ccagcatgac cttcttccaa aattcccgtt accagaccta ccaacgcatg tggaactaca
     2281 tgtactccaa gcagccgagt gtgttcgtga agagcacgga ggaggggatt gccagagtgt
     2341 tgaattccaa ttacgccttc ctgctggagt ctaccatgaa tgagtactac cggcagcgaa
     2401 actgcaacct cactcagatt gggggcctgc tggacaccaa gggctatggg attggcatgc
     2461 cagtcggctc agtgttccgg gatgagttcg acctggccat tctccagctg caggagaaca
     2521 accgcctgga aattctgaag cggaagtggt gggaaggggg aaaatgtccc aaggaggagg
     2581 accatcgagc caaaggcctg ggaatggaga atattggtgg aatctttgtg gttcttattt
     2641 gtggcttaat agtggccatt tttatggcta tgctggagtt tttgtggact ctcagacact
     2701 cagaagcatc agaggtgtct gtgtgtcagg agatggtgac agaactgcgc aacatcatcc
     2761 tgtgccagga caatatccat cccaggcggc ggcgctctgg aggcctgcca ccccagcccc
     2821 cggtcctgga ggagcgccga cccagaggca cagcgacgct cagcaatggc aagctatgtg
     2881 gcgccgggga gccagaccag ctggcgcaga gactggcaca ggaggccgcc ctagtagctc
     2941 gaggctgcac gcacatccgc gtgtgcccag agtgccgccg cttccagggc ctgcgggcgc
     3001 gaccgtcgcc agcgcgcagc gaggagagcc tggagtggga caagaccacc aacagcagcg
     3061 agcccgagta gtggcagcag cgaaggacca tggagccagg cggggaggcg ggagggctaa
     3121 cattacaagt tccttctctc cggattcaag attcaatgac tttacaaagc gatctgagcc
     3181 tgctgcccca gcaggaggcg gatctccctg ccctgtggca gagcggccta tccgagatga
     3241 gacactgcac ccacgtggca gagacgctgt ccctcgtggg cacaaggacc catctcctcc
     3301 cagagagcct ttccctcaca ctcaaataag tggattctgg gttgtggggc cctgccgaga
     3361 gagcagtcca agaattgatg gtgtcatcag ttgaattccc cctaggaagg ggccattgta
     3421 ccctgggtct agttcttaca ggaaaaaaaa attaaactca acagggaagt tttcttttct
     3481 gaatttgt
//
